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Eguchi","year":"2003","journal-title":"Microbiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/jb.174.7.2145-2151.1992","article-title":"The products of the kdpDE operon are required for expression of the Kdp ATPase of <italic>Escherichia coli<\/italic>.","volume":"174","author":"JW Polarek","year":"1992","journal-title":"J Bacteriol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1271\/bbb.60024","article-title":"Characterization of copper-inducible promoters regulated by CpxA\/CpxR in <italic>Escherichia coli<\/italic>.","volume":"70","author":"K Yamamoto","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"26652","DOI":"10.1074\/jbc.M203487200","article-title":"Genome-wide profiling of promoter recognition by the two-component response regulator CpxR-P in <italic>Escherichia coli<\/italic>.","volume":"277","author":"P De 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