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Beyer","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1091\/mbc.11.12.4241","article-title":"Genomic expression programs in the response of yeast cells to environmental changes.","volume":"11","author":"AP Gasch","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1128\/MCB.17.12.6982","article-title":"Yap, a novel family of eight bzip proteins in Saccharomyces cerevisiae with distinct biological functions.","volume":"17","author":"L Fernandes","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0014-5793(98)00249-X","article-title":"Yeast putative transcription factors involved in salt tolerance.","volume":"425","author":"I Mendizabal","year":"1998","journal-title":"FEBS 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