{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:42:53Z","timestamp":1777851773802,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","award":["PICT2020-02080"],"award-info":[{"award-number":["PICT2020-02080"]}]},{"name":"Pontificia Universidad Cat\u00f3lica Argentina"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide, with a mortality rate almost equal to its incidence, highlighting the urgent need for novel biomarkers and therapeutic targets. This pilot study aims to investigate the potential value of histamine H\n                    <jats:sub>3<\/jats:sub>\n                    receptor (H\n                    <jats:sub>3<\/jats:sub>\n                    R) as a prognostic biomarker for this lethal disease. We analyzed the H\n                    <jats:sub>3<\/jats:sub>\n                    R expression in PDAC using the RNA sequencing data set from The Cancer Genome Atlas (Pan-Cancer Atlas). In addition, H\n                    <jats:sub>3<\/jats:sub>\n                    R protein levels were evaluated by immunohistochemistry in 27 PDAC samples and compared with adjacent preneoplastic pancreatic tissue of the same patient, and with 10 non-related healthy pancreatic tissues. This preliminary study shows that the H\n                    <jats:sub>3<\/jats:sub>\n                    R is barely expressed in healthy tissue. Interestingly, H\n                    <jats:sub>3<\/jats:sub>\n                    R was detected in 96% of PDAC samples, and its expression in tumoral tissue was significantly higher when compared with its expression in preneoplastic tissue, and it was associated with a better prognosis in terms of overall survival. Present findings suggest that H\n                    <jats:sub>3<\/jats:sub>\n                    R may serve as a potential prognostic biomarker in PDAC. Future research aimed at elucidating the role of H\n                    <jats:sub>3<\/jats:sub>\n                    R in PDAC biology and its prognostic value in larger patient cohorts is warranted:\n                  <\/jats:p>","DOI":"10.1369\/00221554251410292","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T05:10:03Z","timestamp":1767330603000},"page":"181-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Expression of Histamine H\n                    <sub>3<\/sub>\n                    Receptor In Healthy, Preneoplastic, and Tumoral Pancreatic Tissue: A Pilot Study"],"prefix":"10.1369","volume":"74","author":[{"given":"Daniela","family":"Speisky","sequence":"first","affiliation":[{"name":"Pathology Department, British Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melisa B.","family":"Nicoud","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina, Buenos Aires, Argentina, and National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Iotti","sequence":"additional","affiliation":[{"name":"Pathology Department, British Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-8547","authenticated-orcid":false,"given":"Karina","family":"Formoso","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina, Buenos Aires, Argentina, and National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Lauretta","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina, Buenos Aires, Argentina, and National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-5035","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Garc\u00eda de D\u00e1vila","sequence":"additional","affiliation":[{"name":"Pathology Department, British Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-0729","authenticated-orcid":false,"given":"Vanina A.","family":"Medina","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina, Buenos Aires, Argentina, and National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"issue":"10242","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi JD","year":"2020","unstructured":"Mizrahi JD, Surana R, Valle JW, Shroff RT. 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