{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:48:40Z","timestamp":1770745720525,"version":"3.49.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T00:00:00Z","timestamp":1236902400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1000315","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T17:30:26Z","timestamp":1236879026000},"page":"e1000315","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sm\/Lsm Genes Provide a Glimpse into the Early Evolution of the Spliceosome"],"prefix":"10.1371","volume":"5","author":[{"given":"Stella","family":"Veretnik","sequence":"first","affiliation":[]},{"given":"Christopher","family":"Wills","sequence":"additional","affiliation":[]},{"given":"Philippe","family":"Youkharibache","sequence":"additional","affiliation":[]},{"given":"Ruben E.","family":"Valas","sequence":"additional","affiliation":[]},{"given":"Philip E.","family":"Bourne","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/molbev\/msi091","article-title":"Complex spliceosomal organization ancestral to extant eukaryotes.","volume":"22","author":"L Collins","year":"2005","journal-title":"Mol Biol Evol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0092-8674(00)80550-4","article-title":"Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.","volume":"96","author":"C Kambach","year":"1999","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature04531","article-title":"Introns and the origin of nucleus-cytosol compartmentalization.","volume":"440","author":"W Martin","year":"2006","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BST0330433","article-title":"Lsm proteins and RNA processing.","volume":"33","author":"JD Beggs","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/nsmb1037","article-title":"Eukaryotic Lsm proteins: lessons from bacteria.","volume":"12","author":"CJ Wilusz","year":"2005","journal-title":"(2005) Nat Struct Mol Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s00018-004-4190-0","article-title":"The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein.","volume":"61","author":"D Sch\u00fcmperli","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/emboj\/20.9.2293","article-title":"RNA binding in an Sm core domain: X-ray structure and functional analysis of an archaeal Sm protein complex.","volume":"20","author":"I T\u00f6r\u00f6","year":"2001","journal-title":"EMBO J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bst0290015","article-title":"Structure and assembly of the spliceosomal snRNPs. Novartis Medal Lecture.","volume":"29","author":"K Nagai","year":"2001","journal-title":"Biochem Soc Trans"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/emboj\/cdf322","article-title":"Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.","volume":"21","author":"MA Schumacher","year":"2002","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/nar\/28.1.257","article-title":"SCOP: a structural classification of proteins database.","volume":"28","author":"L Lo Conte","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6807-1-5","article-title":"Functional evolution of two subtly different (similar) folds.","volume":"1","author":"V Agrawal","year":"2001","journal-title":"BMC Struct Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-2836(02)00406-0","article-title":"Archaeal Sm proteins form heptameric and hexameric complexes: crystal structures of the Sm1 and Sm2 proteins from the hyperthermophile Archaeoglobus fulgidus.","volume":"320","author":"I T\u00f6r\u00f6","year":"2002","journal-title":"J Mol Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1242\/jcs.019943","article-title":"Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes.","volume":"120","author":"MP Spiller","year":"2007","journal-title":"J Cell Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0022-2836(02)01470-5","article-title":"A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome.","volume":"326","author":"C Gille","year":"2003","journal-title":"J Mol Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11373-007-9178-y","article-title":"The PNPase, exosome and RNA helicases as the building components of evolutionarily-conserved RNA degradation machines.","volume":"14","author":"S Lin-Chao","year":"2007","journal-title":"J Biomed Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/oxfordjournals.molbev.a026246","article-title":"Origin and evolution of eukaryotic chaperonins: phylogenetic evidence for ancient duplications in CCT genes.","volume":"17","author":"JM Archibald","year":"2000","journal-title":"Mol Biol Evol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"E153","DOI":"10.1038\/35019643","article-title":"Evolution and function of ubiquitin-like protein-conjugation systems.","volume":"2","author":"M Hochstrasser","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1093\/nar\/gki775","article-title":"Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell.","volume":"33","author":"KS Makarova","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0074-7696(08)61370-4","article-title":"Self-splicing RNA: implications for evolution.","volume":"93","author":"TR Cech","year":"1985","journal-title":"Int Rev Cytol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0092-8674(85)90092-3","article-title":"On the origin of RNA splicing and introns.","volume":"42","author":"PA Sharp","year":"1985","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1159\/000084992","article-title":"Group II intron retroelements: function and diversity.","volume":"110","author":"AR Robart","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1261\/rna.2237806","article-title":"Structure of a self-splicing group II intron catalytic effector domain 5: parallels with spliceosomal U6 RNA.","volume":"12","author":"M Seetharaman","year":"2006","journal-title":"RNA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/386417a0","article-title":"Trans-activation of group II intron splicing by nuclear U5 snRNA.","volume":"386","author":"M Hetzer","year":"1997","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1074\/jbc.M207685200","article-title":"Crystal structures of the Pyrococcus abyssi Sm core and its complex with RNA. Common features of RNA binding in archaea and eukarya.","volume":"278","author":"S Thore","year":"2003","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-1119(99)00321-2","article-title":"Module-intron correlation and intron sliding in family F\/10 xylanase genes.","volume":"238","author":"Y Sato","year":"1999","journal-title":"Gene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/molbev\/msh258","article-title":"A globin gene of ancient evolutionary origin in lower vertebrates: evidence for two distinct globin families in animals.","volume":"22","author":"A Roesner","year":"2005","journal-title":"Mol Biol Evol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"10739","DOI":"10.1073\/pnas.94.20.10739","article-title":"Intron \u201csliding\u201d and the diversity of intron positions.","volume":"94","author":"A Stoltzfus","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1073\/pnas.0802941105","article-title":"Alternative splicing: a missing piece in the puzzle of intron gain.","volume":"105","author":"R Tarr\u00edo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0168-9525(00)02096-5","article-title":"Intron sliding in conserved gene families.","volume":"16","author":"IB Rogozin","year":"2000","journal-title":"Trends Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/molbev\/msh120","article-title":"The evolutionary gain of spliceosomal introns: sequence and phase preferences.","volume":"21","author":"W Qiu","year":"2004","journal-title":"Mol Biol Evol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1093\/nar\/gki316","article-title":"Conservation versus parallel gains in intron evolution.","volume":"33","author":"AV Sverdlov","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1073\/pnas.76.11.5495","article-title":"Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus.","volume":"76","author":"MR Lerner","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/219588a0","article-title":"Factor fraction required for the synthesis of bacteriophage Q<sub>\u03b2<\/sub>-RNA.","volume":"219","author":"MT Franze de Fernandez","year":"1968","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1261\/rna.689007","article-title":"An Hfq-like protein in archaea: crystal structure and functional characterization of the Sm protein from Methanococcus jannaschii.","volume":"13","author":"JS Nielsen","year":"2007","journal-title":"RNA"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tibs.2005.07.006","article-title":"LSm proteins form heptameric rings that bind to RNA via repeating motifs.","volume":"30","author":"P Khusial","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.sbi.2006.04.006","article-title":"Comparative genomics and structural biology of the molecular innovations of eukaryotes.","volume":"16","author":"L Aravind","year":"2006","journal-title":"Curr Opin Struct Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0960-9822(03)00558-X","article-title":"Remarkable interkingdom conservation of intron positions and massive, lineage-specific intron loss and gain in eukaryotic evolution.","volume":"13","author":"IB Rogozin","year":"2003","journal-title":"Curr Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1101\/gr.5978207","article-title":"Evolutionarily conserved genes preferentially accumulate introns.","volume":"17","author":"L Carmel","year":"2007","journal-title":"Genome Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tig.2007.01.001","article-title":"A glimpse of a putative pre-intron phase of eukaryotic evolution.","volume":"23","author":"AV Sverdlov","year":"2007","journal-title":"Trends Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1153803","article-title":"Crystal structure of a self-spliced group II intron.","volume":"320","author":"N Toor","year":"2008","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.tcb.2004.03.010","article-title":"Why do cells need an assembly machine for RNA\u2013protein complexes?","volume":"14","author":"J Yong","year":"2004","journal-title":"Trends Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molcel.2004.09.024","article-title":"Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein.","volume":"16","author":"U Narayanan","year":"2004","journal-title":"Mol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1515\/BC.2007.080","article-title":"The spliceosome: a ribozyme at heart?","volume":"388","author":"S Valadkhan","year":"2007","journal-title":"Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-5-113","article-title":"MUSCLE: a multiple sequence alignment method with reduced time and space complexity.","volume":"5","author":"R Edgar","year":"2004","journal-title":"BMC Bioinformatics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","article-title":"A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.","volume":"52","author":"S Guindon","year":"2003","journal-title":"Syst Biol"},{"key":"ref46","author":"A Drummond","year":"2006"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T14:26:23Z","timestamp":1539959183000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000315"}},"subtitle":[],"editor":[{"given":"Andrey","family":"Rzhetsky","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,3,13]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000315","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,13]]}}}