{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:19:02Z","timestamp":1778631542759,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T00:00:00Z","timestamp":1283990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1000928","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T19:16:39Z","timestamp":1284059799000},"page":"e1000928","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["An Integrative Multi-Network and Multi-Classifier Approach to Predict Genetic Interactions"],"prefix":"10.1371","volume":"6","author":[{"given":"Gaurav","family":"Pandey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron N.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad L.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric E.","family":"Schadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrg2085","article-title":"Exploring genetic interactions and networks with yeast.","volume":"8","author":"C Boone","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1091317","article-title":"Global mapping of the yeast genetic interaction network.","volume":"303","author":"AH Tong","year":"2004","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nature05649","article-title":"Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.","volume":"446","author":"SR Collins","year":"2007","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2105-10-17","article-title":"Predicting genetic interactions with random walks on biological networks.","volume":"10","author":"KC Chipman","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/bp0000712","article-title":"Robustness analysis of the Escherichia coli metabolic network.","volume":"16","author":"JS Edwards","year":"2000","journal-title":"Biotechnol Prog"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e3284","DOI":"10.1371\/journal.pone.0003284","article-title":"Predicting quantitative genetic interactions by means of sequential matrix approximation.","volume":"3","author":"AP Jarvinen","year":"2008","journal-title":"PLoS ONE"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1101\/gr.077693.108","article-title":"Finding friends and enemies in an enemies-only network: a graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions.","volume":"18","author":"Y Qi","year":"2008","journal-title":"Genome Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"15682","DOI":"10.1073\/pnas.0406614101","article-title":"Combining biological networks to predict genetic interactions.","volume":"101","author":"SL Wong","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.1123287","article-title":"Genome-wide prediction of C. elegans genetic interactions.","volume":"311","author":"W Zhong","year":"2006","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/bies.20490","article-title":"Genome-wide prediction of genetic interactions in a metazoan.","volume":"28","author":"S Onami","year":"2006","journal-title":"Bioessays"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/1471-2105-9-426","article-title":"Mining protein networks for synthetic genetic interactions.","volume":"9","author":"SR Paladugu","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1073\/pnas.0408709102","article-title":"The landscape of genetic complexity across 5,700 gene expression traits in yeast.","volume":"102","author":"RB Brem","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0092-8674(00)00015-5","article-title":"Functional discovery via a compendium of expression profiles.","volume":"102","author":"TR Hughes","year":"2000","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cell.2004.06.013","article-title":"Exploration of essential gene functions via titratable promoter alleles.","volume":"118","author":"S Mnaimneh","year":"2004","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1091\/mbc.9.12.3273","article-title":"Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.","volume":"9","author":"PT Spellman","year":"1998","journal-title":"Mol Biol Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/ng.167","article-title":"Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks.","volume":"40","author":"J Zhu","year":"2008","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1126\/science.1065810","article-title":"Systematic genetic analysis with ordered arrays of yeast deletion mutants.","volume":"294","author":"AH Tong","year":"2001","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nbt1096","article-title":"Systematic interpretation of genetic interactions using protein networks.","volume":"23","author":"R Kelley","year":"2005","journal-title":"Nat Biotechnol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1145\/1007730.1007734","article-title":"Mining with rarity: a unifying framework.","volume":"6","author":"G Weiss","year":"2004","journal-title":"ACM SIGKDD Explorations Newsletter"},{"key":"ref20","first-page":"1","article-title":"Ensemble methods in machine learning","author":"TG Dietterich","year":"2001"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1126\/science.285.5429.901","article-title":"Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.","volume":"285","author":"EA Winzeler","year":"1999","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ng2012","article-title":"Genetic reconstruction of a functional transcriptional regulatory network.","volume":"39","author":"Z Hu","year":"2007","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1128\/MCB.17.12.6982","article-title":"Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions.","volume":"17","author":"L Fernandes","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1091\/mbc.11.12.4241","article-title":"Genomic expression programs in the response of yeast cells to environmental changes.","volume":"11","author":"AP Gasch","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1000108","DOI":"10.1371\/journal.pcbi.1000108","article-title":"Unraveling protein networks with power graph analysis.","volume":"4","author":"L Royer","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1073\/pnas.0708670105","article-title":"A systems approach to delineate functions of paralogous transcription factors: role of the Yap family in the DNA damage response.","volume":"105","author":"K Tan","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1111\/j.1742-4658.2005.04695.x","article-title":"The yeast stress response. Role of the Yap family of b-ZIP transcription factors. The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw.","volume":"272","author":"C Rodrigues-Pousada","year":"2005","journal-title":"Febs J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bj20031127","article-title":"Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress.","volume":"379","author":"T Nevitt","year":"2004","journal-title":"Biochem J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1128\/EC.4.11.1829-1839.2005","article-title":"Assembly of the Hap2p\/Hap3p\/Hap4p\/Hap5p-DNA complex in Saccharomyces cerevisiae.","volume":"4","author":"DS McNabb","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.1180823","article-title":"The genetic landscape of a cell.","volume":"327","author":"M Costanzo","year":"2010","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nbt861","article-title":"Discovery of uncharacterized cellular systems by genome-wide analysis of functional linkages.","volume":"21","author":"SV Date","year":"2003","journal-title":"Nat Biotechnol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment.","volume":"36","author":"M Kanehisa","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2164-7-187","article-title":"Finding function: evaluation methods for functional genomic data.","volume":"7","author":"CL Myers","year":"2006","journal-title":"BMC Genomics"},{"key":"ref35","first-page":"296","article-title":"An Information-Theoretic Definition of Similarity; 1998","author":"D Lin"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/bioinformatics\/btg153","article-title":"Investigating semantic similarity measures across the Gene Ontology: the relationship between sequence and annotation.","volume":"19","author":"PW Lord","year":"2003","journal-title":"Bioinformatics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"i529","DOI":"10.1093\/bioinformatics\/btm195","article-title":"Information theory applied to the sparse gene ontology annotation network to predict novel gene function.","volume":"23","author":"Y Tao","year":"2007","journal-title":"Bioinformatics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2105-10-142","article-title":"Incorporating functional inter-relationships into protein function prediction algorithms.","volume":"10","author":"G Pandey","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref39","article-title":"Pattern classification","author":"RO Duda","year":"2000"},{"key":"ref40","article-title":"Machine Learning","author":"T Mitchell","year":"1997"},{"key":"ref41","article-title":"Data Mining: Practical machine learning tools and techniques","author":"IH Witten","year":"2005"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:47:34Z","timestamp":1589010454000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1000928"}},"subtitle":[],"editor":[{"given":"Gary D.","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,9,9]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1000928","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,9]]}}}