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Buchler","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"026102","DOI":"10.1063\/1.2204354","article-title":"Frequency domain analysis of noise in simple gene circuits.","volume":"16","author":"CD Cox","year":"2006","journal-title":"Chaos"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.1144331","article-title":"Effects of molecular memory and bursting on flucuations in gene.","volume":"319","author":"JM Pedraza","year":"2008","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1529\/biophysj.106.086157","article-title":"Diffusion of transcription factors can drastically enhance the noise in gene expression.","volume":"91","author":"JS van Zon","year":"2006","journal-title":"Biophys J"},{"key":"ref57","first-page":"1","article-title":"The regulation of bacterial transcription initiation.","volume":"2","author":"DF Browning","year":"2004","journal-title":"Nat Revs Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1021\/bi00116a010","article-title":"Site-specific enthalpic regulation of DNA-transcription at bacteriophage-lambda Or.","volume":"31","author":"KS Koblan","year":"1992","journal-title":"Biochemistry"},{"key":"ref59","article-title":"A Genetic Switch.","author":"M Ptashne","year":"2004"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"17741","DOI":"10.1073\/pnas.0602223104","article-title":"Cooperative DNA binding by cI repressor is dispensable in a phage-lambda variant.","volume":"104","author":"AC Babic","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1093\/emboj\/cdf431","article-title":"Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding.","volume":"21","author":"S Semsey","year":"2002","journal-title":"EMBO 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Opin Genet Dev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jmb.2008.08.027","article-title":"CRP Binding and Transcription Activation at CRP-S Sites.","volume":"383","author":"AD Cameron","year":"2008","journal-title":"J Mol Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1042\/bj2610649","article-title":"Binding of the Escherichia coli cyclic AMP receptor protein toDNA fragments containing consensus nucleotide sequences.","volume":"261","author":"K Gaston","year":"1989","journal-title":"Biochem J"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1126\/science.8091212","article-title":"Synergistic activation of transcription by bacteriophage-lambda cI-protein and escherichia coli CAMP receptor protein.","volume":"265","author":"JK Joung","year":"1994","journal-title":"Science"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1073\/pnas.90.7.3083","article-title":"Synergistic activation of transcription by Escherichia-coli CAMP Receptor Protein.","volume":"90","author":"JK Joung","year":"1993","journal-title":"Proc Natl Acad Sci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1093\/emboj\/17.20.5998","article-title":"Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo.","volume":"17","author":"BS Burz","year":"1998","journal-title":"EMBO J"},{"key":"ref71","first-page":"466","article-title":"Concurrent Fast and Slow Cycling of a Transcriptional Activator at an Endogenous Promoter.","author":"TS Karpova","year":"2008","journal-title":"Science 5862"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1093\/emboj\/20.19.5392","article-title":"Repression of deoP2 in Escherichia coli by CytR: Conversion of a transcription activator into a repressor.","volume":"19","author":"M Shin","year":"2001","journal-title":"EMBO J"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrg2591","article-title":"From DNA sequence to transcriptional behaviour: a quantitative approach.","volume":"10","author":"E Segal","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.1171347","article-title":"Transcriptional regulatory circuits: predicting numbers from alphabets.","volume":"325","author":"HD Kim","year":"2009","journal-title":"Science"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1073\/pnas.0606717104","article-title":"Combinatorial transcriptional control of the lactose operon of Escherichia coli.","volume":"104","author":"T Kuhlman","year":"2007","journal-title":"Proc Natl Acad 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Straney","year":"1987","journal-title":"Cell"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1188308","article-title":"Quantifying <italic>E. coli<\/italic> proteome and transcriptome with single-molecule sensitivity in single cells.","volume":"329","author":"Y Taniguchi","year":"2010","journal-title":"Science"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"011914","DOI":"10.1103\/PhysRevE.80.011914","article-title":"Role of cooperative binding on noise expression.","volume":"80","author":"PS Gutierrez","year":"2009","journal-title":"Phys Rev E"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e1000279","DOI":"10.1371\/journal.pcbi.1000279","article-title":"Precise Regulation of Gene Expression Dynamics Favors Complex Promoter Architectures.","volume":"5","author":"D M\u00fcller","year":"2009","journal-title":"PLoS Comput 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Intriguing role of termination and antitermination.","volume":"105","author":"S Klumpp","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1529\/biophysj.107.105767","article-title":"Fluctuations, pauses and backtracking in DNA transcription.","volume":"94","author":"M Voliotis","year":"2008","journal-title":"Biophys J"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1073\/pnas.0803507106","article-title":"Elongation dynamics shape bursty transcription and translation.","volume":"106","author":"M Dobrzynski","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"e2774","DOI":"10.1371\/journal.pone.0002774","article-title":"The role of input noise in transcriptional regulation.","volume":"3","author":"G Tkacik","year":"2008","journal-title":"PLoS One"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/nar\/gkp134","article-title":"Direct demonstration and quantification of long-range DNA looping by the lambda-bacteriophage repressor.","volume":"37","author":"C Zurla","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/jmbi.1996.0143","article-title":"Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator.","volume":"257","author":"J M\u00fcller","year":"1996","journal-title":"J Mol Biol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(77)90279-0","article-title":"Transcription and translation initiation frequencies of the Escherichia coli lac operon.","volume":"114","author":"D Kennell","year":"1977","journal-title":"J Mol Biol"}],"container-title":["PLoS Computational 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