{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:59:54Z","timestamp":1769579994499,"version":"3.49.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002069","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:42:43Z","timestamp":1308339763000},"page":"e1002069","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":147,"title":["Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning"],"prefix":"10.1371","volume":"7","author":[{"given":"David","family":"Sprinzak","sequence":"first","affiliation":[]},{"given":"Amit","family":"Lakhanpal","sequence":"additional","affiliation":[]},{"given":"Lauren","family":"LeBon","sequence":"additional","affiliation":[]},{"given":"Jordi","family":"Garcia-Ojalvo","sequence":"additional","affiliation":[]},{"given":"Michael B.","family":"Elowitz","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1242\/dev.124.17.3283","article-title":"Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis.","volume":"124","author":"SS Huppert","year":"1997","journal-title":"Development"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1242\/dev.124.10.1919","article-title":"Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing.","volume":"124","author":"JF de Celis","year":"1997","journal-title":"Development"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0092-8674(91)90263-X","article-title":"The choice of cell fate in the epidermis of Drosophila.","volume":"64","author":"P Heitzler","year":"1991","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex.","volume":"7","author":"SJ Bray","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1242\/dev.124.17.3241","article-title":"Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing.","volume":"124","author":"JF de Celis","year":"1997","journal-title":"Development"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1242\/dev.124.8.1485","article-title":"The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate.","volume":"124","author":"CA Micchelli","year":"1997","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/dbio.1997.8564","article-title":"An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila.","volume":"189","author":"T Klein","year":"1997","journal-title":"Dev Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-213X-4-5","article-title":"The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila.","volume":"4","author":"Y Li","year":"2004","journal-title":"BMC Dev Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1242\/dev.027938","article-title":"Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue.","volume":"136","author":"M Matsuda","year":"2009","journal-title":"Development"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.cub.2009.06.042","article-title":"cis-Inhibition of Notch by endogenous Delta biases the outcome of lateral inhibition.","volume":"19","author":"AC Miller","year":"2009","journal-title":"Curr Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature08959","article-title":"Cis-interactions between Notch and Delta generate mutually exclusive signalling states.","volume":"465","author":"D Sprinzak","year":"2010","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.cub.2010.01.058","article-title":"A role of receptor notch in ligand cis-inhibition in Drosophila.","volume":"20","author":"I Becam","year":"2010","journal-title":"Curr Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/dbio.2001.0517","article-title":"Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification.","volume":"241","author":"K Sakamoto","year":"2002","journal-title":"Dev Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1038\/sj.emboj.7601337","article-title":"Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis.","volume":"25","author":"M Glittenberg","year":"2006","journal-title":"EMBO J"},{"key":"ref15","article-title":"Models of biological pattern formation.","author":"H Meinhardt","year":"1982"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s002850100105","article-title":"Pattern formation in discrete cell lattices.","volume":"43","author":"E Plahte","year":"2001","journal-title":"J Math Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0022-5193(80)90318-5","article-title":"Generation and regeneration of sequence of structures during morphogenesis.","volume":"85","author":"H Meinhardt","year":"1980","journal-title":"J Theor Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1101\/gad.7.6.961","article-title":"The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.","volume":"7","author":"MA Sturtevant","year":"1993","journal-title":"Genes Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1242\/dev.127.6.1291","article-title":"The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe.","volume":"127","author":"JF de Celis","year":"2000","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/01677068509102325","article-title":"Genetic interactions in early neurogenesis of Drosophila melanogaster.","volume":"2","author":"H Vassin","year":"1985","journal-title":"J Neurogenet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"ra51","DOI":"10.1126\/scisignal.2000857","article-title":"Error minimization in lateral inhibition circuits.","volume":"3","author":"O Barad","year":"2010","journal-title":"Sci Signal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1147888","article-title":"Stochasticity and cell fate.","volume":"320","author":"R Losick","year":"2008","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.1070919","article-title":"Stochastic gene expression in a single cell.","volume":"297","author":"MB Elowitz","year":"2002","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1523\/JNEUROSCI.17-16-06289.1997","article-title":"Pattern formation in the basilar papilla: evidence for cell rearrangement.","volume":"17","author":"R Goodyear","year":"1997","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1006\/jtbi.1996.0233","article-title":"Pattern formation by lateral inhibition with feedback: a mathematical model of delta-notch intercellular signalling.","volume":"183","author":"JR Collier","year":"1996","journal-title":"J Theor Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0022-5193(71)90154-8","article-title":"Instability and dynamic pattern in cellular networks.","volume":"32","author":"HG Othmer","year":"1971","journal-title":"J Theor Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0092-8674(94)90010-8","article-title":"Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision.","volume":"79","author":"HA Wilkinson","year":"1994","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1063\/1.1349894","article-title":"Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.","volume":"11","author":"JE Ferrell","year":"2001","journal-title":"Chaos"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.sbi.2006.05.008","article-title":"DNA looping: the consequences and its control.","volume":"16","author":"L Saiz","year":"2006","journal-title":"Curr Opin Struct Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1073\/pnas.0606717104","article-title":"Combinatorial transcriptional control of the lactose operon of Escherichia coli.","volume":"104","author":"T Kuhlman","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nbt1308","article-title":"Engineering synthetic signaling proteins with ultrasensitive input\/output control.","volume":"25","author":"JE Dueber","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jmb.2008.09.079","article-title":"Molecular titration and ultrasensitivity in regulatory networks.","volume":"384","author":"NE Buchler","year":"2008","journal-title":"J Mol Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1371\/journal.pbio.0050229","article-title":"Quantitative characteristics of gene regulation by small RNA.","volume":"5","author":"E Levine","year":"2007","journal-title":"PLoS Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0006-3495(03)74839-5","article-title":"Near-critical phenomena in intracellular metabolite pools.","volume":"84","author":"J Elf","year":"2003","journal-title":"Biophys J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/msb.2008.58","article-title":"A quantitative comparison of sRNA-based and protein-based gene regulation.","volume":"4","author":"P Mehta","year":"2008","journal-title":"Mol Syst Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2004.06.009","article-title":"The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae.","volume":"118","author":"DH Lenz","year":"2004","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/msb.2009.30","article-title":"Protein sequestration generates a flexible ultrasensitive response in a genetic network.","volume":"5","author":"NE Buchler","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.mib.2008.09.016","article-title":"Small RNAs establish gene expression thresholds.","volume":"11","author":"E Levine","year":"2008","journal-title":"Curr Opin Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1242\/dev.117.3.1113","article-title":"Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions.","volume":"117","author":"P Heitzler","year":"1993","journal-title":"Development"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molcel.2004.10.014","article-title":"Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.","volume":"16","author":"CJ Fryer","year":"2004","journal-title":"Mol Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1242\/dev.124.10.2015","article-title":"Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila.","volume":"124","author":"L Seugnet","year":"1997","journal-title":"Development"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/dvg.20391","article-title":"Notch and suppressor of Hairless regulate levels but not patterns of Delta expression in Drosophila.","volume":"46","author":"AL Parks","year":"2008","journal-title":"Genesis"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T12:00:34Z","timestamp":1637841634000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002069"}},"subtitle":[],"editor":[{"given":"Denis","family":"Thieffry","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,6,9]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002069","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,9]]}}}