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Synaptic vesicles release neurotransmitters that activate their effector tissues. However, the mechanisms by which neurotransmitters exert individual responses to renal effector cells remain unknown. Here, we investigated the spatial and molecular compositional associations of renal Schwann cells (SC) supporting the nerve terminals in male rats. The nerve terminals of vascular smooth muscle cells (SMCs) enclosed by renal SC processes were exposed through windows facing the effectors with presynaptic specializations. We found that the adrenergic receptors (ARs) \u03b12A, \u03b12C, and \u03b22 were localized in the SMC and the basal side of the tubules, where the nerve terminals were attached, whereas the other subtypes of ARs were distributed in the glomerular and luminal side, where the norepinephrine released from nerve endings may have indirect access to ARs. In addition, integrins \u03b14 and \u03b21 were coexpressed in the nerve terminals. Thus, renal nerve terminals could contact their effectors via integrins and may have a structure, covered by SC processes, suitable for intensive and directional release of neurotransmitters into the blood, rather than specialized structures in the postsynaptic region.<\/jats:p>","DOI":"10.1369\/00221554221106812","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T09:53:51Z","timestamp":1655373231000},"page":"495-513","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Morphology of Schwann Cell Processes Supports Renal Sympathetic Nerve Terminals With Local Distribution of Adrenoceptors"],"prefix":"10.1369","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-7785","authenticated-orcid":false,"given":"Seishi","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell 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