{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:29:29Z","timestamp":1784773769669,"version":"3.55.0"},"reference-count":124,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["GM155451"],"award-info":[{"award-number":["GM155451"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["GM120457"],"award-info":[{"award-number":["GM120457"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases","award":["DK123704"],"award-info":[{"award-number":["DK123704"]}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["GM132055"],"award-info":[{"award-number":["GM132055"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    The gastrointestinal tract harbors a dynamic microbial ecosystem that interfaces with the intestinal epithelium. Among this community,\n                    <jats:italic toggle=\"yes\">Akkermansia muciniphila<\/jats:italic>\n                    , a mucin-degrading microbe, has garnered attention for its impact on gut health. While well studied in the colon, its influence on the small intestine remains underexplored. To examine direct effects of\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    , we used gnotobiotic mice. Germ-free mice were inoculated with Brain Heart Infusion (BHI) media or 10\u2079 viable\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    in BHI. After 21 days, small intestinal tissue was collected. Fluorescence in situ hybridization confirmed\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    colonization. Immunofluorescence staining revealed increased epithelial cell proliferation, unchanged goblet cell numbers, but altered mucus composition with reduced fucose residues. Tuft cell numbers and group 2 innate lymphoid cells (ILC2s) were also elevated in\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    -colonized mice. Analysis of conditioned media and the\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    genome identified succinate production, a metabolite known to expand tuft cells. Thus,\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    alone is sufficient to increase tuft cells in the small intestine, potentially via succinate signaling. These findings reveal a novel role for\n                    <jats:italic toggle=\"yes\">A. muciniphila<\/jats:italic>\n                    in regulating gastrointestinal homeostasis.\n                  <\/jats:p>","DOI":"10.1369\/00221554261417734","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:27:46Z","timestamp":1771237666000},"page":"215-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Akkermansia muciniphila<\/i>\n                    Selectively Reshapes Small Intestinal Cell Populations"],"prefix":"10.1369","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-1399","authenticated-orcid":false,"given":"Rachel","family":"Edens-Valentine","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-1875","authenticated-orcid":false,"given":"Kristen A.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-9932","authenticated-orcid":false,"given":"Melinda A.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology"},{"name":"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-3240","authenticated-orcid":false,"given":"Amy C.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01226-07","article-title":"The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract","volume":"74","author":"Derrien M","year":"2008","unstructured":"Derrien M, Collado MC, Ben-Amor K, Salminen S, de Vos WM. The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Appl Environ Microbiol. 2008;74:1646\u20138.","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1186\/s12864-017-4195-3","article-title":"Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diversity, and global distribution in mammalian gut microbiotas","volume":"18","author":"Guo X","year":"2017","unstructured":"Guo X, Li S, Zhang J, Wu F, Li X, Wu D, Zhang M, Ou Z, Jie Z, Yan Q, Li P, Yi J, Peng Y. Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diversity, and global distribution in mammalian gut microbiotas. BMC Genomics. 2017;18:800.","journal-title":"BMC Genomics"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"2025017","DOI":"10.1080\/19490976.2021.2025017","article-title":"The evolution and competitive strategies of Akkermansia muciniphila in gut","volume":"14","author":"Kim JS","year":"2022","unstructured":"Kim JS, Kang SW, Lee JH, Park SH, Lee JS. The evolution and competitive strategies of Akkermansia muciniphila in gut. Gut Microbes. 2022;14:2025017.","journal-title":"Gut Microbes"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"957439","DOI":"10.3389\/fcimb.2022.957439","article-title":"A thousand metagenome-assembled genomes of Akkermansia reveal phylogroups and geographical and functional variations in the human gut","volume":"12","author":"Lv QB","year":"2022","unstructured":"Lv QB, Li S, Zhang Y, Guo R, Wang YC, Peng Y, Zhang XX. A thousand metagenome-assembled genomes of Akkermansia reveal phylogroups and geographical and functional variations in the human gut. Front Cell Infect Microbiol. 2022;12:957439.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2019-320105","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice","volume":"69","author":"Wang L","year":"2020","unstructured":"Wang L, Tang L, Feng Y, Zhao S, Han M, Zhang C, Yuan G, Zhu J, Cao S, Wu Q, Li L, Zhang Z. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice. Gut. 2020;69:1988\u201397.","journal-title":"Gut"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.281"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16643"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard A","year":"2013","unstructured":"Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Nat Acad Sci. 2013;110:9066\u201371.","journal-title":"Proc Nat Acad Sci"},{"key":"e_1_3_3_10_2","article-title":"The role of Akkermansia muciniphila in inflammatory bowel disease: current knowledge and perspectives","volume":"13","author":"Zheng M","year":"2022","unstructured":"Zheng M, Han R, Yuan Y, Xing Y, Zhang W, Sun Z, Liu Y, Li J, Mao T. The role of Akkermansia muciniphila in inflammatory bowel disease: current knowledge and perspectives. Front Immunol. 2022;13:1089600.","journal-title":"Front Immunol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","DOI":"10.1038\/oby.2012.110","article-title":"The microbiota of the gut in preschool children with normal and excessive body weight","volume":"20","author":"Karlsson CL","year":"2012","unstructured":"Karlsson CL, Onnerf\u00e4lt J, Xu J, Molin G, Ahrn\u00e9 S, Thorngren-Jerneck K. The microbiota of the gut in preschool children with normal and excessive body weight. Obesity (Silver Spring). 2012;20:2257\u201361.","journal-title":"Obesity (Silver Spring)"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308778"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard A","year":"2013","unstructured":"Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Nat Acad Sci. 2013;110:9066\u201371.","journal-title":"Proc Nat Acad Sci"},{"key":"e_1_3_3_14_2","article-title":"Human gut microbiota changes reveal the progression of glucose intolerance","volume":"8","author":"Zhang X","year":"2013","unstructured":"Zhang X, Shen D, Fang Z, Jie Z, Qiu X, Zhang C, Chen Y, Ji L. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS ONE. 2013;8:e71108.","journal-title":"PLoS ONE"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01137"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118680"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510000176"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.191320"},{"key":"e_1_3_3_19_2","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin NR","year":"2014","unstructured":"Shin NR, Lee JC, Lee HY, Kim MS, Whon TW, Lee MS, Bae JW. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2014;63:727\u201335.","journal-title":"Gut"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier H","year":"2017","unstructured":"Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 2017;23:107\u201313.","journal-title":"Nat Med"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11450"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/JME-16-0054"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier C","year":"2019","unstructured":"Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne NM, de Barsy M, Loumaye A, Hermans MP, Thissen JP, de Vos WM, Cani PD. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25:1096\u2013103.","journal-title":"Nat Med"},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fcimb.2019.00239","article-title":"Strain-specific anti-inflammatory properties of two Akkermansia muciniphila strains on chronic colitis in mice","volume":"9","author":"Zhai R","year":"2019","unstructured":"Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C. Strain-specific anti-inflammatory properties of two Akkermansia muciniphila strains on chronic colitis in mice. Front Cell Infect Microbiol. 2019;9:239.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"22119","DOI":"10.1038\/s41598-020-79171-8","article-title":"Modulation of serotonin signaling\/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice","volume":"10","author":"Yaghoubfar R","year":"2020","unstructured":"Yaghoubfar R, Behrouzi A, Ashrafian F, Shahryari A, Moradi HR, Choopani S, Hadifar S, Vaziri F, Nojoumi SA, Fateh A, Khatami S, Siadat SD. Modulation of serotonin signaling\/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice. Sci Rep. 2020;10:22119.","journal-title":"Sci Rep"},{"key":"e_1_3_3_26_2","article-title":"Function of Akkermansia muciniphila in type 2 diabetes and related diseases","volume":"14","author":"Li J","year":"2023","unstructured":"Li J, Yang G, Zhang Q, Liu Z, Jiang X, Xin Y. Function of Akkermansia muciniphila in type 2 diabetes and related diseases. Front Microbiol. 2023;14:1172400.","journal-title":"Front Microbiol"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.15605\/jafes.037.01.13","article-title":"Review of literature on Akkermansia muciniphila and its possible role in the etiopathogenesis and therapy of type 2 diabetes mellitus","volume":"37","author":"Sanjiwani MID","year":"2022","unstructured":"Sanjiwani MID, Aryadi IPH, Semadi IMS. Review of literature on Akkermansia muciniphila and its possible role in the etiopathogenesis and therapy of type 2 diabetes mellitus. J ASEAN Fed Endocr Soc. 2022;37:69\u201374.","journal-title":"J ASEAN Fed Endocr Soc"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","DOI":"10.1007\/s40200-024-01438-y","article-title":"Insights from the potential impact of pasteurized Akkermansia muciniphila in zebrafish models of obesity and diabetes","volume":"23","author":"Hoseini Tavassol Z","year":"2024","unstructured":"Hoseini Tavassol Z, Ejtahed HS, Hasani-Ranjbar S. Insights from the potential impact of pasteurized Akkermansia muciniphila in zebrafish models of obesity and diabetes. J Diabetes Metab Disord. 2024;23:2407\u20139.","journal-title":"J Diabetes Metab Disord"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s40200-024-01518-z","article-title":"Fecal microbiota transplantation as a potential therapeutic approach to improve impaired glucose tolerance via gut microbiota modulation in rat model","volume":"24","author":"Bhatia Z","year":"2025","unstructured":"Bhatia Z, Kumar S, Seshadri S. Fecal microbiota transplantation as a potential therapeutic approach to improve impaired glucose tolerance via gut microbiota modulation in rat model. J Diabetes Metab Disord. 2025;24:28.","journal-title":"J Diabetes Metab Disord"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13073-016-0271-6","article-title":"Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes","volume":"8","author":"Yassour M","year":"2016","unstructured":"Yassour M, Lim MY, Yun HS, Tickle TL, Sung J, Song YM, Lee K, Franzosa EA, Morgan XC, Gevers D, Lander ES, Xavier RJ, Birren BW, Ko G, Huttenhower C. Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes. Genome Med. 2016;8:17.","journal-title":"Genome Med"},{"key":"e_1_3_3_31_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/jgh.16747","article-title":"Role of Akkermansia muciniphila in insulin resistance","volume":"40","author":"Zeng Z","year":"2025","unstructured":"Zeng Z, Chen M, Liu Y, Zhou Y, Liu H, Wang S, Ji Y. Role of Akkermansia muciniphila in insulin resistance. J Gastroenterol Hepatol. 2025;40:19\u201332.","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13329"},{"key":"e_1_3_3_33_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.12.010","article-title":"Akkermansia muciniphila supplementation in patients with overweight\/obese type 2 diabetes: efficacy depends on its baseline levels in the gut","volume":"37","author":"Zhang Y","year":"2025","unstructured":"Zhang Y, Liu R, Chen Y, Cao Z, Liu C, Bao R, Wang Y, Huang S, Pan S, Qin L, Wang J, Ning G, Wang W. Akkermansia muciniphila supplementation in patients with overweight\/obese type 2 diabetes: efficacy depends on its baseline levels in the gut. Cell Metab. 2025;37:592\u2013605.e6.","journal-title":"Cell Metab"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","DOI":"10.1080\/10408398.2018.1517725","article-title":"A next generation probiotic, Akkermansia muciniphila","volume":"59","author":"Zhai Q","year":"2019","unstructured":"Zhai Q, Feng S, Arjan N, Chen W. A next generation probiotic, Akkermansia muciniphila. Crit Rev Food Sci Nutr. 2019;59:3227\u201336.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2016.02.005","article-title":"Akkermansia muciniphila and its role in regulating host functions","volume":"106","author":"Derrien M","year":"2017","unstructured":"Derrien M, Belzer C, de Vos WM. Akkermansia muciniphila and its role in regulating host functions. Microb Pathog. 2017;106:171\u201381.","journal-title":"Microb Pathog"},{"key":"e_1_3_3_36_2","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani PD","year":"2022","unstructured":"Cani PD, Depommier C, Derrien M, Everard A, de Vos WM. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol. 2022;19:625\u201337.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"e_1_3_3_37_2","article-title":"Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment","volume":"14","author":"Qu S","year":"2023","unstructured":"Qu S, Zheng Y, Huang Y, Feng Y, Xu K, Zhang W, Wang Y, Nie K, Qin M. Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment. Front Microbiol. 2023;14:1111911.","journal-title":"Front Microbiol"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00692-13"},{"key":"e_1_3_3_39_2","article-title":"Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults","volume":"8","author":"Weir TL","year":"2013","unstructured":"Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP. Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS ONE. 2013;8:e70803.","journal-title":"PLoS ONE"},{"key":"e_1_3_3_40_2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1303795","article-title":"Akkermansia muciniphila\u2013friend or foe in colorectal cancer?","volume":"14","author":"Gubernatorova EO","year":"2023","unstructured":"Gubernatorova EO, Gorshkova EA, Bondareva MA, Podosokorskaya OA, Sheynova AD, Yakovleva AS, Bonch-Osmolovskaya EA, Nedospasov SA, Kruglov AA, Drutskaya MS. Akkermansia muciniphila\u2013friend or foe in colorectal cancer? Front Immunol. 2023;14:1303795.","journal-title":"Front Immunol"},{"key":"e_1_3_3_41_2","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.1038\/s41598-025-96514-5","article-title":"Baseline abundance of Akkermansia muciniphila and Bacteroides acidifaciens in a healthy state predicts inflammation associated tumorigenesis in the AOM\/DSS mouse model","volume":"15","author":"Achasova KM","year":"2025","unstructured":"Achasova KM, Snytnikova OA, Chanushkina KE, Morozova MV, Tsentalovich YP, Kozhevnikova EN. Baseline abundance of Akkermansia muciniphila and Bacteroides acidifaciens in a healthy state predicts inflammation associated tumorigenesis in the AOM\/DSS mouse model. Sci Rep. 2025;15:12241.","journal-title":"Sci Rep"},{"key":"e_1_3_3_42_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41564-023-01464-1","article-title":"Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice","volume":"8","author":"Parrish A","year":"2023","unstructured":"Parrish A, Boudaud M, Grant ET, Willieme S, Neumann M, Wolter M, Craig SZ, De Sciscio A, Cosma A, Hunewald O, Ollert M, Desai MS. Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice. Nat Microbiol. 2023;8:1863\u201379.","journal-title":"Nat Microbiol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai MS","year":"2016","unstructured":"Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, N\u00fa\u00f1ez G, Martens EC. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell. 2016;167:1339\u201353.e21.","journal-title":"Cell"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay6218"},{"key":"e_1_3_3_45_2","article-title":"Host genetic background and gut microbiota contribute to differential metabolic responses to fructose consumption in mice","volume":"150","author":"Ahn IS","year":"2020","unstructured":"Ahn IS, Lang JM, Olson CA, Diamante G, Zhang G, Ying Z, Byun HR, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis AJ, Hsiao EY, Yang X. Host genetic background and gut microbiota contribute to differential metabolic responses to fructose consumption in mice. J Nutr. 2020;150:2716\u201328.","journal-title":"J Nutr"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04698-22"},{"key":"e_1_3_3_47_2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s44320-024-00036-7","article-title":"Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility","volume":"20","author":"Wolter M","year":"2024","unstructured":"Wolter M, Grant ET, Boudaud M, Pudlo NA, Pereira GV, Eaton KA, Martens EC, Desai MS Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility. Mol Syst Biol. 2024;20:596\u2013625.","journal-title":"Mol Syst Biol"},{"key":"e_1_3_3_48_2","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1507645112","article-title":"Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon","volume":"112","author":"Ijssennagger N","year":"2015","unstructured":"Ijssennagger N, Belzer C, Hooiveld GJ, Dekker J, van Mil SW, M\u00fcller M, Kleerebezem M, van der Meer R. Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon. Proc Natl Acad Sci U S A. 2015;112:10038\u201343.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_3_3_49_2","article-title":"Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation","volume":"209","author":"Jenq RR","year":"2012","unstructured":"Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, Liu C, West ML, Singer NV, Equinda MJ, Gobourne A, Lipuma L, Young LF, Smith OM, Ghosh A, Hanash AM, Goldberg JD, Aoyama K, Blazar BR, Pamer EG, van den Brink MR. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med. 2012;209:903\u201311.","journal-title":"J Exp Med"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2311"},{"key":"e_1_3_3_51_2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay7713","article-title":"Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation","volume":"12","author":"Khuat LT","year":"2020","unstructured":"Khuat LT, Le CT, Pai CS, Shields-Cutler RR, Holtan SG, Rashidi A, Parker SL, Knights D, Luna JI, Dunai C, Wang Z, Sturgill IR, Stoffel KM, Merleev AA, More SK, Maverakis E, Raybould HE, Chen M, Canter RJ, Monjazeb AM, Dave M, Ferrara JLM, Levine JE, Longo DL, Abedi M, Blazar BR, Murphy WJ. Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation. Sci Transl Med. 2020;12:eaay7713.","journal-title":"Sci Transl Med"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00600-9"},{"key":"e_1_3_3_53_2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo3445","article-title":"Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment","volume":"14","author":"Schwabkey ZI","year":"2022","unstructured":"Schwabkey ZI, Wiesnoski DH, Chang CC, Tsai WB, Pham D, Ahmed SS, Hayase T, Ortega Turrubiates MR, El-Himri RK, Sanchez CA, Hayase E, Frenk Oquendo AC, Miyama T, Halsey TM, Heckel BE, Brown AN, Jin Y, Raybaud M, Prasad R, Flores I, McDaniel L, Chapa V, Lorenzi PL, Warmoes MO, Tan L, Swennes AG, Fowler S, Conner M, McHugh K, Graf T, Jensen VB, Peterson CB, Do KA, Zhang L, Shi Y, Wang Y, Galloway-Pena JR, Okhuysen PC, Daniel-MacDougall CR, Shono Y, Burgos da, Silva M, Peled JU, van den Brink MRM, Ajami N, Wargo JA, Reddy P, Valdivia RH, Davey L, Rondon G, Srour SA, Mehta RS, Alousi AM, Shpall EJ, Champlin RE, Shelburne SA, Molldrem JJ, Jamal MA, Karmouch JL, Jenq RR. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment. Sci Transl Med. 2022;14:eabo3445.","journal-title":"Sci Transl Med"},{"key":"e_1_3_3_54_2","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-012-2564-7","article-title":"Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse","volume":"55","author":"Hansen CH","year":"2012","unstructured":"Hansen CH, Krych L, Nielsen DS, Vogensen FK, Hansen LH, S\u00f8rensen SJ, Buschard K, Hansen AK. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. Diabetologia. 2012;55:2285\u201394.","journal-title":"Diabetologia"},{"key":"e_1_3_3_55_2","article-title":"Galacto-oligosaccharides regulate intestinal mucosalsialylation to counteract antibiotic-induced mucin dysbiosis","volume":"15","author":"Xu L","year":"2024","unstructured":"Xu L, Li X, Han S, Mu C, Zhu W. Galacto-oligosaccharides regulate intestinal mucosalsialylation to counteract antibiotic-induced mucin dysbiosis. Food Funct. 2024;15:12016\u201332.","journal-title":"Food Funct"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00156-z"},{"key":"e_1_3_3_57_2","article-title":"Potential of Akkermansia muciniphila and its outer membrane proteins as therapeutic targets for neuropsychological diseases","volume":"14","author":"Zhang F","year":"2023","unstructured":"Zhang F, Wang D. Potential of Akkermansia muciniphila and its outer membrane proteins as therapeutic targets for neuropsychological diseases. Front Microbiol. 2023;14:1191445.","journal-title":"Front Microbiol"},{"key":"e_1_3_3_58_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12915-020-00775-7","article-title":"Parkinson\u2019s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions","volume":"18","author":"Baldini F","year":"2020","unstructured":"Baldini F, Hertel J, Sandt E, Thinnes CC, Neuberger-Castillo L, Pavelka L, Betsou F, Kr\u00fcger R, Thiele I; NCER-PD Consortium. Parkinson\u2019s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions. BMC Biology. 2020;18:62.","journal-title":"BMC Biology"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.18067"},{"key":"e_1_3_3_60_2","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.3390\/jcm10235698","article-title":"Differences in the composition of gut microbiota between patients with Parkinson\u2019s disease and healthy controls: a cohort study","volume":"10","author":"Zapa\u0142a B","year":"2021","unstructured":"Zapa\u0142a B, Stefura T, W\u00f3jcik-P\u0119dziwiatr M, Kabut R, Ba\u0142ajewicz-Nowak M, Milewicz T, Dudek A, St\u00f3j A, Rudzi\u0144ska-Bar M. Differences in the composition of gut microbiota between patients with Parkinson\u2019s disease and healthy controls: a cohort study. J Clin Med. 2021;10:5698.","journal-title":"J Clin Med"},{"key":"e_1_3_3_61_2","article-title":"Microbiota composition and metabolism are associated with gut function in Parkinson\u2019s disease","volume":"35","author":"Cirstea MS","year":"2020","unstructured":"Cirstea MS, Yu AC, Golz E, Sundvick K, Kliger D, Radisavljevic N, Foulger LH, Mackenzie M, Huan T, Finlay BB, Appel-Cresswell S. Microbiota composition and metabolism are associated with gut function in Parkinson\u2019s disease. Mov Disord. 2020;35:1208\u201317.","journal-title":"Mov Disord"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0428-y"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27105"},{"key":"e_1_3_3_64_2","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.593969","article-title":"Intestinal morphogenesis in development, regeneration, and disease: the potential utility of intestinal organoids for studying compartmentalization of the crypt-villus structure","volume":"8","author":"Kwon O","year":"2020","unstructured":"Kwon O, Han TS, Son MY. Intestinal morphogenesis in development, regeneration, and disease: the potential utility of intestinal organoids for studying compartmentalization of the crypt-villus structure. Front Cell Dev Biol. 2020;8:593969.","journal-title":"Front Cell Dev Biol"},{"key":"e_1_3_3_65_2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3389\/fcell.2021.661931","article-title":"The intestinal epithelium\u2013fluid fate and rigid structure from crypt bottom to villus tip","volume":"9","author":"Bonis V","year":"2021","unstructured":"Bonis V, Rossell C, Gehart H. The intestinal epithelium\u2013fluid fate and rigid structure from crypt bottom to villus tip. Front Cell Dev Biol. 2021;9:596\u2013625.","journal-title":"Front Cell Dev Biol"},{"key":"e_1_3_3_66_2","doi-asserted-by":"crossref","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker N","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003\u20137.","journal-title":"Nature"},{"key":"e_1_3_3_67_2","doi-asserted-by":"crossref","first-page":"108633","DOI":"10.1016\/j.celrep.2020.108633","article-title":"A constant pool of Lgr5(+) intestinal stem cells is required for intestinal homeostasis","volume":"34","author":"Tan SH","year":"2021","unstructured":"Tan SH, Phuah P, Tan LT, Yada S, Goh J, Tomaz LB, Chua M, Wong E, Lee B, Barker N. A constant pool of Lgr5(+) intestinal stem cells is required for intestinal homeostasis. Cell Rep. 2021;34:108633.","journal-title":"Cell Rep"},{"key":"e_1_3_3_68_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-0747-3_1","article-title":"Identification and isolation of human LGR5+ cells using an antibody-based strategy","volume":"2171","author":"Dame MK","year":"2020","unstructured":"Dame MK, Huang S, Attili D, Spence JR, Colacino JA. Identification and isolation of human LGR5+ cells using an antibody-based strategy. Methods Mol Biol. 2020;2171:3\u201323.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07935"},{"key":"e_1_3_3_70_2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.micinf.2005.04.003","article-title":"The role of enterocytes in the intestinal barrier function and antigen uptake","volume":"7","author":"Snoeck V","year":"2005","unstructured":"Snoeck V, Goddeeris B, Cox E. The role of enterocytes in the intestinal barrier function and antigen uptake. Microbes Infect. 2005;7:997\u20131004.","journal-title":"Microbes Infect"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12182"},{"key":"e_1_3_3_72_2","article-title":"Intestinal mucus and their glycans: a habitat for thriving microbiota","volume":"31","author":"Luis AS","year":"2023","unstructured":"Luis AS, Hansson GC. Intestinal mucus and their glycans: a habitat for thriving microbiota. Cell Host Microbe. 2023;31:1087\u2013100.","journal-title":"Cell Host Microbe"},{"key":"e_1_3_3_73_2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3389\/fimmu.2020.00587","article-title":"The Paneth cell: the curator and defender of the immature small intestine","volume":"11","author":"Lueschow SR","year":"2020","unstructured":"Lueschow SR, McElroy SJ. The Paneth cell: the curator and defender of the immature small intestine. Front Immunol. 2020;11:587.","journal-title":"Front Immunol"},{"key":"e_1_3_3_74_2","doi-asserted-by":"crossref","first-page":"14330","DOI":"10.1038\/s41598-020-71113-8","article-title":"Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro","volume":"10","author":"Kostopoulos I","year":"2020","unstructured":"Kostopoulos I, Elzinga J, Ottman N, Klievink JT, Blijenberg B, Aalvink S, Boeren S, Mank M, Knol J, de Vos WM, Belzer C. Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro. Sci Rep. 2020;10:14330.","journal-title":"Sci Rep"},{"key":"e_1_3_3_75_2","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.000444","article-title":"Microbe profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa","volume":"163","author":"de Vos WM","year":"2017","unstructured":"de Vos WM. Microbe profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa. Microbiology (Reading). 2017;163:646\u20138.","journal-title":"Microbiology"},{"key":"e_1_3_3_76_2","doi-asserted-by":"crossref","first-page":"880024","DOI":"10.3389\/fphys.2022.880024","article-title":"Acinetobacter calcoaceticus is well adapted to withstand intestinal stressors and modulate the gut epithelium","volume":"13","author":"Glover JS","year":"2022","unstructured":"Glover JS, Browning BD, Ticer TD, Engevik AC, Engevik MA. Acinetobacter calcoaceticus is well adapted to withstand intestinal stressors and modulate the gut epithelium. Front Physiol. 2022;13:880024.","journal-title":"Front Physiol"},{"key":"e_1_3_3_77_2","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1038\/s41598-022-11819-z","article-title":"Characterizing the mucin-degrading capacity of the human gut microbiota","volume":"12","author":"Glover JS","year":"2022","unstructured":"Glover JS, Ticer TD, Engevik MA. Characterizing the mucin-degrading capacity of the human gut microbiota. Sci Rep. 2022;12:8456.","journal-title":"Sci Rep"},{"key":"e_1_3_3_78_2","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.4c01401","article-title":"Revealing glycosylation patterns in in vitro-produced mucus exposed to pasteurized mucus-associated intestinal microbes by MALDI-TOF-MS and PGC-LC-MS\/MS","volume":"72","author":"de Ram C","year":"2024","unstructured":"de Ram C, van der Lugt B, Elzinga J, Geerlings S, Steegenga WT, Belzer C, Schols HA. Revealing glycosylation patterns in in vitro-produced mucus exposed to pasteurized mucus-associated intestinal microbes by MALDI-TOF-MS and PGC-LC-MS\/MS. J Agri Food Chem. 2024;72:15345\u201356.","journal-title":"J Agri Food Chem"},{"key":"e_1_3_3_79_2","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01014-17","article-title":"Genome-scale model and omics analysis of metabolic capacities of Akkermansia muciniphila reveal a preferential mucin-degrading lifestyle","volume":"83","author":"Ottman N","year":"2017","unstructured":"Ottman N, Davids M, Suarez-Diez M, Boeren S, Schaap PJ, Martins Dos Santos VAP, Smidt H, Belzer C, de Vos WM. Genome-scale model and omics analysis of metabolic capacities of Akkermansia muciniphila reveal a preferential mucin-degrading lifestyle. Appl Environ Microbiol. 2017;83:e01014\u20137.","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_3_80_2","first-page":"1","article-title":"Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development","volume":"13","author":"Kim S","year":"2021","unstructured":"Kim S, Shin YC, Kim TY, Kim Y, Lee YS, Lee SH, Kim MN O E, Kim KS, Kweon MN. Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development. Gut Microbes. 2021;13:1\u201320.","journal-title":"Gut Microbes"},{"key":"e_1_3_3_81_2","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.3390\/cells11172666","article-title":"Akkermansia muciniphila reduces peritonitis and improves intestinal tissue wound healing after a colonic transmural defect by a MyD88-dependent mechanism","volume":"11","author":"Bachmann R","year":"2022","unstructured":"Bachmann R, Van Hul M, Baldin P, L\u00e9onard D, Delzenne NM, Belzer C, Ouwerkerk JP, Repsilber D, Rangel I, Kartheuser A, Brummer RJ, De Vos WM, Cani PD. Akkermansia muciniphila reduces peritonitis and improves intestinal tissue wound healing after a colonic transmural defect by a MyD88-dependent mechanism. Cells. 2022;11:2666.","journal-title":"Cells"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2015.21"},{"key":"e_1_3_3_83_2","doi-asserted-by":"crossref","first-page":"2293312","DOI":"10.1080\/19490976.2023.2293312","article-title":"Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid","volume":"15","author":"He KY","year":"2023","unstructured":"He KY, Lei XY, Wu DH, Zhang L, Li JQ, Li QT, Yin WT, Zhao ZL, Liu H, Xiang XY, Zhu LJ, Cui CY, Wang KK, Wang JH, Lv L, Sun QH, Liu GL, Xu ZX, Jian YP. Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid. Gut Microbes. 2023;15:2293312.","journal-title":"Gut Microbes"},{"key":"e_1_3_3_84_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12979-019-0145-z","article-title":"Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 (-\/\u03947) mice","volume":"16","author":"van der Lugt B","year":"2019","unstructured":"van der Lugt B, van Beek AA, Aalvink S, Meijer B, Sovran B, Vermeij WP, Brandt RMC, de Vos WM, Savelkoul HFJ, Steegenga WT, Belzer C. Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 (-\/\u03947) mice. Immun Ageing. 2019;16:6.","journal-title":"Immun Ageing"},{"key":"e_1_3_3_85_2","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00078-24","article-title":"Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut","volume":"15","author":"Gaifem J","year":"2024","unstructured":"Gaifem J, Mendes-Frias A, Wolter M, Steimle A, Garz\u00f3n MJ, Ubeda C, Nobre C, Gonz\u00e1lez A, Pinho SS, Cunha C, Carvalho A, Castro AG, Desai MS, Rodrigues F, Silvestre R. Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut. mBio. 2024;15:e0007824.","journal-title":"mBio"},{"key":"e_1_3_3_86_2","article-title":"Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis","volume":"9","author":"Wang X","year":"2023","unstructured":"Wang X, Lin S, Wang L, Cao Z, Zhang M, Zhang Y, Liu R, Liu J. Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis. Sci Adv. 2023;9:eade5079.","journal-title":"Sci Adv"},{"key":"e_1_3_3_87_2","doi-asserted-by":"crossref","DOI":"10.1111\/j.1462-2920.2011.02533.x","article-title":"Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats","volume":"13","author":"Van den Abbeele P","year":"2011","unstructured":"Van den Abbeele P, G\u00e9rard P, Rabot S, Bruneau A, El Aidy S, Derrien M, Kleerebezem M, Zoetendal EG, Smidt H, Verstraete W, Van de Wiele T, Possemiers S. Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats. Environ Microbiol. 2011;13:2667\u201380.","journal-title":"Environ Microbiol"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00166"},{"key":"e_1_3_3_89_2","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01416-08","article-title":"Development of chemically defined media supporting high-cell-density growth of lactococci, enterococci, and streptococci","volume":"75","author":"Zhang G","year":"2009","unstructured":"Zhang G, Mills DA, Block DE. Development of chemically defined media supporting high-cell-density growth of lactococci, enterococci, and streptococci. Appl Environ Microbiol. 2009;75:1080\u20137.","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00767-7"},{"key":"e_1_3_3_91_2","doi-asserted-by":"crossref","first-page":"102540","DOI":"10.1016\/j.xpro.2023.102540","article-title":"A high-throughput protocol for measuring solution pH of bacterial cultures using UV-Vis absorption spectrophotometry","volume":"4","author":"Engevik KA","year":"2023","unstructured":"Engevik KA, Gonzalez H, Daniels C, Stavert RK, Oezguen N, Engevik MA, Horvath TD. A high-throughput protocol for measuring solution pH of bacterial cultures using UV-Vis absorption spectrophotometry. STAR Protoc. 2023;4:102540.","journal-title":"STAR Protoc"},{"key":"e_1_3_3_92_2","article-title":"Optimized protocol for intestinal swiss rolls and immunofluorescent staining of paraffin embedded tissue","volume":"209","author":"Dooley SA","year":"2024","unstructured":"Dooley SA, Stubler R, Edens RM, McKee PR, Rucker JN, Engevik A. Optimized protocol for intestinal swiss rolls and immunofluorescent staining of paraffin embedded tissue. J Vis Exp. 2024;209:e66977.","journal-title":"J Vis Exp"},{"key":"e_1_3_3_93_2","article-title":"The IMG\/M data management and analysis system v.6.0: new tools and advanced capabilities","volume":"49","author":"Chen IA","year":"2021","unstructured":"Chen IA, Chu K, Palaniappan K, Ratner A, Huang J, Huntemann M, Hajek P, Ritter S, Varghese N, Seshadri R, Roux S, Woyke T, Eloe-Fadrosh EA, Ivanova NN, Kyrpides NC. The IMG\/M data management and analysis system v.6.0: new tools and advanced capabilities. Nucleic Acids Res. 2021;49:D751\u201363.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_3_94_2","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen J","year":"2015","unstructured":"Reunanen J, Kainulainen V, Huuskonen L, Ottman N, Belzer C, Huhtinen H, de Vos WM, Satokari R. Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer. Appl Environ Microbiol. 2015;81:3655\u201362.","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_3_95_2","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2009.05.035","article-title":"OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells","volume":"137","author":"van der Flier LG","year":"2009","unstructured":"van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology. 2009;137:15\u20137.","journal-title":"Gastroenterology"},{"key":"e_1_3_3_96_2","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/s41467-023-37533-6","article-title":"Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria","volume":"14","author":"Shuoker B","year":"2023","unstructured":"Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascue\u00f1a AM, Liu J, Nielsen TS, Holgersson J, Nordberg Karlsson E, Juge N, Meier S, Morth JP, Karlsson NG, Abou Hachem M. Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria. Nat Commun. 2023;14:1833.","journal-title":"Nat Commun"},{"key":"e_1_3_3_97_2","doi-asserted-by":"crossref","DOI":"10.1006\/bbrc.1998.9513","article-title":"Cloning of the novel gene intelectin, which is expressed in intestinal Paneth cells in mice","volume":"251","author":"Komiya T","year":"1998","unstructured":"Komiya T, Tanigawa Y, Hirohashi S. Cloning of the novel gene intelectin, which is expressed in intestinal Paneth cells in mice. Biochem Biophys Res Commun. 1998;251:759\u201362.","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_3_3_98_2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.894649","article-title":"Characterization of an intelectin-1 (Itln1) knockout mouse model","volume":"13","author":"Nonnecke EB","year":"2022","unstructured":"Nonnecke EB, Castillo PA, Akahoshi DT, Goley SM, Bevins CL, L\u00f6nnerdal B. Characterization of an intelectin-1 (Itln1) knockout mouse model. Front Immunol. 2022;13:894649.","journal-title":"Front Immunol"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315832"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.016"},{"key":"e_1_3_3_101_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2020.02.005","article-title":"Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity","volume":"52","author":"McGinty JW","year":"2020","unstructured":"McGinty JW, Ting HA, Billipp TE, Nadjsombati MS, Khan DM, Barrett NA, Liang HE, Matsumoto I, von Moltke J. Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity. Immunity. 2020;52:528\u201341.e7.","journal-title":"Immunity"},{"key":"e_1_3_3_102_2","first-page":"1471","article-title":"GATA3 regulates the development and functions of innate lymphoid cell subsets at multiple stages","volume":"8","author":"Zhu J.","year":"2017","unstructured":"Zhu J. GATA3 regulates the development and functions of innate lymphoid cell subsets at multiple stages. Front Immunol. 2017;8:1471.","journal-title":"Front Immunol"},{"key":"e_1_3_3_103_2","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1038\/s41467-024-47275-8","article-title":"The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation","volume":"15","author":"Kang EJ","year":"2024","unstructured":"Kang EJ, Kim JH, Kim YE, Lee H, Jung KB, Chang DH, Lee Y, Park S, Lee EY, Lee EJ, Kang HB, Rhyoo MY, Seo S, Park S, Huh Y, Go J, Choi JH, Choi YK, Lee IB, Choi DH, Seo YJ, Noh JR, Kim KS, Hwang JH, Jeong JS, Kwon HJ, Yoo HM, Son MY, Kim YG, Lee DH, Kim TY, Kwon HJ, Kim MH, Kim BC, Kim YH, Kang D, Lee CH. The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation. Nat Commun. 2024;15:2983.","journal-title":"Nat Commun"},{"key":"e_1_3_3_104_2","doi-asserted-by":"crossref","DOI":"10.1016\/0021-9975(66)90009-0","article-title":"Influence of diet and bacteria on small intestinal morphology, with special reference to early weaning and Escherichia coli. Studies with germfree and gnotobiotic pigs","volume":"76","author":"Kenworthy R","year":"1966","unstructured":"Kenworthy R, Allen WD. Influence of diet and bacteria on small intestinal morphology, with special reference to early weaning and Escherichia coli. Studies with germfree and gnotobiotic pigs. J Comp Pathol. 1966;76:291\u20136.","journal-title":"J Comp Pathol"},{"key":"e_1_3_3_105_2","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/30.11.1880","article-title":"Microbial effects on mucosal structure and function","volume":"30","author":"Abrams GD.","year":"1977","unstructured":"Abrams GD. Microbial effects on mucosal structure and function. Am J Clin Nutr. 1977;30:1880\u20136.","journal-title":"Am J Clin Nutr"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(72)90120-6"},{"key":"e_1_3_3_107_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2025.04.023","article-title":"Growth of the maternal intestine during reproduction","volume":"188","author":"Ameku T","year":"2025","unstructured":"Ameku T, Laddach A, Beckwith H, Milona A, Rogers LS, Schwayer C, Nye E, Tough IR, Thoumas JL, Gautam UK, Wang YF, Jha S, Castano-Medina A, Amourda C, Vaelli PM, Gevers S, Irvine EE, Meyer L, Andrew I, Choi KL, Patel B, Francis AJ, Studd C, Game L, Young G, Murphy KG, Owen B, Withers DJ, Rodriguez-Colman M, Cox HM, Liberali P, Schwarzer M, Leulier F, Pachnis V, Bellono NW, Miguel-Aliaga I. Growth of the maternal intestine during reproduction. Cell. 2025;188:2738\u201356.e22.","journal-title":"Cell"},{"key":"e_1_3_3_108_2","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1038\/s41467-025-60643-2","article-title":"Positional BMP signaling orchestrates villus length in the small intestine","volume":"16","author":"Wang X","year":"2025","unstructured":"Wang X, Li S, Liu Y, Kuang X, Chen J, Yu P, Zhao L, Zhang Z, Huang M, Liu L, Zhang M, Wang Y, Ji W, Li J, Zhang L, Chen YG. Positional BMP signaling orchestrates villus length in the small intestine. Nat Commun. 2025;16:5461.","journal-title":"Nat Commun"},{"key":"e_1_3_3_109_2","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/897639","article-title":"Probiotics (Bifidobacterium longum) increase bone mass density and upregulate Sparc and Bmp-2 genes in rats with bone loss resulting from ovariectomy","volume":"2015","author":"Parvaneh K","year":"2015","unstructured":"Parvaneh K, Ebrahimi M, Sabran MR, Karimi G, Hwei AN, Abdul-Majeed S, Ahmad Z, Ibrahim Z, Jamaluddin R. Probiotics (Bifidobacterium longum) increase bone mass density and upregulate Sparc and Bmp-2 genes in rats with bone loss resulting from ovariectomy. Biomed Res Int. 2015;2015:897639.","journal-title":"Biomed Res Int"},{"key":"e_1_3_3_110_2","doi-asserted-by":"crossref","DOI":"10.2147\/CIA.S169223","article-title":"Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats","volume":"13","author":"Parvaneh M","year":"2018","unstructured":"Parvaneh M, Karimi G, Jamaluddin R, Ng MH, Zuriati I, Muhammad SI. Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats. Clin Interv Aging. 2018;13:1555\u201364.","journal-title":"Clin Interv Aging"},{"key":"e_1_3_3_111_2","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl6543","article-title":"BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia","volume":"7","author":"Lindholm HT","year":"2022","unstructured":"Lindholm HT, Parmar N, Drurey C, Campillo Poveda M, Vornewald PM, Ostrop J, D\u00edez-Sanchez A, Maizels RM, Oudhoff MJ. BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia. Sci Immunol. 2022;7:eabl6543.","journal-title":"Sci Immunol"},{"key":"e_1_3_3_112_2","article-title":"Correction: regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity","volume":"16","author":"Shang K","year":"2025","unstructured":"Shang K, Qi X, Tian T, Shi H, Zhu Y, Zhang F. Correction: regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity. Front Immunol. 2025;16:1636022.","journal-title":"Front Immunol"},{"key":"e_1_3_3_113_2","article-title":"The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu M","year":"2024","unstructured":"Wu M, Wu S, Chen W, Li YP. The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease. Cell Res. 2024;34:101\u201323.","journal-title":"Cell Res"},{"key":"e_1_3_3_114_2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3390\/agriculture14040598","article-title":"Akkermansia muciniphila promotes bone development and improves eggshell quality during the sexual maturity period of laying hens by increasing osteogenesis","volume":"14","author":"Lyu Z","year":"2024","unstructured":"Lyu Z, Zhang Y, Yuan G, Zhang F, Hu Y, Liu D. Akkermansia muciniphila promotes bone development and improves eggshell quality during the sexual maturity period of laying hens by increasing osteogenesis. Agriculture. 2024;14:598.","journal-title":"Agriculture"},{"key":"e_1_3_3_115_2","article-title":"Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength","volume":"8","author":"Liu JH","year":"2021","unstructured":"Liu JH, Chen CY, Liu ZZ, Luo ZW, Rao SS, Jin L, Wan TF, Yue T, Tan YJ, Yin H, Yang F, Huang FY, Guo J, Wang YY, Xia K, Cao J, Wang ZX, Hong CG, Luo MJ, Hu XK, Liu YW, Du W, Luo J, Hu Y, Zhang Y, Huang J, Li HM, Wu B, Liu HM, Chen TH, Qian YX, Li YY, Feng SK, Chen Y, Qi LY, Xu R, Tang SY, Xie H. Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength. Adv Sci (Weinh). 2021;8:2004831.","journal-title":"Adv Sci (Weinh)"},{"key":"e_1_3_3_116_2","doi-asserted-by":"crossref","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume":"529","author":"von Moltke J","year":"2016","unstructured":"von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016;529:221\u20135.","journal-title":"Nature"},{"key":"e_1_3_3_117_2","article-title":"Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach","volume":"111","author":"Chia LW","year":"2018","unstructured":"Chia LW, Hornung BVH, Aalvink S, Schaap PJ, de Vos WM, Knol J, Belzer C. Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach. Antonie Van Leeuwenhoek. 2018;111:859\u201373.","journal-title":"Antonie Van Leeuwenhoek"},{"key":"e_1_3_3_118_2","doi-asserted-by":"crossref","first-page":"906920","DOI":"10.3389\/fmicb.2022.906920","article-title":"Akkermansia muciniphila alters gut microbiota and immune system to improve cardiovascular diseases in murine model","volume":"13","author":"He X","year":"2022","unstructured":"He X, Bai Y, Zhou H, Wu K. Akkermansia muciniphila alters gut microbiota and immune system to improve cardiovascular diseases in murine model. Front Microbiol. 2022;13:906920.","journal-title":"Front Microbiol"},{"key":"e_1_3_3_119_2","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.3390\/ijms22157921","article-title":"Interleukin-4 promotes tuft cell differentiation and acetylcholine production in intestinal organoids of non-human primate","volume":"22","author":"Inaba A","year":"2021","unstructured":"Inaba A, Arinaga A, Tanaka K, Endo T, Hayatsu N, Okazaki Y, Yamane T, Oishi Y, Imai H, Iwatsuki K. Interleukin-4 promotes tuft cell differentiation and acetylcholine production in intestinal organoids of non-human primate. Int J Mol Sci. 2021;22:7921.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_3_120_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-024-07952-6","article-title":"Tuft cells act as regenerative stem cells in the human intestine","volume":"634","author":"Huang L","year":"2024","unstructured":"Huang L, Bernink JH, Giladi A, Krueger D, van Son GJF, Geurts MH, Busslinger G, Lin L, Begthel H, Zandvliet M, Buskens CJ, Bemelman WA, L\u00f3pez-Iglesias C, Peters PJ, Clevers H. Tuft cells act as regenerative stem cells in the human intestine. Nature. 2024;634:929\u201335.","journal-title":"Nature"},{"key":"e_1_3_3_121_2","doi-asserted-by":"crossref","DOI":"10.1042\/BST20253057","article-title":"Tuft cell-mediated pathogen sensing and inflammation resolution","volume":"53","author":"Huang L","year":"2025","unstructured":"Huang L, Peng YY, Yu D. Tuft cell-mediated pathogen sensing and inflammation resolution. Biochem Soc Trans. 2025;53:1445\u201355.","journal-title":"Biochem Soc Trans"},{"key":"e_1_3_3_122_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41564-023-01407-w","article-title":"A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression","volume":"8","author":"Davey LE","year":"2023","unstructured":"Davey LE, Malkus PN, Villa M, Dolat L, Holmes ZC, Letourneau J, Ansaldo E, David LA, Barton GM, Valdivia RH. A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression. Nat Microbiol. 2023;8:1450\u201367.","journal-title":"Nat Microbiol"},{"key":"e_1_3_3_123_2","article-title":"Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?","volume":"13","author":"Lei W","year":"2023","unstructured":"Lei W, Cheng Y, Gao J, Liu X, Shao L, Kong Q, Zheng N, Ling Z, Hu W. Akkermansia muciniphila in neuropsychiatric disorders: friend or foe? Front Cell Infect Microbiol. 2023;13:1224155.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_3_124_2","article-title":"The multifaceted roles of Akkermansia muciniphila in neurological disorders","volume":"48","author":"Ma X","year":"2025","unstructured":"Ma X, Liu Q, Yang G. The multifaceted roles of Akkermansia muciniphila in neurological disorders. Trends Neurosci. 2025;48:403\u201315.","journal-title":"Trends Neurosci"},{"key":"e_1_3_3_125_2","article-title":"The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential","volume":"49","author":"Xu R","year":"2023","unstructured":"Xu R, Zhang Y, Chen S, Zeng Y, Fu X, Chen T, Luo S, Zhang X. The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential. Crit Rev Microbiol. 2023;49:151\u201376.","journal-title":"Crit Rev Microbiol"}],"container-title":["Journal of Histochemistry &amp; Cytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/00221554261417734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1369\/00221554261417734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/00221554261417734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:26:08Z","timestamp":1777501568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1369\/00221554261417734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":124,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1369\/00221554261417734"],"URL":"https:\/\/doi.org\/10.1369\/00221554261417734","relation":{},"ISSN":["0022-1554","1551-5044"],"issn-type":[{"value":"0022-1554","type":"print"},{"value":"1551-5044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]}}}