{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:40:08Z","timestamp":1789461608083,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>\n                    Regulatory T cells (Treg) are a subset of T lymphocytes that play a central role in immunologic tolerance and in the termination of immune responses. The identification of these cells in normal and inflammatory conditions may contribute to a better understanding of underlying pathology. We investigated the expression of FOXP3 and GITR in normal skin and in a panel of different inflammatory dermatoses. Immunohistochemical double stainings in skin tissue sections revealed that FOXP3 and GITR were almost exclusively present on T cells that express both CD4 and CD25. Further, immunohistochemical double staining, as well as fluorescence-activated cell sorter analysis, on peripheral blood T cells showed that most FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    cells expressed GITR and vice versa, whereas a minority were single-positive for these markers. The mean frequency of FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    T cells in spongiotic dermatitis, psoriasis, and lichen planus was in the same range (25-29%), but the frequency of these cells in leishmaniasis appeared to be lower (\u223c15%), although this was not statistically significant. The mean frequency of GITR\n                    <jats:sup>+<\/jats:sup>\n                    T cells was fairly similar in all conditions studied (14-20%). Normal human skin also contained FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    and GITR\n                    <jats:sup>+<\/jats:sup>\n                    cells in the same frequency range as in diseased skin, but the absolute numbers were, of course, much lower. In conclusion, frequencies of FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    and GITR\n                    <jats:sup>+<\/jats:sup>\n                    T cells were similar in all inflammatory skin diseases studied and normal skin, despite the well-known differences among the inflammatory conditions under investigation.\n                  <\/jats:p>","DOI":"10.1369\/jhc.6a7119.2007","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T20:24:59Z","timestamp":1178223899000},"page":"891-898","source":"Crossref","is-referenced-by-count":72,"title":["Immunohistochemical Analysis of Regulatory T Cell Markers FOXP3 and GITR on CD4\n                    <sup>+<\/sup>\n                    CD25\n                    <sup>+<\/sup>\n                    T Cells in Normal Skin and Inflammatory Dermatoses"],"prefix":"10.1177","volume":"55","author":[{"given":"Onno J. de","family":"Boer","sequence":"first","affiliation":[{"name":"Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M. van der","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Teeling","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allard C. van der","family":"Wal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel B.M.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"bibr1-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.04.005"},{"key":"bibr2-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1245"},{"key":"bibr3-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040812"},{"key":"bibr4-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1038\/nri1032"},{"key":"bibr5-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"bibr6-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"bibr7-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1038\/ni909"},{"key":"bibr8-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20319"},{"key":"bibr9-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1186\/ar1745"},{"key":"bibr10-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.04.010"},{"key":"bibr11-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00280-7"},{"key":"bibr12-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2004.apm1121002.x"},{"key":"bibr13-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.10.014"},{"key":"bibr14-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526189"},{"key":"bibr15-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"bibr16-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1038\/ni759"},{"key":"bibr17-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5008"},{"key":"bibr18-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.164"},{"key":"bibr19-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.040"},{"key":"bibr20-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19441"},{"key":"bibr21-jhc.6A7119.2007","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh165"}],"container-title":["Journal of Histochemistry &amp; Cytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/jhc.6A7119.2007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1369\/jhc.6A7119.2007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1369\/jhc.6A7119.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:27:18Z","timestamp":1777501638000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1369\/jhc.6A7119.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1369\/jhc.6A7119.2007"],"URL":"https:\/\/doi.org\/10.1369\/jhc.6a7119.2007","relation":{},"ISSN":["0022-1554","1551-5044"],"issn-type":[{"value":"0022-1554","type":"print"},{"value":"1551-5044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}