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Interactions between acinar and islet tissues have been well established through numerous studies that reveal the existence of anatomical and functional relationships between these compartments of the gland. Less attention, however, has traditionally been paid to the relationships occurring between the endocrine pancreas and the ductal system. Associations between islet tissue and ducts are considered by most researchers as only a transient epiphenomenon of endocrine development. This article reviews the evidence that has emerged in the last 10 years demonstrating the existence of stable, close, and systematic relationships between these two pancreatic compartments. Functional and pathophysiological implications are considered, and the existence of an \u201cacinar-duct-islet\u201d axis is put forward. The pancreas appears at present to be an integrated organ composed of three functionally related components of well-orchestrated endocrine and exocrine physiological responses.<\/jats:p>","DOI":"10.1369\/jhc.5r6640.2005","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T23:43:25Z","timestamp":1118792605000},"page":"1071-1086","source":"Crossref","is-referenced-by-count":68,"title":["Association between Endocrine Pancreas and Ductal System. 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