{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:46:21Z","timestamp":1780721181967,"version":"3.54.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T00:00:00Z","timestamp":1176422400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.0030068","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T18:01:17Z","timestamp":1176314477000},"page":"e68","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":198,"title":["Synchronization-Induced Rhythmicity of Circadian Oscillators in the Suprachiasmatic Nucleus"],"prefix":"10.1371","volume":"3","author":[{"given":"Samuel","family":"Bernard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Gonze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"\u010cajavec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Herzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,4,13]]},"reference":[{"key":"pcbi-0030068-b001","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nature00965","article-title":"Coordination of circadian timing in mammals.","volume":"418","year":"2002","journal-title":"Nature"},{"key":"pcbi-0030068-b002","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2005.11.001","article-title":"Come together, right...now: Synchronization of rhythms in a mammalian circadian clock.","volume":"48","year":"2005","journal-title":"Neuron"},{"key":"pcbi-0030068-b003","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tins.2005.01.003","article-title":"Orchestrating time: Arrangements of the brain circadian clock.","volume":"28","year":"2005","journal-title":"Trends Neurosci"},{"key":"pcbi-0030068-b004","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0896-6273(95)90214-7","article-title":"Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.","volume":"14","year":"1995","journal-title":"Neuron"},{"key":"pcbi-0030068-b005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neulet.2004.01.022","article-title":"Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period.","volume":"358","year":"2004","journal-title":"Neurosci Lett"},{"key":"pcbi-0030068-b006","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.7433976","article-title":"Temporal precision in circadian systems: A reliable neuronal clock from unreliable components?","volume":"209","year":"1980","journal-title":"Science"},{"key":"pcbi-0030068-b007","doi-asserted-by":"crossref","first-page":"11155","DOI":"10.1523\/JNEUROSCI.3821-05.2005","article-title":"Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling.","volume":"25","year":"2005","journal-title":"J Neurosci"},{"key":"pcbi-0030068-b008","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/417405a","article-title":"Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.","volume":"417","year":"2002","journal-title":"Nature"},{"key":"pcbi-0030068-b009","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0896-6273(00)80876-4","article-title":"GABA synchronizes clock cells within the suprachiasmatic circadian clock.","volume":"25","year":"2000","journal-title":"Neuron"},{"key":"pcbi-0030068-b010","doi-asserted-by":"crossref","first-page":"19188","DOI":"10.1073\/pnas.0607466103","article-title":"GABA and Gi\/o differentially control circadian rhythms and synchrony in clock neurons.","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030068-b011","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/1097-4695(20000615)43:4<379::AID-NEU6>3.0.CO;2-0","article-title":"Rhythmic coupling among cells in the suprachiasmatic nucleus.","volume":"43","year":"2000","journal-title":"J Neurobiol"},{"key":"pcbi-0030068-b012","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.0953-816x.2000.01437.x","article-title":"Vasoactive intestinal polypeptide (VIP) phase-shifts the rat suprachiasmatic nucleus clock in vitro.","volume":"13","year":"2001","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030068-b013","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0092-8674(02)00736-5","article-title":"The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.","volume":"109","year":"2002","journal-title":"Cell"},{"key":"pcbi-0030068-b014","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1460-9568.2003.02425.x","article-title":"The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro.","volume":"17","year":"2003","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030068-b015","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molbrainres.2004.01.010","article-title":"Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents.","volume":"124","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"pcbi-0030068-b016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cne.20168","article-title":"Expression of VIP and\/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites.","volume":"475","year":"2004","journal-title":"J Comp Neurol"},{"key":"pcbi-0030068-b017","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cub.2005.03.051","article-title":"A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock.","volume":"15","year":"2005","journal-title":"Curr Biol"},{"key":"pcbi-0030068-b018","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.cub.2006.02.023","article-title":"Synchronization and maintenance of timekeeping in suprachiasma-tic circadian clock cells by neuropeptidergic signaling.","volume":"16","year":"2006","journal-title":"Curr Biol"},{"key":"pcbi-0030068-b019","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nn1419","article-title":"Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons.","volume":"8","year":"2005","journal-title":"Nat Neurosci"},{"key":"pcbi-0030068-b020","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.1089287","article-title":"Synchronization of cellular clocks in the suprachiasmatic nucleus.","volume":"302","year":"2003","journal-title":"Science"},{"key":"pcbi-0030068-b021","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0092-8674(02)00737-7","article-title":"Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock.","volume":"109","year":"2002","journal-title":"Cell"},{"key":"pcbi-0030068-b022","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0076-6879(05)93033-4","article-title":"Role of neuronal membrane events in circadian rhythm generation.","volume":"393","year":"2005","journal-title":"Methods Enzymol"},{"key":"pcbi-0030068-b023","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1529\/biophysj.104.040824","article-title":"Modeling feedback loops of the mammalian circadian oscillator.","volume":"87","year":"2004","journal-title":"Biophys J"},{"key":"pcbi-0030068-b024","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1111\/j.1460-9568.2004.03784.x","article-title":"The clock in the dorsal suprachiasmatic nucleus runs faster than that in the ventral.","volume":"20","year":"2004","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030068-b025","first-page":"350","article-title":"A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons.","volume":"22","year":"2005","journal-title":"J Neurosci"},{"key":"pcbi-0030068-b026","doi-asserted-by":"crossref","first-page":"178103","DOI":"10.1103\/PhysRevLett.95.178103","article-title":"Molecular communication through stochastic synchronization induced by extracellular fluctuations.","volume":"95","year":"2005","journal-title":"Phys Rev Lett"},{"key":"pcbi-0030068-b027","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1126\/science.288.5465.483","article-title":"Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.","volume":"288","year":"2000","journal-title":"Science"},{"key":"pcbi-0030068-b028","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(00)80473-0","article-title":"Cellular construction of a circadian clock: Period determination in the suprachiasmatic nuclei.","volume":"91","year":"1997","journal-title":"Cell"},{"key":"pcbi-0030068-b029","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/0748730403260776","article-title":"Temporal precision in the mammalian circadian system: A reliable clock from less reliable neurons.","volume":"19","year":"2004","journal-title":"J Biol Rhythms"},{"key":"pcbi-0030068-b030","first-page":"73","article-title":"Neurotransmitters of the retino-hypothalamic tract.","volume":"309","year":"2003","journal-title":"Cell Tissue Res"},{"key":"pcbi-0030068-b031","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1523\/JNEUROSCI.0889-05.2005","article-title":"Differential response of period 1 expression within the suprachiasmatic nucleus.","volume":"25","year":"2005","journal-title":"J Neurosci"},{"key":"pcbi-0030068-b032","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1523\/JNEUROSCI.23-14-06141.2003","article-title":"An abrupt shift in the day\/night cycle causes desynchrony in the mammalian circadian center.","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"pcbi-0030068-b033","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1073\/pnas.1132112100","article-title":"Toward a detailed computational model for the mammalian circadian clock.","volume":"100","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030068-b034","doi-asserted-by":"crossref","first-page":"14806","DOI":"10.1073\/pnas.2036281100","article-title":"A detailed predictive model of the mammalian circadian clock.","volume":"100","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030068-b035","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1101\/gad.397006","article-title":"Differential effects of PER2 phosphorylation: Molecular basis for the human familial advanced sleep phase syndrome (FASPS).","volume":"20","year":"2006","journal-title":"Genes Dev"},{"key":"pcbi-0030068-b036","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-5193(03)00141-3","article-title":"Simulation of circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators.","volume":"224","year":"2003","journal-title":"J Theor Biol"},{"key":"pcbi-0030068-b037","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0748730403253840","article-title":"Gates and oscillators: A network model of the brain clock.","volume":"18","year":"2003","journal-title":"J Biol Rhythms"},{"key":"pcbi-0030068-b038","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/0748730406296319","article-title":"Gates and oscillators II: Zeitgebers and the network model of the brain clock.","volume":"22","year":"2007","journal-title":"J Biol Rhythms"},{"key":"pcbi-0030068-b039","doi-asserted-by":"crossref","first-page":"11104","DOI":"10.1103\/PhysRevE.73.011104","article-title":"Collective synchronization in populations of globally coupled phase oscillators with drifting frequencies.","volume":"73","year":"2006","journal-title":"Phys Rev E"},{"key":"pcbi-0030068-b040","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1006\/jtbi.2002.3000","article-title":"Intercellular coupling mechanism for synchronized and noise-resistant circadian oscillators.","volume":"216","year":"2002","journal-title":"J Theor Biol"},{"key":"pcbi-0030068-b041","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/074873098129000011","article-title":"Molecular circadian oscillators: An alternative hypothesis.","volume":"13","year":"1998","journal-title":"J Biol Rhythms"},{"key":"pcbi-0030068-b042","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nn1395","article-title":"Constant light desynchronizes mammalian clock neurons.","volume":"8","year":"2005","journal-title":"Nat Neurosci"},{"key":"pcbi-0030068-b043","unstructured":"TenenbaumMPollardH 1985 Ordinary differential equations New York Dover Publications 808"},{"issue":"(10)","key":"pcbi-0030068-b044","article-title":"Quantitative analyses of circadian gene expression in mammalian cell cultures.","volume":"2","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"pcbi-0030068-b045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1529\/biophysj.104.058388","article-title":"Spontaneous synchronization of coupled circadian oscillators.","volume":"89","year":"2005","journal-title":"Biophys J"},{"key":"pcbi-0030068-b046","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERB controls circadian transcription within the positive limb of the mammalian circadian oscillator.","volume":"110","year":"2002","journal-title":"Cell"},{"issue":"(8)","key":"pcbi-0030068-b047","article-title":"Transient resetting: A novel mechanism for synchrony and its biological examples.","volume":"2","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"pcbi-0030068-b048","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1098\/rstb.1952.0012","article-title":"The chemical basis of morphogenesis.","volume":"237","year":"1952","journal-title":"Phil Trans Roy Soc Lond, B"},{"key":"pcbi-0030068-b049","doi-asserted-by":"crossref","unstructured":"SmaleS 1976 A mathematical model of two cells via Turing's equation. In: MarsdenJEMcCrackenM The Hopf bifurcation and its applications New York Springer-Verlag 354 367","DOI":"10.1007\/978-1-4612-6374-6_24"},{"key":"pcbi-0030068-b050","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/S0006-3495(93)81539-X","article-title":"Why pancreatic islets burst but single beta cells do not. The heterogeneity hypothesis.","volume":"64","year":"1993","journal-title":"Biophys J"},{"key":"pcbi-0030068-b051","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1152\/jn.1997.77.5.2736","article-title":"Low-amplitude oscillations in the inferior olive: A model based on electrical coupling of neurons with heterogeneous channel densities.","volume":"77","year":"1997","journal-title":"J Neurophysiol"},{"key":"pcbi-0030068-b052","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0167-2789(90)90007-C","article-title":"Amplitude response of coupled oscillators.","volume":"41","year":"1990","journal-title":"Physica D"},{"key":"pcbi-0030068-b053","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0006-8993(01)02890-6","article-title":"Suprachiasmatic nucleus in the mouse: Retinal innervation, intrinsic organization and efferent projections.","volume":"916","year":"2001","journal-title":"Brain Res"},{"key":"pcbi-0030068-b054","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1073\/pnas.0307095101","article-title":"Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing.","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T12:31:15Z","timestamp":1628771475000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030068"}},"subtitle":[],"editor":[{"given":"Karl J","family":"Friston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,4,13]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.0030068","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,13]]}}}