{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:33:31Z","timestamp":1792802011879,"version":"4.5.0"},"reference-count":78,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Grants-in-Aid from the Japan Society for the Promotion of Science","award":["#16K08078"],"award-info":[{"award-number":["#16K08078"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Grants-in-Aid from the Japan Society for the Promotion of Science","award":["#20K06418"],"award-info":[{"award-number":["#20K06418"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Nihon University College of Bioresource Sciences Research Grant","award":["2019-2021"],"award-info":[{"award-number":["2019-2021"]}],"id":[{"id":"https:\/\/ror.org\/05jk51a88","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Nihon University College of Bioresource Sciences Research Grant","award":["2019-2021"],"award-info":[{"award-number":["2019-2021"]}],"id":[{"id":"https:\/\/ror.org\/05jk51a88","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Secretogranin II (SgII) and III (SgIII) function within peptide hormone-producing cells and are involved in secretory granule formation. However, their function in active amine-producing cells is not fully understood. In this study, we analyzed the expression profiles of SgII and SgIII in canine adrenal medulla and pheochromocytomas by immunohistochemical staining. In normal adrenal tissues, the intensity of coexpression of these two secretogranins (Sgs) differed from each chromaffin cell, although a complete match was not observed. The coexpression of vesicular monoamine transporter 2 (VMAT2) with SgIII was similar to that with chromogranin A, but there was a subpopulation of VMAT2-expressing cells that were negative or hardly detectable for SgII. These results are the first to indicate that there are distinct expression patterns for SgII and SgIII in adrenal chromaffin cells. Furthermore, the expression of these two Sgs varied in intensity among pheochromocytomas and did not necessarily correlate with clinical plasma catecholamine levels in patients. However, compared with SgIII, the expression of SgII was shown to be strong at the single-cell level in some tumor tissues. These findings provide a fundamental understanding of the expression differences between SgII and SgIII in normal adrenal chromaffin cells and pheochromocytomas.<\/jats:p>","DOI":"10.1369\/00221554221091000","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T08:20:11Z","timestamp":1649492411000},"page":"335-356","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas"],"prefix":"10.1369","volume":"70","author":[{"given":"Hiroshi","family":"Gomi","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy, College of Bioresource Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nagumo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Bioresource Sciences"},{"name":"Nihon University, Fujisawa, Japan; Division of Companion Animal Surgery, Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University, Morioka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-7974","authenticated-orcid":false,"given":"Kazushi","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Bioresource Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Konosu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy, College of Bioresource Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy, College of Bioresource Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Torii","sequence":"additional","affiliation":[{"name":"Center for Food Science and Wellness, Gunma University, Maebashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hosaka","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"bibr1-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(91)90012-K"},{"key":"bibr2-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021405"},{"key":"bibr3-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0027"},{"key":"bibr4-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-038"},{"key":"bibr5-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(93)90058-M"},{"key":"bibr6-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1740473"},{"key":"bibr7-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.064196"},{"key":"bibr8-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12029"},{"key":"bibr9-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.02-03-0040"},{"key":"bibr10-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310104200"},{"key":"bibr11-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90377-R"},{"key":"bibr12-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)00060-U"},{"key":"bibr13-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161802"},{"key":"bibr14-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03893-9"},{"key":"bibr15-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000112574.07422.C1"},{"key":"bibr16-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000139884.81390.56"},{"key":"bibr17-00221554221091000","doi-asserted-by":"publisher","DOI":"10.2174\/1389203054546334"},{"issue":"4","key":"bibr18-00221554221091000","volume":"57","author":"Schober M","year":"1987","journal-title":"Lab Invest"},{"key":"bibr19-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492518"},{"key":"bibr20-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38833-7"},{"issue":"3","key":"bibr21-00221554221091000","first-page":"394","volume":"67","author":"Lloyd RV","year":"1992","journal-title":"Lab Invest"},{"key":"bibr22-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388804"},{"key":"bibr23-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1021\/bi0156963"},{"key":"bibr24-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100812"},{"key":"bibr25-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.3.721"},{"key":"bibr26-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.6.1505"},{"key":"bibr27-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-09-03135.1990"},{"key":"bibr28-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100211"},{"key":"bibr29-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.67.57"},{"key":"bibr30-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00857.x"},{"key":"bibr31-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/1044-7431(91)90018-J"},{"key":"bibr32-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1385\/EP:14:1:3"},{"key":"bibr33-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0006"},{"key":"bibr34-00221554221091000","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.5024"},{"key":"bibr35-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415575032"},{"key":"bibr36-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1369\/0022155421996845"},{"key":"bibr37-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-336"},{"key":"bibr38-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.196.1.251"},{"key":"bibr39-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-09-06179.1995"},{"key":"bibr40-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8059-y"},{"key":"bibr41-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.06.002"},{"key":"bibr42-00221554221091000","first-page":"766","volume-title":"Tumors in domestic animals","author":"Rosol TJ","year":"2017","edition":"5"},{"key":"bibr43-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00464.x"},{"key":"bibr44-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00636"},{"key":"bibr45-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.20-0427"},{"key":"bibr46-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1369\/0022155414545224"},{"key":"bibr47-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"bibr48-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp202"},{"key":"bibr49-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80108-8"},{"key":"bibr50-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/BF02736730"},{"key":"bibr51-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.5166"},{"key":"bibr52-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00049-2"},{"issue":"1","key":"bibr53-00221554221091000","volume":"1404","author":"Tooze SA","year":"1998","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"bibr54-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01907-3"},{"key":"bibr55-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0531"},{"key":"bibr56-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1060"},{"issue":"8","key":"bibr57-00221554221091000","volume":"83","author":"Anouar Y","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr58-00221554221091000","doi-asserted-by":"publisher","DOI":"10.3109\/07435809809032678"},{"key":"bibr59-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.04.023"},{"key":"bibr60-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000127634.38052.84"},{"key":"bibr61-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-010-9203-2"},{"issue":"3","key":"bibr62-00221554221091000","volume":"360","author":"Hoflehner J","year":"1995","journal-title":"FEBS Lett"},{"key":"bibr63-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.17755"},{"key":"bibr64-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0206rev"},{"key":"bibr65-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0817rev"},{"key":"bibr66-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1100-5"},{"key":"bibr67-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10993"},{"key":"bibr68-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb07476.x"},{"key":"bibr69-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-010-9575-z"},{"key":"bibr70-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5198(19)52558-6"},{"key":"bibr71-00221554221091000","volume":"248","author":"Baum D","year":"1985","journal-title":"Am J Physiol"},{"key":"bibr72-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00026-8"},{"key":"bibr73-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021748"},{"key":"bibr74-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1530\/JME-11-0077"},{"key":"bibr75-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1353.056"},{"key":"bibr76-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2004.t01-1-apm1121005.x"},{"key":"bibr77-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.02.011"},{"key":"bibr78-00221554221091000","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-010-9585-x"}],"container-title":["Journal of Histochemistry &amp; Cytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/00221554221091000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1369\/00221554221091000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/00221554221091000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:25:41Z","timestamp":1777501541000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1369\/00221554221091000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,9]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1369\/00221554221091000"],"URL":"https:\/\/doi.org\/10.1369\/00221554221091000","relation":{},"ISSN":["0022-1554","1551-5044"],"issn-type":[{"value":"0022-1554","type":"print"},{"value":"1551-5044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,9]]}}}