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While its expression has been extensively studied in various tissues, its presence in the nervous system, particularly in peripheral glial cells, remains largely unexplored. In this study, we examined WT1 expression in the Schwann cells of mechanosensory corpuscles, nerve bundles, and free nerve endings (FNEs) within human penile tissues. Using single and double immunohistology, we analyzed WT1 coexpression with Schwann cell markers (S100, nestin, SOX10) and its association with axonal (neurofilaments, neuron-specific enolase, tyrosine hydroxylase) and perineurial\/endoneurial markers (Glut-1, \u03b1-SMA, CD34). We found consistent WT1 cytoplasmic expression in the Schwann cells of Pacinian, Meissner, Krause, genital, Golgi-Mazzoni, and Ruffini-like corpuscles, with variable staining intensity. Confocal microscopy revealed WT1 colocalized with nestin but not S100, suggesting involvement in cytoskeletal organization. In addition, we documented WT1 in myelinating Schwann cells of nerve bundles, with distinct staining patterns in Cajal bands and Schmidt\u2013Lanterman incisures, as well as in non-myelinating Schwann cells of FNEs. This is the first study to describe WT1 expression in sensory corpuscles, implicating it in Schwann cell development, maintenance, or plasticity, with potential relevance for peripheral nerve biology, pathology, and mechanosensation.<\/jats:p>","DOI":"10.1369\/00221554251338066","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T08:28:11Z","timestamp":1747729691000},"page":"197-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Human Mechanosensory Corpuscles: A New Schwann Cell Localization of the Wilms\u2019 Tumor Protein WT1"],"prefix":"10.1369","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-2733","authenticated-orcid":false,"given":"Alfonso","family":"Cepeda-Emiliani","sequence":"first","affiliation":[{"name":"Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-5776","authenticated-orcid":false,"given":"Mar\u00eda","family":"Otero-Al\u00e9n","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Garc\u00eda-Caballero","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Department of Pathology, University Clinical Hospital, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-4680","authenticated-orcid":false,"given":"Rosal\u00eda","family":"Gallego","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-1263","authenticated-orcid":false,"given":"Luc\u00eda","family":"Garc\u00eda-Caballero","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Zelen\u00e1 J. 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