{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:40:55Z","timestamp":1775281255152,"version":"3.50.1"},"reference-count":103,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T00:00:00Z","timestamp":1317859200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002208","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T21:50:43Z","timestamp":1317937843000},"page":"e1002208","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":86,"title":["Evolution of Networks for Body Plan Patterning; Interplay of Modularity, Robustness and Evolvability"],"prefix":"10.1371","volume":"7","author":[{"given":"Kirsten H.","family":"ten Tusscher","sequence":"first","affiliation":[]},{"given":"Paulien","family":"Hogeweg","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,10,6]]},"reference":[{"key":"ref1","article-title":"The Evolution of Developmental Pathways.","author":"A Wilkins","year":"2002"},{"key":"ref2","article-title":"The Regulatory Genome.","author":"E Davidson","year":"2006"},{"key":"ref3","article-title":"Principles of Development.","author":"L Wolpert","year":"2007"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0959-437X(00)00130-1","article-title":"Evolution of transcriptional regulation.","volume":"10","author":"D Tautz","year":"2000","journal-title":"Curr Opin Genet Dev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature01763","article-title":"Transcription regulation and animal diversity.","volume":"424","author":"M Levine","year":"2003","journal-title":"Nature"},{"key":"ref6","first-page":"675","article-title":"Transcriptional regulation and the evolution of development.","volume":"47","author":"G Wray","year":"2003","journal-title":"Int J Dev Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrg2063","article-title":"The evolutionary significance of cis-regulatory mutations.","volume":"8","author":"G Wray","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1558-5646.2007.00105.x","article-title":"The locus of evolution: Evo devo and the genetics of adaptation.","volume":"61","author":"H Hoekstra","year":"2007","journal-title":"Evolution"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/bies.20544","article-title":"The relationship between non-protein-coding dna and eukaryotic complexity.","volume":"29","author":"R Taft","year":"2007","journal-title":"Bioessays"},{"key":"ref10","first-page":"125","article-title":"Gene duplications and the origins of vertebrate development.","volume":"1994","author":"P Holland","year":"1994","journal-title":"Dev Suppl"},{"key":"ref11","first-page":"39","article-title":"The evolution of signalling pathways in animal development.","volume":"4","author":"A Pires-daSilva","year":"2002","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/bfgp\/elp056","article-title":"Lineage-specific trasncription factors and the evolution of gene regulatory networks.","volume":"9","author":"K Nowick","year":"2010","journal-title":"Brief Funct Genomics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/(SICI)1097-010X(19991215)285:4<307::AID-JEZ2>3.0.CO;2-V","article-title":"Modularity in animal development and evolution: elements of a conceptual framework for evodevo.","volume":"285","author":"GV Dassow","year":"1999","journal-title":"J Exp Zool"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1525-142x.2000.00069.x","article-title":"Dissociability, modularity, evolvability.","volume":"2","author":"E Raff","year":"2000","journal-title":"Evol Dev"},{"key":"ref15","article-title":"Modularity in Development and Evolution.","author":"G Schlosser","year":"2004"},{"issue":"Suppl 1","key":"ref16","doi-asserted-by":"crossref","first-page":"8582","DOI":"10.1073\/pnas.0701035104","article-title":"The theory of facilitated variation.","volume":"104","author":"J Gerhart","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/jtbi.2001.2335","article-title":"A logical analysis of the drosophila gap-gene system.","volume":"211","author":"L Sanchez","year":"2001","journal-title":"J Theor Biol"},{"key":"ref18","first-page":"517","article-title":"Segmenting the fly embryo: a logical analysis of the pair-rule crossregulatory module.","volume":"224","author":"L Sanchez","year":"2003","journal-title":"J Theor Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1387\/ijdb.072439ls","article-title":"Segmenting the fly embryo: logical analysis of the role of the segment polarity cross-regulatory module.","volume":"52","author":"L Sanchez","year":"2008","journal-title":"Int J Dev Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/msb4100111","article-title":"Robustness and modular design of the drosophila segment polarity network.","volume":"2","author":"W Ma","year":"2006","journal-title":"Mol Syst Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/bioinformatics\/15.7.593","article-title":"Genetic control of flower morphogenesis in arabidopsis thaliana: a logical analysis.","volume":"15","author":"L Mendoza","year":"1999","journal-title":"Bioinformatics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.semcdb.2009.11.010","article-title":"From ABC genes to regulatory networks, epigenetic landscapes and flower morphogenesis: Making biological sense of theoretical approaches.","volume":"21","author":"E Alvarez-Buylla","year":"2010","journal-title":"Semin Cell Dev Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s12038-009-0075-6","article-title":"Looking at the origin of phenotypic variation from pattern formation gene networks.","volume":"34","author":"I Salazar-Ciudad","year":"2009","journal-title":"J Biosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1000206","DOI":"10.1371\/journal.pcbi.1000206","article-title":"Facilitated variation: how evolution learns from past environments to generalize to new environments.","volume":"4","author":"M Parter","year":"2008","journal-title":"Plos Comp Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1000355","DOI":"10.1371\/journal.pcbi.1000355","article-title":"An analytically solvable model for rapid evolution of modular structure.","volume":"5","author":"N Kashtan","year":"2009","journal-title":"Plos Comp Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1111\/j.1558-5646.2009.00684.x","article-title":"Extinctions in heterogeneous environments and the evolution of modularity.","volume":"63","author":"N Kashtan","year":"2009","journal-title":"Evolution"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1000719","DOI":"10.1371\/journal.pcbi.1000719","article-title":"Specialization can drive the evolution of modularity.","volume":"6","author":"C Espinosa-Soto","year":"2010","journal-title":"Plos Comp Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1126\/science.1089370","article-title":"The origins of genome complexity.","volume":"302","author":"M Lynch","year":"2003","journal-title":"Science"},{"key":"ref29","article-title":"The Origins of Genome Architecture.","author":"M Lynch","year":"2007"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/molbev\/msl060","article-title":"Feed-forward loop circuits as a side effect of genome evolution.","volume":"23","author":"O Cordero","year":"2006","journal-title":"Mol Biol Evol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrg2267","article-title":"The road to modularity.","volume":"8","author":"G Wagner","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pcbi.0030107","article-title":"In search of the biological significance of modular structures in protein networks.","volume":"3","author":"Z Wang","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref33","first-page":"036104","article-title":"Modularity and community structure in networks.","volume":"74","author":"M Newman","year":"2006","journal-title":"Phys Rev E"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1073\/pnas.0601602103","article-title":"Finding community structure in networks using the eigenvectors of matrices.","volume":"103","author":"M Newman","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7155\/jgaa.00124","article-title":"Computing communities in large networks using random walks.","volume":"10","author":"P Pons","year":"2006","journal-title":"J Graph Algorithms Appl"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/1471-2105-8-413","article-title":"Identifying dynamical modules from genetic regulatory systems: applications to the segment polarity network.","volume":"25","author":"D Irons","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/cr.2008.16","article-title":"Understanding biological functions through molecular networks.","volume":"18","author":"J Han","year":"2008","journal-title":"Cell Res"},{"key":"ref38","first-page":"pe44","article-title":"Understanding modularity in molecular networks requires dynamics.","volume":"28","author":"R Alexander","year":"2009","journal-title":"Sci Signal"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1039\/b904960f","article-title":"On the basic computational structure of gene regulatory networks.","volume":"5","author":"C Rodriguez-Caso","year":"2009","journal-title":"Mol Biosyst"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3233\/IDA-2010-0415","article-title":"From digital genetics to knowledge discovery: Perspectives in genetic network understanding.","volume":"14","author":"G Beslon","year":"2010","journal-title":"Intelligent Data Analysis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/msb4100192","article-title":"Deriving structure from evolution: metazoan segmentation.","volume":"3","author":"P Francois","year":"2007","journal-title":"Mol Syst Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e2772","DOI":"10.1371\/journal.pone.0002772","article-title":"Network evolution of body plans.","volume":"3","author":"K Fujimoto","year":"2008","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1242\/dev.048033","article-title":"Predicting embryonic patterning using mutual entropy fitness and in silico evolution.","volume":"137","author":"P Francois","year":"2007","journal-title":"Development"},{"key":"ref44","first-page":"21000112","article-title":"Evolution of evolvability in gene regulatory networks.","volume":"11","author":"A Crombach","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2148-9-159","article-title":"The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation.","volume":"9","author":"K Ten Tusscher","year":"2009","journal-title":"BMC Evol Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e434","DOI":"10.1371\/journal.pone.0000434","article-title":"Evolution of robustness to noise and mutation in gene expression dynamics.","volume":"2","author":"K Kaneko","year":"2007","journal-title":"Plos One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1093\/molbev\/msm033","article-title":"Chromosome rearrangements and the evolution of genome structuring and adaptability.","volume":"24","author":"A Crombach","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1558-5646.2007.00303.x","article-title":"Evolution of evolvability in a developmental model.","volume":"62","author":"J Draghi","year":"2008","journal-title":"Evolution"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1420-9101.2008.01663.x","article-title":"The evolutionary dynamics of evolvability in a gene network model.","volume":"22","author":"J Draghi","year":"2009","journal-title":"J Evol Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.febslet.2005.01.063","article-title":"Robustness, evolvability, and neutrality.","volume":"579","author":"A Wagner","year":"2005","journal-title":"FEBS Lett"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1098\/rspb.2007.1137","article-title":"Robustness and evolvability: a paradox resolved.","volume":"275","author":"A Wagner","year":"2008","journal-title":"Proc Biol Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/978-3-642-81703-8_24","article-title":"On the relation between the logical structure of systems and their ability to generate multiple steady states or sustained oscillations.","volume":"9","author":"R Thomas","year":"1981","journal-title":"Springer series in Synergetics"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1063\/1.1350439","article-title":"Multistationarity, the basis of cell differentiation and memory. i. structural conditions of multistationarity and other nontrivial behavior.","volume":"11","author":"R Thomas","year":"2001","journal-title":"Chaos"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1063\/1.1349893","article-title":"Multistationarity, the basis of cell differentiation and memory. ii. logical analysis of regulatory networks in terms of feedback circuits.","volume":"11","author":"R Thomas","year":"2001","journal-title":"Chaos"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nature04863","article-title":"Minimal protohox cluster inferred from bilaterian and cnidarian hox complements.","volume":"442","author":"D Chourrout","year":"2006","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1371\/journal.pone.0000153","article-title":"Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.","volume":"2","author":"J Ryan","year":"2007","journal-title":"Plos One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0070-2153(09)88002-2","article-title":"Evolution of the hox gene complex from an evolutionary ground state.","volume":"88","author":"WJ Gehring","year":"2009","journal-title":"Curr Top Dev Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1387\/ijdb.072425jc","article-title":"Segmentation, metamerism and the cambrian explosion.","volume":"53","author":"J Couso","year":"2009","journal-title":"Int J Dev Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"M68","DOI":"10.1016\/S0962-8924(99)01663-3","article-title":"The origin and evolution of segmentation.","volume":"9","author":"GK Davis","year":"1999","journal-title":"Trends Cell Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"R708","DOI":"10.1016\/j.cub.2003.08.045","article-title":"Evolution of segmentation: rolling back the clock.","volume":"13","author":"A Peel","year":"2003","journal-title":"Curr Biol"},{"key":"ref61","first-page":"583","article-title":"Segmentation: mono- or polyphyletic?","volume":"47","author":"EC Seaver","year":"2003","journal-title":"Int J Dev Biol"},{"key":"ref62","first-page":"160","article-title":"The ancestry of segmentation.","volume":"319","author":"N Patel","year":"2003","journal-title":"Dev Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.devcel.2004.08.008","article-title":"Segmentation.","volume":"7","author":"D Tautz","year":"2004","journal-title":"Dev Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00427-008-0264-6","article-title":"And Lophotrochozoa makes three: Notch\/Hes signaling in annelid segmentation.","volume":"219","author":"AS Rivera","year":"2009","journal-title":"Dev Genes Evol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1162\/106454600568339","article-title":"Shapes in the shadow: evolutionary dynamics of morphogenesis.","volume":"6","author":"P Hogeweg","year":"2000","journal-title":"Artif Life"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/jtbi.2000.1087","article-title":"Evolving mechanisms of morphogenesis: on the interplay between differential adhesion and cell differentiation.","volume":"203","author":"P Hogeweg","year":"2000","journal-title":"J Theor Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtbi.2004.03.021","article-title":"Simulation study on effects of signaling network structure on the developmental increase in complexity.","volume":"231","author":"S Keraenen","year":"2004","journal-title":"J Theor Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"041905","DOI":"10.1103\/PhysRevE.81.041905","article-title":"Optimizing information flow in small genetic networks. ii: Feed-forward interactions.","volume":"81","author":"AM Walczak","year":"2010","journal-title":"Phys Rev E"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/jtbi.2000.2092","article-title":"Gene networks capable of pattern formation: from induction to reaction-diffusion.","volume":"205","author":"I Salazar-Ciudad","year":"2000","journal-title":"J Theor Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1162\/106454698568459","article-title":"Emergence of multicellular organisms with dynamic differentiation and spatial pattern.","volume":"4","author":"C Furusawa","year":"1998","journal-title":"Artif Life"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0022-5193(76)80131-2","article-title":"A clock and wavefront model for control of the number of repeated structures during animal morphogenesis.","volume":"58","author":"J Cooke","year":"1976","journal-title":"J Theor Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1006\/jtbi.2000.2085","article-title":"A clock and trail model for somite formation, specialization and polarization.","volume":"205","author":"M Kerszberg","year":"2000","journal-title":"J Theor Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"R632","DOI":"10.1016\/S0960-9822(03)00567-0","article-title":"Segmentation clock: insights from computational models.","volume":"13","author":"O Pourquie","year":"2003","journal-title":"Curr Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ydbio.2006.01.018","article-title":"A clock and wavefront mechanism for somite formation.","volume":"293","author":"R Baker","year":"2006","journal-title":"Dev Biol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtbi.2007.05.003","article-title":"The segmentation clock in mice: interaction between the Wnt and Notch signalling pathways.","volume":"248","author":"J Rodriguez-Gonzalez","year":"2007","journal-title":"J Theor Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jtbi.2008.01.006","article-title":"Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways.","volume":"252","author":"A Goldbeter","year":"2008","journal-title":"J Theor Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)80451-1","article-title":"Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis.","volume":"91","author":"I Palmeirim","year":"1997","journal-title":"Cell"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0070-2153(08)60722-X","article-title":"Segmentation of the paraxial mesoderm and vertebrate somitogenesis.","volume":"47","author":"O Pourquie","year":"2000","journal-title":"Curr Top Dev Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/(SICI)1521-1878(200001)22:1<72::AID-BIES12>3.0.CO;2-S","article-title":"A clock-work somite.","volume":"22","author":"KJ Dale","year":"2000","journal-title":"Bioessays"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1101\/gad.1217404","article-title":"Segmentation in vertebrates: clock and gradient finally joined.","volume":"18","author":"A Aulehla","year":"2004","journal-title":"Genes Dev"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1242\/dev.009167","article-title":"FGF signaling acts upstream of the Notch and Wnt signaling pathways to control segmentation clock oscillations in mouse somitogenesis.","volume":"134","author":"MB Wahl","year":"2007","journal-title":"Development"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature01682","article-title":"Involvement of Notch and Delta genes in spider segmentation.","volume":"423","author":"A Stollewerk","year":"2003","journal-title":"Nature"},{"key":"ref83","first-page":"2","article-title":"The segmentation cascade in the centipede Strigamia maritima: involvement of the Notch pathway and pair-rule gene homologues.","volume":"5","author":"A Chipman","year":"2008","journal-title":"Dev Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"16614","DOI":"10.1073\/pnas.0804093105","article-title":"Ancestral Notch-mediated segmentation revealed in the cockroach Periplaneta americana.","volume":"105","author":"JI Pueyo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref85","first-page":"597","article-title":"Vertebrate somitogenesis: a novel paradigm for animal segmentation?","volume":"47","author":"O Pourquie","year":"2003","journal-title":"Int J Dev Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1242\/jcs.1992.Supplement_16.6","article-title":"Transcriptional control by drosophila gap genes.","volume":"16","author":"H Jackle","year":"1992","journal-title":"J Cell Sci Suppl"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1242\/dev.120.10.2945","article-title":"Positioning adjacent pair-rule stripes in the posterior drosophila embryo.","volume":"120","author":"J Langeland","year":"1994","journal-title":"Development"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0925-4773(94)00310-J","article-title":"Mechanism of eve stripe formation.","volume":"49","author":"J Reinitz","year":"1995","journal-title":"Mech Dev"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0092-8674(00)80749-7","article-title":"Breaking colinearity in the mouse HoxD complex.","volume":"97","author":"T Kondo","year":"1999","journal-title":"Cell"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1101\/gad.14.2.198","article-title":"Mechanisms of hox gene colinearity: transposition of the anterior hoxb1 gene into the posterior hoxd complex.","volume":"14","author":"M Kmita","year":"2000","journal-title":"Genes Dev"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1101\/gad.292104","article-title":"Chromatin decondensation and nuclear reorganization of the hoxb locus upon induction of transcription.","volume":"18","author":"S Chambeyron","year":"2004","journal-title":"Genes Dev"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1242\/dev.02779","article-title":"Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to hox gene activation.","volume":"134","author":"C Morey","year":"2007","journal-title":"Development"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"e1000398","DOI":"10.1371\/journal.pgen.1000398","article-title":"Uncoupling time and space in the collinear regulation of Hox genes.","volume":"5","author":"P Tschopp","year":"2009","journal-title":"PLoS Genet"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0070-2153(09)88007-1","article-title":"Establishment of Hox vertebral identities in the embryonic spine precursors.","volume":"88","author":"T Iimura","year":"2009","journal-title":"Curr Top Dev Biol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/SQB.1997.062.01.038","article-title":"Cross-regulatory interactions between Hox genes and the control of segmental expression in the vertebrate central nervous system.","volume":"62","author":"S Nonchev","year":"1997","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref96","first-page":"635","article-title":"Initiation, establishment and maintenance of Hox gene expression patterns in the mouse.","volume":"43","author":"J Deschamps","year":"1999","journal-title":"Int J Dev Biol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0092-8674(01)00437-8","article-title":"FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation.","volume":"106","author":"J Dubrulle","year":"2001","journal-title":"Cell"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0092-8674(01)00436-6","article-title":"Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock.","volume":"106","author":"J Zakany","year":"2001","journal-title":"Cell"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1242\/dev.01519","article-title":"Coupling segmentation to axis formation.","volume":"131","author":"J Dubrulle","year":"2004","journal-title":"Development"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1242\/dev.01030","article-title":"Specification of vertebral identity is coupled to Notch signalling and the segmentation clock.","volume":"131","author":"R Cordes","year":"2004","journal-title":"Development"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/bies.20080","article-title":"Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis.","volume":"26","author":"RD del Corral","year":"2004","journal-title":"Bioessays"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.mod.2006.03.001","article-title":"Interaction between X-Delta-2 and Hox genes regulates segmentation and patterning of the anteroposterior axis.","volume":"123","author":"J Peres","year":"2006","journal-title":"Mech Dev"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"a000869","DOI":"10.1101\/cshperspect.a000869","article-title":"Signalling gradients during paraxial mesoderm development.","volume":"2","author":"A Aulehla","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T08:54:39Z","timestamp":1639040079000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002208"}},"subtitle":[],"editor":[{"given":"Erik","family":"van Nimwegen","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,10,6]]},"references-count":103,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2011,10,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002208","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,6]]}}}