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Schutter","year":"2005","journal-title":"Trends Neurosci"},{"key":"ref13","article-title":"Computational systems biology: Elsevier.","year":"2006"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1069492","article-title":"Systems biology: a brief overview.","volume":"295","author":"H Kitano","year":"2002","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","article-title":"A quantitative description of membrane current and its application to conduction and excitation in nerve.","volume":"117","author":"AL Hodgkin","year":"1952","journal-title":"J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00422-007-0190-0","article-title":"Lapicque's 1907 paper: from frogs to integrate-and-fire.","volume":"97","author":"N Brunel","year":"2007","journal-title":"Biol Cybern"},{"key":"ref17","first-page":"620","article-title":"Recherches 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Cybern"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12021-007-9002-x","article-title":"SpikeShaper: A simple tool for exploring Hodgkin-Huxley models.","volume":"5","author":"WJ Heitler","year":"2007","journal-title":"Neuroinformatics."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0014-4886(59)90046-9","article-title":"Branching dendritic trees and motoneuron membrane resistivity.","volume":"1","author":"W Rall","year":"1959","journal-title":"Exp Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1749-6632.1962.tb54120.x","article-title":"Theory of physiological properties of dendrites.","volume":"96","author":"W Rall","year":"1962","journal-title":"Ann N Y Acad Sci"},{"key":"ref24","first-page":"73","article-title":"Theoretical significance of dendritic trees for neuronal input-output relations.","author":"W Rall","year":"1964"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4612-1634-6","article-title":"The book of GENESIS: exploring realistic neural models with the GEneral NEural SImulation System.","author":"JM Bower","year":"1998"},{"key":"ref26","article-title":"The Neuron book.","author":"NT Carnevale","year":"2005"},{"key":"ref27","first-page":"3","article-title":"Overview of Wilfrid Rall's contributions to understanding dendritic function.","author":"I Segev","year":"1995"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF02478259","article-title":"A logical calculus of ideas immanent in nervous activity.","volume":"5","author":"W McCulloch","year":"1943","journal-title":"Bull Math Biophys"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/1781049a0","article-title":"Time courses of motoneuronal responses.","volume":"178","author":"JS Coombs","year":"1956","journal-title":"Nature"},{"key":"ref30","first-page":"27","article-title":"Introduction to Rall (1957, 1959, 1960).","author":"J Jack","year":"1995"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1126\/science.126.3271.454","article-title":"Membrane time constant of motoneurons.","volume":"126","author":"W Rall","year":"1957","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1152\/jn.1961.24.3.272","article-title":"Electrophysiology of hippocampal neurons. IV. Fast prepotentials.","volume":"24","author":"WA Spencer","year":"1961","journal-title":"J Neurophysiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0006-3495(74)85948-5","article-title":"Transient response in a dendritic neuron model for current injected at one branch.","volume":"14","author":"J Rinzel","year":"1974","journal-title":"Biophys J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1113\/jphysiol.1979.sp012971","article-title":"A mathematical model for conduction of action potentials along bifurcating axons.","volume":"295","author":"I Parnas","year":"1979","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0010-4809(76)90051-3","article-title":"A computer program for simulating a network of interacting neurons III. Applications.","volume":"9","author":"DH Perkel","year":"1976","journal-title":"Comput Biomed Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.1971.sp009474","article-title":"The time course of minimal excitory post-synaptic potentials evoked in spinal motoneurones by group Ia afferent fibres.","volume":"215","author":"JJ Jack","year":"1971","journal-title":"J Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0306-4522(77)90066-5","article-title":"A computer model of cerebellar Purkinje cells.","volume":"2","author":"A Pellionisz","year":"1977","journal-title":"Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0006-8993(79)90625-5","article-title":"Neocortical pyramidal cells: a model with dendritic calcium conductance reproduces repetitive firing and epileptic behavior.","volume":"173","author":"RD Traub","year":"1979","journal-title":"Brain Res"},{"key":"ref39","article-title":"The organization of behavior: a neuropsychological theory.","author":"DO Hebb","year":"1949"},{"key":"ref40","article-title":"Extrapolation, interpolation and smoothing of stationary time series with engineering applications.","author":"N Wiener","year":"1949"},{"key":"ref41","article-title":"Principles of neurodynamics: perceptrons and the theory of brain mechanisms.","author":"F Rosenblatt","year":"1962"},{"key":"ref42","first-page":"303","article-title":"Autocorrelation, a principle for evaluation of sensory information by the central nervous system.","author":"W Reichardt","year":"1961"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0020-7101(89)90007-X","article-title":"A program for simulation of nerve equations with branching geometries.","volume":"24","author":"M Hines","year":"1989","journal-title":"Int J Biomed Comput"},{"key":"ref44","first-page":"485","article-title":"GENESIS: a system for simulating neural networks.","author":"MA Wilson","year":"1989"},{"key":"ref45","article-title":"Methods in neuronal modeling: from synapses to networks.","year":"1989"},{"key":"ref46","article-title":"Systems theory and biology.","year":"1968"},{"key":"ref47","article-title":"General system theory: foundations, development, applications.","author":"L Von Bertalanffy","year":"1968"},{"key":"ref48","first-page":"65","article-title":"The control of flux.","volume":"27","author":"H Kacser","year":"1973","journal-title":"Symposia of the Society for Exp Biol"},{"key":"ref49","first-page":"365","article-title":"Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions.","volume":"25","author":"MA Savageau","year":"1969","journal-title":"J Theor Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical reactions.","volume":"81","author":"DT Gillespie","year":"1977","journal-title":"J Phys Chem A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/188495b0","article-title":"Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations.","volume":"188","author":"D Noble","year":"1960","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF00289234","article-title":"A theory of biological pattern formation.","volume":"12","author":"A Gierer","year":"1972","journal-title":"Kybernetik"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1242\/jcs.15.2.321","article-title":"Applications of a theory of biological pattern formation based on lateral inhibition.","volume":"15","author":"H Meinhardt","year":"1974","journal-title":"J Cell Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.282.5389.682","article-title":"New goals for the U.S. Human Genome Project: 1998\u20132003.","volume":"282","author":"FS Collins","year":"1998","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/elps.1150191103","article-title":"Proteome and proteomics: new technologies, new concepts, and new words.","volume":"19","author":"NL Anderson","year":"1998","journal-title":"Electrophor"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.genom.2.1.343","article-title":"A new approach to 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Bhalla","year":"2002","journal-title":"Bioinformatics"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.298.5594.824","article-title":"Network motifs: simple building blocks of complex networks.","volume":"298","author":"R Milo","year":"2002","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"ii172","DOI":"10.1093\/bioinformatics\/btg1075","article-title":"A description of dynamical graphs associated to elementary regulatory circuits.","volume":"19","author":"E Remy","year":"2003","journal-title":"Bioinformatics"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1385\/NI:2:2:145","article-title":"The small world of the cerebral cortex.","volume":"2","author":"O Sporns","year":"2004","journal-title":"Neuroinformatics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1523\/JNEUROSCI.23-33-10503.2003","article-title":"Resonant synchronization in heterogeneous networks of inhibitory neurons.","volume":"23","author":"R Maex","year":"2003","journal-title":"Journal Neurosci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1523\/JNEUROSCI.16-20-06402.1996","article-title":"Gamma oscillations by synapic inhibition in a hippocampal interneuronal network model.","volume":"16","author":"X-J Wang","year":"1996","journal-title":"J Neurosci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1162\/089976698300017214","article-title":"Chaotic balanced state in a model of cortical circuits.","volume":"10","author":"C van Vreeswijk","year":"1998","journal-title":"Neural Comput"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1371\/journal.pbio.0020329","article-title":"Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure.","volume":"2","author":"W Denk","year":"2004","journal-title":"PLoS Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1371\/journal.pcbi.0010042","article-title":"The human connectome: a structural description of the human brain.","volume":"1","author":"O Sporns","year":"2005","journal-title":"PLoS Comput Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1385\/NI:4:3:213","article-title":"The ups and downs of neuroscience shares.","volume":"4","author":"GA Ascoli","year":"2006","journal-title":"Neuroinformatics"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1385\/NI:4:4:271","article-title":"Where's the beef ? Missing data in the information age.","volume":"4","author":"D Kennedy","year":"2006","journal-title":"Neuroinformatics"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"(Epub ahead of print)","DOI":"10.1007\/s12021-008-9009-y","article-title":"Data sharing for computational neuroscience.","volume":"6","author":"JL Teeters","year":"2008","journal-title":"Neuroinformatics."},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1371\/journal.pcbi.0020087","article-title":"Scientific software development is not an oxymoron.","volume":"2","author":"SM Baxter","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0167-7799(01)01636-5","article-title":"Whole-cell simulation: a grand challenge of the 21st century.","volume":"19","author":"M Tomita","year":"2001","journal-title":"Trends Biotechnol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuron.2007.03.025","article-title":"neuroConstruct: a tool for modeling networks of neurons in 3D space.","volume":"54","author":"P Gleeson","year":"2007","journal-title":"Neuron"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tcb.2003.09.002","article-title":"Quantitative cell biology with the Virtual Cell.","volume":"13","author":"BM Slepchenko","year":"2003","journal-title":"Trends Cell Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1049\/sb:20045008","article-title":"Evolving a lingua franca and associated software infrastructure for computational systems biology: the Systems Biology Markup Language (SBML) project.","volume":"1","author":"M Hucka","year":"2004","journal-title":"Systems Biology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12021-007-0003-6","article-title":"MorphML: level 1 of the NeuroML standards for neuronal morphology data and model specification.","volume":"5","author":"S Crook","year":"2007","journal-title":"Neuroinformatics"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.pbiomolbio.2004.01.004","article-title":"CellML: its future, present and past.","volume":"85","author":"CM Lloyd","year":"2004","journal-title":"Progr Biophys Mol Biol"},{"key":"ref79","article-title":"Fast Monte Carlo simulation methods for biological reaction-diffusion systems in solution and on surfaces.","author":"RA Kerr","year":"2008","journal-title":"SIAM J Scient Comput: xxxx. In press"},{"key":"ref80","first-page":"87","article-title":"Monte Carlo methods for simulating realistic synaptic microphysiology using MCell.","author":"JR Stiles","year":"2000"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuron.2006.10.025","article-title":"Anomalous diffusion in Purkinje cell dendrites caused by dendritic spines.","volume":"52","author":"F Santamaria","year":"2006","journal-title":"Neuron"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10827-007-0038-6","article-title":"Simulation of networks of spiking neurons: a review of tools and strategies.","volume":"23","author":"R Brette","year":"2007","journal-title":"J Comput Neurosci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0166-2236(92)90011-V","article-title":"A consumer guide to neuronal modeling software.","volume":"15","author":"E De Schutter","year":"1992","journal-title":"Trends Neurosci"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12021-007-0004-5","article-title":"Interoperability of neuroscience modeling software: current status and future directions.","volume":"5","author":"RC Cannon","year":"2007","journal-title":"Neuroinformatics"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1385\/NI:1:1:135","article-title":"ModelDB: making models publicly accessible to support computational neuroscience.","volume":"1","author":"M Migliore","year":"2003","journal-title":"Neuroinformatics"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1371\/journal.pcbi.0020094","article-title":"Complex parameter landscape for a complex neuron model.","volume":"2","author":"P Achard","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.biosystems.2005.06.016","article-title":"A hybrid approach for efficient and robust parameter estimation in biochemical pathways.","volume":"83","author":"M Rodriguez-Fernandez","year":"2006","journal-title":"BioSystems"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1752-0509-1-28","article-title":"The long journey to a Systems Biology of neuronal function.","volume":"1","author":"N Le Novere","year":"2007","journal-title":"BMC Syst Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0959-4388(03)00075-8","article-title":"Dendrites: bug or feature?","volume":"13","author":"M Hausser","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1073\/pnas.91.11.4736","article-title":"Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs.","volume":"91","author":"E De Schutter","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"l4","DOI":"10.1126\/stke.2192004pl4","article-title":"Developing complex signaling models using GENESIS\/Kinetikit.","volume":"2004","author":"SJ Vayttaden","year":"2004","journal-title":"Science STKE"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1371\/journal.pcbi.0020179","article-title":"Nitric oxide regulates input specificity of long-term depression and context dependence of cerebellar learning.","volume":"3","author":"H Ogasawara","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref93","first-page":"461","article-title":"Simulating large networks of neurons.","author":"AD Protopapas","year":"1998"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1073\/pnas.93.12.5747","article-title":"Miniature endplate current rise times less than 100 microseconds from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle.","volume":"93","author":"JR Stiles","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1162\/0899766054026648","article-title":"Advancing the boundaries of high-connectivity network simulation with distributed computing.","volume":"17","author":"A Morrison","year":"2005","journal-title":"Neural Comput"},{"key":"ref96","first-page":"672","article-title":"Efficient parallel simulation of large-scale neuronal networks on clusters of multiprocessor computers.","author":"HE Plesser","year":"2007","journal-title":"Lecture Notes in Computer Science. Volume 4641"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrn1848","article-title":"The blue brain project.","volume":"7","author":"H Markram","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10827-006-7949-5","article-title":"Parallel network simulations with NEURON.","volume":"21","author":"M Migliore","year":"2006","journal-title":"J Comput Neurosci"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0006-3495(02)75205-3","article-title":"Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways.","volume":"83","author":"US Bhalla","year":"2002","journal-title":"Biophys J"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"pe20","DOI":"10.1126\/stke.2322004pe20","article-title":"Hysteresis vs. graded responses: the connections make all the difference.","volume":"2004","author":"AJ Ninfa","year":"2004","journal-title":"Science STKE"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.genet.39.073003.113656","article-title":"Switches in bacteriophage lambda development.","volume":"39","author":"AB Oppenheim","year":"2005","journal-title":"Ann Rev Genet"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature03010","article-title":"Synaptic computation.","volume":"431","author":"LF Abbott","year":"2004","journal-title":"Nature"},{"key":"ref103","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/3413.001.0001","article-title":"The handbook of brain theory and neural networks.","author":"MA Arbib","year":"2002"},{"key":"ref104","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/1888.001.0001","article-title":"Cognitive modeling.","author":"TA Polk","year":"2002"},{"key":"ref105","article-title":"The mathematical theory of communication.","author":"CE Shannon","year":"1949"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1167\/6.4.13","article-title":"Spike-triggered neural characterization.","volume":"6","author":"O Schwartz","year":"2006","journal-title":"J Vis"},{"key":"ref107","article-title":"Balancing of conductances may explain irregular cortical spiking. Institute for Neural Computation, UCSD.","author":"AJ Bell","year":"1994","journal-title":"INC Technical Report INC-9502"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neunet.2004.02.004","article-title":"Binocular disparity encoding cells generated through an Infomax based learning algorithm.","volume":"17","author":"K Okajima","year":"2004","journal-title":"Neural Netw"},{"key":"ref109","article-title":"Bayesian Brain: Probabilistic Approaches to Neural Coding (Computational Neuroscience)","year":"2007"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1088\/0954-898X_11_1_302","article-title":"Learning with two sites of synaptic integration.","volume":"11","author":"KP Kording","year":"2000","journal-title":"Network"},{"key":"ref111","first-page":"705","article-title":"An information theoretic framework for eukaryotic gradient sensing. Advances in neural information processing systems 19.","author":"JM Kimmel","year":"2007"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1073\/pnas.0608963104","article-title":"Noisy information processing through transcriptional regulation.","volume":"104","author":"E Libby","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1385\/NI:4:2:129","article-title":"On the future of the human brain project.","volume":"4","author":"E De Schutter","year":"2006","journal-title":"Neuroinformatics"},{"key":"ref114","article-title":"Dendrites. 2nd ed.","year":"2007"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/445160a","article-title":"Bioinformatics: industrializing neuroscience.","volume":"445","author":"H Markram","year":"2007","journal-title":"Nature"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:11:41Z","timestamp":1684422701000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000078"}},"subtitle":[],"editor":[{"given":"Karl J.","family":"Friston","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2008,5,30]]},"references-count":115,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000078","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,30]]}}}