{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:52:50Z","timestamp":1761929570217},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002218","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T21:45:01Z","timestamp":1321566301000},"page":"e1002218","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Robust Signal Processing in Living Cells"],"prefix":"10.1371","volume":"7","author":[{"given":"Ralf","family":"Steuer","sequence":"first","affiliation":[]},{"given":"Steffen","family":"Waldherr","sequence":"additional","affiliation":[]},{"given":"Victor","family":"Sourjik","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Kollmann","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.mib.2004.02.002","article-title":"Robust control in bacterial regulatory circuits.","volume":"7","author":"M Goulian","year":"2004","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cell.2004.09.008","article-title":"Robustness of cellular functions.","volume":"118","author":"J Stelling","year":"2004","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.1113834","article-title":"Interlinked fast and slow positive feedback loops drive reliable cell decisions.","volume":"310","author":"O Brandman","year":"2005","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/msb4100179","article-title":"Towards a theory of biological robustness.","volume":"3","author":"H Kitano","year":"2007","journal-title":"Mol Syst Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1183372","article-title":"Structural sources of robustness in biochemical reaction networks.","volume":"327","author":"G Shinar","year":"2010","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1126\/science.1190544","article-title":"A general mechanism for network-dosage compensation in gene circuits.","volume":"329","author":"M Acar","year":"2010","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1156951","article-title":"Robust, tunable biological oscillations from interlinked positive and negative feedback loops.","volume":"321","author":"TYC Tsai","year":"2008","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4613-1161-4","article-title":"The regulation of cellular systems","author":"R Heinrich","year":"1996"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1073\/pnas.97.9.4649","article-title":"Robust perfect adaptation in bacterial chemotaxis through integral feedback control.","volume":"97","author":"TM Yi","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2009.04.047","article-title":"A systems-level analysis of perfect adaptation in yeast osmoregulation.","volume":"138","author":"D Muzzey","year":"2009","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1073\/pnas.0234782100","article-title":"Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system.","volume":"100","author":"E Batchelor","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"19931","DOI":"10.1073\/pnas.0706792104","article-title":"Input output robustness in simple bacterial signaling systems.","volume":"104","author":"G Shinar","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bpj.2009.06.030","article-title":"The control of the controller: molecular mechanisms for robust perfect adaptation and temperature compensation.","volume":"97","author":"XY Ni","year":"2009","journal-title":"Biophys J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature04228","article-title":"Design principles of a bacterial signalling network.","volume":"438","author":"M Kollmann","year":"2005","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1365-2958.2008.06227.x","article-title":"Stochastic assembly of chemoreceptor clusters in <italic>Escherichia coli<\/italic>.","volume":"68","author":"S Thiem","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1000137","DOI":"10.1371\/journal.pbio.1000137","article-title":"Self-organization of the <italic>Escherichia coli<\/italic> chemotaxis network imaged with super-resolution light microscopy.","volume":"7","author":"D Greenfield","year":"2009","journal-title":"PLoS Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jbiotec.2007.01.024","article-title":"Co-expression of signaling proteins improves robustness of the bacterial chemotaxis pathway.","volume":"129","author":"L L\u00f8vdok","year":"2007","journal-title":"J Biotechnol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1000171","DOI":"10.1371\/journal.pbio.1000171","article-title":"Role of translational coupling in robustness of bacterial chemotaxis pathway.","volume":"7","author":"L L\u00f8vdok","year":"2009","journal-title":"PLoS Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1073\/pnas.011589998","article-title":"Receptor sensitivity in bacterial chemotaxis.","volume":"99","author":"V Sourjik","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/msb4100084","article-title":"A quantitative study of the benefits of co-regulation using the spoIIA operon as an example.","volume":"2","author":"D Iber","year":"2006","journal-title":"Mol Syst Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1128\/JB.00426-11","article-title":"Identification of an anchor residue for CheA-CheY interactions in the chemotaxis system of <italic>Escherichia coli<\/italic>.","volume":"193","author":"H Thakor","year":"2011","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000297","DOI":"10.1371\/journal.pcbi.1000297","article-title":"Robustness in glyoxylate bypass regulation.","volume":"5","author":"G Shinar","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.cell.2008.04.040","article-title":"Rewiring the specificity of two-component signal transduction systems.","volume":"133","author":"JM Skerker","year":"2008","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1160311","article-title":"Higher-order cellular information processing with synthetic RNA devices.","volume":"322","author":"MN Win","year":"2008","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nature07513","article-title":"Negative feedback that improves information transmission in yeast signalling.","volume":"456","author":"RC Yu","year":"2008","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/(SICI)1097-0290(19980720)59:2<239::AID-BIT11>3.0.CO;2-9","article-title":"Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes.","volume":"59","author":"BN Kholodenko","year":"1998","journal-title":"Biotechnol Bioeng"},{"key":"ref27","first-page":"105","article-title":"Computational Models of Metabolism: Stability and Regulation in Metabolic Networks.","author":"R Steuer","year":"2008"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/msb.2010.37","article-title":"A modular gradient-sensing network for chemotaxis in <italic>Escherichia coli<\/italic> revealed by responses to time-varying stimuli.","volume":"6","author":"TS Shimizu","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1073\/pnas.0507438103","article-title":"Chemosensing in <italic>Escherichia coli<\/italic> : two regimes of two-state receptors.","volume":"103","author":"JE Keymer","year":"2006","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T18:56:04Z","timestamp":1539975364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002218"}},"subtitle":[],"editor":[{"given":"Christopher V.","family":"Rao","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,11,17]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002218","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,17]]}}}