{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:40:49Z","timestamp":1790469649747,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n                    Germinal center dendritic cells (GCDCs) have been identified as CD11c\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    cells located in GCs with the ability of inducing marked proliferation of allogenic T cells. Using immunofluorescence techniques, we have observed that this CD11c\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    immunophenotype identified GCDCs but also a subset of extrafollicular DCs. By flow cytometry, we were able to discriminate the GCDCs (CD11c\n                    <jats:sup>high<\/jats:sup>\n                    CD4\n                    <jats:sup>high<\/jats:sup>\n                    lin\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) from the other tonsil DCs. By immunofluorescence and flow cytometry, we found that dendritic cells of germinal centers express more intracellular adhesion molecule-1 (ICAM-1) (CD54) than extrafollicular dendritic cells. Proliferation of peripheral blood mononuclear cells (PBMCs) induced by coculture with purified CD11c\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD3\n                    <jats:sup>\u2212<\/jats:sup>\n                    DCs was reduced by addition of blocking anti-CD54 antibodies. In summary, distinct levels of ICAM-1 expression allow the distinction between GCDCs and extrafollicular DCs, and cellular interactions mediated by CD54 are likely to play a role in the capacity of GCDC to stimulate allogenic PBMC proliferation.\n                  <\/jats:p>","DOI":"10.1369\/jhc.5a6740.2005","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T20:33:33Z","timestamp":1124742813000},"page":"75-84","source":"Crossref","is-referenced-by-count":9,"title":["Germinal Center Dendritic Cells Express More ICAM-1 Than Extrafollicular Dendritic Cells and ICAM-1\/LFA-1 Interactions are Involved in the Capacity of Dendritic Cells to Induce PBMCs Proliferation"],"prefix":"10.1177","volume":"54","author":[{"given":"Jean-Jacques","family":"Goval","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Liege, CHU of Liege, Liege, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Greimers","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Liege, CHU of Liege, Liege, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Boniver","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Liege, CHU of Liege, Liege, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Liege, CHU of Liege, Liege, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"bibr1-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1038\/42716"},{"key":"bibr2-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80376-3"},{"key":"bibr3-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270531"},{"key":"bibr4-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14736"},{"key":"bibr5-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1128\/jvi.70.12.8997-9002.1996","volume":"70","author":"Christensen JP","year":"1996","journal-title":"J Virol"},{"key":"bibr6-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.4049\/jimmunol.148.11.3327","volume":"148","author":"Clark EA","year":"1992","journal-title":"J Immunol"},{"key":"bibr7-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4049\/jimmunol.160.4.1666","volume":"160","author":"de Saint-Vis B","year":"1998","journal-title":"J Immunol"},{"key":"bibr8-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4049\/jimmunol.155.1.45","volume":"155","author":"Dubey C","year":"1995","journal-title":"J Immunol"},{"key":"bibr9-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.4049\/jimmunol.162.6.3428","volume":"162","author":"Dubois B","year":"1999","journal-title":"J Immunol"},{"key":"bibr10-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.137.1.245","volume":"137","author":"Dustin ML","year":"1986","journal-title":"J Immunol"},{"key":"bibr11-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6037"},{"key":"bibr12-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1823"},{"key":"bibr13-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240141"},{"key":"bibr14-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1038\/384364a0"},{"key":"bibr15-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.6.1101"},{"key":"bibr16-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-6-3"},{"key":"bibr17-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.4049\/jimmunol.152.8.3760","volume":"152","author":"Koopman G","year":"1994","journal-title":"J Immunol"},{"key":"bibr18-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.6.1297"},{"key":"bibr19-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.4049\/jimmunol.144.9.3281","volume":"144","author":"Kuijpers KC","year":"1990","journal-title":"J Immunol"},{"key":"bibr20-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200109)31:9<2547::AID-IMMU2547>3.0.CO;2-J"},{"key":"bibr21-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210115"},{"key":"bibr22-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.6.1077"},{"key":"bibr23-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01160-2"},{"key":"bibr24-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05904.x"},{"key":"bibr25-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3284"},{"key":"bibr26-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115633"},{"key":"bibr27-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1038\/342929a0"},{"key":"bibr28-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3023"},{"key":"bibr29-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1007\/s004290100210"},{"key":"bibr30-jhc.5A6740.2005","first-page":"487","volume":"82","author":"O'Doherty U","year":"1994","journal-title":"Immunology"},{"key":"bibr31-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80528-0"},{"key":"bibr32-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930501)71:9<2817::AID-CNCR2820710922>3.0.CO;2-Z"},{"key":"bibr33-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(99)00114-9"},{"key":"bibr34-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1183"},{"key":"bibr35-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.4049\/jimmunol.161.10.5138","volume":"161","author":"Salomon B","year":"1998","journal-title":"J Immunol"},{"key":"bibr36-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1415"},{"key":"bibr37-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60489-7"},{"key":"bibr38-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1710"},{"key":"bibr39-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10118"},{"key":"bibr40-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61694-X"},{"key":"bibr41-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1990.tb00573.x"},{"key":"bibr42-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02086-5"},{"key":"bibr43-jhc.5A6740.2005","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.4049\/jimmunol.144.12.4579","volume":"144","author":"Van Seventer GA","year":"1990","journal-title":"J Immunol"},{"key":"bibr44-jhc.5A6740.2005","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200105)31:5<1544::AID-IMMU1544>3.0.CO;2-I"}],"container-title":["Journal of Histochemistry &amp; Cytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/jhc.5A6740.2005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1369\/jhc.5A6740.2005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/jhc.5A6740.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:26:31Z","timestamp":1777501591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1369\/jhc.5A6740.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1369\/jhc.5A6740.2005"],"URL":"https:\/\/doi.org\/10.1369\/jhc.5a6740.2005","relation":{},"ISSN":["0022-1554","1551-5044"],"issn-type":[{"value":"0022-1554","type":"print"},{"value":"1551-5044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}