{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:32:04Z","timestamp":1772620324908,"version":"3.50.1"},"reference-count":100,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.1000247","type":"journal-article","created":{"date-parts":[[2009,11,23]],"date-time":"2009-11-23T17:37:27Z","timestamp":1258997847000},"page":"e1000247","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":234,"title":["Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation"],"prefix":"10.1371","volume":"7","author":[{"given":"Nicole L.","family":"Washington","sequence":"first","affiliation":[]},{"given":"Melissa A.","family":"Haendel","sequence":"additional","affiliation":[]},{"given":"Christopher J.","family":"Mungall","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Ashburner","sequence":"additional","affiliation":[]},{"given":"Monte","family":"Westerfield","sequence":"additional","affiliation":[]},{"given":"Suzanna E.","family":"Lewis","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/cfg.181","article-title":"From genotype to phenotype: linking bioinformatics and medical informatics ontologies.","volume":"3","author":"E Holloway","year":"2002","journal-title":"Comp Funct Genomics"},{"key":"ref2","first-page":"2169","article-title":"A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.","volume":"118","author":"A. J Schuhmacher","year":"2008","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ng867","article-title":"Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome.","volume":"31","author":"G. B Collin","year":"2002","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1210\/me.2005-0494","article-title":"Fat aussie\u2013a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis.","volume":"20","author":"T Arsov","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders.","volume":"33","author":"A Hamosh","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1371\/journal.pbio.0030134","article-title":"Systematic association of genes to phenotypes by genome and literature mining.","volume":"3","author":"J. O Korbel","year":"2005","journal-title":"PLoS Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool.","volume":"215","author":"S. F Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/bioinformatics\/btm112","article-title":"OBO-Edit\u2013an ontology editor for biologists.","volume":"23","author":"J Day-Richter","year":"2007","journal-title":"Bioinformatics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/1521-1878(200012)22:12<1095::AID-BIES7>3.0.CO;2-A","article-title":"From genotype to phenotype: buffering mechanisms and the storage of genetic information.","volume":"22","author":"S. L Rutherford","year":"2000","journal-title":"Bioessays"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"D440","DOI":"10.1093\/nar\/gkm883","article-title":"The Gene Ontology project in 2008.","volume":"36","author":"T. G. O Consortium","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/jez.b.21181","article-title":"Connecting evolutionary morphology to genomics using ontologies: a case study from Cypriniformes including zebrafish.","volume":"308","author":"P. M Mabee","year":"2007","journal-title":"J Exp Zoolog B Mol Dev Evol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tree.2007.03.013","article-title":"Phenotype ontologies: the bridge between genomics and evolution.","volume":"22","author":"P. M Mabee","year":"2007","journal-title":"Trends Ecol Evol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"D768","DOI":"10.1093\/nar\/gkm956","article-title":"The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes.","volume":"36","author":"J Sprague","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0021-8782.2005.00376.x","article-title":"Anatomics: the intersection of anatomy and bioinformatics.","volume":"206","author":"J. B Bard","year":"2005","journal-title":"J Anat"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2105-10-S5-S2","article-title":"Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data.","volume":"10","author":"T Beck","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref16","article-title":"Uberon: towards a comprehensive multi-species anatomy ontology.","year":"2009"},{"key":"ref17","article-title":"Integrating phenotype ontologies across multiple species.","author":"C Mungall","year":"2009","journal-title":"Submitted to Genome Biology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/1471-2105-9-327","article-title":"Gene Ontology term overlap as a measure of gene functional similarity.","volume":"9","author":"M Mistry","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/bioinformatics\/btm087","article-title":"A new method to measure the semantic similarity of GO terms.","volume":"23","author":"J. Z Wang","year":"2007","journal-title":"Bioinformatics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1613\/jair.514","article-title":"Semantic similarity in a taxonomy: an information-based measure and its application to problems of ambiguity in natural language.","volume":"11","author":"P Resnik","year":"1999","journal-title":"J Artificial Intelligence Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000443","DOI":"10.1371\/journal.pcbi.1000443","article-title":"Semantic similarity in biomedical ontologies.","volume":"5","author":"C Pesquita","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"D434","DOI":"10.1093\/nar\/gkm806","article-title":"FunSimMat: a comprehensive functional similarity database.","volume":"36","author":"A Schlicker","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"D696","DOI":"10.1093\/nar\/gkl662","article-title":"PhenomicDB: a new cross-species genotype\/phenotype resource.","volume":"35","author":"P Groth","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref24","year":"2009"},{"key":"ref25","first-page":"5415","article-title":"The foundational model of anatomy: a template for the symbolic representation of multi-scale physiological functions.","volume":"7","author":"D. L Cook","year":"2004","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/gb-2005-6-2-r21","article-title":"An ontology for cell types.","volume":"6","author":"J Bard","year":"2005","journal-title":"Genome Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gkm791","article-title":"ChEBI: a database and ontology for chemical entities of biological interest.","volume":"36","author":"K Degtyarenko","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref28","year":"2009"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","article-title":"Mutations affecting segment number and polarity in Drosophila.","volume":"287","author":"C Nusslein-Volhard","year":"1980","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ygeno.2007.09.001","article-title":"Expression profiling identifies novel Hh\/Gli-regulated genes in developing zebrafish embryos.","volume":"91","author":"S. A Bergeron","year":"2008","journal-title":"Genomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment.","volume":"36","author":"M Kanehisa","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"D724","DOI":"10.1093\/nar\/gkm961","article-title":"The Mouse Genome Database (MGD): mouse biology and model systems.","volume":"36","author":"C. J Bult","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref33","year":"2008"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng0504-431","article-title":"The genetic association database.","volume":"36","author":"K. G Becker","year":"2004","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1523\/JNEUROSCI.5241-03.2004","article-title":"Beta1-integrins are critical for cerebellar granule cell precursor proliferation.","volume":"24","author":"S Blaess","year":"2004","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1016\/S0960-9822(02)00704-2","article-title":"Wnt signalling: a moving picture emerges from van gogh.","volume":"12","author":"C. P Heisenberg","year":"2002","journal-title":"Curr Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.mod.2007.07.003","article-title":"Zebrafish colgate\/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration.","volume":"124","author":"R. M Nambiar","year":"2007","journal-title":"Mech Dev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.00558","article-title":"bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish.","volume":"130","author":"T Leung","year":"2003","journal-title":"Development"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/dbio.1999.9479","article-title":"The nieuwkoid\/dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula.","volume":"215","author":"D. S Koos","year":"1999","journal-title":"Dev Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.123.1.1","article-title":"The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.","volume":"123","author":"P Haffter","year":"1996","journal-title":"Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"C1485","DOI":"10.1152\/ajpcell.00010.2008","article-title":"Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1.","volume":"294","author":"M. L Styers","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/labinvest.2008.163","article-title":"Sonic hedgehog ligand partners with caveolin-1 for intracellular transport.","volume":"89","author":"H Mao","year":"2009","journal-title":"Lab Invest"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"19503","DOI":"10.1074\/jbc.M010832200","article-title":"The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane.","volume":"276","author":"H. E Karpen","year":"2001","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.devcel.2006.04.004","article-title":"The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.","volume":"10","author":"T Tenzen","year":"2006","journal-title":"Dev Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1056\/NEJM196907242810403","article-title":"Muscle contracture induced by exercise: a syndrome attributable to decreased relaxing factor.","volume":"281","author":"I. A Brody","year":"1969","journal-title":"N Engl J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1242\/dev.004531","article-title":"Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease.","volume":"134","author":"H Hirata","year":"2007","journal-title":"Development"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12021-008-9031-0","article-title":"Textpresso for neuroscience: searching the full text of thousands of neuroscience research papers.","volume":"6","author":"H. M Muller","year":"2008","journal-title":"Neuroinformatics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ajmg.a.32601","article-title":"Elements of morphology: introduction.","volume":"149A","author":"J. E Allanson","year":"2009","journal-title":"Am J Med Genet A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ajhg.2008.09.017","article-title":"The Human Phenotype Ontology: a tool for annotating and analyzing human hereditary disease.","volume":"83","author":"P. N Robinson","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nbt1346","article-title":"The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration.","volume":"25","author":"B Smith","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.1038\/npre.2009.3565.1","article-title":"Developing a mammalian behaviour ontology.","author":"T Beck","year":"2009"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1093\/bioinformatics\/bth433","article-title":"Ontologies for behavior.","volume":"20","author":"P. E Midford","year":"2004","journal-title":"Bioinformatics"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jsb.2007.10.003","article-title":"The cell centered database project: an update on building community resources for managing and sharing 3D imaging data.","volume":"161","author":"M. E Martone","year":"2008","journal-title":"J Struct Biol"},{"key":"ref54","year":"2009"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1755-8794-1-48","article-title":"The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study.","volume":"1","author":"A. P Davis","year":"2008","journal-title":"BMC Med Genomics"},{"key":"ref56","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1407s23","article-title":"PharmGKB: an integrated resource of pharmacogenomic data and knowledge.","volume":"Chapter 14: Unit14 17","author":"L Gong","year":"2008","journal-title":"Curr Protoc Bioinformatics"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1073\/pnas.0700488104","article-title":"Emerging principles of regulatory evolution.","volume":"104","author":"B Prud'homme","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1111\/j.1558-5646.2008.00450.x","article-title":"The loci of evolution: how predictable is genetic evolution?","volume":"62","author":"D. L Stern","year":"2008","journal-title":"Evolution"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tig.2004.08.001","article-title":"Subfunction partitioning, the teleost radiation and the annotation of the human genome.","volume":"20","author":"J Postlethwait","year":"2004","journal-title":"Trends Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev.genet.30.1.529","article-title":"Paralogous Hox genes: function and regulation.","volume":"30","author":"M Maconochie","year":"1996","journal-title":"Annu Rev Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000095104","article-title":"The zebrafish genome: a review and msx gene case study.","volume":"2","author":"J. H Postlethwait","year":"2006","journal-title":"Genome Dyn"},{"key":"ref62","year":"2009"},{"key":"ref63","year":"2008"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"D54","DOI":"10.1093\/nar\/gki031","article-title":"Entrez gene: gene-centered information at NCBI.","volume":"33","author":"D Maglott","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref65","year":"2008"},{"key":"ref66","year":"2007"},{"key":"ref67","first-page":"327","article-title":"CARO - the common anatomy reference ontology.","author":"M Haendel","year":"2008"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1534\/genetics.108.088591","article-title":"Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus.","volume":"179","author":"J Favor","year":"2008","journal-title":"Genetics"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.pgen.0040029","article-title":"Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.","volume":"4","author":"D. A Kleinjan","year":"2008","journal-title":"PLoS Genet"},{"key":"ref70","year":"2009"},{"key":"ref71","article-title":"Drosophila ey<sup>\u2212\/\u2212<\/sup>","author":"A Singh","year":"2009"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ydbio.2004.01.022","article-title":"Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo.","volume":"269","author":"Y Nakano","year":"2004","journal-title":"Dev Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1101\/gad.13.4.388","article-title":"Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning.","volume":"13","author":"R. O Karlstrom","year":"1999","journal-title":"Genes Dev"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ydbio.2006.07.005","article-title":"Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish.","volume":"299","author":"E. V Semina","year":"2006","journal-title":"Dev Biol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ydbio.2006.05.001","article-title":"Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.","volume":"297","author":"H Ochi","year":"2006","journal-title":"Dev Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ydbio.2006.02.032","article-title":"Scube2 mediates Hedgehog signalling in the zebrafish embryo.","volume":"294","author":"G. E Hollway","year":"2006","journal-title":"Dev Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1101\/gad.195801","article-title":"The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo.","volume":"15","author":"S Roy","year":"2001","journal-title":"Genes Dev"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/dbio.2000.0150","article-title":"Regulation of dharma\/bozozok by the Wnt pathway.","volume":"231","author":"S. L Ryu","year":"2001","journal-title":"Dev Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1242\/dev.00364","article-title":"Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development.","volume":"130","author":"R. O Karlstrom","year":"2003","journal-title":"Development"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.neuron.2004.11.029","article-title":"Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer).","volume":"44","author":"J. S Lee","year":"2004","journal-title":"Neuron"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1242\/dev.01061","article-title":"Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways.","volume":"131","author":"D. J Bornemann","year":"2004","journal-title":"Development"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1242\/dev.02084","article-title":"HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development.","volume":"132","author":"W. H Norton","year":"2005","journal-title":"Development"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mod.2005.10.005","article-title":"Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS.","volume":"123","author":"V. T Cunliffe","year":"2006","journal-title":"Mech Dev"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1242\/dev.127.18.3889","article-title":"Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.","volume":"127","author":"F Muller","year":"2000","journal-title":"Development"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1101\/gad.406007","article-title":"Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt\/beta catenin and Wnt\/PCP activities, through interaction with the Dally-like homolog Knypek.","volume":"21","author":"L Caneparo","year":"2007","journal-title":"Genes Dev"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0960-9822(01)00229-9","article-title":"Wnt signals are targets and mediators of Gli function.","volume":"11","author":"J. L Mullor","year":"2001","journal-title":"Curr Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1101\/SQB.1997.062.01.028","article-title":"WNT5 is required for tail formation in the zebrafish embryo.","volume":"62","author":"G-J Rauch","year":"1997","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.01698","article-title":"Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system.","volume":"132","author":"N Miyasaka","year":"2005","journal-title":"Development"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature05246","article-title":"Boc is a receptor for sonic hedgehog in the guidance of commissural axons.","volume":"444","author":"A Okada","year":"2006","journal-title":"Nature"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.mcn.2007.10.013","article-title":"Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment.","volume":"37","author":"Z Ke","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ydbio.2006.08.016","article-title":"Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblasts differentiation and function.","volume":"299","author":"A Smith","year":"2006","journal-title":"Dev Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0960-9822(01)00631-5","article-title":"Opponent activities of Shh and BMP signaling during floor plate induction in vivo.","volume":"12","author":"I Patten","year":"2002","journal-title":"Curr Biol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ng899","article-title":"Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites.","volume":"31","author":"M Nikaido","year":"2002","journal-title":"Nat Genet"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/dbio.1998.9169","article-title":"Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.","volume":"208","author":"K. E Lewis","year":"1999","journal-title":"Dev Biol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1471-213X-7-126","article-title":"Nodal signaling is required for closure of the anterior neural tube in zebrafish.","volume":"7","author":"A Aquilina-Beck","year":"2007","journal-title":"BMC Dev Biol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/384176a0","article-title":"Biochemical evidence that patched is the Hedgehog receptor.","volume":"384","author":"V Marigo","year":"1996","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.4161\/cc.6.23.4950","article-title":"Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis.","volume":"6","author":"S Fischer","year":"2007","journal-title":"Cell Cycle"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1242\/dev.007112","article-title":"Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance.","volume":"134","author":"K. A Palaisa","year":"2007","journal-title":"Development"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/neu.20161","article-title":"Morphogen signaling at the vertebrate growth cone: a few cases or a general strategy?","volume":"64","author":"P Bovolenta","year":"2005","journal-title":"J Neurobiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.devcel.2005.12.013","article-title":"Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.","volume":"10","author":"J Svard","year":"2006","journal-title":"Dev Cell"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1000247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T14:10:24Z","timestamp":1634220624000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1000247"}},"subtitle":[],"editor":[{"given":"Kenneth H.","family":"Buetow","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,11,24]]},"references-count":100,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1000247","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3583956.3291054","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,24]]}}}