{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:34:48Z","timestamp":1770816888482,"version":"3.50.1"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T00:00:00Z","timestamp":1253232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1000511","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T00:28:21Z","timestamp":1253233701000},"page":"e1000511","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Estimating the Continuous-Time Dynamics of Energy and Fat Metabolism in Mice"],"prefix":"10.1371","volume":"5","author":[{"given":"Juen","family":"Guo","sequence":"first","affiliation":[]},{"given":"Kevin D.","family":"Hall","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1210\/er.2006-0032","article-title":"Understanding and addressing the epidemic of obesity: an energy balance perspective.","volume":"27","author":"JO Hill","year":"2006","journal-title":"Endocr Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/j.1550-8528.1997.tb00585.x","article-title":"How NOT to approach the obesity problem.","volume":"5","author":"JP Flatt","year":"1997","journal-title":"Obes Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/sj.ijo.0803280","article-title":"Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals.","volume":"30","author":"JR Arch","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1086\/430234","article-title":"Comparison of different approaches for the calculation of energy expenditure using doubly labeled water in a small mammal.","volume":"78","author":"JR Speakman","year":"2005","journal-title":"Physiol Biochem Zool"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e5370","DOI":"10.1371\/journal.pone.0005370","article-title":"Persistent diet-induced obesity in male C57BL\/6 mice resulting from temporary obesigenic diets.","volume":"4","author":"J Guo","year":"2009","journal-title":"PLoS ONE"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1753-4887.1987.tb02684.x","article-title":"Lean body mass-body fat interrelationships in humans.","volume":"45","author":"GB Forbes","year":"1987","journal-title":"Nutr Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/sj.ijo.0803608","article-title":"How adaptations of substrate utilization regulate body composition.","volume":"31","author":"KD Hall","year":"2007","journal-title":"Int J Obes (Lond)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/ajcn\/87.3.692","article-title":"Dynamic coordination of macronutrient balance during infant growth: insights from a mathematical model.","volume":"87","author":"PN Jordan","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1152\/ajpendo.00523.2005","article-title":"Computational model of in vivo human energy metabolism during semistarvation and refeeding.","volume":"291","author":"KD Hall","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cmet.2008.10.010","article-title":"Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity.","volume":"9","author":"H Funato","year":"2009","journal-title":"Cell Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1079\/BJN2001441","article-title":"Limitations of conventional models and a conceptual framework for a nutrient flow representation of energy utilization by animals.","volume":"86","author":"S Birkett","year":"2001","journal-title":"Br J Nutr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1079\/BJN20041321","article-title":"Partitioning of limiting protein and energy in the growing pig: description of the problem, possible rules and their qualitative evaluation.","volume":"93","author":"FB Sandberg","year":"2005","journal-title":"Br J Nutr"},{"key":"ref13","first-page":"E86","article-title":"Partitioning of energy intake to heat, protein, and fat in growing pigs.","volume":"81","author":"J van Milgen","year":"2003","journal-title":"J Anim Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1017\/S1357729800058185","article-title":"Technical review of the energy and protein requirements of growing pigs: energy.","volume":"73","author":"CT Whittemore","year":"2001","journal-title":"Animal Science"},{"key":"ref15","article-title":"The energy cost of protein turnover is arbitrarily distributed between maintenance requirements and protein retention efficiency.","author":"KD Hall","year":"2009","journal-title":"Br J Nutr: in press"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1017\/S0007114508047697","article-title":"Use of theoretical efficiencies of protein and fat synthesis to calculate energy requirements for growth in pigs.","volume":"101","author":"CZ Roux","year":"2009","journal-title":"Br J Nutr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/sj.ijo.0803720","article-title":"What is the required energy deficit per unit weight loss?","volume":"32","author":"KD Hall","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/ajcn\/48.2.240","article-title":"Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man.","volume":"48","author":"KJ Acheson","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1079\/BJN20051373","article-title":"Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats.","volume":"93","author":"M Morifuji","year":"2005","journal-title":"Br J Nutr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1000045","DOI":"10.1371\/journal.pcbi.1000045","article-title":"The dynamics of human body weight change.","volume":"4","author":"CC Chow","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511791277","article-title":"Bayesian Logical Data Analysis for the Physical Sciences","author":"PC Gregory","year":"2005"},{"key":"ref22","article-title":"Evaluating the accuracy of sampling-based approaches to calculating posterior moments.","author":"J Geweke","year":"1992"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T18:05:45Z","timestamp":1558548345000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000511"}},"subtitle":[],"editor":[{"given":"Jorg","family":"Stelling","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,9,18]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000511","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,18]]}}}