{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:31:37Z","timestamp":1776587497870,"version":"3.51.2"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T00:00:00Z","timestamp":1319068800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002240","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T17:12:36Z","timestamp":1319130756000},"page":"e1002240","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":532,"title":["Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome"],"prefix":"10.1371","volume":"7","author":[{"given":"David","family":"Venet","sequence":"first","affiliation":[]},{"given":"Jacques E.","family":"Dumont","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Detours","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMra0801289","article-title":"Gene-expression signatures in breast cancer.","volume":"360","author":"C Sotiriou","year":"2009","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMoa021967","article-title":"A gene-expression signature as a predictor of survival in breast cancer.","volume":"347","author":"MJ van de Vijver","year":"2002","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1056\/NEJMoa041588","article-title":"A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.","volume":"351","author":"S Paik","year":"2004","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"R953","DOI":"10.1186\/bcr1325","article-title":"Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts.","volume":"7","author":"Y Pawitan","year":"2005","journal-title":"Breast Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2407-7-61","article-title":"Identification of a robust gene signature that predicts breast cancer outcome in independent data sets.","volume":"7","author":"JE Korkola","year":"2007","journal-title":"BMC Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1158\/0008-5472.CAN-04-3953","article-title":"A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients.","volume":"65","author":"H Dai","year":"2005","journal-title":"Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/bcr2124","article-title":"Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures.","volume":"10","author":"P Wirapati","year":"2008","journal-title":"Breast Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1158\/1078-0432.CCR-07-4756","article-title":"Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes.","volume":"14","author":"C Desmedt","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/bioinformatics\/btn374","article-title":"A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?","volume":"24","author":"B Haibe-Kains","year":"2008","journal-title":"Bioinformatics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1073\/pnas.0931261100","article-title":"Gene expression profiles of human breast cancer progression.","volume":"100","author":"X-J Ma","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"10292","DOI":"10.1158\/0008-5472.CAN-05-4414","article-title":"Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.","volume":"66","author":"AV Ivshina","year":"2006","journal-title":"Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/jnci\/djj052","article-title":"Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.","volume":"98","author":"C Sotiriou","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1172\/JCI23412","article-title":"Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.","volume":"115","author":"GV Glinsky","year":"2005","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ng.127","article-title":"An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors.","volume":"40","author":"I Ben-Porath","year":"2008","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.stem.2008.02.009","article-title":"Module map of stem cell genes guides creation of epithelial cancer stem cells.","volume":"2","author":"DJ Wong","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/ng1861","article-title":"A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.","volume":"38","author":"SL Carter","year":"2006","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1371\/journal.pbio.0020007","article-title":"Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.","volume":"2","author":"HY Chang","year":"2004","journal-title":"PLoS Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1073\/pnas.0409462102","article-title":"Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.","volume":"102","author":"HY Chang","year":"2005","journal-title":"Proc Natl Acad Sc U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1371\/journal.pmed.0030047","article-title":"Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.","volume":"3","author":"J-T Chi","year":"2006","journal-title":"PLoS Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/sj.bjc.6605450","article-title":"Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene.","volume":"102","author":"FM Buffa","year":"2010","journal-title":"Br J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1371\/journal.pbio.0030187","article-title":"Determination of stromal signatures in breast carcinoma.","volume":"3","author":"RB West","year":"2005","journal-title":"PLoS Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1073\/pnas.1004900107","article-title":"Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes.","volume":"107","author":"JH Taube","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1073\/pnas.0702095104","article-title":"The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.","volume":"104","author":"AL Welm","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1186\/gb-2007-8-9-r191","article-title":"Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer.","volume":"8","author":"M Buess","year":"2007","journal-title":"Genome Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"13550","DOI":"10.1073\/pnas.0506230102","article-title":"An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.","volume":"102","author":"LD Miller","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1128\/MCB.00787-08","article-title":"Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase\/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.","volume":"28","author":"SE Wang","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7564","DOI":"10.1073\/pnas.0702507104","article-title":"Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.","volume":"104","author":"LH Saal","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2007.11.031","article-title":"An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.","volume":"13","author":"TC Hallstrom","year":"2008","journal-title":"Cancer Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1073\/pnas.0710331105","article-title":"Bromodomain 4 activation predicts breast cancer survival.","volume":"105","author":"NPS Crawford","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.cell.2009.03.047","article-title":"A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.","volume":"137","author":"S Valastyan","year":"2009","journal-title":"Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ccr.2009.03.004","article-title":"CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.","volume":"15","author":"X-H Pei","year":"2009","journal-title":"Cancer Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.cell.2009.04.043","article-title":"Genomic antagonism between retinoic acid and estrogen signaling in breast cancer.","volume":"137","author":"S Hua","year":"2009","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/onc.2009.139","article-title":"Anchorage-independent cell growth signature identifies tumors with metastatic potential.","volume":"28","author":"S Mori","year":"2009","journal-title":"Oncogene"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1158\/0008-5472.CAN-07-0382","article-title":"Revealing targeted therapy for human cancer by gene module maps.","volume":"68","author":"DJ Wong","year":"2008","journal-title":"Cancer Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1056\/NEJMoa052933","article-title":"Concordance among gene-expression-based predictors for breast cancer.","volume":"355","author":"C Fan","year":"2006","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/1471-2164-9-394","article-title":"Comparison of prognostic gene expression signatures for breast cancer.","volume":"9","author":"B Haibe-Kains","year":"2008","journal-title":"BMC Genomics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1755-8794-1-11","article-title":"Cell cycle correlated genes dictate the prognostic power of breast cancer gene lists.","volume":"1","author":"JD Mosley","year":"2008","journal-title":"BMC Med Genomics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/bjc.1957.43","article-title":"Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.","volume":"11","author":"HJ Bloom","year":"1957","journal-title":"Br J Cancer"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/1097-0142(19810301)47:5<937::AID-CNCR2820470520>3.0.CO;2-6","article-title":"Kinetic parameters and the course of the disease in breast cancer.","volume":"47","author":"M Tubiana","year":"1981","journal-title":"Cancer"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","article-title":"Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.","volume":"19","author":"CW Elston","year":"1991","journal-title":"Histopathology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients.","volume":"123","author":"B Gy\u00f6rffy","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e17911","DOI":"10.1371\/journal.pone.0017911","article-title":"GOBO: Gene Expression-Based Outcome for Breast Cancer Online.","volume":"6","author":"M Ringn\u00e9r","year":"2011","journal-title":"PLoS ONE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000089228","article-title":"Laughter regulates gene expression in patients with type 2 diabetes.","volume":"75","author":"T Hayashi","year":"2006","journal-title":"Psychother Psychosom"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1371\/journal.pgen.0020119","article-title":"Anatomic demarcation by positional variation in fibroblast gene expression programs.","volume":"2","author":"JL Rinn","year":"2006","journal-title":"PLoS Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.","volume":"131","author":"V Krishnan","year":"2007","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies.","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/bioinformatics\/bth469","article-title":"Outcome signature genes in breast cancer: is there a unique set?","volume":"21","author":"L Ein-Dor","year":"2005","journal-title":"Bioinformatics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1091\/mbc.02-02-0030","article-title":"Identification of genes periodically expressed in the human cell cycle and their expression in tumors.","volume":"13","author":"ML Whitfield","year":"2002","journal-title":"Mol Biol Cell"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"9212","DOI":"10.1073\/pnas.96.16.9212","article-title":"Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.","volume":"96","author":"CM Perou","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours.","volume":"406","author":"CM Perou","year":"2000","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrc1802","article-title":"Common markers of proliferation.","volume":"6","author":"ML Whitfield","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2007.05.003","article-title":"PCNA, the maestro of the replication fork.","volume":"129","author":"G-L Moldovan","year":"2007","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ygeno.2005.04.008","article-title":"Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues.","volume":"86","author":"X Ge","year":"2005","journal-title":"Genomics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2164-7-96","article-title":"The molecular portraits of breast tumors are conserved across microarray platforms.","volume":"7","author":"Z Hu","year":"2006","journal-title":"BMC Genomics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1200\/JCO.2006.07.1522","article-title":"Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade.","volume":"25","author":"S Loi","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors.","volume":"33","author":"S Ramaswamy","year":"2003","journal-title":"Nat Genet"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ccr.2009.04.002","article-title":"Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.","volume":"15","author":"JA Reuter","year":"2009","journal-title":"Cancer Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2008.11.013","article-title":"MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.","volume":"15","author":"G Hu","year":"2009","journal-title":"Cancer Cell"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"10669","DOI":"10.1158\/0008-5472.CAN-07-0539","article-title":"High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates.","volume":"67","author":"G Alexe","year":"2007","journal-title":"Cancer Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1158\/0008-5472.CAN-07-5206","article-title":"The humoral immune system has a key prognostic impact in node-negative breast cancer.","volume":"68","author":"M Schmidt","year":"2008","journal-title":"Cancer Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1186\/bcr2192","article-title":"A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer.","volume":"10","author":"F Reyal","year":"2008","journal-title":"Breast Cancer Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1186\/bcr2138","article-title":"A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer.","volume":"10","author":"AE Teschendorff","year":"2008","journal-title":"Breast Cancer Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1186\/1471-2407-10-604","article-title":"Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules.","volume":"10","author":"AE Teschendorff","year":"2010","journal-title":"BMC Cancer"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/gb-2010-11-2-r18","article-title":"A fuzzy gene expression-based computational approach improves breast cancer prognostication.","volume":"11","author":"B Haibe-Kains","year":"2010","journal-title":"Genome Biol"},{"key":"ref66","article-title":"R: A Language and Environment for Statistical Computing.","volume":"1"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics.","volume":"5","author":"RC Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A model-based background adjustment for oligonucleotide expression arrays.","volume":"99","author":"Z Wu","year":"2004","journal-title":"J Amer Statistical Assoc"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:12:22Z","timestamp":1588975942000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002240"}},"subtitle":[],"editor":[{"given":"Isidore","family":"Rigoutsos","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,10,20]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2011,10,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002240","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13360978.793557096","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13360978.14731077","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13360978.14782210","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13360978.15216056","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13360978.792452850","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,20]]}}}