{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:43:01Z","timestamp":1791272581452,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>\n                    Increased levels of endothelin-1 (ET-1) in the carotid body (CB) contribute to the enhancement of chemosensory responses to acute hypoxia in cats exposed to chronic intermittent hypoxia (CIH). However, it is not known if the ET receptor types A (ET\n                    <jats:sub>A<\/jats:sub>\n                    -R) and B (ET\n                    <jats:sub>B<\/jats:sub>\n                    -R) are upregulated. Thus, we studied the expression and localization of ET\n                    <jats:sub>A<\/jats:sub>\n                    -R and ET\n                    <jats:sub>B<\/jats:sub>\n                    -R using Western blot and immunohistochemistry (IHC) in CBs from cats exposed to cyclic hypoxic episodes, repeated during 8 hr for 4 days. In addition, we determined if ET-1 is expressed in the chemoreceptor cells using double immunofluorescence for ET-1 and tyrosine hydroxylase (TH). We found that ET-1 expression was ubiquitous in the blood vessels and CB parenchyma, although double ET-1 and TH-positive chemoreceptor cells were mostly found in the parenchyma. ET\n                    <jats:sub>A<\/jats:sub>\n                    -R was expressed in most chemoreceptor cells and blood vessels of the CB vascular pole. ET\n                    <jats:sub>B<\/jats:sub>\n                    -R was expressed in chemoreceptor cells, parenchymal capillaries, and blood vessels of the vascular pole. CIH upregulated ET\n                    <jats:sub>B<\/jats:sub>\n                    -R expression by \u223c2.1 (Western blot) and 1.6-fold (IHC) but did not change ET\n                    <jats:sub>A<\/jats:sub>\n                    -R expression. Present results suggest that ET-1, ET\n                    <jats:sub>A<\/jats:sub>\n                    -R, and ET\n                    <jats:sub>B<\/jats:sub>\n                    -R are involved in the enhanced CB chemosensory responses to acute hypoxia induced by CIH.\n                  <\/jats:p>","DOI":"10.1369\/jhc.6a7079.2006","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T22:47:36Z","timestamp":1161125256000},"page":"167-174","source":"Crossref","is-referenced-by-count":39,"title":["Expression and Immunolocalization of Endothelin Peptides and Its Receptors, ET\n                    <sub>A<\/sub>\n                    and ET\n                    <sub>B<\/sub>\n                    , in the Carotid Body Exposed to Chronic Intermittent Hypoxia"],"prefix":"10.1177","volume":"55","author":[{"given":"Sergio","family":"Rey","sequence":"first","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Nefrolog\u00eda y Centro de Investigaciones M\u00e9dicas, Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Corthorn","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Nefrolog\u00eda y Centro de Investigaciones M\u00e9dicas, Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Nefrolog\u00eda y Centro de Investigaciones M\u00e9dicas, Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Iturriaga","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Nefrolog\u00eda y Centro de Investigaciones M\u00e9dicas, Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,2,1]]},"reference":[{"key":"bibr1-jhc.6A7079.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00113-4"},{"key":"bibr2-jhc.6A7079.2006","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00454.2001"},{"key":"bibr3-jhc.6A7079.2006","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-001-0728-2"},{"key":"bibr4-jhc.6A7079.2006","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1152\/jappl.2001.90.4.1600","volume":"90","author":"Fletcher EC","year":"2001","journal-title":"J Appl 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