{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:01:08Z","timestamp":1761919268176},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1000518","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T12:11:57Z","timestamp":1253880717000},"page":"e1000518","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Integrating Extrinsic and Intrinsic Cues into a Minimal Model of Lineage Commitment for Hematopoietic Progenitors"],"prefix":"10.1371","volume":"5","author":[{"given":"Santhosh","family":"Palani","sequence":"first","affiliation":[]},{"given":"Casim A.","family":"Sarkar","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrm1713","article-title":"The molecular repertoire of the \u2018almighty\u2019 stem cell.","volume":"6","author":"CE Eckfeldt","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(00)80453-5","article-title":"Identification of clonogenic common lymphoid progenitors in mouse bone marrow.","volume":"91","author":"M Kondo","year":"1997","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.","volume":"404","author":"K Akashi","year":"2000","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2005.02.013","article-title":"Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.","volume":"121","author":"J Adolfsson","year":"2005","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev.immunol.21.120601.141007","article-title":"Biology of hematopoietic stem cells and progenitors: implications for clinical application.","volume":"21","author":"M Kondo","year":"2003","journal-title":"Ann Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nri2024","article-title":"Transcription factors in myeloid development: balancing differentiation with transformation.","volume":"7","author":"F Rosenbauer","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(03)00242-5","article-title":"GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte\/erythrocyte lineages.","volume":"19","author":"H Iwasaki","year":"2003","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cell.2006.06.052","article-title":"Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.","volume":"126","author":"P Laslo","year":"2006","journal-title":"Cell"},{"key":"ref9","first-page":"1549","article-title":"PU.1 (Spi-1) autoregulates its expression in myeloid cells.","volume":"11","author":"H Chen","year":"1995","journal-title":"Oncogene"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1101\/gad.5.6.919","article-title":"Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.","volume":"5","author":"SF Tsai","year":"1991","journal-title":"Gene Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0959-437X(00)00226-4","article-title":"Hematopoietic development: a balancing act.","volume":"11","author":"AB Cantor","year":"2001","journal-title":"Current opinion in genetics & development; Curr Opin Genet Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1073\/pnas.1432147100","article-title":"GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling.","volume":"100","author":"JA Grass","year":"2003","journal-title":"P Natl Acad Sci USA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"28296","DOI":"10.1074\/jbc.M602830200","article-title":"Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.","volume":"281","author":"CW Liew","year":"2006","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1038\/sj.onc.1210756","article-title":"Cytokine receptors and hematopoietic differentiation.","volume":"26","author":"L Robb","year":"2007","journal-title":"Oncogene"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1182\/blood-2007-03-079681","article-title":"Hematopoietic cytokines.","volume":"111","author":"D Metcalf","year":"2008","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1385\/IR:32:1-3:193","article-title":"Fate vs choice: the immune system reloaded.","volume":"32","author":"KM Murphy","year":"2005","journal-title":"Immunol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nm0296-190","article-title":"Evidence that hematopoiesis may be a stochastic process <italic>in vivo<\/italic>.","volume":"2","author":"J Abkowitz","year":"1996","journal-title":"Nat Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1182\/blood.V92.2.348","article-title":"Do stem cells play dice?","volume":"92","author":"T Enver","year":"1998","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1147888","article-title":"Stochasticity and cell fate.","volume":"320","author":"R Losick","year":"2008","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1171461","article-title":"Hematopoietic cytokines can instruct lineage choice.","volume":"325","author":"M Rieger","year":"2009","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/blood.V92.2.345b","article-title":"Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation.","volume":"92","author":"D Metcalf","year":"1998","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1093\/nar\/19.14.3843","article-title":"GATA-1 transactivates erythropoietin receptor gene, and erythropoietin receptor-mediated signals enhance GATA-1 gene expression.","volume":"19","author":"T Chiba","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/MCB.14.1.373","article-title":"The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.","volume":"14","author":"DE Zhang","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1128\/MCB.15.10.5830","article-title":"PU.1 (Spi-1) and C\/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.","volume":"15","author":"S Hohaus","year":"1995","journal-title":"Mol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1182\/blood.V88.4.1234.bloodjournal8841234","article-title":"PU.1 (Spi-1) and C\/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.","volume":"88","author":"LT Smith","year":"1996","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1182\/blood-2005-06-2516","article-title":"Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase\/AKT signaling pathway.","volume":"107","author":"W Zhao","year":"2006","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ni973","article-title":"Regulation of macrophage and neutrophil cell fates by the PU.1:C\/EBPalpha ratio and granulocyte colony-stimulating factor.","volume":"4","author":"R Dahl","year":"2003","journal-title":"Nat Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2567.2005.02142.x","article-title":"Immunology and mathematics: crossing the divide.","volume":"115","author":"RE Callard","year":"2005","journal-title":"Immunology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1063\/1.1349894","article-title":"Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.","volume":"11","author":"JE Ferrell","year":"2001","journal-title":"Chaos"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0955-0674(02)00314-9","article-title":"Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.","volume":"14","author":"JE Ferrell","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1073\/pnas.0406841102","article-title":"Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations.","volume":"102","author":"M Samoilov","year":"2005","journal-title":"P Natl Acad Sci USA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1083\/jcb.200308060","article-title":"Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades.","volume":"164","author":"NI Markevich","year":"2004","journal-title":"J Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jtbi.2006.01.021","article-title":"Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1.","volume":"241","author":"I Roeder","year":"2006","journal-title":"J Theor Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ydbio.2007.02.036","article-title":"Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.","volume":"305","author":"S Huang","year":"2007","journal-title":"Dev Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1529\/biophysj.107.120600","article-title":"Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch.","volume":"95","author":"S Palani","year":"2008","journal-title":"Biophys J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature06965","article-title":"Transcriptome-wide noise controls lineage choice in mammalian progenitor cells.","volume":"453","author":"HH Chang","year":"2008","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1128\/MCB.24.2.741-756.2004","article-title":"Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro.","volume":"24","author":"L Bruno","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nri2488","article-title":"The different faces of Notch in T-helper-cell differentiation.","volume":"9","author":"D Amsen","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical-reactions.","volume":"81","author":"DT Gillespie","year":"1977","journal-title":"J Phys Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1021286607354","article-title":"Deterministic versus stochastic models for circadian rhythms.","volume":"28","author":"D Gonze","year":"2002","journal-title":"J Biol Phys"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1529\/biophysj.106.096891","article-title":"Dynamics of a minimal model of interlocked positive and negative feedback loops of transcriptional regulation by cAMP-response element binding proteins.","volume":"92","author":"H Song","year":"2007","journal-title":"Biophys J"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:16:56Z","timestamp":1590153416000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000518"}},"subtitle":[],"editor":[{"given":"Anand R.","family":"Asthagiri","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,9,25]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000518","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,25]]}}}