{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:43:53Z","timestamp":1781304233782,"version":"3.54.1"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002143","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T04:32:42Z","timestamp":1315542762000},"page":"e1002143","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery"],"prefix":"10.1371","volume":"7","author":[{"given":"Annabelle","family":"Ballesta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Dulong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi","family":"Abbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Okyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Clairambault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1200\/JCO.2006.06.1440","article-title":"Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Cancer Chronotherapy Group.","volume":"24","author":"S Giacchetti","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref2","article-title":"Approche exp\u00e9rimentale de la personnalisation de la chronoth\u00e9rapeutique par irinotecan, PhD thesis, Universit\u00e9 Paris 11","author":"C Ahowesso","year":"2011"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/sj.bjc.6605061","article-title":"Treatment in advanced colorectal cancer: what, when and how?","volume":"100","author":"I Chau","year":"2009","journal-title":"Br J Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0022-3565(24)37141-1","article-title":"Cell cycle-dependent chronotoxicity of irinotecan hydrochloride in mice.","volume":"283","author":"S Ohdo","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/sj.bjc.6600168","article-title":"Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma.","volume":"86","author":"TG Granda","year":"2002","journal-title":"Br J Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ejca.2005.03.012","article-title":"Randomised phase II study of standard versus chronomodulated CPT11 plus chronomodulated 5-fluorouracil and folinic acid in advanced colorectal cancer patients.","volume":"42","author":"C Garufi","year":"2006","journal-title":"Eur J Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1634\/theoncologist.11-10-1072","article-title":"Chronomodulated irinotecan, oxaliplatin, and leucovorin-modulated 5-Fluorouracil as ambulatory salvage therapy in patients with irinotecan- and oxaliplatin-resistant metastatic colorectal cancer.","volume":"11","author":"D Gholam","year":"2006","journal-title":"Oncologist"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.pharmtox.48.113006.094626","article-title":"Circadian timing in cancer treatments.","volume":"50","author":"F Levi","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.pharmtox.47.120505.105208","article-title":"Circadian rhythms: mechanisms and therapeutic implications.","volume":"47","author":"F Levi","year":"2007","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.cub.2004.11.057","article-title":"Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression.","volume":"14","author":"DK Welsh","year":"2004","journal-title":"Curr Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncb1232","article-title":"Imaging of single light-responsive clock cells reveals fluctuating free-running periods.","volume":"7","author":"AJ Carr","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0092-8674(00)81199-X","article-title":"A serum shock induces circadian gene expression in mammalian tissue culture cells.","volume":"93","author":"A Balsalobre","year":"1998","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1371\/journal.pcbi.0020136","article-title":"Quantitative analyses of circadian gene expression in mammalian cell cultures.","volume":"2","author":"M Izumo","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S0960-9822(02)01145-4","article-title":"Rhythms of mammalian body temperature can sustain peripheral circadian clocks.","volume":"12","author":"SA Brown","year":"2002","journal-title":"Curr Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1080\/07420520500395011","article-title":"Human intestinal circadian clock: expression of clock genes in colonocytes lining the crypt.","volume":"22","author":"L Pardini","year":"2005","journal-title":"Chronobiol Int"},{"key":"ref16","first-page":"2182","article-title":"Clinical pharmacokinetics and metabolism of irinotecan (CPT11).","volume":"7","author":"RH Mathijssen","year":"2001","journal-title":"Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0163-7258(95)02009-8","article-title":"Molecular, cellular, and clinical aspects of the pharmacology of 20(S)camptothecin and its derivatives.","volume":"68","author":"LP Rivory","year":"1995","journal-title":"Pharmacol Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/00498250110057341","article-title":"Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin.","volume":"31","author":"N Hanioka","year":"2001","journal-title":"Xenobiotica"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1124\/dmd.104.003491","article-title":"Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms.","volume":"33","author":"MN Tallman","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/(SICI)1097-0215(19991112)83:4<491::AID-IJC10>3.0.CO;2-M","article-title":"pH-dependent uptake of irinotecan and its active metabolite, SN38, by intestinal cells.","volume":"83","author":"K Kobayashi","year":"1999","journal-title":"Int J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00280-004-0937-4","article-title":"Uptake of irinotecan metabolite SN38 by the human intestinal cell line Caco-2.","volume":"55","author":"T Itoh","year":"2005","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tiv.2005.06.045","article-title":"Pharmacogenetics of irinotecan metabolism and transport: an update.","volume":"20","author":"NF Smith","year":"2006","journal-title":"Toxicol In Vitro"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1741-7015-2-16","article-title":"Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2).","volume":"2","author":"AK Lalloo","year":"2004","journal-title":"BMC Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc1977","article-title":"Topoisomerase I inhibitors: camptothecins and beyond.","volume":"6","author":"Y Pommier","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/1568011033482378","article-title":"Apoptosis induced by topoisomerase inhibitors.","volume":"3","author":"O Sordet","year":"2003","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"ref26","first-page":"2116","article-title":"Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.","volume":"55","author":"F Goldwasser","year":"1995","journal-title":"Cancer Res"},{"key":"ref27","first-page":"2097","article-title":"Analysis of topoisomerase I\/DNA complexes in patients administered topotecan.","volume":"55","author":"D Subramanian","year":"1995","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bcp.2005.12.034","article-title":"Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones.","volume":"71","author":"Y Kuramoto","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e20393","DOI":"10.1371\/journal.pone.0020393","article-title":"Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum.","volume":"6","author":"A Okyar","year":"2011","journal-title":"Plos One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/07420520500180231","article-title":"Daily rhythms of P-glycoprotein expression in mice.","volume":"22","author":"H Ando","year":"2005","journal-title":"Chronobiol Int"},{"key":"ref31","first-page":"560","article-title":"Modeling in the analysis of solute and water exchange in the microvasculature.","author":"JB Bassingthwaighte","year":"1984"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0003-2697(02)00282-8","article-title":"A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.","volume":"310","author":"LB Tabas","year":"2002","journal-title":"Anal Biochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1128\/JB.187.18.6363-6369.2005","article-title":"Drug-lipid A interactions on the Escherichia coli ABC transporter MsbA.","volume":"187","author":"B Woebking","year":"2005","journal-title":"J Bacteriol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1124\/jpet.106.103606","article-title":"A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor.","volume":"319","author":"XX Yang","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0006-2952(96)00457-1","article-title":"Conversion of irinotecan (CPT11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase.","volume":"52","author":"LP Rivory","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2125.2005.02477.x","article-title":"The in vitro metabolism of irinotecan (CPT11) by carboxylesterase and beta-glucuronidase in human colorectal tumours.","volume":"62","author":"P Tobin","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/mol.62.3.608","article-title":"Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).","volume":"62","author":"JF Gagn\u00e9","year":"2002","journal-title":"Mol Pharmacol"},{"key":"ref38","first-page":"75","article-title":"The CMA evolution strategy: a comparing review. Towards a new evolutionary computation. Advances on estimation of distribution algorithms.","author":"N Hansen","year":"2006"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1098\/rsta.2008.0114","article-title":"Implications of circadian clocks for the rhythmic delivery of cancer therapeutics.","volume":"366","author":"F Levi","year":"2008","journal-title":"Philos Transact A Math Phys Eng Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1051\/m2an:2005052","article-title":"Optimisation of time-scheduled regimen for anti-cancer drug infusion.","volume":"39","author":"C Basdevant","year":"2005","journal-title":"ESAIM:M2AN"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/1087057105284576","article-title":"A high-throughput cell-based assay for inhibitors of ABCG2 activity.","volume":"11","author":"CJ Henrich","year":"2006","journal-title":"J Biomol Screen"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ejps.2008.08.004","article-title":"Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.","volume":"35","author":"R Hayeshi","year":"2008","journal-title":"Eur J Pharm Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.clpt.2005.11.001","article-title":"The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates.","volume":"79","author":"GL Lemma","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.febslet.2011.02.038","article-title":"Kinases and phosphatases in the mammalian circadian clock. FEBS Lett.","volume":"585","author":"S Reischl","year":"2011","journal-title":"FEBS Lett"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0959-8049(02)00598-1","article-title":"Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression.","volume":"39","author":"B Porsin","year":"2003","journal-title":"Eur J Cancer"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0079-6603(06)81005-6","article-title":"Repair of topoisomerase I-mediated DNA damage.","volume":"81","author":"Y Pommier","year":"2006","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.febslet.2010.03.017","article-title":"Circadian clock control of the cellular response to DNA damage.","volume":"584","author":"A Sancar","year":"2010","journal-title":"FEBS Lett"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1081\/CBI-120002595","article-title":"Rhythms in human gastrointestinal mucosa and skin.","volume":"19","author":"GA Bjarnason","year":"2002","journal-title":"Chronobiol Int"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1096\/fj.04-2665fje","article-title":"Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor.","volume":"19","author":"TG Granda","year":"2005","journal-title":"FASEB J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/978-3-642-03845-7_10","article-title":"On coupling models using model-checking: effects of irinotecan injections on the mammalian cell cycle.","volume":"5688","author":"E De Maria","year":"2009","journal-title":"Lecture Notes in Computer Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/sj.bjc.6690364","article-title":"CPT11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues.","volume":"80","author":"S Guichard","year":"1999","journal-title":"Br J Cancer"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1124\/dmd.107.019448","article-title":"Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta.","volume":"36","author":"K May","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nprot.2006.83","article-title":"The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on.","volume":"1","author":"P Chomczynski","year":"2006","journal-title":"Nat Protoc"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1248\/cpb.42.2135","article-title":"Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT11 and SN38, in aqueous solution.","volume":"42","author":"K Akimoto","year":"1994","journal-title":"Chem Pharm Bull"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-4347(94)00340-8","article-title":"Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT11, and its metabolite SN38 in plasma.","volume":"661","author":"LP Rivory","year":"1994","journal-title":"J Chromatogr B Biomed Appl"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00280-001-0416-0","article-title":"Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines.","volume":"49","author":"V Pavillard","year":"2002","journal-title":"Cancer Chemother Pharmacol"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:31:23Z","timestamp":1741591883000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002143"}},"subtitle":[],"editor":[{"given":"Thomas","family":"Lengauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,9,8]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002143","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,8]]}}}