{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:50:16Z","timestamp":1793159416612,"version":"4.5.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002107","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T20:50:04Z","timestamp":1311886204000},"page":"e1002107","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":378,"title":["Models of Neocortical Layer 5b Pyramidal Cells Capturing a\u00a0Wide Range of Dendritic and Perisomatic Active Properties"],"prefix":"10.1371","volume":"7","author":[{"given":"Etay","family":"Hay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Markram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idan","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1997.sp022031","article-title":"Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.","volume":"500 (Pt 2)","author":"H Markram","year":"1997","journal-title":"J Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1152\/jn.00397.2007","article-title":"Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.","volume":"98","author":"AM Hattox","year":"2007","journal-title":"J Neurophysiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1093\/cercor\/bhq069","article-title":"Cell type-specific thalamic innervation in a column of rat vibrissal cortex.","volume":"20","author":"HS Meyer","year":"2010","journal-title":"Cereb Cortex"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1093\/cercor\/bhl127","article-title":"Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex.","volume":"17","author":"JV Le Be","year":"2007","journal-title":"Cereb Cortex"},{"key":"ref5","first-page":"617","article-title":"Action potential initiation and propagation in rat neocortical pyramidal neurons.","volume":"3)","author":"G Stuart","year":"1997","journal-title":"J Physiol 505 ( Pt"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/18686","article-title":"A new cellular mechanism for coupling inputs arriving at different cortical layers.","volume":"398","author":"ME Larkum","year":"1999","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1523\/JNEUROSCI.22-16-06991.2002","article-title":"Signaling of layer 1 and whisker-evoked Ca2+ and Na+ action potentials in distal and terminal dendrites of rat neocortical pyramidal neurons in vitro and in vivo.","volume":"22","author":"ME Larkum","year":"2002","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.1171958","article-title":"Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle.","volume":"325","author":"ME Larkum","year":"2009","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/35005094","article-title":"NMDA spikes in basal dendrites of cortical pyramidal neurons.","volume":"404","author":"J Schiller","year":"2000","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nn1826","article-title":"Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.","volume":"10","author":"T Nevian","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"11891","DOI":"10.1523\/JNEUROSCI.5250-08.2009","article-title":"Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons.","volume":"29","author":"A Polsky","year":"2009","journal-title":"J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/367069a0","article-title":"Active propagation of somatic action potentials into neocortical pyramidal cell dendrites.","volume":"367","author":"GJ Stuart","year":"1994","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1523\/JNEUROSCI.3664-05.2006","article-title":"Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output.","volume":"26","author":"MH Kole","year":"2006","journal-title":"J Neurosci"},{"key":"ref14","first-page":"1171","article-title":"The role of single neurons in information processing.","volume":"3","author":"C Koch","year":"2000"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1523\/JNEUROSCI.18-11-04325.1998","article-title":"Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations.","volume":"18","author":"BW Mel","year":"1998","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/71125","article-title":"A model for intradendritic computation of binocular disparity.","volume":"3","author":"KA Archie","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nn1253","article-title":"Computational subunits in thin dendrites of pyramidal cells.","volume":"7","author":"A Polsky","year":"2004","journal-title":"Nat Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1000493","DOI":"10.1371\/journal.pcbi.1000493","article-title":"The role of ongoing dendritic oscillations in single-neuron dynamics.","volume":"5","author":"MW Remme","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature02266","article-title":"Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortex.","volume":"427","author":"M Brecht","year":"2004","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06447","article-title":"Behavioural report of single neuron stimulation in somatosensory cortex.","volume":"451","author":"AR Houweling","year":"2008","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/cercor\/3.1.26","article-title":"Regenerative activity in apical dendrites of pyramidal cells in neocortex.","volume":"3","author":"Y Amitai","year":"1993","journal-title":"Cereb Cortex"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1469-7793.1997.605ba.x","article-title":"Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons.","volume":"505 (Pt 3)","author":"J Schiller","year":"1997","journal-title":"J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"14600","DOI":"10.1073\/pnas.96.25.14600","article-title":"Calcium electrogenesis in distal apical dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action potentials.","volume":"96","author":"ME Larkum","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nature07663","article-title":"Dendritic encoding of sensory stimuli controlled by deep cortical interneurons.","volume":"457","author":"M Murayama","year":"2009","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"20482","DOI":"10.1073\/pnas.0910379106","article-title":"Enhanced dendritic activity in awake rats.","volume":"106","author":"M Murayama","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/82910","article-title":"Dendritic coincidence detection of EPSPs and action potentials.","volume":"4","author":"GJ Stuart","year":"2001","journal-title":"Nat Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.275.5297.213","article-title":"Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs.","volume":"275","author":"H Markram","year":"1997","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1152\/jn.00612.2010","article-title":"Interregional synaptic competition in neurons with multiple STDP-inducing signals.","volume":"105","author":"L Bar Ilan","year":"2011","journal-title":"J Neurophysiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"11985","DOI":"10.1073\/pnas.93.21.11985","article-title":"Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells.","volume":"93","author":"M Rapp","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/382363a0","article-title":"Influence of dendritic structure on firing pattern in model neocortical neurons.","volume":"382","author":"ZF Mainen","year":"1996","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1152\/jn.00046.2003","article-title":"Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern.","volume":"89","author":"AT Schaefer","year":"2003","journal-title":"J Neurophysiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nn2040","article-title":"Action potential generation requires a high sodium channel density in the axon initial segment.","volume":"11","author":"MH Kole","year":"2008","journal-title":"Nat Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1152\/jn.00408.2005","article-title":"Constraining compartmental models using multiple voltage recordings and genetic algorithms.","volume":"94","author":"N Keren","year":"2005","journal-title":"J Neurophysiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1113\/jphysiol.2008.167130","article-title":"Experimentally guided modelling of dendritic excitability in rat neocortical pyramidal neurones.","volume":"587","author":"N Keren","year":"2009","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0896-6273(03)00148-X","article-title":"Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell.","volume":"37","author":"P Poirazi","year":"2003","journal-title":"Neuron"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/neuro.01.1.1.001.2007","article-title":"A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data.","volume":"1","author":"S Druckmann","year":"2007","journal-title":"Front Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1008972005316","article-title":"A comparative survey of automated parameter-search methods for compartmental neural models.","volume":"7","author":"MC Vanier","year":"1999","journal-title":"J Comput Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00422-008-0257-6","article-title":"Automated neuron model optimization techniques: a review.","volume":"99","author":"W Van Geit","year":"2008","journal-title":"Biol Cybern"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/cercor\/bhh092","article-title":"Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex.","volume":"14","author":"M Toledo-Rodriguez","year":"2004","journal-title":"Cereb Cortex"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/78800","article-title":"Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons.","volume":"3","author":"JC Magee","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1152\/jn.2000.83.5.3177","article-title":"Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons.","volume":"83","author":"SR Williams","year":"2000","journal-title":"J Neurophysiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1152\/jn.00377.2003","article-title":"Hyperpolarization-activated current Ih disconnects somatic and dendritic spike initiation zones in layer V pyramidal neurons.","volume":"90","author":"T Berger","year":"2003","journal-title":"J Neurophysiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.neuron.2007.11.015","article-title":"HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons.","volume":"56","author":"D Tsay","year":"2007","journal-title":"Neuron"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1469-7793.2001.0447a.x","article-title":"Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons.","volume":"533","author":"ME Larkum","year":"2001","journal-title":"J Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1152\/jn.1999.82.6.3006","article-title":"Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings.","volume":"82","author":"GY Shen","year":"1999","journal-title":"J Neurophysiol"},{"key":"ref46","first-page":"497","article-title":"Multi-objective optimization using evolutionary algorithms.","author":"K Deb","year":"2001","journal-title":"Chichester ;"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1523\/JNEUROSCI.18-10-03501.1998","article-title":"Determinants of voltage attenuation in neocortical pyramidal neuron dendrites.","volume":"18","author":"G Stuart","year":"1998","journal-title":"J Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0014-4886(59)90046-9","article-title":"Branching dendritic trees and motoneuron membrane resistivity.","volume":"1","author":"W Rall","year":"1959","journal-title":"Exp Neurol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0006-3495(74)85947-3","article-title":"Changes of action potential shape and velocity for changing core conductor geometry.","volume":"14","author":"SS Goldstein","year":"1974","journal-title":"Biophys J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1152\/jn.2001.85.2.926","article-title":"Propagation of action potentials in dendrites depends on dendritic morphology.","volume":"85","author":"P Vetter","year":"2001","journal-title":"J Neurophysiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nn.2105","article-title":"Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities.","volume":"11","author":"M Okun","year":"2008","journal-title":"Nat Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2010.01.006","article-title":"Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice.","volume":"65","author":"LJ Gentet","year":"2010","journal-title":"Neuron"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/cercor\/bhh065","article-title":"Top-down dendritic input increases the gain of layer 5 pyramidal neurons.","volume":"14","author":"ME Larkum","year":"2004","journal-title":"Cereb Cortex"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nn.2404","article-title":"Functional consequences of animal-to-animal variation in circuit parameters.","volume":"12","author":"JM Goaillard","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nn.2359","article-title":"Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation.","volume":"12","author":"W Hu","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1469-7793.2000.00571.x","article-title":"Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites.","volume":"526 Pt 3","author":"JJ Zhu","year":"2000","journal-title":"J Physiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nn0602-857","article-title":"Ion channel properties underlying axonal action potential initiation in pyramidal neurons.","volume":"5","author":"CM Colbert","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nn.2574","article-title":"Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma.","volume":"13","author":"IA Fleidervish","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.neuron.2009.01.032","article-title":"Activity-dependent control of neuronal output by local and global dendritic spike attenuation.","volume":"61","author":"S Remy","year":"2009","journal-title":"Neuron"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"16829","DOI":"10.1073\/pnas.0903766106","article-title":"A state-mutating genetic algorithm to design ion-channel models.","volume":"106","author":"V Menon","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1523\/JNEUROSCI.13-12-05301.1993","article-title":"Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology.","volume":"13","author":"HG Kim","year":"1993","journal-title":"J Neurosci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1109\/4235.996017","article-title":"A fast and elitist multiobjective genetic algorithm: NSGA-II.","volume":"6","author":"K Deb","year":"2002","journal-title":"Ieee Transactions on Evolutionary Computation"},{"key":"ref63","first-page":"832","article-title":"Indicator-based selection in multiobjective search.","volume":"3242","author":"E Zitzler","year":"2004","journal-title":"Parallel Problem Solving from Nature - Ppsn Viii"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.ejor.2006.08.008","article-title":"SMS-EMOA: Multiobjective selection based on dominated hypervolume.","volume":"181","author":"N Beume","year":"2007","journal-title":"Eur J Oper Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/B:JCNS.0000023869.22017.2e","article-title":"ModelDB: A Database to Support Computational Neuroscience.","volume":"17","author":"ML Hines","year":"2004","journal-title":"J Comput Neurosci"},{"key":"ref66","article-title":"The NEURON book. Cambridge, UK; New York: Cambridge University Press.","volume":"457","author":"NT Carnevale","year":"2006","journal-title":"xix,"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrn1848","article-title":"The blue brain project.","volume":"7","author":"H Markram","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/cne.903060209","article-title":"Dendritic morphology of pyramidal neurones of the visual cortex of the rat: III. Spine distributions.","volume":"306","author":"AU Larkman","year":"1991","journal-title":"J Comp Neurol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/jn.1992.68.4.1438","article-title":"Estimating the electrotonic structure of neurons with compartmental models.","volume":"68","author":"WR Holmes","year":"1992","journal-title":"J Neurophysiol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1523\/JNEUROSCI.4812-05.2006","article-title":"Site of action potential initiation in layer 5 pyramidal neurons.","volume":"26","author":"LM Palmer","year":"2006","journal-title":"J Neurosci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1085\/jgp.114.4.491","article-title":"Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study.","volume":"114","author":"J Magistretti","year":"1999","journal-title":"J Gen Physiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1113\/jphysiol.1982.sp014357","article-title":"M-Currents and Other Potassium Currents in Bullfrog Sympathetic Neurons.","volume":"330","author":"PR Adams","year":"1982","journal-title":"J Physiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1469-7793.2000.00621.x","article-title":"Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients.","volume":"525","author":"A Korngreen","year":"2000","journal-title":"J Physiol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/j.1460-2075.1992.tb05312.x","article-title":"Characterization of a Shaw-Related Potassium Channel Family in Rat-Brain.","volume":"11","author":"J Rettig","year":"1992","journal-title":"Embo Journal"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00961734","article-title":"Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.","volume":"1","author":"A Destexhe","year":"1994","journal-title":"J Comput Neurosci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1523\/JNEUROSCI.13-11-04609.1993","article-title":"Stepwise repolarization from Ca2+ plateaus in neocortical pyramidal cells: evidence for nonhomogeneous distribution of HVA Ca2+ channels in dendrites.","volume":"13","author":"I Reuveni","year":"1993","journal-title":"J Neurosci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1523\/JNEUROSCI.16-18-05567.1996","article-title":"Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons.","volume":"16","author":"RB Avery","year":"1996","journal-title":"J Neurosci"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0028-3908(97)00086-5","article-title":"Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels.","volume":"36","author":"AD Randall","year":"1997","journal-title":"Neuropharmacology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.273.5282.1709","article-title":"Small-conductance, calcium-activated potassium channels from mammalian brain.","volume":"273","author":"M Kohler","year":"1996","journal-title":"Science"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T14:34:06Z","timestamp":1560436446000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002107"}},"subtitle":[],"editor":[{"given":"Lyle J.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,7,28]]},"references-count":79,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002107","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,28]]}}}