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Tyrosine hydroxylase-positive innervation was significantly increased in the dopamine-denervated striatum of rats receiving intrastriatal LGF infusions (160 ng\/day\/rat \u00d7 15 days) as compared with a vehicle-infused group. There was no evidence of dopaminergic neurogenesis in the striatum or substantia nigra in any experimental group at the times studied. However, in those animals undergoing IS-LGF infusion for 48 hr, we found a significant increase in both microglial proliferation and in the number of microglial cells that acquired the ameboid morphology. This is characteristic of activated microglia\/macrophages that has been reported to play an important role in dopamine terminal sprouting. In summary, our study shows that IS infusion of LGF stimulates the outgrowth of tyrosine hydroxylase-positive terminals in the striatum of 6-hydroxydopamine-treated rats. As apomorphine-induced rotational behavior was also reduced in these animals, we propose LGF as a novel factor that, when delivered to the striatum, may be useful in the treatment of Parkinson's disease.<\/jats:p>","DOI":"10.1369\/jhc.5a6805.2005","type":"journal-article","created":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T20:50:23Z","timestamp":1134420623000},"page":"457-465","source":"Crossref","is-referenced-by-count":33,"title":["Intrastriatal Infusion of Liver Growth Factor Stimulates Dopamine Terminal Sprouting and Partially Restores Motor Function in 6-Hydroxydopamine-lesioned Rats"],"prefix":"10.1177","volume":"54","author":[{"given":"Diana","family":"Reimers","sequence":"first","affiliation":[{"name":"Servicio de Neurobiolog\u00eda, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio S.","family":"Herranz","sequence":"additional","affiliation":[{"name":"Servicio de Neurobiolog\u00eda, Hospital 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