{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:24:01Z","timestamp":1791174241045,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>There is a lack of agreement on the distribution of islet amyloid polypeptide (IAPP) in the pancreases of healthy and diabetic subjects. Therefore, a detailed morphometrical and immunohistochemical study was performed to obtain information on the distribution of cells expressing insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and IAPP in the pancreases of non-diabetic ( n=4) and diabetic individuals ( n=6). In the non-diabetic cases, \u03b2-cells contributed to \u223c64%, \u03b1-cells to 26%, \u03b4-cells to 8%, PP cells to 0.3%, and IAPP cells to 34% of the islet cell population. The ratio of IAPP\/insulin was \u223c1:2. In diabetic cases, \u03b2-cells were decreased by 24%, and IAPP was decreased by 57%. The \u03b1- and \u03b4-cells were increased by 40% and 58%, respectively. IAPP\/insulin ratio was decreased by 41%. Thus, only 50% of the \u03b2-cells in non-diabetics and only 30% in diabetics coexpressed IAPP. In diabetics, more \u03b4-cells coexpressed IAPP than in non-diabetics. The results seem to argue against the notion that the secretion of IAPP is increased in diabetics. It is possible that an increase in somatostatin and glucagon plays a greater role in diabetes than IAPP.<\/jats:p>","DOI":"10.1369\/jhc.6a7024.2006","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T20:56:34Z","timestamp":1158612994000},"page":"111-118","source":"Crossref","is-referenced-by-count":35,"title":["Distribution of Pancreatic Endocrine Cells Including IAPP-expressing Cells in Non-diabetic and Type 2 Diabetic Cases"],"prefix":"10.1177","volume":"55","author":[{"given":"Katsumichi","family":"Iki","sequence":"first","affiliation":[{"name":"UNMC Eppley Cancer Center University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz M.","family":"Pour","sequence":"additional","affiliation":[{"name":"UNMC Eppley Cancer Center University of Nebraska Medical Center, Omaha, Nebraska"},{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,2,1]]},"reference":[{"key":"bibr1-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370643"},{"key":"bibr2-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.2007.S20"},{"key":"bibr3-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.6.1509"},{"key":"bibr4-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2304"},{"key":"bibr5-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01075-O"},{"key":"bibr6-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1007\/BF03168183"},{"key":"bibr7-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91815-8"},{"key":"bibr8-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(92)90074-2"},{"key":"bibr9-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90584-2"},{"key":"bibr10-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(92)90073-Z"},{"key":"bibr11-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.7283"},{"key":"bibr12-jhc.6A7024.2006","first-page":"245","volume":"135","author":"Johnson KH","year":"1989","journal-title":"Am J Pathol"},{"key":"bibr13-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199706)14:6<472::AID-DIA388>3.0.CO;2-Q"},{"key":"bibr14-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050751"},{"key":"bibr15-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200008000-00015"},{"key":"bibr16-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-1-143"},{"key":"bibr17-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(03)00004-4"},{"key":"bibr18-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410276"},{"key":"bibr19-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(95)03646-O"},{"key":"bibr20-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418536"},{"key":"bibr21-jhc.6A7024.2006","doi-asserted-by":"crossref","first-page":"E684","DOI":"10.1152\/ajpendo.2000.278.4.E684","volume":"278","author":"Mulder H","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"bibr22-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90118-X"},{"key":"bibr23-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.18511"},{"key":"bibr24-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.4.1338"},{"key":"bibr25-jhc.6A7024.2006","volume-title":"Toxicology of the Pancreas","author":"Pour PM","year":"2006"},{"key":"bibr26-jhc.6A7024.2006","first-page":"397","volume":"140","author":"Pour PM","year":"1994","journal-title":"Zentralbl Pathol"},{"key":"bibr27-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1007\/BF01660981"},{"key":"bibr28-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.2337\/diab.31.8.694"},{"key":"bibr29-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90362-C"},{"key":"bibr30-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.3109\/02841869109092400"},{"key":"bibr31-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(96)01294-6"},{"key":"bibr32-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90276-6"},{"key":"bibr33-jhc.6A7024.2006","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020735"}],"container-title":["Journal of Histochemistry &amp; 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