{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:23:18Z","timestamp":1761895398977},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002297","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T21:49:47Z","timestamp":1323380987000},"page":"e1002297","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Information Routing Driven by Background Chatter in a Signaling Network"],"prefix":"10.1371","volume":"7","author":[{"given":"N\u00faria","family":"Domedel-Puig","sequence":"first","affiliation":[]},{"given":"Pau","family":"Ru\u00e9","sequence":"additional","affiliation":[]},{"given":"Antonio J.","family":"Pons","sequence":"additional","affiliation":[]},{"given":"Jordi","family":"Garc\u00eda-Ojalvo","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm1838","article-title":"Cell-signalling dynamics in time and space.","volume":"7","author":"BN Kholodenko","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref2","article-title":"The biochemistry of cell signaling","author":"E Helmreich","year":"2001"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e4189","DOI":"10.1371\/journal.pone.0004189","article-title":"G-protein coupled receptor signaling architecture of mammalian immune cells.","volume":"4","author":"N Polouliakh","year":"2009","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2005.0010","DOI":"10.1038\/msb4100014","article-title":"A comprehensive pathway map of epidermal growth factor receptor signaling.","volume":"1","author":"K Oda","year":"2005","journal-title":"Mol Syst Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2006.0015","DOI":"10.1038\/msb4100057","article-title":"A comprehensive map of the toll-like receptor signaling network.","volume":"2","author":"K Oda","year":"2006","journal-title":"Mol Syst Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/msb.2010.73","article-title":"A comprehensive molecular interaction map of the budding yeast cell cycle.","volume":"6","author":"K Kaizu","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration.","volume":"178","author":"PJ Murray","year":"2007","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1101\/gad.1700308","article-title":"Signal integration in bacterial two-component regulatory systems.","volume":"22","author":"AY Mitrophanov","year":"2008","journal-title":"Gene Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1073\/pnas.0810878106","article-title":"Complexity in bacterial cell-cell com- munication: quorum signal integration and subpopulation signaling in the Bacillus subtilis phos- phorelay.","volume":"106","author":"IB Bischofs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1042\/bj3180729","article-title":"Signal-transducing protein phosphorylation cascades mediated by Ras\/Rho proteins in the mammalian cell: the potential for multiplex signalling.","volume":"318","author":"DT Denhardt","year":"1996","journal-title":"Biochem J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ncb1418","article-title":"A global analysis of cross- talk in a mammalian cellular signalling network.","volume":"8","author":"M Natarajan","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng1957","article-title":"Cross-talk and decision making in MAP kinase pathways.","volume":"39","author":"MN McClean","year":"2007","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ng.110","article-title":"Stochastic switching as a survival strategy influctuating environments.","volume":"40","author":"M Acar","year":"2008","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nature07211","article-title":"Metabolic gene regulation in a dynamically changing environment.","volume":"454","author":"MR Bennett","year":"2008","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1073\/pnas.0705088105","article-title":"Emergent decision-making in biological signal transduction networks.","volume":"105","author":"T Helikar","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/bioinformatics\/15.7.593","article-title":"Genetic control of flower morphogenesis in Arabidopsis thaliana: a logical analysis.","volume":"15","author":"L Mendoza","year":"1999","journal-title":"Bioinformatics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature02456","article-title":"Integrating high-throughput and computational data elucidates bacterial networks.","volume":"429","author":"MW Covert","year":"2004","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1093\/bioinformatics\/btl210","article-title":"Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle.","volume":"22","author":"A Faure","year":"2006","journal-title":"Bioinformatics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1672","DOI":"10.1371\/journal.pone.0001672","article-title":"Boolean network model predicts cell cycle sequence of fission yeast.","volume":"3","author":"MI Davidich","year":"2008","journal-title":"PLoS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/excr.2000.5044","article-title":"Shape-dependent control of cell growth, differentiation, and apoptosis: Switching between attractors in cell regulatory networks.","volume":"261","author":"S Huang","year":"2000","journal-title":"Exp Cell Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000912","DOI":"10.1371\/journal.pcbi.1000912","article-title":"Diversity and plasticity of Th cell types predicted from regulatory network modelling.","volume":"6","author":"A Naldi","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5193(03)00035-3","article-title":"The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in drosophila melanogaster.","volume":"223","author":"R Albert","year":"2003","journal-title":"J Theor Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1371\/journal.pcbi.0030163","article-title":"A logical model provides insights into T cell receptor signaling.","volume":"3","author":"J Saez-Rodriguez","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1000438","DOI":"10.1371\/journal.pcbi.1000438","article-title":"The logic of EGFR\/ErbB signaling: theoretical properties and analysis of high-throughput data.","volume":"5","author":"R Samaga","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jtbi.2010.03.025","article-title":"Receptor cross-talk in angiogenesis: Mapping environmental cues to cell phenotype using a stochastic, boolean signaling network model.","volume":"264","author":"AL Bauer","year":"2010","journal-title":"J Theor Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"045110","DOI":"10.1063\/1.3524908","article-title":"Relaxation dynamics and frequency response of a noisy cell signaling network.","volume":"20","author":"P Rue","year":"2010","journal-title":"Chaos"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nrm2530","article-title":"Design principles of biochemical oscillators.","volume":"9","author":"B Nov\u00e1k","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1111\/j.1742-4658.2008.06399.x","article-title":"Collective behavior in gene regulation: the cell is an oscillator, the cell cycle a developmental process.","volume":"275","author":"RR Klevecz","year":"2008","journal-title":"FEBS J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"21407","DOI":"10.1073\/pnas.0906361106","article-title":"A circadian clock in macrophages controls inflammatory immune responses.","volume":"106","author":"M Keller","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1098\/rsif.2008.0132.focus","article-title":"Boolean network models of cellular regulation: prospects and limitations.","volume":"5","author":"S Bornholdt","year":"2008","journal-title":"J R Soc Interface"},{"key":"ref31","first-page":"121","article-title":"A new implementation of Yen&apos;s ranking loopless paths algorithm.","volume":"1","author":"EQV Martins","year":"2003","journal-title":"4OR - Q J Oper Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1374","article-title":"Mathematical and computational models of immune-receptor signalling.","volume":"4","author":"B Goldstein","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tcb.2006.11.007","article-title":"A driving force for change: interstitial flow as a morphoregulator.","volume":"17","author":"JM Rutkowski","year":"2007","journal-title":"Trends Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bit.22826","article-title":"Fibroblast response to interstitial flow: A state-of-the-art review.","volume":"107","author":"L Dan","year":"2010","journal-title":"Biotechnol Bioeng"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.molonc.2010.09.001","article-title":"Cancer secretomics reveal pathophysiological pathways in cancer molecular oncology.","volume":"4","author":"GS Karagiannis","year":"2010","journal-title":"Mol Oncol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"ra22","DOI":"10.1126\/scisignal.2000054","article-title":"Deciphering signaling outcomes from a system of complex networks.","volume":"2","author":"RC Hsueh","year":"2009","journal-title":"Science Signaling"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-065X.2007.00501.x","article-title":"Oscillations in the immune system.","volume":"216","author":"J Stark","year":"2007","journal-title":"Immunol Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1742-2094-2-26","article-title":"Cytokine responses during chronic denervation.","volume":"2","author":"S Ruohonen","year":"2005","journal-title":"J Neuroinflamm"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1073\/pnas.0501122102","article-title":"An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels.","volume":"102","author":"MR Thomas","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1074-7613(00)80483-5","article-title":"Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response.","volume":"4","author":"Y Sykulev","year":"1996","journal-title":"Immunity"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nature01076","article-title":"Direct observation of ligand recognition by T cells.","volume":"419","author":"DJ Irvine","year":"2002","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"12146","DOI":"10.1074\/jbc.M710590200","article-title":"Activation of cyclic AMP signaling in Ae2-deficient mouse fibroblasts.","volume":"283","author":"P Mardones","year":"2008","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0960-9822(00)00699-0","article-title":"Transient deactivation of ERK signalling is sufficient for stable entry into G0 in primary avian fibroblasts.","volume":"10","author":"E Black","year":"2000","journal-title":"Curr Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/373033a0","article-title":"Stochastic resonance and the benefits of noise: from ice ages to crayfish and squids.","volume":"373","author":"K Wiesenfeld","year":"1995","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cell.2008.08.034","article-title":"Cytokine-induced signaling networks prioritize dynamic range over signal strength.","volume":"135","author":"KA Janes","year":"2008","journal-title":"Cell"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T16:44:43Z","timestamp":1686501883000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002297"}},"subtitle":[],"editor":[{"given":"Jason A.","family":"Papin","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,12,8]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002297","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,8]]}}}