{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:07:24Z","timestamp":1761894444834},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1371\/journal.pcbi.0020173","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T00:56:01Z","timestamp":1164848161000},"page":"e173","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Protein Homology Network Families Reveal Step-Wise Diversification of Type III and Type IV Secretion Systems"],"prefix":"10.1371","volume":"2","author":[{"given":"Duccio","family":"Medini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Covacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Donati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","reference":[{"key":"journal-pcbi-0020173-b001","first-page":"86","volume":"221","author":"Dayhoff","year":"1969","journal-title":"Sci Am","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8733","issn-type":"print"},{"key":"journal-pcbi-0020173-b002","first-page":"2132","volume":"35","author":"Dayhoff","year":"1976","journal-title":"Fed Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0014-9446","issn-type":"print"},{"key":"journal-pcbi-0020173-b003","first-page":"631","volume":"278","author":"Tatusov","year":"1997","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pcbi-0020173-b004","first-page":"483","volume":"2","author":"Feil","year":"2004","journal-title":"Nat Rev Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/1740-1526","issn-type":"print"},{"key":"journal-pcbi-0020173-b005","first-page":"462","volume":"3","author":"Joyce","year":"2002","journal-title":"Nat Rev Genet","ISSN":"http:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"key":"journal-pcbi-0020173-b006","first-page":"2124","volume":"284","author":"Doolittle","year":"1999","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pcbi-0020173-b007","first-page":"379","volume":"62","author":"Hueck","year":"1998","journal-title":"Microbiol Mol Biol Rev","ISSN":"http:\/\/id.crossref.org\/issn\/1092-2172","issn-type":"print"},{"key":"journal-pcbi-0020173-b008","first-page":"1322","volume":"284","author":"Galan","year":"1999","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pcbi-0020173-b009","first-page":"116","volume":"50","author":"Winstanley","year":"2001","journal-title":"J Med Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2615","issn-type":"print"},{"key":"journal-pcbi-0020173-b010","first-page":"8778","volume":"97","author":"Cornelis","year":"2000","journal-title":"Proc Natl Acad Sci U S A","ISSN":"http:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pcbi-0020173-b011","first-page":"1328","volume":"284","author":"Covacci","year":"1999","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pcbi-0020173-b012","first-page":"3201","volume":"147","author":"Cao","year":"2001","journal-title":"Microbiology","ISSN":"http:\/\/id.crossref.org\/issn\/0026-2617","issn-type":"print"},{"key":"journal-pcbi-0020173-b013","first-page":"137","volume":"1","author":"Cascales","year":"2003","journal-title":"Nat Rev Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/1740-1526","issn-type":"print"},{"key":"journal-pcbi-0020173-b014","first-page":"451","volume":"59","author":"Christie","year":"2005","journal-title":"Annu Rev Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4227","issn-type":"print"},{"key":"journal-pcbi-0020173-b015","first-page":"7149","volume":"181","author":"Macnab","year":"1999","journal-title":"J Bacteriol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"journal-pcbi-0020173-b016","first-page":"3027","volume":"100","author":"Blocker","year":"2003","journal-title":"Proc Natl Acad Sci U S A","ISSN":"http:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pcbi-0020173-b017","first-page":"294","volume":"40","author":"Christie","year":"2001","journal-title":"Mol Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/0950-382X","issn-type":"print"},{"key":"journal-pcbi-0020173-b018","first-page":"3389","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"key":"journal-pcbi-0020173-b019","first-page":"47","volume":"74","author":"Albert","year":"2002","journal-title":"Rev Mod Physics","ISSN":"http:\/\/id.crossref.org\/issn\/0034-6861","issn-type":"print"},{"key":"journal-pcbi-0020173-b020","first-page":"290","volume":"6","author":"Erdös","year":"1959","journal-title":"Publ Math (Debrecen)","ISSN":"http:\/\/id.crossref.org\/issn\/0033-3883","issn-type":"print"},{"key":"journal-pcbi-0020173-b021","first-page":"1551","volume":"297","author":"Ravasz","year":"2002","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pcbi-0020173-b022","first-page":"167","volume":"45","author":"Newman","year":"2003","journal-title":"Siam Review","ISSN":"http:\/\/id.crossref.org\/issn\/0036-1445","issn-type":"print"},{"key":"journal-pcbi-0020173-b023","first-page":"26113","volume":"69","author":"Newman","year":"2004","journal-title":"Phys Rev E","ISSN":"http:\/\/id.crossref.org\/issn\/1063-651X","issn-type":"print"},{"key":"journal-pcbi-0020173-b024","first-page":"12123","volume":"100","author":"Spirin","year":"2003","journal-title":"Proc Natl Acad Sci U S A","ISSN":"http:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pcbi-0020173-b025","first-page":"D138","volume":"32","author":"Bateman","year":"2004","journal-title":"Nucleic Acids Res","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"key":"journal-pcbi-0020173-b026","first-page":"125","volume":"2","author":"Nguyen","year":"2000","journal-title":"J Mol Microbiol Biotechnol","ISSN":"http:\/\/id.crossref.org\/issn\/1464-1801","issn-type":"print"},{"key":"journal-pcbi-0020173-b027","first-page":"37","volume":"55","author":"Foultier","year":"2002","journal-title":"J Mol Evol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2844","issn-type":"print"},{"key":"journal-pcbi-0020173-b028","first-page":"201","volume":"29","author":"Pallen","year":"2005","journal-title":"FEMS Microbiol Rev","ISSN":"http:\/\/id.crossref.org\/issn\/0168-6445","issn-type":"print"},{"key":"journal-pcbi-0020173-b029","first-page":"13950","volume":"102","author":"Tettelin","year":"2005","journal-title":"Proc Natl Acad Sci U S A","ISSN":"http:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pcbi-0020173-b030","first-page":"703","volume":"124","author":"Raskin","year":"2006","journal-title":"Cell","ISSN":"http:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"journal-pcbi-0020173-b031","first-page":"179","volume":"340","author":"Adai","year":"2004","journal-title":"J Mol Biol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:30:25Z","timestamp":1540254625000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0020173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.0020173","relation":{},"ISSN":["1553-734X","1553-7358"],"issn-type":[{"value":"1553-734X","type":"print"},{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}