{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:46:57Z","timestamp":1769050017342,"version":"3.49.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T00:00:00Z","timestamp":1250812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1000477","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T21:19:54Z","timestamp":1250803194000},"page":"e1000477","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Can Molecular Motors Drive Distance Measurements in Injured Neurons?"],"prefix":"10.1371","volume":"5","author":[{"given":"Naaman","family":"Kam","sequence":"first","affiliation":[]},{"given":"Yitzhak","family":"Pilpel","sequence":"additional","affiliation":[]},{"given":"Mike","family":"Fainzilber","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1471-4159.2006.04089.x","article-title":"Retrograde signaling in injured nerve - the axon reaction revisited.","volume":"99","author":"S Hanz","year":"2006","journal-title":"J Neurochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2006.12.001","article-title":"Regulation of intrinsic neuronal properties for axon growth and regeneration.","volume":"81","author":"F Rossi","year":"2007","journal-title":"Prog Neurobiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.expneurol.2007.08.004","article-title":"Growth factors and combinatorial therapies for CNS regeneration.","volume":"209","author":"P Lu","year":"2008","journal-title":"Exp Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.expneurol.2007.05.025","article-title":"Rewiring the injured CNS: lessons from the optic nerve.","volume":"209","author":"L Benowitz","year":"2008","journal-title":"Exp Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1046\/j.1460-9568.2003.02809.x","article-title":"Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomy.","volume":"18","author":"MR Mason","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7912","DOI":"10.1523\/JNEUROSCI.18-19-07912.1998","article-title":"Retrograde regulation of growth-associated gene expression in adult rat Purkinje cells by myelin-associated neurite growth inhibitory proteins.","volume":"18","author":"M Zagrebelsky","year":"1998","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1046\/j.1460-9568.2003.02940.x","article-title":"Extrinsic regulation of injury\/growth-related gene expression in the inferior olive of the adult rat.","volume":"18","author":"A Buffo","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1523\/JNEUROSCI.18-04-01318.1998","article-title":"Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo.","volume":"18","author":"AM Kenney","year":"1998","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0006-8993(96)01402-3","article-title":"Timing of c-jun protein induction in lumbar dorsal root ganglia after sciatic nerve transection varies with lesion distance.","volume":"751","author":"AM Kenney","year":"1997","journal-title":"Brain Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/(SICI)1096-9861(19991129)414:4<495::AID-CNE6>3.0.CO;2-S","article-title":"Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M.","volume":"414","author":"KJ Fernandes","year":"1999","journal-title":"J Comp Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/mcne.1999.0814","article-title":"Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury.","volume":"15","author":"H Tsujino","year":"2000","journal-title":"Mol Cell Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0896-6273(91)90066-9","article-title":"Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury.","volume":"6","author":"SK Doster","year":"1991","journal-title":"Neuron"},{"key":"ref13","first-page":"3165","article-title":"Axonal Regeneration of Retinal Ganglion Cells Depending on the Distance of Axotomy in Adult Hamsters.","volume":"41","author":"S-W You","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cne.902300403","article-title":"The axon reaction of the goldfish mauthner cell and factors that influence its morphological variability.","volume":"230","author":"SJ Zottoli","year":"1984","journal-title":"J Comp Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/BF01611989","article-title":"Survival and subsequent regeneration of olfactory neurons after a distal axonal lesion.","volume":"16","author":"PF Cancalon","year":"1987","journal-title":"J Neurocytol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(70)90345-8","article-title":"What is the signal for chromatolysis?","volume":"23","author":"BG Cragg","year":"1970","journal-title":"Brain Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0074-7742(08)60183-X","article-title":"The axon reaction: a review of the principal features of perikaryal responses to axon injury.","volume":"14","author":"AR Lieberman","year":"1971","journal-title":"Int Rev Neurobiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1242\/jeb.00298","article-title":"Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors.","volume":"206","author":"BN Kholodenko","year":"2003","journal-title":"J Exp Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/msb4100108","article-title":"Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades.","volume":"2","author":"NI Markevich","year":"2006","journal-title":"Mol Syst Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00285-008-0162-6","article-title":"Signaling cascades as cellular devices for spatial computations.","volume":"58","author":"J Stelling","year":"2009","journal-title":"J Math Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/neu.10316","article-title":"From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons.","volume":"58","author":"E Perlson","year":"2004","journal-title":"J Neurobiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.conb.2008.06.005","article-title":"Nerve injury signaling.","volume":"18","author":"N Abe","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/neu.10323","article-title":"Signaling endosome hypothesis: A cellular mechanism for long distance communication.","volume":"58","author":"CL Howe","year":"2004","journal-title":"J Neurobiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tcb.2007.09.003","article-title":"Message in a bottle: long-range retrograde signaling in the nervous system.","volume":"17","author":"CF Ibanez","year":"2007","journal-title":"Trends Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-4682-2-43","article-title":"Modeling the signaling endosome hypothesis: why a drive to the nucleus is better than a (random) walk.","volume":"2","author":"CL Howe","year":"2005","journal-title":"Theor Biol Med Model"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1096\/fj.04-1805fje","article-title":"Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity.","volume":"18","author":"G Mandolesi","year":"2004","journal-title":"Faseb J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jtbi.2008.12.011","article-title":"A quantitative examination of the role of cargo-exerted forces in axonal transport.","volume":"257","author":"CS Mitchell","year":"2009","journal-title":"J Theor Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/ncb1421","article-title":"Processive bidirectional motion of dynein-dynactin complexes in vitro.","volume":"8","author":"JL Ross","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuron.2006.08.018","article-title":"Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway.","volume":"52","author":"K Deinhardt","year":"2006","journal-title":"Neuron"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0896-6273(03)00770-0","article-title":"Axoplasmic importins enable retrograde injury signaling in lesioned nerve.","volume":"40","author":"S Hanz","year":"2003","journal-title":"Neuron"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuron.2005.01.023","article-title":"Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve.","volume":"45","author":"E Perlson","year":"2005","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuron.2008.05.029","article-title":"Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve.","volume":"59","author":"D Yudin","year":"2008","journal-title":"Neuron"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/cne.901710106","article-title":"A quantitative study of retrograde neuronal changes in Clarke&apos;s column.","volume":"171","author":"AD Loewy","year":"1977","journal-title":"J Comp Neurol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1113\/jphysiol.1968.sp008528","article-title":"Observations on the nucleolar and total cell body nucleic acid of injured nerve cells.","volume":"196","author":"WE Watson","year":"1968","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature02293","article-title":"Cytoplasmic dynein functions as a gear in response to load.","volume":"427","author":"R Mallik","year":"2004","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.148.5.945","article-title":"Dynein-mediated cargo transport in vivo. A switch controls travel distance.","volume":"148","author":"SP Gross","year":"2000","journal-title":"J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/bies.20118","article-title":"From modulator to mediator: rapid effects of BDNF on ion channels.","volume":"26","author":"CR Rose","year":"2004","journal-title":"Bioessays"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1083\/jcb.200803150","article-title":"A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.","volume":"181","author":"J Ha","year":"2008","journal-title":"J Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3181\/0709-MR-241","article-title":"Action potentials: to the nucleus and beyond.","volume":"233","author":"RN Saha","year":"2008","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref40","first-page":"997","article-title":"Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway.","volume":"44","author":"KR Thompson","year":"2004","journal-title":"Neuron"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.pbio.0060034","article-title":"Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus.","volume":"6","author":"DC Dieterich","year":"2008","journal-title":"PLoS Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1242\/dev.126.9.1947","article-title":"Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells.","volume":"126","author":"V Ambros","year":"1999","journal-title":"Development"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.immunol.14.1.233","article-title":"CD28\/B7 system of T cell costimulation.","volume":"14","author":"DJ Lenschow","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/comjnl\/7.4.308","article-title":"A Simplex Method for Function Minimization.","volume":"7","author":"JA Nelder","year":"1965","journal-title":"The Computer Journal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1137\/S1052623496303470","article-title":"Convergence Properties of the Nelder-Mead Simplex Method in Low Dimensions.","volume":"9","author":"JC Lagarias","year":"1998","journal-title":"SIAM Journal of Optimization"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T22:02:27Z","timestamp":1633816947000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000477"}},"subtitle":[],"editor":[{"given":"Jorg","family":"Stelling","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,8,21]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000477","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,21]]}}}