{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:15:36Z","timestamp":1770549336917,"version":"3.49.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.1001550","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:16:52Z","timestamp":1392250612000},"page":"e1001550","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":126,"title":["JAGGED Controls Arabidopsis Petal Growth and Shape by Interacting with a Divergent Polarity Field"],"prefix":"10.1371","volume":"11","author":[{"given":"Susanna","family":"Sauret-G\u00fceto","sequence":"first","affiliation":[]},{"given":"Katharina","family":"Schiessl","sequence":"additional","affiliation":[]},{"given":"Andrew","family":"Bangham","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Sablowski","sequence":"additional","affiliation":[]},{"given":"Enrico","family":"Coen","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.pp.40.060189.001003","article-title":"The sink-source transition in leaves","volume":"40","author":"R Turgeon","year":"1989","journal-title":"Annu Rev Plant Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1469-8137.2012.04273.x","article-title":"Coming of leaf age: control of growth by hydraulics and metabolics during leaf ontogeny","volume":"196","author":"F Pantin","year":"2012","journal-title":"New Phytol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tree.2005.05.001","article-title":"Facing herbivory as you grow up: the ontogeny of resistance in plants","volume":"20","author":"K Boege","year":"2005","journal-title":"Trends Ecol Evol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1086\/282909","article-title":"Adaptive patterns in alkaloid physiology","volume":"108","author":"D McKey","year":"1974","journal-title":"Am Nat"},{"key":"ref5","unstructured":"Rhoades DF (1979) Evolution of plant chemical defences against herbivory. In: Rosenthal GA, Janzen DH, editors. Herbivores: their interaction with secondary metabolites. Academic Press. pp. 3\u201354."},{"key":"ref6","unstructured":"Zangerl AR, Bazzaz FA (1992) Theory and pattern in plant defense allocation. In: Fritz RS, Simms EL, editors. Plant resistance to herbivores and pathogens. University of Chicago Press. pp. 363\u2013391."},{"key":"ref7","first-page":"33","article-title":"The war of the whorls: genetic interactions controlling flower development","volume":"353","author":"ES Coen","year":"1991","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0959-437X(00)00216-1","article-title":"Turning floral organs into leaves, leaves into floral organs","volume":"11","author":"K Goto","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1086\/414425","article-title":"Developmental constraints and evolution","volume":"60","author":"J Maynard-Smith","year":"1985","journal-title":"Q Rev Biol"},{"key":"ref10","unstructured":"Raff RA (1966) The shape of life: genes, development, and the evolution of animal form. Chicago: University of Chicago Press. 544 p."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1126\/science.1140429","article-title":"Evolution and development of inflorescence architectures","volume":"316","author":"P Prusinkiewicz","year":"2007","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/dbio.1999.9443","article-title":"Cell cycling and cell enlargement in developing leaves of Arabidopsis","volume":"215","author":"PM Donnelly","year":"1999","journal-title":"Dev Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1387\/ijdb.041921ht","article-title":"Leaf shape: genetic controls and environmental factors","volume":"49","author":"H Tsukaya","year":"2005","journal-title":"Int J Dev Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.pbi.2007.07.012","article-title":"From genes to shape: regulatory interactions in leaf development","volume":"10","author":"M Barkoulas","year":"2007","journal-title":"Curr Opin Plant Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.1214678","article-title":"Generation of leaf shape through early patterns of growth and tissue polarity","volume":"335","author":"EE Kuchen","year":"2012","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1104\/pp.112.194662","article-title":"Computational method for quantifying growth patterns at the adaxial leaf surface in three dimensions","volume":"159","author":"L Remmler","year":"2012","journal-title":"Plant Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.devcel.2011.11.011","article-title":"Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process","volume":"22","author":"M Andriankaja","year":"2012","journal-title":"Dev Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.tplants.2012.02.003","article-title":"Leaf size control: complex coordination of cell division and expansion","volume":"17","author":"N Gonzalez","year":"2012","journal-title":"Trends in Plant Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.1402406","article-title":"Control of leaf vascular patterning by polar auxin transport","volume":"20","author":"E Scarpella","year":"2006","journal-title":"Genes Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-313X.2006.02977.x","article-title":"Dynamics of MONOPTEROS and PIN-FORMED1 expression during leaf vein pattern formation in Arabidopsis thaliana","volume":"49","author":"CL Wenzel","year":"2007","journal-title":"Plant J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature02081","article-title":"Regulation of phyllotaxis by polar auxin transport","volume":"426","author":"D Reinhardt","year":"2003","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1073\/pnas.1015162108","article-title":"Model for the regulation of Arabidopsis thaliana leaf margin development","volume":"108","author":"GD Bilsborough","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1139\/b89-375","article-title":"Floral development in Arabidopsis thaliana: a comparison of the wild type and the homeotic pistillata mutant","volume":"67","author":"JP Hill","year":"1989","journal-title":"Can J Bot"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1105\/tpc.2.8.755","article-title":"Early flower development in Arabidopsis","volume":"2","author":"DR Smyth","year":"1990","journal-title":"Plant Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1104\/pp.116.2.797","article-title":"Plastid ontogeny during petal development in Arabidopsis","volume":"116","author":"KA Pyke","year":"1998","journal-title":"Plant Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1242\/dev.00949","article-title":"The role of JAGGED in shaping lateral organs","volume":"131","author":"JR Dinneny","year":"2004","journal-title":"Development"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2007.10.001","article-title":"Control of plant organ size by KLUH\/CYP78A5-dependent intercellular signaling","volume":"13","author":"E Anastasiou","year":"2007","journal-title":"Developmental Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tplants.2008.05.006","article-title":"The Arabidopsis petal: a model for plant organogenesis","volume":"13","author":"VF Irish","year":"2008","journal-title":"Trends Plant Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1365-313X.2012.05023.x","article-title":"PETAL LOSS is a boundary gene that inhibits growth between developing sepals in Arabidopsis thaliana","volume":"71","author":"ER Lampugnani","year":"2012","journal-title":"Plant J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1242\/dev.084582","article-title":"Auxin controls petal initiation in Arabidopsis","volume":"140","author":"ER Lampugnani","year":"2013","journal-title":"Development"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cub.2005.12.026","article-title":"The E3 ubiquitin Ligase BIG BROTHER controls Arabidopsis organ size in a dosage-dependent manner","volume":"16","author":"S Disch","year":"2006","journal-title":"Curr Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1242\/dev.00991","article-title":"The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development","volume":"131","author":"CK Ohno","year":"2004","journal-title":"Development"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-313x.2000.00851.x","article-title":"FRL1 is required for petal and sepal development in Arabidopsis","volume":"24","author":"Y Hase","year":"2000","journal-title":"Plant J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/jxb\/eri122","article-title":"Ectopic endoreduplication caused by sterol alteration results in serrated petals in Arabidopsis","volume":"56","author":"Y Hase","year":"2005","journal-title":"J Exp Bot"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.cub.2012.07.020","article-title":"JAGGED controls growth anisotropy and coordination between cell size and cell cycle during plant organogenesis","volume":"22","author":"K Schiessl","year":"2012","journal-title":"Curr Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1242\/dev.129.13.3207","article-title":"Combined SHOOT MERISTEMLESS and WUSCHEL trigger ectopic organogenesis in <italic>Arabidopsis<\/italic>","volume":"129","author":"JL Gallois","year":"2002","journal-title":"Development"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1469-8137.2012.04083.x","article-title":"The plant-specific G protein \u03b3 subunit AGG3 influences organ size and shape in Arabidopsis thaliana","volume":"194","author":"S Li","year":"2012","journal-title":"New Phytologist"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1000537","DOI":"10.1371\/journal.pbio.1000537","article-title":"Genetic control of organ shape and tissue polarity","volume":"8","author":"AA Green","year":"2010","journal-title":"PLoS Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1002071","DOI":"10.1371\/journal.pcbi.1002071","article-title":"Generation of diverse biological forms through combinatorial interactions between tissue polarity and growth","volume":"7","author":"R Kennaway","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1073\/pnas.0306308101","article-title":"The genetics of geometry","volume":"101","author":"E Coen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0092-8674(03)00924-3","article-title":"Local, efflux-dependent auxin gradients as a common module for plant organ formation","volume":"115","author":"E Benkov\u00e1","year":"2003","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature02085","article-title":"Efflux-dependent auxin gradients establish the apical\u2013basal axis of Arabidopsis","volume":"426","author":"J Friml","year":"2003","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1242\/dev.041277","article-title":"Role of PIN-mediated auxin efflux in apical hook development of Arabidopsis thaliana","volume":"137","author":"P \u017d\u00e1dn\u00edkov\u00e1","year":"2010","journal-title":"Development"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1242\/dev.01279","article-title":"PETAL LOSS, a trihelix transcription factor gene, regulates perianth architecture in the Arabidopsis flower","volume":"131","author":"PB Brewer","year":"2004","journal-title":"Development"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1242\/dev.030353","article-title":"Auxin transport routes in plant development","volume":"136","author":"J Petr\u00e1\u0161ek","year":"2009","journal-title":"Development"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1073\/pnas.0509839103","article-title":"An auxin-driven polarized transport model for phyllotaxis","volume":"103","author":"H J\u00f6nsson","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1073\/pnas.0510457103","article-title":"A plausible model of phyllotaxis","volume":"103","author":"RS Smith","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtbi.2009.01.019","article-title":"Regulated transport as a mechanism for pattern generation: capabilities for phyllotaxis and beyond","volume":"258","author":"P Sahlin","year":"2009","journal-title":"J Theor Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1365-313X.2005.02581.x","article-title":"Reviewing models of auxin canalization in the context of leaf vein pattern formation in Arabidopsis","volume":"44","author":"A-G Rolland-Lagan","year":"2005","journal-title":"Plant J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e1000207","DOI":"10.1371\/journal.pcbi.1000207","article-title":"Flux-based transport enhancement as a plausible unifying mechanism for auxin transport in meristem development","volume":"4","author":"S Stoma","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1101\/gad.497009","article-title":"Integration of transport-based models for phyllotaxis and midvein formation","volume":"23","author":"EM Bayer","year":"2009","journal-title":"Genes Dev"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e1000516","DOI":"10.1371\/journal.pbio.1000516","article-title":"Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport","volume":"8","author":"MG Heisler","year":"2010","journal-title":"PLoS Biol"},{"key":"ref53","volume":"6","unstructured":"Wabnik K, Kleine-Vehn J, Balla J, Sauer M, Naramoto S, <etal>et al<\/etal>.. (2010) Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling. Mol Syst Biol <volume>6<\/volume>.."},{"key":"ref54","article-title":"An intracellular partitioning-based framework for tissue cell polarity in plants and animals","author":"K Abley","year":"2013","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e1000367","DOI":"10.1371\/journal.pbio.1000367","article-title":"Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana","volume":"8","author":"AHK Roeder","year":"2010","journal-title":"PLoS Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev.cellbio.20.082503.103053","article-title":"Anisotropic expansion of the plant cell wall","volume":"21","author":"TI Baskin","year":"2005","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.crvi.2010.01.007","article-title":"Regulation of anisotropic cell expansion in higher plants","volume":"333","author":"EF Crowell","year":"2010","journal-title":"C R Biologies"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1105\/tpc.105.040725","article-title":"Endogenous and synthetic microRNAs stimulate simultaneous, efficient, and localized regulation of multiple targets in diverse species","volume":"18","author":"JP Alvarez","year":"2006","journal-title":"Plant Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1073\/pnas.95.1.376","article-title":"A transcription activation system for regulated gene expression in transgenic plants","volume":"95","author":"I Moore","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/BF00014672","article-title":"The small, versatile pPZP family of Agrobacterium binary vectors for plant transformation","volume":"25","author":"P Hajdukiewicz","year":"1994","journal-title":"Plant Mol Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1365-313X.2011.04817.x","article-title":"Transient gibberellin application promotes Arabidopsis thaliana hypocotyl cell elongation without maintaining transverse orientation of microtubules on the outer tangential wall of epidermal cells","volume":"69","author":"S Sauret-G\u00fceto","year":"2012","journal-title":"Plant J"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1105\/tpc.107.056069","article-title":"High-resolution whole-mount imaging of three-dimensional tissue organization and gene expression enables the study of phloem development and structure in Arabidopsis","volume":"20","author":"E Truernit","year":"2008","journal-title":"Plant Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2013Delta Delta C(T)) method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1001550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T13:14:15Z","timestamp":1648300455000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1001550"}},"subtitle":[],"editor":[{"given":"Ottoline","family":"Leyser","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1001550","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}