{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:39:33Z","timestamp":1777851573206,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Inhibins and activins are important regulators of the female reproductive system. A novel inhibin subunit, named \u03b2C, has been identified and demonstrated to be expressed in several human tissues. We demonstrate here that inhibin \u03b2C is expressed in human placenta. Expression of the inhibin \u03b2C subunit was demonstrated at the protein level by means of immunohistochemical evaluation and at the transcriptional level by an inhibin \u03b2C-specific RT-PCR analysis. Expression of inhibin \u03b2C was detected in the human chorionic carcinoma cell lines JEG and BeWo. Although the precise role of this novel inhibin subunit in human placenta development and homeostasis is unclear, analogies with other inhibin sub-units and the strong expression of \u03b2C in normal human trophoblast cells and chorionic carcinoma cells suggest that \u03b2C may be involved in autocrine\/paracrine signaling pathways, angiogenesis, decidualization, and tissue remodeling under normal and malignant conditions. Additionally, JEG and BeWo express \u03b2C and, therefore, can be used as a cell culture model for further functional analysis of this subunit in the human placenta.<\/jats:p>","DOI":"10.1369\/jhc.2010.956185","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T00:29:56Z","timestamp":1273537796000},"page":"751-757","source":"Crossref","is-referenced-by-count":5,"title":["Immunohistochemical Labeling of the Inhibin\/Activin \u03b2C Subunit in Normal Human Placental Tissue and Chorionic Carcinoma Cell Lines"],"prefix":"10.1177","volume":"58","author":[{"given":"Tobias","family":"Weissenbacher","sequence":"first","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Ludwig\u2013Maximilians-University Munich, Munich, Germany (TW,AB,TK,AG,IM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Br\u00fcning","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Ludwig\u2013Maximilians-University Munich, Munich, Germany (TW,AB,TK,AG,IM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Kimmich","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Ludwig\u2013Maximilians-University Munich, Munich, Germany (TW,AB,TK,AG,IM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Makovitzky","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University of Heidelberg, Heidelberg, Germany (JM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gingelmaier","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Ludwig\u2013Maximilians-University Munich, Munich, Germany (TW,AB,TK,AG,IM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Mylonas","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Ludwig\u2013Maximilians-University Munich, Munich, Germany (TW,AB,TK,AG,IM)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,10]]},"reference":[{"key":"bibr1-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341904"},{"key":"bibr2-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem011"},{"key":"bibr3-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-009-0595-z"},{"key":"bibr4-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.04.005"},{"key":"bibr5-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.9.5403"},{"key":"bibr6-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag029"},{"key":"bibr7-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0388"},{"key":"bibr8-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0003"},{"key":"bibr9-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222700201"},{"key":"bibr10-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.103771"},{"key":"bibr11-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.8.743"},{"key":"bibr12-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6850"},{"key":"bibr13-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1715"},{"key":"bibr14-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-008-9194-x"},{"key":"bibr15-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00503-2"},{"key":"bibr16-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080296"},{"key":"bibr17-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2004.05.007"},{"key":"bibr18-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.01657"},{"key":"bibr19-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-7-70"},{"key":"bibr20-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1086"},{"key":"bibr21-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00581.x"},{"key":"bibr22-jhc.2010.956185","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0451"},{"key":"bibr23-jhc.2010.956185","doi-asserted-by":"crossref","unstructured":"Kimmich T, Bruning A, Kaufl SD, Makovitzky J, Kuhn C, Jeschke U, Friese K,  (In Press) Inhibin\/activin-betaC and -betaE sub-units in the Ishikawa human endometrial adenocarcinoma cell line. 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