{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:53:46Z","timestamp":1763830426853},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1001077","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:15:15Z","timestamp":1297383315000},"page":"e1001077","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["A Hybrid Model of Mammalian Cell Cycle Regulation"],"prefix":"10.1371","volume":"7","author":[{"given":"Rajat","family":"Singhania","sequence":"first","affiliation":[]},{"given":"R. Michael","family":"Sramkoski","sequence":"additional","affiliation":[]},{"given":"James W.","family":"Jacobberger","sequence":"additional","affiliation":[]},{"given":"John J.","family":"Tyson","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"ref1","article-title":"The Biology of the Cell Cycle","author":"JM Mitchison","year":"1971"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0955-0674(95)80067-0","article-title":"What is the restriction point?","volume":"7","author":"A Zetterberg","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1091\/mbc.11.1.369","article-title":"Kinetic analysis of a molecular model of the budding yeast cell cycle.","volume":"11","author":"KC Chen","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1063\/1.1345725","article-title":"Mathematical model of the cell division cycle of fission yeast.","volume":"11","author":"B Novak","year":"2001","journal-title":"Chaos"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1091\/mbc.E03-11-0794","article-title":"Integrative analysis of cell cycle control in budding yeast.","volume":"15","author":"KC Chen","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/msb4100171","article-title":"Dynamical modeling of syncytial mitotic cycles in Drosophila embryos.","volume":"3","author":"L Calzone","year":"2007","journal-title":"Mol Syst Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1242\/jcs.106.4.1153","article-title":"Numerical analysis of a comprehensive model of M-phase control in <italic>Xenopus<\/italic> oocyte extracts and intact embryos.","volume":"106","author":"B Novak","year":"1993","journal-title":"J Cell Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2005.06.016","article-title":"Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.","volume":"122","author":"JR Pomerening","year":"2005","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2184.1999.3250321.x","article-title":"The kinetic origins of the restriction point in the mammalian cell cycle.","volume":"32","author":"BD Aguda","year":"1999","journal-title":"Cell Prolif"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"C349","DOI":"10.1152\/ajpcell.00066.2002","article-title":"Regulation of the mammalian cell cycle: a model of the G1-to-S transition.","volume":"284","author":"Z Qu","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jtbi.2004.04.039","article-title":"A model for restriction point control of the mammalian cell cycle.","volume":"230","author":"B Novak","year":"2004","journal-title":"J Theor Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1073\/pnas.0235349100","article-title":"Hysteresis drives cell-cycle transitions in <italic>Xenopus laevis<\/italic> egg extracts.","volume":"100","author":"W Sha","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ncb954","article-title":"Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.","volume":"5","author":"JR Pomerening","year":"2003","journal-title":"Nature Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1073\/pnas.0305937101","article-title":"The yeast cell-cycle network is robustly designed.","volume":"101","author":"F Li","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e1672","DOI":"10.1371\/journal.pone.0001672","article-title":"Boolean network model predicts cell cycle sequence of fission yeast.","volume":"3","author":"MI Davidich","year":"2008","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1093\/bioinformatics\/btl210","article-title":"Dynamical analysis of a generic Boolean model for the control of mammalian cell cycle.","volume":"22","author":"A Faure","year":"2006","journal-title":"Bioinformatics"},{"key":"ref17","first-page":"11","article-title":"Division timing: controls, models and mechanisms.","author":"PA Fantes","year":"1981"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/bies.950020208","article-title":"The coordination of cell growth and division \u2013 intentional or incidental?","volume":"2","author":"JJ Tyson","year":"1985","journal-title":"Bioessays"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0022-5193(87)80146-7","article-title":"Size control of cell division.","volume":"126","author":"JJ Tyson","year":"1987","journal-title":"J Theor Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/cyto.a.20003","article-title":"Cytometry of the cell cycle: cycling through history.","volume":"58","author":"Z Darzynkiewicz","year":"2004","journal-title":"Cytometry A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0022-5193(73)90208-7","article-title":"The logical analysis of continuous, non-linear biochemical control networks.","volume":"39","author":"L Glass","year":"1973","journal-title":"J Theor Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02547797","article-title":"Stable oscillations in mathematical models of biological control systems.","volume":"6","author":"L Glass","year":"1978","journal-title":"J Math Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1142\/S021972000600176X","article-title":"A new regulatory interaction suggested by simulations for circadian genetic control mechanism in mammals.","volume":"4","author":"H Matsuno","year":"2006","journal-title":"J Bioinform Comput Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1752-0509-1-13","article-title":"Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery.","volume":"1","author":"WJ Bosl","year":"2007","journal-title":"BMC Syst Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1752-0509-3-42","article-title":"Simulation-based model checking approach to cell fate specification during Caenorhabditis elegans vulval development by hybrid functional Petri net with extension.","volume":"3","author":"C Li","year":"2009","journal-title":"BMC Syst Biol"},{"key":"ref26","first-page":"14","article-title":"Hierarchical Hybrid Modeling of Embedded Systems.","author":"R Alur","year":"2001"},{"key":"ref27","doi-asserted-by":"crossref","DOI":"10.1201\/9781420010855","article-title":"Handbook of dynamic system modeling","author":"PA Fishwick","year":"2007"},{"key":"ref28","article-title":"Simulation of dynamic systems with MATLAB and Simulink","author":"H Klee","year":"2011"},{"key":"ref29","first-page":"165","article-title":"An Overview of Hybrid Simulation Phenomena and Their Support by Simulation Packages.","author":"P Mosterman","year":"1999"},{"key":"ref30","first-page":"113","article-title":"SHIFT: A Formalism and a Programming Language for Dynamic Networks of Hybrid Automata.","author":"A Deshpande","year":"1997"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1109\/9.664163","article-title":"The SHIFT programming language and run-time system for dynamic networks of hybrid systems.","volume":"43","author":"A Deshpande","year":"1998","journal-title":"IEEE Trans Automat Contr"},{"key":"ref32","first-page":"6","article-title":"Modular Specification of Hybrid Systems in CHARON.","author":"R Alur","year":"2000"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrm714","article-title":"Sibling viralry in the E2F family.","volume":"3","author":"JM Trimarchi","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/ncb1217","article-title":"FoxM1 is required for execution of the mitotic programme and chromosome stability.","volume":"7","author":"J Laoukili","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1515\/BC.2007.159","article-title":"FOXM1, a typical proliferation-associated transcription factor.","volume":"388","author":"I Wierstra","year":"2007","journal-title":"Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrm1471","article-title":"The SCF ubiquitin ligase: insights into a molecular machine.","volume":"5","author":"T Cardozo","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1097-2765(03)00287-9","article-title":"Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.","volume":"12","author":"M Welcker","year":"2003","journal-title":"Mol Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.1013102","article-title":"The anaphase-promoting complex: it is not just for mitosis any more.","volume":"16","author":"JW Harper","year":"2002","journal-title":"Genes Dev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S1097-2765(02)00540-3","article-title":"The anaphase-promoting complex proteolysis in mitosis and beyond.","volume":"9","author":"JM Peters","year":"2002","journal-title":"Mol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1083\/jcb.153.1.137","article-title":"Anaphase-promoting complex\/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.","volume":"153","author":"S Geley","year":"2001","journal-title":"J Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1101\/gad.14.6.655","article-title":"The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.","volume":"14","author":"CM Pfleger","year":"2000","journal-title":"Genes Dev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1158\/1535-7163.1147.3.9","article-title":"CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.","volume":"3","author":"T Yan","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"ref43","first-page":"4285","article-title":"Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines.","volume":"54","author":"J Gong","year":"1994","journal-title":"Cancer Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e7064","DOI":"10.1371\/journal.pone.0007064","article-title":"Cell cycle-related cyclin b1 quantification.","volume":"4","author":"PS Frisa","year":"2009","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/(SICI)1097-0320(19990301)35:3<284::AID-CYTO12>3.0.CO;2-K","article-title":"Estimation of kinetic cell-cycle-related gene expression in G1 and G2 phases from immunofluorescence flow cytometry data.","volume":"35","author":"JW Jacobberger","year":"1999","journal-title":"Cytometry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19960901)25:1<1::AID-CYTO1>3.0.CO;2-N","article-title":"Cytometry of cyclin proteins.","volume":"25","author":"Z Darzynkiewicz","year":"1996","journal-title":"Cytometry"},{"key":"ref47","first-page":"707","article-title":"Numerical recipes in C. The art of scientific computing","author":"WH Press","year":"1992"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yexcr.2005.03.025","article-title":"CDK2 translational down-regulation during endothelial senescence.","volume":"307","author":"DA Freedman","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cyto.990130109","article-title":"Fixation of mammalian cells for flow cytometric evaluation of DNA content and nuclear immunofluorescence.","volume":"13","author":"KJ Schimenti","year":"1992","journal-title":"Cytometry"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1001077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T05:52:18Z","timestamp":1685944338000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1001077"}},"subtitle":[],"editor":[{"given":"Daniel A.","family":"Beard","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,2,10]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1001077","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,10]]}}}