{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:42:58Z","timestamp":1777851778796,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>\n                    The endothelin\/endothelin-receptor system is a key player in the regulation of vascular tone in mammals. We raised and characterized an antiserum against rat ET\n                    <jats:sub>B<\/jats:sub>\n                    receptor and investigated the distribution of ET\n                    <jats:sub>B<\/jats:sub>\n                    receptors in different vascular beds during postnatal development (day 0 through day 28) and in the adult rat. We report the tissue-specific and age-dependent presence of vasoconstrictor ET\n                    <jats:sub>B<\/jats:sub>\n                    receptors. At the time of birth, vascular smooth muscle cells from all tissues examined did not exhibit ET\n                    <jats:sub>B<\/jats:sub>\n                    receptor immunoreactivity. The occurrence of ET\n                    <jats:sub>B<\/jats:sub>\n                    receptor immunoreactivity in the postnatal development was time dependent and started in small coronary and meningeal arteries at day 5, followed by small mesenteric arteries as well as brachial artery and vein at day 14. At day 21, ET\n                    <jats:sub>B<\/jats:sub>\n                    receptors were present in the media of muscular segments of pulmonary artery, large coronary arteries, and intracerebral arterioles. At day 28, ET\n                    <jats:sub>B<\/jats:sub>\n                    receptor immunoreactivity was evident in interlobular renal arteries, vas afferens, and efferens. Large renal arteries, mesenteric artery, and elastic segments of pulmonary arteries, as well as coronary and mesenteric veins, did not exhibit ET\n                    <jats:sub>B<\/jats:sub>\n                    receptor immunoreactivity. These data demonstrate the age-dependent and tissue-specific presence of ET\n                    <jats:sub>B<\/jats:sub>\n                    receptors, mainly on arterial smooth muscle cells in the vascular system of the rat.\n                  <\/jats:p>","DOI":"10.1369\/jhc.4a6474.2005","type":"journal-article","created":{"date-parts":[[2005,1,31]],"date-time":"2005-01-31T14:43:44Z","timestamp":1107182624000},"page":"187-196","source":"Crossref","is-referenced-by-count":10,"title":["Muscular ET\n                    <sub>B<\/sub>\n                    Receptors Develop Postnatally and Are Differentially Distributed in Specific Segments of the Rat Vasculature"],"prefix":"10.1177","volume":"53","author":[{"given":"Martina","family":"Wendel","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Technical University of Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kummer","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Knels","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Technical University of Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Schmeck","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thea","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Technical University of Dresden, Dresden, 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