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The role of SAA in human malignancies has not been elucidated. We investigated the expression of SAA at various stages of human colon carcinoma progression. Nonradioactive in situ hybridization applied on paraffin tissue sections from 26 colon cancer patients revealed barely detected SAA mRNA expression in normal looking colonic epithelium. Expression was increased gradually as epithelial cells progressed through dysplasia to neoplasia. Deeply invading colon carcinoma cells showed the highest levels of SAA. Expression was also found in colon carcinoma metastases. Cells of lymphoid follicles of the intestinal wall, inflammatory cells, ganglion cells, and endothelial cells, also expressed SAA mRNA. Immunohistochemical staining revealed SAA protein expression that colocalized with SAA mRNA expression. RT-PCR analysis confirmed the expression of the SAA1 and SAA4 genes in colon carcinomas, expression that was barely detectable in normal colon tissues. These findings indicate local and differential expression of SAA in human colon cancer tissues and suggest its role in colonic tumorigenesis.<\/jats:p>","DOI":"10.1369\/jhc.5a6645.2005","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T20:33:33Z","timestamp":1124742813000},"page":"63-73","source":"Crossref","is-referenced-by-count":65,"title":["Expression of Serum Amyloid A, in Normal, Dysplastic, and Neoplastic Human Colonic Mucosa: Implication for a Role in Colonic Tumorigenesis"],"prefix":"10.1177","volume":"54","author":[{"given":"Orit","family":"Gutfeld","sequence":"first","affiliation":[{"name":"Department of Oncology (OG), Hadassah-Hebrew University Medical Center, Mount Scopus and Ein-Kerem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Prus","sequence":"additional","affiliation":[{"name":"Department of Pathology (DP), Hadassah-Hebrew University Medical Center, Mount Scopus and Ein-Kerem, 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