{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:10:51Z","timestamp":1774066251766,"version":"3.50.1"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.0020004","type":"journal-article","created":{"date-parts":[[2006,1,13]],"date-time":"2006-01-13T18:38:52Z","timestamp":1137177532000},"page":"e4","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":161,"title":["Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays"],"prefix":"10.1371","volume":"2","author":[{"given":"Charles W","family":"Sugnet","sequence":"first","affiliation":[]},{"given":"Karpagam","family":"Srinivasan","sequence":"additional","affiliation":[]},{"given":"Tyson A","family":"Clark","sequence":"additional","affiliation":[]},{"given":"Georgeann","family":"O'Brien","sequence":"additional","affiliation":[]},{"given":"Melissa S","family":"Cline","sequence":"additional","affiliation":[]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Alan","family":"Williams","sequence":"additional","affiliation":[]},{"given":"David","family":"Kulp","sequence":"additional","affiliation":[]},{"given":"John E","family":"Blume","sequence":"additional","affiliation":[]},{"given":"David","family":"Haussler","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Ares","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"pcbi-0020004-b001","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biochem.72.121801.161720","article-title":"Mechanisms of alternative pre-messenger RNA splicing.","volume":"72","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"pcbi-0020004-b002","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ceb.2005.03.002","article-title":"Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells.","volume":"17","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"pcbi-0020004-b003","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1073\/pnas.0136770100","article-title":"Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans.","volume":"100","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"(Suppl 1)","key":"pcbi-0020004-b004","first-page":"i118","article-title":"Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes.","volume":"19","year":"2003","journal-title":"Bioinformatics"},{"key":"pcbi-0020004-b005","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1073\/pnas.94.18.9782","article-title":"smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans.","volume":"94","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0020004-b006","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-662-09728-1_7","article-title":"Alternative pre-mRNA splicing and neuronal function.","volume":"31","year":"2003","journal-title":"Prog Mol Subcell Biol"},{"key":"pcbi-0020004-b007","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0301-0082(01)00007-7","article-title":"Alternative RNA splicing in the nervous system.","volume":"65","year":"2001","journal-title":"Prog Neurobiol"},{"key":"pcbi-0020004-b008","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/ng1575","article-title":"Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms.","volume":"37","year":"2005","journal-title":"Nat Genet"},{"key":"pcbi-0020004-b009","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0968-0004(00)01604-2","article-title":"Alternative pre-mRNA splicing: The logic of combinatorial control.","volume":"25","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"pcbi-0020004-b010","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/sj.emboj.7600630","article-title":"Nova autoregulation reveals dual functions in neuronal splicing.","volume":"24","year":"2005","journal-title":"EMBO J"},{"key":"pcbi-0020004-b011","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1093\/nar\/gki561","article-title":"Identification of CELF splicing activation and repression domains in vivo.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b012","first-page":"reviews0008","article-title":"Finding signals that regulate alternative splicing in the post-genomic era.","volume":"3","year":"2002","journal-title":"Genome Biol"},{"key":"pcbi-0020004-b013","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1128\/MCB.25.22.10005-10016.2005","article-title":"Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.","volume":"25","year":"2005","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b014","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/nar\/gki338","article-title":"Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b015","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1261\/rna.7780504","article-title":"Specificity of the STAR\/GSG domain protein Qk1: Implications for the regulation of myelination.","volume":"10","year":"2004","journal-title":"RNA"},{"key":"pcbi-0020004-b016","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nsmb706","article-title":"RNA target specificity of the STAR\/GSG domain post-transcriptional regulatory protein GLD-1.","volume":"11","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"pcbi-0020004-b017","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1064719","article-title":"Structural basis for recognition of the intron branch site RNA by splicing factor 1.","volume":"294","year":"2001","journal-title":"Science"},{"key":"pcbi-0020004-b018","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1073\/pnas.072090399","article-title":"Function of quaking in myelination: Regulation of alternative splicing.","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0020004-b019","doi-asserted-by":"crossref","first-page":"29202","DOI":"10.1074\/jbc.274.41.29202","article-title":"The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.","volume":"274","year":"1999","journal-title":"J Biol Chem"},{"key":"pcbi-0020004-b020","first-page":"662","article-title":"Genomic organization and expression analysis of the mouse qkI locus.","volume":"10","year":"1999","journal-title":"Mamm Genome"},{"key":"pcbi-0020004-b021","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/nar\/gkg129","article-title":"The UCSC Genome Browser Database.","volume":"31","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b022","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1093\/nar\/gkg355","article-title":"Conservation of human alternative splice events in mouse.","volume":"31","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b023","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/nar\/29.11.2338","article-title":"Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing.","volume":"29","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b024","doi-asserted-by":"crossref","unstructured":"SugnetCWKentWJAresMJrHausslerD 2004 Transcriptome and genome conservation of alternative splicing events in humans and mice. Pac Symp Biocomput 66 77","DOI":"10.1142\/9789812704856_0007"},{"key":"pcbi-0020004-b025","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1101\/gr.1208803","article-title":"Intronic sequences flanking alternatively spliced exons are conserved between human and mouse.","volume":"13","year":"2003","journal-title":"Genome Res"},{"key":"pcbi-0020004-b026","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.0409742102","article-title":"Identification and analysis of alternative splicing events conserved in human and mouse.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0020004-b027","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1159","article-title":"Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and\/or loss.","volume":"34","year":"2003","journal-title":"Nat Genet"},{"key":"pcbi-0020004-b028","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1093\/nar\/29.13.2850","article-title":"Genome-wide detection of alternative splicing in expressed sequences of human genes.","volume":"29","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b029","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1101\/gr.2572604","article-title":"A non-EST-based method for exon-skipping prediction.","volume":"14","year":"2004","journal-title":"Genome Res"},{"key":"pcbi-0020004-b030","first-page":"897","article-title":"Accurate identification of alternatively spliced exons using support vector machine.","volume":"21","year":"2004","journal-title":"Bioinformatics"},{"key":"pcbi-0020004-b031","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1126\/science.1069415","article-title":"Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays.","volume":"296","year":"2002","journal-title":"Science"},{"key":"pcbi-0020004-b032","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1126\/science.1090100","article-title":"Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.","volume":"302","year":"2003","journal-title":"Science"},{"key":"pcbi-0020004-b033","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1074\/jbc.M411976200","article-title":"Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"pcbi-0020004-b034","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/gb-2003-4-10-r66","article-title":"Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing.","volume":"4","year":"2003","journal-title":"Genome Biol"},{"issue":"(Suppl 1)","key":"pcbi-0020004-b035","first-page":"i315","article-title":"Gene structure-based splice variant deconvolution using a microarray platform.","volume":"19","year":"2003","journal-title":"Bioinformatics"},{"key":"pcbi-0020004-b036","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nbt0402-353","article-title":"Profiling alternative splicing on fiber-optic arrays.","volume":"20","year":"2002","journal-title":"Nat Biotechnol"},{"key":"pcbi-0020004-b037","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1093\/nar\/gnh173","article-title":"Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data.","volume":"32","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b038","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.molcel.2004.12.004","article-title":"Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform.","volume":"16","year":"2004","journal-title":"Mol Cell"},{"key":"pcbi-0020004-b039","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nsmb891","article-title":"Exploring functional relationships between components of the gene expression machinery.","volume":"12","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"pcbi-0020004-b040","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gni047","article-title":"A microarray configuration to quantify expression levels and relative abundance of splice variants.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b041","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1101\/gad.1314205","article-title":"Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila.","volume":"19","year":"2005","journal-title":"Genes Dev"},{"key":"pcbi-0020004-b042","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/bioinformatics\/18.12.1593","article-title":"Analysis of high density expression microarrays with signed-rank call algorithms.","volume":"18","year":"2002","journal-title":"Bioinformatics"},{"key":"pcbi-0020004-b043","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.1990438","article-title":"Light-directed, spatially addressable parallel chemical synthesis.","volume":"251","year":"1991","journal-title":"Science"},{"key":"pcbi-0020004-b044","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1073\/pnas.91.11.5022","article-title":"Light-generated oligonucleotide arrays for rapid DNA sequence analysis.","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0020004-b045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0888-7543(03)00207-6","article-title":"Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene.","volume":"83","year":"2004","journal-title":"Genomics"},{"key":"pcbi-0020004-b046","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1261\/rna.2470903","article-title":"Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes.","volume":"9","year":"2003","journal-title":"RNA"},{"key":"pcbi-0020004-b047","doi-asserted-by":"crossref","first-page":"14017","DOI":"10.1074\/jbc.M414492200","article-title":"Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb.","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"pcbi-0020004-b048","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1089\/1066527041410472","article-title":"Combining phylogenetic and hidden Markov models in biosequence analysis.","volume":"11","year":"2004","journal-title":"J Comput Biol"},{"key":"pcbi-0020004-b049","first-page":"468","article-title":"Phylogenetic estimation of context-dependent substitution rates by maximum likelihood.","volume":"21","year":"2004","journal-title":"Mol Biol Evol"},{"key":"pcbi-0020004-b050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2105-2-8","article-title":"Noncoding RNA gene detection using comparative sequence analysis.","volume":"2","year":"2001","journal-title":"BMC Bioinformatics"},{"key":"pcbi-0020004-b051","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(00)80260-9","article-title":"Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing.","volume":"5","year":"2000","journal-title":"Mol Cell"},{"key":"pcbi-0020004-b052","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1128\/MCB.20.20.7463-7479.2000","article-title":"Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.","volume":"20","year":"2000","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b053","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/emboj\/cdg089","article-title":"A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.","volume":"22","year":"2003","journal-title":"EMBO J"},{"key":"pcbi-0020004-b054","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1128\/MCB.17.6.3194","article-title":"The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.","volume":"17","year":"1997","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b055","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/j.1460-2075.1994.tb06369.x","article-title":"RNA binding specificity of hnRNP A1: Significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.","volume":"13","year":"1994","journal-title":"EMBO J"},{"key":"pcbi-0020004-b056","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1128\/MCB.23.13.4687-4700.2003","article-title":"Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer.","volume":"23","year":"2003","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b057","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/neu.10072","article-title":"Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons.","volume":"52","year":"2002","journal-title":"J Neurobiol"},{"key":"pcbi-0020004-b058","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0896-6273(00)80900-9","article-title":"Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.","volume":"25","year":"2000","journal-title":"Neuron"},{"key":"pcbi-0020004-b059","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/nar\/gki210","article-title":"The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b060","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1128\/MCB.18.7.3900","article-title":"Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats.","volume":"18","year":"1998","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b061","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.1073\/pnas.94.23.12343","article-title":"Control of alternative pre-mRNA splicing by distributed pentameric repeats.","volume":"94","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0020004-b062","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1101\/gad.8.13.1561","article-title":"Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element.","volume":"8","year":"1994","journal-title":"Genes Dev"},{"key":"pcbi-0020004-b063","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1126\/science.1102216","article-title":"Environmentally induced foregut remodeling by PHA-4\/FoxA and DAF-12\/NHR.","volume":"305","year":"2004","journal-title":"Science"},{"key":"pcbi-0020004-b064","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in biopolymers.","volume":"2","year":"1994","journal-title":"Proc Int Conf Intell Syst Mol Biol"},{"key":"pcbi-0020004-b065","first-page":"303","article-title":"ParaMEME: A parallel implementation and a web interface for a DNA and protein motif discovery tool.","volume":"12","year":"1996","journal-title":"Comput Appl Biosci"},{"key":"pcbi-0020004-b066","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00018-003-3364-5","article-title":"MAGUKs in synapse assembly and function: An emerging view.","volume":"61","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"pcbi-0020004-b067","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/bies.950190606","article-title":"PDZ domains: targeting signalling molecules to sub-membranous sites.","volume":"19","year":"1997","journal-title":"Bioessays"},{"issue":"(Suppl 1)","key":"pcbi-0020004-b068","first-page":"i107","article-title":"ANOSVA: A statistical method for detecting splice variation from expression data.","volume":"21","year":"2005","journal-title":"Bioinformatics"},{"key":"pcbi-0020004-b069","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0896-6273(00)80444-4","article-title":"Splicing in the inner ear: A familiar tune, but what are the instruments?","volume":"20","year":"1998","journal-title":"Neuron"},{"key":"pcbi-0020004-b070","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1126\/science.1090095","article-title":"CLIP identifies Nova-regulated RNA networks in the brain.","volume":"302","year":"2003","journal-title":"Science"},{"key":"pcbi-0020004-b071","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/MCB.17.11.6537","article-title":"A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon.","volume":"17","year":"1997","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b072","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1182\/blood.V98.13.3809","article-title":"Multiple cis elements regulate an alternative splicing event at 4.1R pre-mRNA during erythroid differentiation.","volume":"98","year":"2001","journal-title":"Blood"},{"key":"pcbi-0020004-b073","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1128\/MCB.12.10.4545","article-title":"Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex.","volume":"12","year":"1992","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b074","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1128\/MCB.21.15.5232-5241.2001","article-title":"Recognition of RNA branch point sequences by the KH domain of splicing factor 1 (mammalian branch point binding protein) in a splicing factor complex.","volume":"21","year":"2001","journal-title":"Mol Cell Biol"},{"key":"pcbi-0020004-b075","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1091\/mbc.e04-11-1034","article-title":"Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.","volume":"16","year":"2005","journal-title":"Mol Biol Cell"},{"key":"pcbi-0020004-b076","doi-asserted-by":"crossref","first-page":"38059","DOI":"10.1074\/jbc.M001483200","article-title":"Kinetic role for mammalian SF1\/BBP in spliceosome assembly and function after polypyrimidine tract recognition by U2AF.","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"key":"pcbi-0020004-b077","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jmb.2005.02.058","article-title":"Solution structure and backbone dynamics of the KH-QUA2 region of the Xenopus STAR\/GSG quaking protein.","volume":"348","year":"2005","journal-title":"J Mol Biol"},{"key":"pcbi-0020004-b078","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1101\/gad.860301","article-title":"Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer.","volume":"15","year":"2001","journal-title":"Genes Dev"},{"key":"pcbi-0020004-b079","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1101\/gr.229202","article-title":"BLAT\u2014The BLAST-like alignment tool.","volume":"12","year":"2002","journal-title":"Genome Res"},{"key":"pcbi-0020004-b080","doi-asserted-by":"crossref","unstructured":"WheelerR 2002 A method of consolidating and combining EST and mRNA alignments to a genome to enumerate supported splice variants. In: GuigoRGusfieldD Algorithms in Bioinformatics: Second International Workshop, WABI 2002, Rome, Italy, September 17\u201321, 2002, Proceedings Berlin\/New York Springer pp. 201 209.","DOI":"10.1007\/3-540-45784-4_15"},{"key":"pcbi-0020004-b081","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.","volume":"19","year":"2003","journal-title":"Bioinformatics"},{"key":"pcbi-0020004-b082","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data.","volume":"31","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0020004-b083","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data.","volume":"4","year":"2003","journal-title":"Biostatistics"},{"key":"pcbi-0020004-b084","unstructured":"FisherRA 1970 Statistical Methods for Research Workers Darien (Colorado) Hafner Press 362 p."},{"key":"pcbi-0020004-b085","unstructured":"WilcoxRR 2003 Applying Contemporary Statistical Techniques Amsterdam\/Boston Academic Press"},{"key":"pcbi-0020004-b086","unstructured":"R Development Core Team 2005 R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing. Available: http:\/\/www.r-project.org Accessed 21 December 2005"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0020004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:31:00Z","timestamp":1736220660000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0020004"}},"subtitle":[],"editor":[{"given":"Steven","family":"Brenner","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2006,1,20]]},"references-count":86,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.0020004","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,20]]}}}