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Each type of ABH antigen is expressed tissue specifically, and aberrant expression of ABH antigens is often observed during oncogenesis. We immunohistochemically examined the expression of A type 3 antigens in wounded and diseased skin tissues (A and AB blood groups). In uninjured skin, the expression of A type 3 antigens was restricted to the eccrine sweat gland. In addition to the sweat glands, A type 3 antigens were found in vascular endothelial cells of the wound sites. The extent of A type 3 antigens expression related to postinfliction intervals. A significantly higher expression rate of A type 3 antigens in endothelial cells was also observed in diseased skin, suggesting that inflammation might induce A type 3 antigen expression in endothelial cells. Double-color immunofluorescence staining of the specimens showed that von Willebrand factor (vWF) was a core-protein of A type 3 determinants aberrantly expressed in endothelial cells in inflamed tissues, suggesting that aberrant expression of A type 3 antigens is involved in stabilization of vWF in inflammation.<\/jats:p>","DOI":"10.1369\/jhc.7a7290.2007","type":"journal-article","created":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T21:43:38Z","timestamp":1194903818000},"page":"223-231","source":"Crossref","is-referenced-by-count":14,"title":["Aberrant Expression of Histo-blood Group A Type 3 Antigens in Vascular Endothelial Cells in Inflammatory Sites"],"prefix":"10.1177","volume":"56","author":[{"given":"Mizuho","family":"Nosaka","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Wakayama Medical University, Wakayama, 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