{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:08:11Z","timestamp":1774116491789,"version":"3.50.1"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T00:00:00Z","timestamp":1291248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1001024","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T20:51:26Z","timestamp":1291323086000},"page":"e1001024","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["A Systems Model for Immune Cell Interactions Unravels the Mechanism of Inflammation in Human Skin"],"prefix":"10.1371","volume":"6","author":[{"given":"Najl V.","family":"Valeyev","sequence":"first","affiliation":[]},{"given":"Christian","family":"Hundhausen","sequence":"additional","affiliation":[]},{"given":"Yoshinori","family":"Umezawa","sequence":"additional","affiliation":[]},{"given":"Nikolay V.","family":"Kotov","sequence":"additional","affiliation":[]},{"given":"Gareth","family":"Williams","sequence":"additional","affiliation":[]},{"given":"Alex","family":"Clop","sequence":"additional","affiliation":[]},{"given":"Crysanthi","family":"Ainali","sequence":"additional","affiliation":[]},{"given":"Christos","family":"Ouzounis","sequence":"additional","affiliation":[]},{"given":"Sophia","family":"Tsoka","sequence":"additional","affiliation":[]},{"given":"Frank O.","family":"Nestle","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2010,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/0929867043455972","article-title":"Cytokines in the thymus: production and biological effects.","volume":"11","author":"AA Yarilin","year":"2004","journal-title":"Curr Med Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.clindermatol.2007.08.011","article-title":"The cytokine and chemokine network in psoriasis.","volume":"25","author":"BJ Nickoloff","year":"2007","journal-title":"Clin Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"xiii","DOI":"10.1111\/j.1749-6632.2002.tb04195.x","article-title":"Altered neuroendocrine immune (NEI) networks in rheumatology.","volume":"966","author":"M Cutolo","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/107327480901600206","article-title":"The biological basis for immunotherapy in patients with chronic myelogenous leukemia.","volume":"16","author":"J Pinilla-Ibarz","year":"2009","journal-title":"Cancer Control"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/CRD.0b013e3181709fd8","article-title":"Toll-like receptors: new therapeutic targets for the treatment of atherosclerosis, acute coronary syndromes, and myocardial failure.","volume":"16","author":"B Erickson","year":"2008","journal-title":"Cardiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/978-0-387-09789-3_21","article-title":"Immune receptor signaling, aging and autoimmunity.","volume":"640","author":"A Larbi","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease.","volume":"9","author":"JL Round","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.physiol.010908.163200","article-title":"Immunobiology of asthma.","volume":"71","author":"Q Hamid","year":"2009","journal-title":"Annu Rev Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1365-2133.2005.06701.x","article-title":"Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis.","volume":"152","author":"O Boyman","year":"2005","journal-title":"Br J Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.it.2006.12.005","article-title":"The pathogenic role of tissue-resident immune cells in psoriasis.","volume":"28","author":"O Boyman","year":"2007","journal-title":"Trends Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.20031482","article-title":"Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.","volume":"199","author":"O Boyman","year":"2004","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2174\/1568010043343958","article-title":"Epidemiology of psoriasis.","volume":"3","author":"L Naldi","year":"2004","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/jid.2009.59","article-title":"The IL-23\/Th17 axis in the immunopathogenesis of psoriasis.","volume":"129","author":"A Di Cesare","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12016-007-0039-2","article-title":"Immunopathogenesis of psoriasis.","volume":"33","author":"BJ Nickoloff","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis.","volume":"361","author":"FO Nestle","year":"2009","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1142\/p101","article-title":"Recent Advances in Psoriasis: The Role of the Immune System","author":"RS Baker","year":"2000"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.","volume":"41","author":"RP Nair","year":"2009","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20090746","article-title":"Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.","volume":"206","author":"G Darrasse-Jeze","year":"2009","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/jid.2009.65","article-title":"Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis.","volume":"129","author":"EG Harper","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.","volume":"8","author":"L Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.4049\/jimmunol.0801875","article-title":"Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation.","volume":"182","author":"G Penna","year":"2009","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(03)00002-3","article-title":"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.","volume":"112","author":"D Sosic","year":"2003","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.20082118","article-title":"Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.","volume":"206","author":"L Gabrysova","year":"2009","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/msb.2009.49","article-title":"Cell-cell interaction networks regulate blood stem and progenitor cell fate.","volume":"5","author":"DC Kirouac","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1000362","DOI":"10.1371\/journal.pcbi.1000362","article-title":"Tumor-immune interaction, surgical treatment, and cancer recurrence in a mathematical model of melanoma.","volume":"5","author":"S Eikenberry","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1371\/journal.pmed.0040177","article-title":"Understanding the slow depletion of memory CD4+ T cells in HIV infection.","volume":"4","author":"A Yates","year":"2007","journal-title":"PLoS Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1000014","DOI":"10.1371\/journal.pcbi.1000014","article-title":"Translational systems biology of inflammation.","volume":"4","author":"Y Vodovotz","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e10066","DOI":"10.1371\/journal.pone.0010066","article-title":"Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis.","volume":"5","author":"JC Arciero","year":"2010","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2119\/2006-00012.Prince","article-title":"In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice.","volume":"12","author":"JM Prince","year":"2006","journal-title":"Mol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"624","DOI":"10.4049\/jimmunol.0900936","article-title":"Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients.","volume":"184","author":"G Raimondi","year":"2010","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/SHK.0b013e318193cc2b","article-title":"Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus.","volume":"32","author":"A Torres","year":"2009","journal-title":"Shock"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jpedsurg.2006.10.053","article-title":"Mathematical modeling in necrotizing enterocolitis\u2013a new look at an ongoing problem.","volume":"42","author":"JS Upperman","year":"2007","journal-title":"J Pediatr Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1385\/IR:36:1:237","article-title":"Deciphering the complexity of acute inflammation using mathematical models.","volume":"36","author":"Y Vodovotz","year":"2006","journal-title":"Immunol Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.gene.6364351","article-title":"Psoriasis: genetic associations and immune system changes.","volume":"8","author":"Y Liu","year":"2007","journal-title":"Genes Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-2133.2001.04143.x","article-title":"Cytokine gene polymorphisms in psoriasis.","volume":"144","author":"NM Craven","year":"2001","journal-title":"Br J Dermatol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2249.2007.03511.x","article-title":"A role for T cell-derived interleukin 22 in psoriatic skin inflammation.","volume":"150","author":"K Boniface","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/intimm\/dxh247","article-title":"IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages.","volume":"17","author":"N Schuetze","year":"2005","journal-title":"Int Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1136\/thx.2007.092205","article-title":"Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosis.","volume":"63","author":"K Dheda","year":"2008","journal-title":"Thorax"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/ibd.20855","article-title":"Genetic epistasis of IL23\/IL17 pathway genes in Crohn's disease.","volume":"15","author":"DP McGovern","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1111\/j.1600-6143.2008.02321.x","article-title":"The role of the IL23\/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation.","volume":"8","author":"BM Vanaudenaerde","year":"2008","journal-title":"Am J Transplant"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2567.2005.02142.x","article-title":"Immunology and mathematics: crossing the divide.","volume":"115","author":"RE Callard","year":"2005","journal-title":"Immunology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1155\/MI.2005.273","article-title":"Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.","volume":"2005","author":"O Arican","year":"2005","journal-title":"Mediators Inflamm"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00439-007-0397-0","article-title":"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.","volume":"122","author":"F Capon","year":"2007","journal-title":"Hum Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.jid.5700085","article-title":"IL-13-stimulated human keratinocytes preferentially attract CD4+CCR4+ T cells: possible role in atopic dermatitis.","volume":"126","author":"R Purwar","year":"2006","journal-title":"J Invest Dermatol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jtbi.2006.02.015","article-title":"A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration.","volume":"242","author":"J Day","year":"2006","journal-title":"J Theor Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/SHK.0b013e318067dcfe","article-title":"A mathematical simulation of the inflammatory response to anthrax infection.","volume":"29","author":"R Kumar","year":"2008","journal-title":"Shock"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jtbi.2004.04.044","article-title":"The dynamics of acute inflammation.","volume":"230","author":"R Kumar","year":"2004","journal-title":"J Theor Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1524-475X.2009.00567.x","article-title":"Systems biology applied to wound healing.","volume":"18","author":"M Martins-Green","year":"2010","journal-title":"Wound Repair Regen"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jtbi.2006.02.016","article-title":"A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation.","volume":"242","author":"A Reynolds","year":"2006","journal-title":"J Theor Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/01.ccx.0000139360.30327.69","article-title":"Mathematical models of the acute inflammatory response.","volume":"10","author":"Y Vodovotz","year":"2004","journal-title":"Curr Opin Crit Care"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mbs.2008.07.013","article-title":"Mechanistic simulations of inflammation: current state and future prospects.","volume":"217","author":"Y Vodovotz","year":"2009","journal-title":"Math Biosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2174\/1566524043359944","article-title":"Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies.","volume":"4","author":"Y Vodovotz","year":"2004","journal-title":"Curr Mol Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nature08102","article-title":"Unlimited multistability in multisite phosphorylation systems.","volume":"460","author":"M Thomson","year":"2009","journal-title":"Nature"},{"key":"ref55","article-title":"Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis.","author":"K Guilloteau","year":"2010","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/edrv-6-1-45","article-title":"Assessment of insulin sensitivity in vivo.","volume":"6","author":"RN Bergman","year":"1985","journal-title":"Endocr Rev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1001024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T11:30:12Z","timestamp":1740742212000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1001024"}},"subtitle":[],"editor":[{"given":"Ioannis P.","family":"Androulakis","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2010,12,2]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1001024","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,2]]}}}