{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:54:17Z","timestamp":1769925257300,"version":"3.49.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T00:00:00Z","timestamp":1174608000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.0030055","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T18:03:03Z","timestamp":1174327383000},"page":"e55","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":88,"title":["Dynamic Simulations on the Arachidonic Acid Metabolic Network"],"prefix":"10.1371","volume":"3","author":[{"given":"Kun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luhua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"pcbi-0030055-b001","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1016\/S0002-9343(97)00204-0","article-title":"Use and benefits of nonsteroidal anti-inflammatory drugs.","volume":"104","year":"1998","journal-title":"Am J Med"},{"key":"pcbi-0030055-b002","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/S0002-9343(98)00274-5","article-title":"Nonsteroidal anti-inflammatory drug-related gastrointestinal toxicity: Definitions and epidemiology.","volume":"105","year":"1998","journal-title":"Am J Med"},{"key":"pcbi-0030055-b003","doi-asserted-by":"crossref","first-page":"11202","DOI":"10.1073\/pnas.91.23.11202","article-title":"Mechanism of selective inhibition of the inducible isoform of prostaglandin G\/H synthase.","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030055-b004","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1111\/j.1572-0241.2003.07598.x","article-title":"The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.","volume":"98","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"pcbi-0030055-b005","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1056\/NEJMe058042","article-title":"COX-2 inhibitors\u2014Lessons in drug safety.","volume":"352","year":"2005","journal-title":"N Engl J Med"},{"key":"pcbi-0030055-b006","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.coph.2005.02.001","article-title":"Cardiovascular hazard and non-steroidal anti-inflammatory drugs.","volume":"5","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"pcbi-0030055-b007","first-page":"816","article-title":"Merck withdraws arthritis drug worldwide.","volume":"329","year":"2004","journal-title":"BMJ"},{"key":"pcbi-0030055-b008","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJMp058055","article-title":"Raising the safety bar\u2014The FDA's coxib meeting.","volume":"352","year":"2005","journal-title":"N Engl J Med"},{"key":"pcbi-0030055-b009","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1056\/NEJMc045711","article-title":"Cardiovascular toxicity of valdecoxib.","volume":"351","year":"2004","journal-title":"N Engl J Med"},{"key":"pcbi-0030055-b010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1056\/NEJMoa050405","article-title":"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention.","volume":"352","year":"2005","journal-title":"N Engl J Med"},{"key":"pcbi-0030055-b011","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1359-6446(04)03316-1","article-title":"Target-based drug discovery: Is something wrong?.","volume":"10","year":"2005","journal-title":"Drug Discov Today"},{"key":"pcbi-0030055-b012","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/437491a","article-title":"Pharmaceuticals: A new grammar for drug discovery.","volume":"437","year":"2005","journal-title":"Nature"},{"key":"pcbi-0030055-b013","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1359-6446(02)02403-0","article-title":"Systems biology: The new darling of drug discovery?.","volume":"7","year":"2002","journal-title":"Drug Discov Today"},{"key":"pcbi-0030055-b014","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nature01254","article-title":"Computational systems biology.","volume":"420","year":"2002","journal-title":"Nature"},{"key":"pcbi-0030055-b015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0047-6374(02)00164-1","article-title":"Systems biology: Integrating technology, biology, and computation.","volume":"124","year":"2003","journal-title":"Mech Ageing Dev"},{"key":"pcbi-0030055-b016","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nbt1017","article-title":"Systems biology in drug discovery.","volume":"22","year":"2004","journal-title":"Nat Biotechnol"},{"key":"pcbi-0030055-b017","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tips.2005.02.006","article-title":"Techniques: Application of systems biology to absorption, distribution, metabolism, excretion and toxicity.","volume":"26","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"pcbi-0030055-b018","doi-asserted-by":"crossref","first-page":"23367","DOI":"10.1016\/S0021-9258(17)31662-9","article-title":"A model for the tissue factor pathway to thrombin. II. A mathematical simulation.","volume":"269","year":"1994","journal-title":"J Biol Chem"},{"key":"pcbi-0030055-b019","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1359-6446(01)02096-7","article-title":"The dynamics of molecular networks: Applications to therapeutic discovery.","volume":"6","year":"2001","journal-title":"Drug Discov Today"},{"key":"pcbi-0030055-b020","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cbpa.2005.06.008","article-title":"Systems modeling: A pathway to drug discovery.","volume":"9","year":"2005","journal-title":"Curr Opin Chem Biol"},{"key":"pcbi-0030055-b021","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkj102","article-title":"From genomics to chemical genomics: New developments in KEGG.","volume":"34","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0030055-b022","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1016\/S0021-9258(18)90946-4","article-title":"Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes.","volume":"259","year":"1984","journal-title":"J Biol Chem"},{"key":"pcbi-0030055-b023","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0005-2760(95)00241-3","article-title":"Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative.","volume":"1300","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"pcbi-0030055-b024","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1357-2725(97)00123-4","article-title":"Leukotriene B4.","volume":"30","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"pcbi-0030055-b025","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1096\/fasebj.12.12.1109","article-title":"Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils.","volume":"12","year":"1998","journal-title":"FASEB J"},{"key":"pcbi-0030055-b026","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/pupt.1997.0090","article-title":"The effects of ML 3000 on antigen-induced responses in sheep.","volume":"10","year":"1997","journal-title":"Pulm Pharmacol Ther"},{"key":"pcbi-0030055-b027","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1021\/jm9802416","article-title":"New cyclooxygenase-2\/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: Variations at the 5 position.","volume":"41","year":"1998","journal-title":"J Med Chem"},{"key":"pcbi-0030055-b028","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bcp.2005.03.031","article-title":"Licofelone, a novel 5-LOX\/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.","volume":"70","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"pcbi-0030055-b029","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/med.10065","article-title":"Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: Role in atherosclerosis.","volume":"24","year":"2004","journal-title":"Med Res Rev"},{"key":"pcbi-0030055-b030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0197-4580(02)00021-0","article-title":"Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity.","volume":"23","year":"2002","journal-title":"Neurobiol Aging"},{"key":"pcbi-0030055-b031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0928-4257(01)00004-3","article-title":"The ever-emerging anti-inflammatories. Have there been any real advances?.","volume":"95","year":"2001","journal-title":"J Physiol Paris"},{"key":"pcbi-0030055-b032","first-page":"115","article-title":"Clinical pharmacokinetics of meloxicam. A cyclo-oxygenase-2 preferential nonsteroidal anti-inflammatory drug.","volume":"36","year":"1999","journal-title":"Clin Pharmacokinet"},{"issue":"(Supplement 1)","key":"pcbi-0030055-b033","first-page":"i21","article-title":"Licofelone\u2014Clinical update on a novel LOX\/COX inhibitor for the treatment of osteoarthritis.","volume":"43","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"pcbi-0030055-b034","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1572-0241.2004.04133.x","article-title":"The gastrointestinal tolerability of the LOX\/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: Results from a randomized, controlled trial.","volume":"99","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"pcbi-0030055-b035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0022-1759(81)90040-5","article-title":"A rapid method for purification of human granulocytes using percoll. A comparison with dextran sedimentation.","volume":"43","year":"1981","journal-title":"J Immunol Methods"},{"key":"pcbi-0030055-b036","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0021-9258(19)40034-3","article-title":"MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.","volume":"265","year":"1990","journal-title":"J Biol Chem"},{"key":"pcbi-0030055-b037","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11060-004-1721-3","article-title":"Inhibition of human neuroblastoma cell growth by CAY10404, a highly selective Cox-2 inhibitor.","volume":"71","year":"2005","journal-title":"J Neurooncol"},{"key":"pcbi-0030055-b038","first-page":"1407","article-title":"The anti-inflammatory effect of total flavonoids isolated from Platychadus orientalis and its mechanism.","volume":"19","year":"2003","journal-title":"Chinese Pharmacol Bull"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T16:06:26Z","timestamp":1628697986000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030055"}},"subtitle":[],"editor":[{"given":"Robert B","family":"Russell","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2007,3,23]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.0030055","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,23]]}}}