{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:11:49Z","timestamp":1789949509967,"version":"4.0.1"},"reference-count":55,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>Helicobacter pylori infects over half the population worldwide and is a leading cause of chronic gastritis and gastric cancer. However, the mechanism by which this organism induces inflammation and carcinogenesis is not fully understood. In the present study we used insulin-gastrin (INS-GAS) transgenic mice that fully develop gastric adenocarcinoma after infection of H. pylori-related Helicobacter felis. Histological examination revealed that more than half of those mice developed invasive adenocarcinoma after 8 months of infection. These carcinomas were stained by NCC-ST-439 and HECA-452 that recognize 6-sulfated and non-sulfated sialyl Lewis X. Lymphocytic infiltration predominantly to submucosa was observed in most H. felis-infected mice, and this was associated with the formation of peripheral lymph node addressin (PNAd) on high endothelial venule (HEV)-like vessels detected by MECA-79. Time-course analysis of gene expression by using gene microarray revealed upregulation of several inflammation-associated genes including chemokines, adhesion molecules, surfactant protein D (SP-D), and CD74 in the infected stomach. Immunohistochemical analysis demonstrated that SP-D is expressed in hyperplasia and adenocarcinoma whereas CD74 is expressed in adenocarcinoma in situ and invasive carcinoma. These results as a whole indicate that H. felis induces HEV-like vessels and inflammation-associated chemokines and chemokine receptors, followed by adenocarcinoma formation.<\/jats:p>","DOI":"10.1369\/jhc.6a7097.2006","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T21:39:25Z","timestamp":1163453965000},"page":"263-274","source":"Crossref","is-referenced-by-count":20,"title":["A Distinctive Set of Genes Is Upregulated During the Inflammation-Carcinoma Sequence in Mouse Stomach Infected by\n                    <i>Helicobacter felis<\/i>"],"prefix":"10.1177","volume":"55","author":[{"given":"Motohiro","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeseob","family":"Lee","sequence":"additional","affiliation":[{"name":"Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Schaffer","sequence":"additional","affiliation":[{"name":"DNA Array Core Facility, The Scripps Research Institute, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Gilmartin","sequence":"additional","affiliation":[{"name":"DNA Array Core Facility, The Scripps Research Institute, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Head","sequence":"additional","affiliation":[{"name":"DNA Array Core Facility, The Scripps Research Institute, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Takaishi","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,3,1]]},"reference":[{"key":"bibr1-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00257-6"},{"key":"bibr2-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1007\/BF02592984"},{"key":"bibr3-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"bibr4-jhc.6A7097.2006","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1016\/S0021-9258(18)98555-8","volume":"266","author":"Berg EL","year":"1991","journal-title":"J Biol Chem"},{"key":"bibr5-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2736-2743.2005"},{"key":"bibr6-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.185"},{"key":"bibr7-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1983.tb00446.x"},{"key":"bibr8-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81025-9"},{"key":"bibr9-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1823"},{"key":"bibr10-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00395-3"},{"key":"bibr11-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81798-5"},{"key":"bibr12-jhc.6A7097.2006","first-page":"1416","volume":"57","author":"Furihata C","year":"1997","journal-title":"Cancer Res"},{"key":"bibr13-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501708200"},{"key":"bibr14-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1038\/26026"},{"key":"bibr15-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.474"},{"key":"bibr16-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.373"},{"key":"bibr17-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099250"},{"key":"bibr18-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1038\/ni1259"},{"key":"bibr19-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407503101"},{"key":"bibr20-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8824"},{"key":"bibr21-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1080\/mic.10.3-4.313.323"},{"key":"bibr22-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030286"},{"key":"bibr23-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069076"},{"key":"bibr24-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"bibr25-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.11019"},{"key":"bibr26-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.2.445"},{"key":"bibr27-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242741699"},{"key":"bibr28-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.3.1481-1487.2002"},{"key":"bibr29-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1038\/337179a0"},{"key":"bibr30-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70167-7"},{"key":"bibr31-jhc.6A7097.2006","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/IAI.66.2.444-447.1998","volume":"66","author":"Namavar F","year":"1998","journal-title":"Infect Immun"},{"key":"bibr32-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.041"},{"key":"bibr33-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020201"},{"key":"bibr34-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"bibr35-jhc.6A7097.2006","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1016\/S0021-9258(19)39427-X","volume":"265","author":"Persson A","year":"1990","journal-title":"J Biol Chem"},{"key":"bibr36-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64210-1"},{"key":"bibr37-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.81-88.2001"},{"key":"bibr38-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.090501.080131"},{"key":"bibr39-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62313-9"},{"key":"bibr40-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251241"},{"key":"bibr41-jhc.6A7097.2006","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1128\/IAI.67.10.5151-5156.1999","volume":"67","author":"Schreiber S","year":"1999","journal-title":"Infect Immun"},{"key":"bibr42-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.11106"},{"key":"bibr43-jhc.6A7097.2006","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1016\/S0021-9258(18)53139-2","volume":"268","author":"Sgroi D","year":"1993","journal-title":"J Biol Chem"},{"key":"bibr44-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.4.669"},{"key":"bibr45-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098333"},{"key":"bibr46-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<633::AID-IMMU633>3.0.CO;2-I"},{"key":"bibr47-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117788"},{"key":"bibr48-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1038\/nri1222"},{"key":"bibr49-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.6.1355"},{"key":"bibr50-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116708"},{"key":"bibr51-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70412-4"},{"key":"bibr52-jhc.6A7097.2006","doi-asserted-by":"crossref","first-page":"17735","DOI":"10.1016\/S0021-9258(18)45441-5","volume":"262","author":"Weinstein J","year":"1987","journal-title":"J Biol Chem"},{"key":"bibr53-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00394-4"},{"key":"bibr54-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.5.3215"},{"key":"bibr55-jhc.6A7097.2006","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1141"}],"container-title":["Journal of Histochemistry &amp; Cytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/jhc.6A7097.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1369\/jhc.6A7097.2006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/jhc.6A7097.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:27:08Z","timestamp":1777501628000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1369\/jhc.6A7097.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1369\/jhc.6A7097.2006"],"URL":"https:\/\/doi.org\/10.1369\/jhc.6a7097.2006","relation":{},"ISSN":["0022-1554","1551-5044"],"issn-type":[{"value":"0022-1554","type":"print"},{"value":"1551-5044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}