{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:03:38Z","timestamp":1781975018985,"version":"3.54.5"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2005,9,6]],"date-time":"2005-09-06T00:00:00Z","timestamp":1125964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.0030314","type":"journal-article","created":{"date-parts":[[2005,8,29]],"date-time":"2005-08-29T13:15:28Z","timestamp":1125321328000},"page":"e314","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":1289,"title":["Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate"],"prefix":"10.1371","volume":"3","author":[{"given":"Paramvir","family":"Dehal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Boore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2005,9,6]]},"reference":[{"key":"JOURNAL-PBIO-0030314-B01","first-page":"160","author":"Ohno","year":"1970","journal-title":"Evolution by gene duplication"},{"key":"JOURNAL-PBIO-0030314-B02","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"Lander","year":"2001","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B03","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.1058040","volume":"291","author":"Venter","year":"2001","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B04","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/geno.1993.1133","volume":"16","author":"Lundin","year":"1993","journal-title":"Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/0888-7543","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B05","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0955-0674(99)00039-3","volume":"11","author":"Meyer","year":"1999","journal-title":"Curr Opin Cell Biol","ISSN":"https:\/\/id.crossref.org\/issn\/0955-0674","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B06","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0014-5793(96)01351-8","volume":"400","author":"Spring","year":"1997","journal-title":"FEBS Lett","ISSN":"https:\/\/id.crossref.org\/issn\/0014-5793","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B07","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s002390010069","volume":"51","author":"Wang","year":"2000","journal-title":"J Mol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2844","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B08","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1101\/gr.445702","volume":"12","author":"Larhammar","year":"2002","journal-title":"Genome Res","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B09","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/mpev.1996.0071","volume":"6","author":"Guigo","year":"1996","journal-title":"Mol Phylogenet Evol","ISSN":"https:\/\/id.crossref.org\/issn\/1055-7903","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ng884","volume":"31","author":"McLysaght","year":"2002","journal-title":"Nat Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng902","volume":"31","author":"Gu","year":"2002","journal-title":"Nat Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/molbev\/msg017","volume":"20","author":"Friedman","year":"2003","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B13","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1101\/gr.200601","volume":"11","author":"Friedman","year":"2001","journal-title":"Genome Res","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0014-5793(01)02187-1","volume":"491","author":"Popovici","year":"2001","journal-title":"FEBS Lett","ISSN":"https:\/\/id.crossref.org\/issn\/0014-5793","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B15","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","volume":"287","author":"Adams","year":"2000","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/PL00006499","volume":"48","author":"Hughes","year":"1999","journal-title":"J Mol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2844","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1098\/rstb.2001.1035","volume":"357","author":"Furlong","year":"2002","journal-title":"Philos Trans R Soc Lond B Biol Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0962-8436","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B18","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/oxfordjournals.molbev.a004207","volume":"19","author":"Escriva","year":"2002","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B19","first-page":"125","author":"Holland","year":"1994","journal-title":"Dev Suppl"},{"key":"JOURNAL-PBIO-0030314-B20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/A:1022656931587","volume":"3","author":"Holland","year":"2003","journal-title":"J Struct Funct Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1345-711X","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng855","volume":"31","author":"Abi-Rached","year":"2002","journal-title":"Nat Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B22","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1101\/gr.874803","volume":"13","author":"Panopoulou","year":"2003","journal-title":"Genome Res","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00239-003-2538-y","volume":"58","author":"Leveugle","year":"2004","journal-title":"J Mol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2844","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/35072009","volume":"2","author":"Wolfe","year":"2001","journal-title":"Nat Rev Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B25","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/genetics\/159.4.1789","volume":"159","author":"Lynch","year":"2001","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B26","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.290.5494.1151","volume":"290","author":"Lynch","year":"2000","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B27","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1073\/pnas.142101099","volume":"99","author":"Wong","year":"2002","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B28","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1126\/science.290.5499.2114","volume":"290","author":"Vision","year":"2000","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nature02424","volume":"428","author":"Kellis","year":"2004","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.1095781","volume":"304","author":"Dietrich","year":"2004","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/geno.1996.0328","volume":"35","author":"Katsanis","year":"1996","journal-title":"Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/0888-7543","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/oxfordjournals.molbev.a026022","volume":"15","author":"Pebusque","year":"1998","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1042\/bst0280259","volume":"28","author":"Gibson","year":"2000","journal-title":"Biochem Soc Trans","ISSN":"https:\/\/id.crossref.org\/issn\/0300-5127","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B34","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/molbev\/msg127","volume":"20","author":"Vienne","year":"2003","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B35","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1073\/pnas.0836141100","volume":"100","author":"Luke","year":"2003","journal-title":"Proc Natl Acad Sci USA","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B36","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s00251-004-0642-9","volume":"55","author":"Castro","year":"2004","journal-title":"Immunogenetics","ISSN":"https:\/\/id.crossref.org\/issn\/0093-7711","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1525-142X.2003.03052.x","volume":"5","author":"Castro","year":"2003","journal-title":"Evol Dev","ISSN":"https:\/\/id.crossref.org\/issn\/1520-541X","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B38","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1126\/science.1080049","volume":"298","author":"Dehal","year":"2002","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B39","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1126\/science.1072104","volume":"297","author":"Aparicio","year":"2002","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B40","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","volume":"420","author":"Waterston","year":"2002","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1022652814749","volume":"3","author":"Van de Peer","year":"2003","journal-title":"J Struct Funct Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1345-711X","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B42","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature03025","volume":"431","author":"Jaillon","year":"2004","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jez.b.40","volume":"299","author":"Horton","year":"2003","journal-title":"J Exp Zool B Mol Dev Evol","ISSN":"https:\/\/id.crossref.org\/issn\/1552-5015","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/molbev\/msg059","volume":"20","author":"Seoighe","year":"2003","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B45","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000130828","volume":"19","author":"Tymowska","year":"1977","journal-title":"Cytogenet Cell Genet","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0171","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(80)90493-6","volume":"21","author":"Jeffreys","year":"1980","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B47","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1098\/rstb.2001.0975","volume":"356","author":"Taylor","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0962-8436","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B48","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1105\/tpc.021345","volume":"16","author":"Blanc","year":"2004","journal-title":"Plant Cell","ISSN":"https:\/\/id.crossref.org\/issn\/1040-4651","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B49","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B50","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"key":"JOURNAL-PBIO-0030314-B51","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/bioinformatics\/18.3.502","volume":"18","author":"Schmidt","year":"2002","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T16:58:18Z","timestamp":1626454698000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.0030314"}},"subtitle":[],"editor":[{"given":"Peter","family":"Holland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2005,9,6]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2005,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.0030314","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1028295.337125","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,6]]}}}