{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:18Z","timestamp":1761058998252},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T00:00:00Z","timestamp":1259884800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1000583","type":"journal-article","created":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T00:18:31Z","timestamp":1259885911000},"page":"e1000583","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Oxidized Calmodulin Kinase II Regulates Conduction Following Myocardial Infarction: A Computational Analysis"],"prefix":"10.1371","volume":"5","author":[{"given":"Matthew D.","family":"Christensen","sequence":"first","affiliation":[]},{"given":"Wen","family":"Dun","sequence":"additional","affiliation":[]},{"given":"Penelope A.","family":"Boyden","sequence":"additional","affiliation":[]},{"given":"Mark E.","family":"Anderson","sequence":"additional","affiliation":[]},{"given":"Peter J.","family":"Mohler","sequence":"additional","affiliation":[]},{"given":"Thomas J.","family":"Hund","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1006\/jmcc.2002.2038","article-title":"Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond.","volume":"34","author":"LS Maier","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cardiores.2006.12.009","article-title":"Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus.","volume":"73","author":"ME Anderson","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.RES.84.6.713","article-title":"Identification and expression of delta-isoforms of the multifunctional Ca<sup>2+<\/sup>\/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.","volume":"84","author":"B Hoch","year":"1999","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The delta<sub>C<\/sub> isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.","volume":"92","author":"T Zhang","year":"2003","journal-title":"Circ Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M108525200","article-title":"The cardiac-specific nuclear delta<sub>B<\/sub> isoform of Ca<sup>2+<\/sup>\/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.","volume":"277","author":"T Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm1215","article-title":"Calmodulin kinase II inhibition protects against structural heart disease.","volume":"11","author":"R Zhang","year":"2005","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1073\/pnas.0813013106","article-title":"The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.","volume":"106","author":"J Backs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI38022","article-title":"Requirement for Ca<sup>2+<\/sup>\/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.","volume":"119","author":"H Ling","year":"2009","journal-title":"J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/01.CIR.0000027583.73268.E7","article-title":"Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.","volume":"106","author":"Y Wu","year":"2002","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/CIRCULATIONAHA.106.644583","article-title":"Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.","volume":"114","author":"MS Khoo","year":"2006","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj20020228","article-title":"Structure-function of the multifunctional Ca<sup>2+<\/sup>\/calmodulin-dependent protein kinase II.","volume":"364","author":"A Hudmon","year":"2002","journal-title":"Biochem J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.","volume":"133","author":"JR Erickson","year":"2008","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.108.183475","article-title":"Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling.","volume":"104","author":"LH Xie","year":"2009","journal-title":"Circ Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.RES.87.5.392","article-title":"Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress.","volume":"87","author":"S Kinugawa","year":"2000","journal-title":"Circ Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/01.RES.63.1.182","article-title":"Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts.","volume":"63","author":"SM Dillon","year":"1988","journal-title":"Circ Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/01.CIR.55.5.702","article-title":"Re-entrant ventricular arrhythmias in the late myocardial infarction period. 2. Patterns of initiation and termination of re-entry.","volume":"55","author":"N El-Sherif","year":"1977","journal-title":"Circulation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.CIR.55.5.686","article-title":"Re-entrant ventricular arrhythmias in the late myocardial infarction period. 1. Conduction characteristics in the infarction zone.","volume":"55","author":"N El-Sherif","year":"1977","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/01.RES.57.3.432","article-title":"Reentrant ventricular arrhythmias in the late myocardial infarction period in the dog. 13. Correlation of activation and refractory maps.","volume":"57","author":"WB Gough","year":"1985","journal-title":"Circ Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1161\/01.CIR.85.3.1175","article-title":"Abnormal electrical properties of myocytes from chronically infarcted canine heart. Alterations in V<sub>max<\/sub> and the transient outward current.","volume":"85","author":"WM Lue","year":"1992","journal-title":"Circulation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yjmcc.2008.06.007","article-title":"Role of activated CaMKII in abnormal calcium homeostasis and I<sub>Na<\/sub> remodeling after myocardial infarction: Insights from mathematical modeling.","volume":"45","author":"TJ Hund","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/cvr\/cvn348","article-title":"Regulation of the ankyrin-B-based targeting pathway following myocardial infarction.","volume":"81","author":"TJ Hund","year":"2009","journal-title":"Cardiovasc Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.81.1.110","article-title":"Alterations of Na<sup>+<\/sup> currents in myocytes from epicardial border zone of the infarcted heart. A possible ionic mechanism for reduced excitability and postrepolarization refractoriness.","volume":"81","author":"J Pu","year":"1997","journal-title":"Circ Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/01.RES.81.5.727","article-title":"Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling.","volume":"81","author":"RM Shaw","year":"1997","journal-title":"Circ Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1161\/01.CIR.0000147231.69595.D3","article-title":"Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model.","volume":"110","author":"TJ Hund","year":"2004","journal-title":"Circulation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1016\/S0006-3495(01)75965-6","article-title":"Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic model of the cardiac cell.","volume":"81","author":"TJ Hund","year":"2001","journal-title":"Biophys J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0143-4160(03)00152-0","article-title":"Sensitivity of CaM kinase II to the frequency of Ca<sup>2+<\/sup> oscillations: a simple model.","volume":"34","author":"G Dupont","year":"2003","journal-title":"Cell Calcium"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1529\/biophysj.108.128728","article-title":"Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca<sup>2+<\/sup> in cardiac myocytes.","volume":"95","author":"JJ Saucerman","year":"2008","journal-title":"Biophys J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.bpj.2008.11.055","article-title":"CaMKII-induced shift in modal gating explains L-type Ca<sup>2+<\/sup> current facilitation: a modeling study.","volume":"96","author":"YL Hashambhoy","year":"2009","journal-title":"Biophys J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0003-2697(88)90369-7","article-title":"Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma.","volume":"175","author":"B Frei","year":"1988","journal-title":"Anal Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0014-5793(00)02197-9","article-title":"Hydrogen peroxide in the human body.","volume":"486","author":"B Halliwell","year":"2000","journal-title":"FEBS Lett"},{"key":"ref31","first-page":"772","article-title":"Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis.","volume":"147","author":"J Slezak","year":"1995","journal-title":"Am J Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1073\/pnas.84.5.1404","article-title":"Direct measurement of free radical generation following reperfusion of ischemic myocardium.","volume":"84","author":"JL Zweier","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","first-page":"31","article-title":"The paradoxes of reperfusion in the ischemic heart.","volume":"37","author":"NS Dhalla","year":"2007","journal-title":"Heart Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/01.RES.0000195844.31466.e9","article-title":"Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels.","volume":"97","author":"K Fukuda","year":"2005","journal-title":"Circ Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/01.RES.56.3.436","article-title":"Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing.","volume":"56","author":"PC Ursell","year":"1985","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCULATIONAHA.108.809301","article-title":"Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.","volume":"119","author":"DH Lau","year":"2009","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cardiores.2006.07.005","article-title":"Heterogeneous gap junction remodeling in reentrant circuits in the epicardial border zone of the healing canine infarct.","volume":"72","author":"C Cabo","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.CIR.95.4.988","article-title":"Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia.","volume":"95","author":"NS Peters","year":"1997","journal-title":"Circulation"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"H372","DOI":"10.1152\/ajpheart.00512.2002","article-title":"Electrical remodeling of the epicardial border zone in the canine infarcted heart: a computational analysis.","volume":"284","author":"C Cabo","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0008-6363(02)00613-2","article-title":"What happens when cardiac Na channels lose their function? 1\u2013numerical studies of the vulnerable period in tissue expressing mutant channels.","volume":"57","author":"CF Starmer","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1172\/JCI26620","article-title":"Ca\/calmodulin-dependent protein kinase II regulates cardiac Na channels.","volume":"116","author":"S Wagner","year":"2006","journal-title":"J Clin Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1016\/j.bpj.2009.01.014","article-title":"Extracellular space attenuates the effect of gap junctional remodeling on wave propagation: a computational study.","volume":"96","author":"C Cabo","year":"2009","journal-title":"Biophys J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","article-title":"Oxygen, oxidative stress, hypoxia, and heart failure.","volume":"115","author":"FJ Giordano","year":"2005","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/CIRCRESAHA.108.181651","article-title":"miR-1 overexpression enhances Ca<sup>2+<\/sup> release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.","volume":"104","author":"D Terentyev","year":"2009","journal-title":"Circ Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"H109","DOI":"10.1152\/ajpheart.00059.2007","article-title":"Molecular basis for PP2A regulatory subunit B56 alpha targeting in cardiomyocytes.","volume":"293","author":"N Bhasin","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"31968","DOI":"10.1074\/jbc.M806050200","article-title":"Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.","volume":"283","author":"SR Cunha","year":"2008","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1073\/pnas.0402546101","article-title":"A cardiac arrhythmia syndrome caused by loss of ankyrin-B function.","volume":"101","author":"PJ Mohler","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","first-page":"1114","article-title":"Mapping of a gene for long QT syndrome to chromosome 4q25-27.","volume":"57","author":"JJ Schott","year":"1995","journal-title":"Am J Hum Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nature01335","article-title":"Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.","volume":"421","author":"PJ Mohler","year":"2003","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"12484","DOI":"10.1074\/jbc.M313597200","article-title":"Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca<sup>2+<\/sup>-calmodulin-dependent protein kinase II.","volume":"279","author":"TR Gaertner","year":"2004","journal-title":"J Biol Chem"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T06:51:48Z","timestamp":1558680708000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000583"}},"subtitle":[],"editor":[{"given":"Andrew D.","family":"McCulloch","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,12,4]]},"references-count":50,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000583","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,4]]}}}