{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:35:20Z","timestamp":1785407720304,"version":"3.56.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2007,4,6]],"date-time":"2007-04-06T00:00:00Z","timestamp":1175817600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.0030066","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T16:15:58Z","timestamp":1175703358000},"page":"e66","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":140,"title":["Towards Complete Sets of Farnesylated and Geranylgeranylated Proteins"],"prefix":"10.1371","volume":"3","author":[{"given":"Sebastian","family":"Maurer-Stroh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Koranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Benetka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda L","family":"Sirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Eisenhaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,4,6]]},"reference":[{"key":"pcbi-0030066-b001","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1074\/jbc.271.10.5289","article-title":"Protein prenyltransferases.","volume":"271","year":"1996","journal-title":"J Biol Chem"},{"key":"pcbi-0030066-b002","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/gb-2003-4-4-212","article-title":"Protein prenyltransferases.","volume":"4","year":"2003","journal-title":"Genome Biol"},{"key":"pcbi-0030066-b003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-291X(03)00323-1","article-title":"Protein prenylation: A pivotal posttranslational process.","volume":"303","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"pcbi-0030066-b004","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1097-2765(03)00044-3","article-title":"Structure of rab escort protein-1 in complex with rab geranylgeranyltransferase.","volume":"11","year":"2003","journal-title":"Mol Cell"},{"key":"pcbi-0030066-b005","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-5793(01)02483-8","article-title":"Prenylation of Rab GTPases: Molecular mechanisms and involvement in genetic disease.","volume":"498","year":"2001","journal-title":"FEBS Lett"},{"key":"pcbi-0030066-b006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1388-1981(00)00149-9","article-title":"Functional aspects of polyisoprenoid protein substituents: Roles in protein\u2013protein interaction and trafficking.","volume":"1529","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"pcbi-0030066-b007","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1038\/sj.onc.1204146","article-title":"Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies.","volume":"19","year":"2000","journal-title":"Oncogene"},{"key":"pcbi-0030066-b008","first-page":"977","article-title":"Protein prenyltransferases: Anchor size, pseudogenes, and parasites.","volume":"384","year":"2003","journal-title":"Biol Chem"},{"key":"pcbi-0030066-b009","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0166-6851(02)00282-7","article-title":"Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.","volume":"126","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"pcbi-0030066-b010","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/gb-2005-6-6-r55","article-title":"Refinement and prediction of protein prenylation motifs.","volume":"6","year":"2005","journal-title":"Genome Biol"},{"key":"pcbi-0030066-b011","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1006\/jmbi.2002.5426","article-title":"N-terminal N-myristoylation of proteins: Prediction of substrate proteins from amino acid sequence.","volume":"317","year":"2002","journal-title":"J Mol Biol"},{"key":"pcbi-0030066-b012","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/jmbi.2002.5425","article-title":"N-terminal N-myristoylation of proteins: Refinement of the sequence motif and its taxon-specific differences.","volume":"317","year":"2002","journal-title":"J Mol Biol"},{"key":"pcbi-0030066-b013","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/gb-2004-5-3-r21","article-title":"MYRbase: Analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.","volume":"5","year":"2004","journal-title":"Genome Biol"},{"key":"pcbi-0030066-b014","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/hmg\/ddi194","article-title":"Species-specific membrane anchoring of nyctalopin, a small leucine-rich repeat protein.","volume":"14","year":"2005","journal-title":"Hum Mol Genet"},{"key":"pcbi-0030066-b015","doi-asserted-by":"crossref","first-page":"30608","DOI":"10.1074\/jbc.M103928200","article-title":"Conserved cysteine and tryptophan residues of the endothelin-converting enzyme-1 CXAW motif are critical for protein maturation and enzyme activity.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"pcbi-0030066-b016","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1186\/gb-2004-5-12-r97","article-title":"Hidden localization motifs: naturally occurring peroxisomal targeting signals in non-peroxisomal proteins.","volume":"5","year":"2004","journal-title":"Genome Biol"},{"key":"pcbi-0030066-b017","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nrc1234","article-title":"Opinion: Searching for the elusive targets of farnesyltransferase inhibitors.","volume":"3","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"pcbi-0030066-b018","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2091-7-6","article-title":"Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.","volume":"7","year":"2006","journal-title":"BMC Biochem"},{"key":"pcbi-0030066-b019","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0014-5793(93)80897-4","article-title":"Isoprenylation of Rab proteins possessing a C-terminal CaaX motif.","volume":"330","year":"1993","journal-title":"FEBS Lett"},{"issue":"( Part 3)","key":"pcbi-0030066-b020","first-page":"497","article-title":"Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases.","volume":"333","year":"1998","journal-title":"Biochem J"},{"key":"pcbi-0030066-b021","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: A new generation of protein database search programs.","volume":"25","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0030066-b022","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/nar\/30.7.1575","article-title":"An efficient algorithm for large-scale detection of protein families.","volume":"30","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0030066-b023","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0006-291X(02)00675-7","article-title":"Two C-terminal cysteines are necessary for proper folding of the peptidase neprilysin\/CD10.","volume":"295","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"pcbi-0030066-b024","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/pmic.200300781","article-title":"Prediction of sequence signals for lipid post-translational modifications: Insights from case studies.","volume":"4","year":"2004","journal-title":"Proteomics"},{"key":"pcbi-0030066-b025","first-page":"478","article-title":"Farnesyltransferase inhibitors as anticancer agents: Critical crossroads.","volume":"7","year":"2004","journal-title":"Curr Opin Drug Discov Devel"},{"key":"pcbi-0030066-b026","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1021\/bi00233a001","article-title":"The ras protein family: Evolutionary tree and role of conserved amino acids.","volume":"30","year":"1991","journal-title":"Biochemistry"},{"key":"pcbi-0030066-b027","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1006\/jmbi.2001.5072","article-title":"Evolution of the Rab family of small GTP-binding proteins.","volume":"313","year":"2001","journal-title":"J Mol Biol"},{"key":"pcbi-0030066-b028","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1104\/pp.013052","article-title":"Analysis of the small GTPase gene superfamily of Arabidopsis.","volume":"131","year":"2003","journal-title":"Plant Physiol"},{"key":"pcbi-0030066-b029","doi-asserted-by":"crossref","first-page":"25251","DOI":"10.1016\/S0021-9258(18)47239-0","article-title":"Novel isoprenylated proteins identified by an expression library screen.","volume":"269","year":"1994","journal-title":"J Biol Chem"},{"key":"pcbi-0030066-b030","doi-asserted-by":"crossref","first-page":"R787","DOI":"10.1016\/j.cub.2004.09.020","article-title":"APC\/C and SCF: Controlling each other and the cell cycle.","volume":"14","year":"2004","journal-title":"Curr Biol"},{"key":"pcbi-0030066-b031","doi-asserted-by":"crossref","first-page":"12479","DOI":"10.1073\/pnas.0403413101","article-title":"A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030066-b032","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1073\/pnas.89.20.9554","article-title":"Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: Localization by conversion to S-ethylcysteine and by tandem mass spectrometry.","volume":"89","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030066-b033","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1124\/mol.105.019133","article-title":"Dexamethasone-induced ras protein 1 negatively regulates protein kinase C \u03b4: Implications for adenylyl cyclase 2 signaling.","volume":"69","year":"2006","journal-title":"Mol Pharmacol"},{"key":"pcbi-0030066-b034","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/oxfordjournals.jbchem.a021670","article-title":"HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria.","volume":"121","year":"1997","journal-title":"J Biochem (Tokyo)"},{"key":"pcbi-0030066-b035","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1021\/bi973194c","article-title":"Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.","volume":"37","year":"1998","journal-title":"Biochemistry"},{"key":"pcbi-0030066-b036","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1432-1033.1996.0833p.x","article-title":"Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini.","volume":"237","year":"1996","journal-title":"Eur J Biochem"},{"key":"pcbi-0030066-b037","doi-asserted-by":"crossref","first-page":"20033","DOI":"10.1016\/S0021-9258(19)88661-1","article-title":"Post-translational modifications of p21rho proteins.","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"pcbi-0030066-b038","first-page":"249","article-title":"Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle.","volume":"11","year":"2003","journal-title":"Int J Mol Med"},{"key":"pcbi-0030066-b039","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0092-8674(02)00715-8","article-title":"Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.","volume":"109","year":"2002","journal-title":"Cell"},{"key":"pcbi-0030066-b040","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/ncb1271","article-title":"Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.","volume":"7","year":"2005","journal-title":"Nat Cell Biol"},{"key":"pcbi-0030066-b041","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cub.2005.03.040","article-title":"Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation.","volume":"15","year":"2005","journal-title":"Curr Biol"},{"key":"pcbi-0030066-b042","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0960-9822(03)00240-9","article-title":"Zebrafish prickle, a modulator of noncanonical Wnt\/Fz signaling, regulates gastrulation movements.","volume":"13","year":"2003","journal-title":"Curr Biol"},{"key":"pcbi-0030066-b043","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cub.2004.12.041","article-title":"Ascidian prickle regulates both mediolateral and anterior\u2013posterior cell polarity of notochord cells.","volume":"15","year":"2005","journal-title":"Curr Biol"},{"key":"pcbi-0030066-b044","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1126\/science.1081867","article-title":"A giant virus in amoebae.","volume":"299","year":"2003","journal-title":"Science"},{"key":"pcbi-0030066-b045","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3201\/eid1202.050434","article-title":"Ameba-associated microorganisms and diagnosis of nosocomial pneumonia.","volume":"12","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"pcbi-0030066-b046","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.virusres.2005.07.011","article-title":"Genomic and evolutionary aspects of Mimivirus.","volume":"117","year":"2006","journal-title":"Virus Res"},{"key":"pcbi-0030066-b047","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.virusres.2006.01.009","article-title":"Evolutionary genomics of nucleo-cytoplasmic large DNA viruses.","volume":"117","year":"2006","journal-title":"Virus Res"},{"key":"pcbi-0030066-b048","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1073\/pnas.91.4.1275","article-title":"Consequences of altered isoprenylation targets on a-factor export and bioactivity.","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030066-b049","first-page":"363","article-title":"RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.","volume":"13","year":"2002","journal-title":"Cell Growth Differ"},{"key":"pcbi-0030066-b050","doi-asserted-by":"crossref","first-page":"48518","DOI":"10.1074\/jbc.M107129200","article-title":"Gbetagamma affinity for bovine rhodopsin is determined by the carboxyl-terminal sequences of the gamma subunit.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"pcbi-0030066-b051","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/359147a0","article-title":"Isoprenylation in regulation of signal transduction by G-protein\u2013coupled receptor kinases.","volume":"359","year":"1992","journal-title":"Nature"},{"key":"pcbi-0030066-b052","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/MCB.12.6.2606","article-title":"Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.","volume":"12","year":"1992","journal-title":"Mol Cell Biol"},{"key":"pcbi-0030066-b053","doi-asserted-by":"crossref","first-page":"38029","DOI":"10.1074\/jbc.M104658200","article-title":"Prenylation of target GTPases contributes to signaling specificity of Ras-guanine nucleotide exchange factors.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"pcbi-0030066-b054","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/35101096","article-title":"Actin' up: RhoB in cancer and apoptosis.","volume":"1","year":"2001","journal-title":"Nat Rev Cancer"},{"key":"pcbi-0030066-b055","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/1097-0134(20001001)41:1<98::AID-PROT120>3.0.CO;2-S","article-title":"Practical limits of function prediction.","volume":"41","year":"2000","journal-title":"Proteins"},{"key":"pcbi-0030066-b056","doi-asserted-by":"crossref","unstructured":"Pawlowski K Jaroszewski L Rychlewski L Godzik A 2000 Sensitive sequence comparison as protein function predictor. Pac Symp Biocomput 42 53","DOI":"10.1142\/9789814447331_0005"},{"key":"pcbi-0030066-b057","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1006\/jmbi.2001.4513","article-title":"Evolution of function in protein superfamilies, from a structural perspective.","volume":"307","year":"2001","journal-title":"J Mol Biol"},{"key":"pcbi-0030066-b058","first-page":"D476","article-title":"Inparanoid: A comprehensive database of eukaryotic orthologs.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pcbi-0030066-b059","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1006\/jmbi.2000.5197","article-title":"Automatic clustering of orthologs and in-paralogs from pairwise species comparisons.","volume":"314","year":"2001","journal-title":"J Mol Biol"},{"key":"pcbi-0030066-b060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0168-9525(02)02793-2","article-title":"Orthology, paralogy, and proposed classification for paralog subtypes.","volume":"18","year":"2002","journal-title":"Trends Genet"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T13:55:13Z","timestamp":1736949313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030066"}},"subtitle":[],"editor":[{"given":"Burkhard","family":"Rost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,4,6]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.0030066","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,6]]}}}