{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:09:33Z","timestamp":1780607373282,"version":"3.54.1"},"reference-count":127,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T00:00:00Z","timestamp":1196380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.0030221","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T16:30:54Z","timestamp":1196267454000},"page":"e221","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":116,"title":["STDP in a Bistable Synapse Model Based on CaMKII and Associated Signaling Pathways"],"prefix":"10.1371","volume":"3","author":[{"given":"Michael","family":"Graupner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Brunel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,11,30]]},"reference":[{"key":"pcbi-0030221-b001","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.275.5297.213","article-title":"Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs.","volume":"275","year":"1997","journal-title":"Science"},{"key":"pcbi-0030221-b002","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1523\/JNEUROSCI.18-24-10464.1998","article-title":"Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type.","volume":"18","year":"1998","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b003","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1073\/pnas.89.10.4363","article-title":"Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.","volume":"89","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b004","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0896-6273(01)00542-6","article-title":"Rate, timing, and cooperativity jointly determine cortical synaptic plasticity.","volume":"32","year":"2001","journal-title":"Neuron"},{"key":"pcbi-0030221-b005","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1523\/JNEUROSCI.20-07-02451.2000","article-title":"Synaptic activity modulates the induction of bidirectional synaptic changes in adult mouse hippocampus.","volume":"20","year":"2000","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b006","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/383076a0","article-title":"A neuronal learning rule for sub-millisecond temporal coding.","volume":"383","year":"1996","journal-title":"Nature"},{"key":"pcbi-0030221-b007","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/78829","article-title":"Competitive Hebbian learning through spike-timing\u2013dependent synaptic plasticity.","volume":"3","year":"2000","journal-title":"Nat Neurosci"},{"key":"pcbi-0030221-b008","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1162\/089976601300014628","article-title":"An algorithm for modifying neurotransmitter release probability based on pre- and postsynaptic spike timing.","volume":"13","year":"2001","journal-title":"Neural Comput"},{"key":"pcbi-0030221-b009","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00422-002-0351-0","article-title":"Mechanisms and significance of spike-timing dependent plasticity.","volume":"87","year":"2002","journal-title":"Biol Cybern"},{"key":"pcbi-0030221-b010","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1073\/pnas.152343099","article-title":"A unified model of NMDA receptor-dependent bidirectional synaptic plasticity.","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b011","doi-asserted-by":"crossref","first-page":"031902","DOI":"10.1103\/PhysRevE.65.031902","article-title":"Synchrony arising from a balanced synaptic plasticity in a network of heterogeneous neural oscillators.","volume":"65","year":"2002","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"pcbi-0030221-b012","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00422-002-0353-y","article-title":"Mathematical formulations of hebbian learning.","volume":"87","year":"2002","journal-title":"Biol Cybern"},{"key":"pcbi-0030221-b013","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00422-003-0422-x","article-title":"Biophysical model of synaptic plasticity dynamics.","volume":"89","year":"2003","journal-title":"Biol Cybern"},{"key":"pcbi-0030221-b014","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1523\/JNEUROSCI.1425-06.2006","article-title":"Triplets of spikes in a model of spike timing-dependent plasticity.","volume":"26","year":"2006","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b015","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1073\/pnas.82.9.3055","article-title":"A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.","volume":"82","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b016","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.283.5400.381","article-title":"Emergent properties of networks of biological signaling pathways.","volume":"283","year":"1999","journal-title":"Science"},{"key":"pcbi-0030221-b017","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/S0006-3495(00)76469-1","article-title":"Bistability in the Ca(2+)\/calmodulin-dependent protein kinase-phosphatase system.","volume":"79","year":"2000","journal-title":"Biophys J"},{"key":"pcbi-0030221-b018","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/PL00007960","article-title":"Switching characteristics of a model for biochemical-reaction networks describing autophosphorylation versus dephosphorylation of Ca(2+)\/calmodulin-dependent protein kinase II.","volume":"82","year":"2000","journal-title":"Biol Cybern"},{"key":"pcbi-0030221-b019","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1098\/rstb.2002.1242","article-title":"Long-term potentiation: outstanding questions and attempted synthesis.","volume":"358","year":"2003","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"pcbi-0030221-b020","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1073\/pnas.95.8.4732","article-title":"All-or-none potentiation at CA3-CA1 synapses.","volume":"95","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b021","doi-asserted-by":"crossref","first-page":"9679","DOI":"10.1073\/pnas.0502332102","article-title":"Graded bidirectional synaptic plasticity is composed of switch-like unitary events.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b022","doi-asserted-by":"crossref","first-page":"14434","DOI":"10.1073\/pnas.0501956102","article-title":"Long-term potentiation of exogenous glutamate responses at single dendritic spines.","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b023","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0959-4388(02)00327-6","article-title":"Molecular mechanisms of CaMKII activation in neuronal plasticity.","volume":"12","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"pcbi-0030221-b024","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.bi.61.070192.003015","article-title":"Neuronal Ca(2+)\/calmodulin-dependent protein kinase.","volume":"61","year":"1992","journal-title":"Annu Rev Biochem"},{"key":"pcbi-0030221-b025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1126\/science.284.5411.162","article-title":"Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.","volume":"284","year":"1999","journal-title":"Science"},{"key":"pcbi-0030221-b026","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1126\/science.287.5461.2262","article-title":"Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.","volume":"287","year":"2000","journal-title":"Science"},{"key":"pcbi-0030221-b027","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrn753","article-title":"The molecular basis of CaMKII function in synaptic and behavioural memory.","volume":"3","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"pcbi-0030221-b028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20031547","article-title":"Targeting of calcium\/calmodulin-dependent protein kinase II.","volume":"378","year":"2004","journal-title":"Biochem J"},{"key":"pcbi-0030221-b029","doi-asserted-by":"crossref","first-page":"32528","DOI":"10.1074\/jbc.272.51.32528","article-title":"Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium\/calmodulin-dependent kinase II.","volume":"272","year":"1997","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b030","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1073\/pnas.96.6.3269","article-title":"Ca(2+)\/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors.","volume":"96","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b031","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.279.5352.870","article-title":"Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.","volume":"279","year":"1998","journal-title":"Science"},{"key":"pcbi-0030221-b032","first-page":"607","article-title":"Introduction. Long-term potentiation and structure of the issue.","volume":"358","year":"2003","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"pcbi-0030221-b033","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tins.2006.06.009","article-title":"alphaCaMKII autophosphorylation: a fast track to memory.","volume":"29","year":"2006","journal-title":"Trends Neurosci"},{"key":"pcbi-0030221-b034","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1152\/jn.2001.85.4.1368","article-title":"Is persistent activity of calcium\/calmodulin-dependent kinase required for the maintenance of LTP?","volume":"85","year":"2001","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b035","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1152\/jn.00735.2003","article-title":"Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.","volume":"91","year":"2004","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b036","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1111\/j.1460-9568.2004.03748.x","article-title":"Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus.","volume":"20","year":"2004","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030221-b037","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/369486a0","article-title":"Involvement of a calcineurin\/inhibitor-1 phosphatase cascade in hippocampal long-term depression.","volume":"369","year":"1994","journal-title":"Nature"},{"key":"pcbi-0030221-b038","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1126\/science.280.5371.1940","article-title":"Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.","volume":"280","year":"1998","journal-title":"Science"},{"key":"pcbi-0030221-b039","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0896-6273(01)00554-2","article-title":"Regulation of synaptic strength by protein phosphatase 1.","volume":"32","year":"2001","journal-title":"Neuron"},{"key":"pcbi-0030221-b040","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nn1506","article-title":"Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses.","volume":"8","year":"2005","journal-title":"Nat Neurosci"},{"key":"pcbi-0030221-b041","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/brain\/awl082","article-title":"Plasticity in the human central nervous system.","volume":"129","year":"2006","journal-title":"Brain"},{"key":"pcbi-0030221-b042","article-title":"Molecular switches at the synapse emerge from receptor and kinase traffic.","volume":"1","year":"2005","journal-title":"PLoS Comput Biol"},{"key":"pcbi-0030221-b043","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nn1387","article-title":"Coactivation and timing-dependent integration of synaptic potentiation and depression.","volume":"8","year":"2005","journal-title":"Nat Neurosci"},{"key":"pcbi-0030221-b044","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1152\/jn.00803.2004","article-title":"Calcium time course as a signal for spike-timing-dependent plasticity.","volume":"93","year":"2005","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b045","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1046\/j.1460-9568.2003.02693.x","article-title":"Bidirectional synaptic plasticity as a consequence of interdependent Ca(2+)-controlled phosphorylation and dephosphorylation pathways.","volume":"17","year":"2003","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030221-b046","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1101\/lm.80705","article-title":"A model of bidirectional synaptic plasticity: from signaling network to channel conductance.","volume":"12","year":"2005","journal-title":"Learn Mem"},{"key":"pcbi-0030221-b047","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1074\/jbc.270.17.10043","article-title":"Interaction of autophosphorylated Ca2+\/calmodulin-dependent protein kinase II with neuronal cytoskeletal proteins. characterization of binding to a 190-kDa postsynaptic density protein.","volume":"270","year":"1995","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b048","doi-asserted-by":"crossref","first-page":"20991","DOI":"10.1074\/jbc.M202154200","article-title":"Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+\/calmodulin-dependent protein kinase II.","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b049","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev.biochem.71.110601.135410","article-title":"Neuronal Ca(2+)\/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.","volume":"71","year":"2002","journal-title":"Annu Rev Biochem"},{"key":"pcbi-0030221-b050","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cell.2005.10.029","article-title":"Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.","volume":"123","year":"2005","journal-title":"Cell"},{"key":"pcbi-0030221-b051","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/387278a0","article-title":"Synaptic plasticity in a cerebellum-like structure depends on temporal order.","volume":"387","year":"1997","journal-title":"Nature"},{"key":"pcbi-0030221-b052","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1126\/science.275.5297.209","article-title":"A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons.","volume":"275","year":"1997","journal-title":"Science"},{"issue":"(Part 1)","key":"pcbi-0030221-b053","first-page":"237","article-title":"Long-term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures.","volume":"507","year":"1998","journal-title":"J Physiol"},{"key":"pcbi-0030221-b054","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0896-6273(02)00573-1","article-title":"The life cycle of Ca(2+) ions in dendritic spines.","volume":"33","year":"2002","journal-title":"Neuron"},{"key":"pcbi-0030221-b055","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1523\/JNEUROSCI.1749-06.2006","article-title":"Spine Ca2+ signaling in spike-timing-dependent plasticity.","volume":"26","year":"2006","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b056","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.1523\/JNEUROSCI.23-35-11270.2003","article-title":"Distribution of postsynaptic density (PSD)-95 and Ca2+\/calmodulin-dependent protein kinase II at the PSD.","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b057","article-title":"The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover.","volume":"3","year":"2005","journal-title":"PLoS Biol"},{"key":"pcbi-0030221-b058","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/20187","article-title":"Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated.","volume":"399","year":"1999","journal-title":"Nature"},{"key":"pcbi-0030221-b059","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/35046076","article-title":"Analysis of calcium channels in single spines using optical fluctuation analysis.","volume":"408","year":"2000","journal-title":"Nature"},{"key":"pcbi-0030221-b060","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0092-8674(01)00264-1","article-title":"Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.","volume":"104","year":"2001","journal-title":"Cell"},{"key":"pcbi-0030221-b061","doi-asserted-by":"crossref","first-page":"9574","DOI":"10.1073\/pnas.86.23.9574","article-title":"A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.","volume":"86","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b062","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/78783","article-title":"Molecular memory by reversible translocation of calcium\/calmodulin-dependent protein kinase II.","volume":"3","year":"2000","journal-title":"Nat Neurosci"},{"key":"pcbi-0030221-b063","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.mcn.2006.01.010","article-title":"Postsynaptic protein mobility in dendritic spines: long-term regulation by synaptic NMDA receptor activation.","volume":"31","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"pcbi-0030221-b064","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1073\/pnas.96.8.4650","article-title":"A selective role of calcineurin A-alpha in synaptic depotentiation in hippocampus.","volume":"96","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b065","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/35016089","article-title":"Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity.","volume":"405","year":"2000","journal-title":"Nature"},{"key":"pcbi-0030221-b066","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1046\/j.1460-9568.2003.02831.x","article-title":"Different phosphatase-dependent mechanisms mediate long-term depression and depotentiation of long-term potentiation in mouse hippocampal CA1 area.","volume":"18","year":"2003","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030221-b067","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1152\/jn.00047.2005","article-title":"Dissection of bidirectional synaptic plasticity into saturable unidirectional processes.","volume":"94","year":"2005","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b068","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1046\/j.1460-9568.1998.00389.x","article-title":"Rapid increase in PKA activity during long-term potentiation in the hippocampal afferent fibre system to the prefrontal cortex in vivo.","volume":"10","year":"1998","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030221-b069","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/374421a0","article-title":"Adenylyl cyclases and the interaction between calcium and cAMP signalling.","volume":"374","year":"1995","journal-title":"Nature"},{"key":"pcbi-0030221-b070","doi-asserted-by":"crossref","first-page":"21435","DOI":"10.1016\/S0021-9258(20)88197-6","article-title":"Protein phosphatases come of age.","volume":"264","year":"1989","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b071","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.cb.10.110194.000415","article-title":"Protein serine\/threonine phosphatases\u2014new avenues for cell regulation.","volume":"10","year":"1994","journal-title":"Annu Rev Cell Biol"},{"key":"pcbi-0030221-b072","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.pharmtox.44.101802.121415","article-title":"DARPP-32: an integrator of neurotransmission.","volume":"44","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"pcbi-0030221-b073","doi-asserted-by":"crossref","first-page":"13467","DOI":"10.1074\/jbc.272.21.13467","article-title":"Translocation of autophosphorylated calcium\/calmodulin-dependent protein kinase II to the postsynaptic density.","volume":"272","year":"1997","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b074","doi-asserted-by":"crossref","first-page":"48108","DOI":"10.1074\/jbc.M106388200","article-title":"Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b075","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1469-7793.2001.0459f.x","article-title":"An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat.","volume":"532","year":"2001","journal-title":"J Physiol"},{"key":"pcbi-0030221-b076","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1469-7793.2001.0285f.x","article-title":"Three Ca(2+) levels affect plasticity differently: the LTP zone, the LTD zone and no man's land.","volume":"532","year":"2001","journal-title":"J Physiol"},{"key":"pcbi-0030221-b077","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0893-6080(00)00028-9","article-title":"A generalized Hebbian rule for activity-dependent synaptic modifications.","volume":"13","year":"2000","journal-title":"Neural Netw"},{"key":"pcbi-0030221-b078","doi-asserted-by":"crossref","first-page":"031914","DOI":"10.1103\/PhysRevE.72.031914","article-title":"Synaptic plasticity with discrete state synapses.","volume":"72","year":"2005","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"pcbi-0030221-b079","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1152\/jn.1999.81.2.781","article-title":"Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation.","volume":"81","year":"1999","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b080","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0959-4388(99)80045-2","article-title":"Calcium- and activity-dependent synaptic plasticity.","volume":"9","year":"1999","journal-title":"Curr Opin Neurobiol"},{"key":"pcbi-0030221-b081","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1046\/j.0953-816x.2001.01679.x","article-title":"Differential induction of LTP and LTD is not determined solely by instantaneous calcium concentration: an essential involvement of a temporal factor.","volume":"14","year":"2001","journal-title":"Eur J Neurosci"},{"key":"pcbi-0030221-b082","doi-asserted-by":"crossref","first-page":"9847","DOI":"10.1523\/JNEUROSCI.0738-04.2004","article-title":"The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression.","volume":"24","year":"2004","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b083","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1152\/jn.00504.2004","article-title":"Stochastic properties of synaptic transmission affect the shape of spike time-dependent plasticity curves.","volume":"93","year":"2005","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b084","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0031-9384(02)00933-2","article-title":"Temporal asymmetry in spike timing-dependent synaptic plasticity.","volume":"77","year":"2002","journal-title":"Physiol Behav"},{"key":"pcbi-0030221-b085","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/416433a","article-title":"Spike-timing-dependent synaptic modification induced by natural spike trains.","volume":"416","year":"2002","journal-title":"Nature"},{"key":"pcbi-0030221-b086","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1152\/jn.00910.2005","article-title":"Contribution of individual spikes in burst-induced long-term synaptic modification.","volume":"95","year":"2006","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b087","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature03366","article-title":"Spike-timing-dependent synaptic plasticity depends on dendritic location.","volume":"434","year":"2005","journal-title":"Nature"},{"key":"pcbi-0030221-b088","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1523\/JNEUROSCI.5388-05.2006","article-title":"Malleability of spike-timing-dependent plasticity at the CA3-CA1 synapse.","volume":"26","year":"2006","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b089","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1152\/jn.00860.2006","article-title":"Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticity.","volume":"97","year":"2007","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b090","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1523\/JNEUROSCI.0176-06.2006","article-title":"Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.","volume":"26","year":"2006","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b091","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuron.2006.06.017","article-title":"A cooperative switch determines the sign of synaptic plasticity in distal dendrites of neocortical pyramidal neurons.","volume":"51","year":"2006","journal-title":"Neuron"},{"key":"pcbi-0030221-b092","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1152\/jn.00895.2006","article-title":"Effect of stochastic synaptic and dendritic dynamics on synaptic plasticity in visual cortex and hippocampus.","volume":"97","year":"2007","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b093","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1523\/JNEUROSCI.4940-06.2007","article-title":"Identification of compartment- and process-specific molecules required for \u201csynaptic tagging\u201d during long-term potentiation and long-term depression in hippocampal CA1.","volume":"27","year":"2007","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b094","doi-asserted-by":"crossref","first-page":"8290","DOI":"10.1523\/JNEUROSCI.20-22-08290.2000","article-title":"Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca2+ channels.","volume":"20","year":"2000","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0165-6147(94)90028-0","article-title":"Phenylglycine derivatives as antagonists of metabotropic glutamate receptors.","volume":"15","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"pcbi-0030221-b096","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0166-2236(96)20019-0","article-title":"Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?","volume":"19","year":"1996","journal-title":"Trends Neurosci"},{"key":"pcbi-0030221-b097","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0301-0082(01)00013-2","article-title":"Long-term depression: a cascade of induction and expression mechanisms.","volume":"65","year":"2001","journal-title":"Prog Neurobiol"},{"key":"pcbi-0030221-b098","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0962-8924(00)01800-6","article-title":"Calmodulin: a prototypical calcium sensor.","volume":"10","year":"2000","journal-title":"Trends Cell Biol"},{"key":"pcbi-0030221-b099","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.1073\/pnas.0606433103","article-title":"Ca(2+)\/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums.","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi-0030221-b100","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1016\/S0021-9258(18)92938-8","article-title":"Calcium binding to calmodulin and its globular domains.","volume":"266","year":"1991","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b101","unstructured":"KleeC 1988 Calmodulin Amsterdam Elsevier 35 56"},{"key":"pcbi-0030221-b102","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.256.5060.1199","article-title":"Calmodulin trapping by calcium-calmodulin-dependent protein kinase.","volume":"256","year":"1992","journal-title":"Science"},{"key":"pcbi-0030221-b103","doi-asserted-by":"crossref","first-page":"32217","DOI":"10.1074\/jbc.271.50.32217","article-title":"Localization of unique functional determinants in the calmodulin lobes to individual EF hands.","volume":"271","year":"1996","journal-title":"J Biol Chem"},{"key":"pcbi-0030221-b104","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1050-1738(01)00144-X","article-title":"Calmodulin is a limiting factor in the cell.","volume":"12","year":"2002","journal-title":"Trends Cardiovasc Med"},{"key":"pcbi-0030221-b105","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1523\/JNEUROSCI.0729-06.2006","article-title":"Role of the neurogranin concentrated in spines in the induction of long-term potentiation.","volume":"26","year":"2006","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b106","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1162\/089976698300017070","article-title":"Site-selective autophosphorylation of Ca(2+)\/calmodulin-dependent protein kinase II as a synaptic encoding mechanism.","volume":"10","year":"1998","journal-title":"Neural Comput"},{"key":"pcbi-0030221-b107","first-page":"66","article-title":"Models of calmodulin trapping and CaM kinase II activation in a dendritic spine.","volume":"8","year":"2000","journal-title":"J Comput Neurosci"},{"key":"pcbi-0030221-b108","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1023\/A:1013727331979","article-title":"Transient versus asymptotic dynamics of CaM kinase II: possible roles of phosphatase.","volume":"11","year":"2001","journal-title":"J Comput Neurosci"},{"key":"pcbi-0030221-b109","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0143-4160(03)00152-0","article-title":"Sensitivity of CaM kinase II to the frequency of Ca(2+) oscillations: a simple model.","volume":"34","year":"2003","journal-title":"Cell Calcium"},{"key":"pcbi-0030221-b110","first-page":"333","article-title":"Die Kinetik der Invertinwirkung.","volume":"49","year":"1913","journal-title":"Biochem Z"},{"key":"pcbi-0030221-b111","doi-asserted-by":"crossref","first-page":"D961","DOI":"10.2741\/A336","article-title":"Physiologic importance of protein phosphatase inhibitors.","volume":"3","year":"1998","journal-title":"Front Biosci"},{"key":"pcbi-0030221-b112","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.febslet.2004.03.121","article-title":"The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.","volume":"567","year":"2004","journal-title":"FEBS Lett"},{"key":"pcbi-0030221-b113","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/bi00188a015","article-title":"Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B.","volume":"33","year":"1994","journal-title":"Biochemistry"},{"key":"pcbi-0030221-b114","doi-asserted-by":"crossref","first-page":"10409","DOI":"10.1523\/JNEUROSCI.18-24-10409.1998","article-title":"Postsynaptic Ca2+ influx mediated by three different pathways during synaptic transmission at a calyx-type synapse.","volume":"18","year":"1998","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b115","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0006-3495(96)79653-4","article-title":"Ca2+ buffering and action potential-evoked Ca(2+) signaling in dendrites of pyramidal neurons.","volume":"70","year":"1996","journal-title":"Biophys J"},{"issue":"(Part 2)","key":"pcbi-0030221-b116","first-page":"403","article-title":"Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes.","volume":"485","year":"1995","journal-title":"J Physiol"},{"key":"pcbi-0030221-b117","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0006-3495(96)79782-5","article-title":"Simultaneous measurement of Ca(2+) influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels.","volume":"70","year":"1996","journal-title":"Biophys J"},{"key":"pcbi-0030221-b118","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0896-6273(03)00148-X","article-title":"Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell.","volume":"37","year":"2003","journal-title":"Neuron"},{"key":"pcbi-0030221-b119","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1152\/jn.00703.2004","article-title":"Ionic current model of a hypoglossal motoneuron.","volume":"93","year":"2005","journal-title":"J Neurophysiol"},{"key":"pcbi-0030221-b120","unstructured":"DestexheAMainenZFSejnowskiTJ 1998 Methods in neuronal modelling Cambridge (Massachusetts) MIT Press"},{"key":"pcbi-0030221-b121","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1523\/JNEUROSCI.19-21-09587.1999","article-title":"Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory.","volume":"19","year":"1999","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b122","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1523\/JNEUROSCI.10-06-01830.1990","article-title":"A quantitative description of NMDA receptor-channel kinetic behavior.","volume":"10","year":"1990","journal-title":"J Neurosci"},{"key":"pcbi-0030221-b123","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.279.5348.227","article-title":"Sensitivity of CaM kinase II to the frequency of Ca(2+) oscillations.","volume":"279","year":"1998","journal-title":"Science"},{"key":"pcbi-0030221-b124","unstructured":"BhallaUSIyengarR 2002 DOQCS database http:\/\/doqcs.ncbs.res.in\/"},{"key":"pcbi-0030221-b125","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1021\/bi952940f","article-title":"Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.","volume":"35","year":"1996","journal-title":"Biochemistry"},{"key":"pcbi-0030221-b126","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.290.5492.750","article-title":"Signal-processing machines at the postsynaptic density.","volume":"290","year":"2000","journal-title":"Science"},{"key":"pcbi-0030221-b127","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1523\/JNEUROSCI.5066-03.2004","article-title":"The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines.","volume":"24","year":"2004","journal-title":"J Neurosci"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T09:12:46Z","timestamp":1630228366000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.0030221"}},"subtitle":[],"editor":[{"given":"Karl J","family":"Friston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,11,30]]},"references-count":127,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2007,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.0030221","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,30]]}}}