{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:08:49Z","timestamp":1772752129827,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T00:00:00Z","timestamp":1296691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1001073","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T21:37:15Z","timestamp":1296769035000},"page":"e1001073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System"],"prefix":"10.1371","volume":"7","author":[{"given":"Hung-Yun","family":"Lin","sequence":"first","affiliation":[]},{"given":"Cornelia B.","family":"Landersdorfer","sequence":"additional","affiliation":[]},{"given":"David","family":"London","sequence":"additional","affiliation":[]},{"given":"Ran","family":"Meng","sequence":"additional","affiliation":[]},{"given":"Chang-Uk","family":"Lim","sequence":"additional","affiliation":[]},{"given":"Cassie","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Sharon","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Heng-Yuan","family":"Tang","sequence":"additional","affiliation":[]},{"given":"David","family":"Brown","sequence":"additional","affiliation":[]},{"given":"Brian","family":"Van Scoy","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Kulawy","sequence":"additional","affiliation":[]},{"given":"Lurdes","family":"Queimado","sequence":"additional","affiliation":[]},{"given":"George L.","family":"Drusano","sequence":"additional","affiliation":[]},{"given":"Arnold","family":"Louie","sequence":"additional","affiliation":[]},{"given":"Faith B.","family":"Davis","sequence":"additional","affiliation":[]},{"given":"Shaker A.","family":"Mousa","sequence":"additional","affiliation":[]},{"given":"Paul J.","family":"Davis","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1210\/en.2005-0102","article-title":"Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis.","volume":"146","author":"JJ Bergh","year":"2005","journal-title":"Endocrinology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7270","DOI":"10.1158\/0008-5472.CAN-05-4365","article-title":"Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.","volume":"66","author":"FB Davis","year":"2006","journal-title":"Cancer Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/carcin\/bgm239","article-title":"Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated.","volume":"29","author":"HY Lin","year":"2008","journal-title":"Carcinogenesis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.steroids.2006.11.014","article-title":"Thyroid hormone is a MAPK-dependent growth factor for thyroid cancer cells and is anti-apoptotic.","volume":"72","author":"HY Lin","year":"2007","journal-title":"Steroids"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1161\/01.RES.0000130784.90237.4a","article-title":"Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface.","volume":"94","author":"FB Davis","year":"2004","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10456-007-9088-7","article-title":"Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor.","volume":"11","author":"SA Mousa","year":"2008","journal-title":"Angiogenesis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E1238","DOI":"10.1152\/ajpendo.00480.2009","article-title":"Translational implications of nongenomic actions of thyroid hormone initiated at its integrin receptor.","volume":"297","author":"PJ Davis","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.4161\/cc.8.21.9963","article-title":"Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).","volume":"8","author":"AB Glinskii","year":"2009","journal-title":"Cell Cycle"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1210\/jc.2009-1926","article-title":"Tetraiodothyroacetic acid (tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid.","volume":"95","author":"M Yalcin","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/thy.2007.0248","article-title":"Metabolic effects of thyroid hormone derivatives.","volume":"18","author":"M Moreno","year":"2008","journal-title":"Thyroid"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/jac\/15.suppl_A.131","article-title":"Two compartment kinetic model with multiple artificial capillary units.","volume":"15","author":"J Blaser","year":"1985","journal-title":"J Antimicrob Chemother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1128\/AAC.38.6.1386","article-title":"Effect of 2\u2032,3\u2032-didehydro-3\u2032-deoxythymidine in an in vitro hollow-fiber pharmacodynamic model system correlates with results of dose-ranging clinical studies.","volume":"38","author":"JA Bilello","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1128\/AAC.00006-09","article-title":"Pharmacodynamics of levofloxacin in a murine pneumonia model of Pseudomonas aeruginosa infection: determination of epithelial lining fluid targets.","volume":"53","author":"A Louie","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.abb.2009.01.018","article-title":"Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms.","volume":"486","author":"M Athar","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/eje.0.1440145","article-title":"Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy.","volume":"144","author":"N Lameloise","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/thy.2009.0249","article-title":"Tetraiodothyroacetic acid and tetraiodothyroacetic acid nanoparticle effectively inhibit the growth of human follicular thyroid cell carcinoma.","volume":"20","author":"M Yalcin","year":"2010","journal-title":"Thyroid"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jcem.87.3.8345","article-title":"Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism.","volume":"87","author":"A Shih","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1096\/fj.06-5743fje","article-title":"Integrin alphaVbeta3 contains a receptor site for resveratrol.","volume":"20","author":"HY Lin","year":"2006","journal-title":"FASEB J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/j.seminoncol.2006.04.003","article-title":"Epidermal growth factor receptor targeting in cancer.","volume":"33","author":"J Mendelsohn","year":"2006","journal-title":"Semin Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1592\/phco.28.11-supp.31S","article-title":"Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer.","volume":"28","author":"DK Patel","year":"2008","journal-title":"Pharmacotherapy"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1056\/NEJMoa0808268","article-title":"Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer.","volume":"360","author":"J Tol","year":"2009","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa0805019","article-title":"Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.","volume":"360","author":"E Van Cutsem","year":"2009","journal-title":"N Engl J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2184.2007.00449.x","article-title":"Differential impact of Cetuximab, Pertuzumab and Trastuzumab on BT474 and SK-BR-3 breast cancer cell proliferation.","volume":"40","author":"G Brockhoff","year":"2007","journal-title":"Cell Prolif"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1210\/en.2003-0742","article-title":"Disparate effects of thyroid hormone on actions of epidermal growth factor and transforming growth factor-alpha are mediated by 3\u2032,5\u2032-cyclic adenosine 5\u2032-monophosphate-dependent protein kinase II.","volume":"145","author":"A Shih","year":"2004","journal-title":"Endocrinology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0022-5347(05)64739-8","article-title":"Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line.","volume":"168","author":"HY Lin","year":"2002","journal-title":"J Urol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1158\/1535-7163.1355.3.11","article-title":"Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.","volume":"3","author":"A Shih","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/sj.bjc.6601902","article-title":"Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells.","volume":"91","author":"S Zhang","year":"2004","journal-title":"Br J Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02322290","article-title":"The quantitation problem of pharmacology [in German].","volume":"27","author":"S Loewe","year":"1928","journal-title":"Ergebn Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/AAC.00489-08","article-title":"Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa.","volume":"53","author":"JB Bulitta","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10928-004-8319-4","article-title":"Assessment of drug interactions relevant to pharmacodynamic indirect response models.","volume":"31","author":"J Earp","year":"2004","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2042-7158.1964.tb07461.x","article-title":"A molecular basis for drug action. The interaction of one or more drugs with different receptors.","volume":"16","author":"EJ Ariens","year":"1964","journal-title":"J Pharm Pharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.","volume":"22","author":"TC Chou","year":"1984","journal-title":"Adv Enzyme Regul"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/jps.3000","article-title":"Pharmacodynamic interaction of recombinant human interleukin-10 and prednisolone using in vitro whole blood lymphocyte proliferation.","volume":"91","author":"A Chakraborty","year":"2002","journal-title":"J Pharm Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/scbi.1998.0097","article-title":"Regulation of p53 downstream genes.","volume":"8","author":"WS el-Deiry","year":"1998","journal-title":"Semin Cancer Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(95)90411-5","article-title":"Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.","volume":"80","author":"E Yang","year":"1995","journal-title":"Cell"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1001073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T03:09:02Z","timestamp":1685934542000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1001073"}},"subtitle":[],"editor":[{"given":"Bernd","family":"Meibohm","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,2,3]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1001073","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,3]]}}}