{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:42:48Z","timestamp":1777851768645,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"VTR Fimlab","award":["X5211"],"award-info":[{"award-number":["X5211"]}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","award":["2024"],"award-info":[{"award-number":["2024"]}],"id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008368","name":"Suomen Tuberkuloosin Vastustamisyhdistyksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","award":["2024, 2025"],"award-info":[{"award-number":["2024, 2025"]}],"id":[{"id":"10.13039\/501100008368","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Chemokine-like receptor 1 (CMKLR-1) is a G-protein-coupled receptor that functions as the binding site of chemerin. It induces chemotaxis in various immune cells, and it has recently been linked to vascular remodeling in inflammation. In this study, we investigated CMKLR-1 expression in human aorta samples, focusing on its distribution across different cell types and its potential association with clinical and histomorphological data, particularly concerning aortic dissection and aneurysms. We analyzed 62 aorta samples taken from patients undergoing dissection surgery (n = 27) or aneurysm\/dilatation (n = 35) using immunohistochemical CMKLR-1 staining. CMKLR-1 expression was primarily observed in the smooth muscle cells (SMCs) of the aortic media layer, and band-like coloring appeared in the unstained center section. CMKLR-1 positivity in the inner and outer parts of the media layer was observed in only a few cases. One-third of the vasa vasorum exhibited staining. Staining in lymphocytes, macrophages, and endothelia was rare. No significant differences in CMKLR-1 expression were found between the dissection and aneurysm cases, and the clinical or histomorphological data. Although CMKLR-1 expression did not distinguish between the studied conditions, its presence in the aortic media, especially in SMCs, is noteworthy.<\/jats:p>","DOI":"10.1369\/00221554251350743","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T05:26:34Z","timestamp":1750742794000},"page":"237-249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity"],"prefix":"10.1369","volume":"73","author":[{"given":"Hannes","family":"\u00d6ster","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"},{"name":"Department of Pathology, Fimlab Laboratories, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7768-2642","authenticated-orcid":false,"given":"Trina","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"},{"name":"Department of Pathology, Fimlab Laboratories, Tampere, Finland"},{"name":"Department of Cardiothoracic Surgery, Tampere University Heart Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Mennander","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"},{"name":"Department of Cardiothoracic Surgery, Tampere University Heart Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Paavonen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"},{"name":"Department of Pathology, Fimlab Laboratories, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-0450","authenticated-orcid":false,"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"},{"name":"Department of Pathology, Fimlab Laboratories, Tampere, Finland"},{"name":"Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Department of Clinical Pathology, Diagnostic Imaging Centre, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"issue":"13","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.3390\/diagnostics13132166","article-title":"Thoracic aorta: anatomy and pathology","volume":"13","author":"di Gioia CRT","year":"2023","unstructured":"di Gioia CRT, Ascione A, Carletti R, Giordano C. Thoracic aorta: anatomy and pathology. Diagnostics. 2023;13(13):2166.","journal-title":"Diagnostics"},{"key":"e_1_3_3_3_2","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult","volume":"35","author":"Erbel R","year":"2014","unstructured":"Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenw\u00f6ger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ; ESC Committee for Practice Guidelines. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. Eur Heart J. 2014;35:2873\u2013926.","journal-title":"Eur Heart J"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIR.0b013e3181d47d48","article-title":"American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines; American Association for Thoracic Surgery; American College of Radiology; American Stroke Association; Society of Cardiovascular Anesthesiologists; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology; Society of Thoracic Surgeons; Society for Vascular Medicine. 2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","volume":"121","author":"Hiratzka LF","year":"2010","unstructured":"Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey DEJr., Eagle KA, Hermann LK, Isselbacher EM, Kazerooni EA, Kouchoukos NT, Lytle BW, Milewicz DM, Reich DL, Sen S, Shinn JA, Svensson LG, Williams DM; American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines; American Association for Thoracic Surgery; American College of Radiology; American Stroke Association; Society of Cardiovascular Anesthesiologists; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology; Society of Thoracic Surgeons; Society for Vascular Medicine. 2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation. 2010;121:266\u2013369.","journal-title":"Circulation"},{"issue":"4","key":"e_1_3_3_5_2","doi-asserted-by":"crossref","DOI":"10.1007\/s40292-013-0026-z","article-title":"Aortic wall stress in hypertension and ascending thoracic aortic aneurysms: implications for antihypertensive therapy","volume":"20","author":"Rabkin SW","year":"2013","unstructured":"Rabkin SW, Janusz MT. Aortic wall stress in hypertension and ascending thoracic aortic aneurysms: implications for antihypertensive therapy. High Blood Press Cardiovasc Prev. 2013;20(4):265\u201371.","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"2","key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/biom10020182","article-title":"The genetics of thoracic aortic aneurysms and dissection: a clinical perspective","volume":"10","author":"Ostberg NP","year":"2020","unstructured":"Ostberg NP, Zafar MA, Ziganshin BA, Elefteriades JA. 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Obesity and acute type A aortic dissection: unraveling surgical outcomes through the lens of the upper hemisternotomy approach. Front Cardiovasc Med. 2024;11:1301895.","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"e_1_3_3_10_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"Bl\u00fcher M.","year":"2019","unstructured":"Bl\u00fcher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288\u201398.","journal-title":"Nat Rev Endocrinol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-012-9230-8"},{"issue":"6","key":"e_1_3_3_12_2","article-title":"Effects of chemerin\/CMKLR1 in obesity-induced hypertension and potential mechanism","volume":"9","author":"Weng C","year":"2017","unstructured":"Weng C, Shen Z, Li X, Jiang W, Peng L, Yuan H, Yang K, Wang J. 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J Exp Med. 2005;201:509\u201315.","journal-title":"J Exp Med"},{"issue":"8","key":"e_1_3_3_21_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2006.03.011","article-title":"Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands","volume":"34","author":"Zabel BA","year":"2006","unstructured":"Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. 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Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J Immunol. 2005;174(1):244\u201351.","journal-title":"J Immunol"},{"issue":"9","key":"e_1_3_3_24_2","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2006-08-038844","article-title":"The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues","volume":"109","author":"Parolini S","year":"2007","unstructured":"Parolini S, Santoro A, Marcenaro E, Luini W, Massardi L, Facchetti F, Communi D, Parmentier M, Majorana A, Sironi M, Tabellini G, Moretta A, Sozzani S. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. 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