{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:06:23Z","timestamp":1772885183096,"version":"3.50.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:00:00Z","timestamp":1323907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002310","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T21:44:13Z","timestamp":1323985453000},"page":"e1002310","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":83,"title":["Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)"],"prefix":"10.1371","volume":"7","author":[{"given":"Zhichao","family":"Liu","sequence":"first","affiliation":[]},{"given":"Qiang","family":"Shi","sequence":"additional","affiliation":[]},{"given":"Don","family":"Ding","sequence":"additional","affiliation":[]},{"given":"Reagan","family":"Kelly","sequence":"additional","affiliation":[]},{"given":"Hong","family":"Fang","sequence":"additional","affiliation":[]},{"given":"Weida","family":"Tong","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.22177","article-title":"Acute liver failure: Summary of a workshop.","volume":"47","author":"WM Lee","year":"2008","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/rtph.2000.1399","article-title":"Concordance of the toxicity of pharmaceuticals in humans and in animals.","volume":"32","author":"H Olson","year":"2000","journal-title":"Regul Toxicol Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd1750","article-title":"Idiosyncratic drug hepatotoxicity.","volume":"4","author":"N Kaplowitz","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1056\/NEJM199510263331702","article-title":"Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.","volume":"333","author":"R McKenzie","year":"1995","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMra052270","article-title":"Drug-related hepatotoxicity.","volume":"354","author":"VJ Navarro","year":"2006","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1586\/egh.10.8","article-title":"Biomarkers for drug-induced liver injury.","volume":"4","author":"Q Shi","year":"2010","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kfn109","article-title":"Cellular imaging predictions of clinical drug-induced liver injury.","volume":"105","author":"JHJ Xu","year":"2008","journal-title":"Toxicol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1124\/dmd.110.037077","article-title":"Development of A Highly Sensitive Cytotoxicity Assay System for CYP3A4-mediated Metabolic Activation.","volume":"39","author":"H Hosomi","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1124\/pr.109.001727","article-title":"Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models.","volume":"61","author":"XM Deng","year":"2009","journal-title":"Pharmacol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.taap.2006.12.013","article-title":"Mitochondrial abnonnalities - A link to idiosyncratic drug hepatotoxicity?","volume":"220","author":"UA Boelsterli","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/toxsci\/kfp216","article-title":"Toxicogenomics Applied to Cultures of Human Hepatocytes Enabled an Identification of Novel Petasites hybridus Extracts for the Treatment of Migraine with Improved Hepatobiliary Safety.","volume":"112","author":"N Anderson","year":"2009","journal-title":"Toxicol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/msb.2009.98","article-title":"A side effect resource to capture phenotypic effects of drugs.","volume":"6","author":"M Kuhn","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.drudis.2011.05.007","article-title":"FDA-approved drug labeling for the study of drug-induced liver injury.","volume":"16","author":"M Chen","year":"2011","journal-title":"Drug Discov Today"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/tx1000865","article-title":"Developing Structure-Activity Relationships for the Prediction of Hepatotoxicity.","volume":"23","author":"N Greene","year":"2010","journal-title":"Chem Res Toxicol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00204-006-0091-3","article-title":"High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.","volume":"80","author":"PJ O'Brien","year":"2006","journal-title":"Arch Toxicol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nbt1338","article-title":"Drug-target network.","volume":"25","author":"MA Yildirim","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/462167a","article-title":"Drug Discovery: Predicting promiscuity.","volume":"462","author":"AL Hopkins","year":"2009","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1021\/tx900326k","article-title":"Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species.","volume":"23","author":"D Fourches","year":"2010","journal-title":"Chem Res Toxicol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1124\/dmd.110.035113","article-title":"A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury.","volume":"38","author":"S Ekins","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrd2925","article-title":"Translational medicine.","volume":"8","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-0029-1240009","article-title":"Genetic Association Studies in Drug-Induced Liver Injury.","volume":"29","author":"AK Daly","year":"2009","journal-title":"Semin Liver Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1155\/2006\/356434","article-title":"Rofecoxib-induced hepatotoxicity: A forgotten complication of the coxibs.","volume":"20","author":"B Yan","year":"2006","journal-title":"Can J Gastroenterol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ng.632","article-title":"A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.","volume":"42","author":"JB Singer","year":"2010","journal-title":"Nat Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrrheum.2010.214","article-title":"Hepatotoxicity related to antirheumatic drugs.","volume":"7","author":"GP Aithal","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2210-8-5","article-title":"A global view of drug-therapy interactions.","volume":"8","author":"JC Nacher","year":"2008","journal-title":"BMC Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ng.379","article-title":"HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.","volume":"41","author":"AK Daly","year":"2009","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1158\/0008-5472.CAN-05-2857","article-title":"Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.","volume":"66","author":"J Thibaudeau","year":"2006","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clpt.2003.10.006","article-title":"A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity.","volume":"75","author":"Y Duguay","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/j.gastro.2006.11.023","article-title":"Genetic susceptibility to diclofenac-induced hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.","volume":"132","author":"AK Daly","year":"2007","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/bdra.20023","article-title":"A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.","volume":"Part A 70","author":"LE Jensen","year":"2004","journal-title":"Birth Defects Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/archderm.134.5.595","article-title":"Consensus workshop on the toxic effects of long-term PUVA therapy.","volume":"134","author":"WL Morison","year":"1998","journal-title":"Arch Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1164\/rccm.2108091","article-title":"Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment.","volume":"166","author":"SK Sharma","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/sj.tpj.6500442","article-title":"Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study.","volume":"8","author":"K Hirata","year":"2008","journal-title":"Pharmacogenomics J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/sj.tpj.6500458","article-title":"Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis.","volume":"8","author":"A Kindmark","year":"2008","journal-title":"Pharmacogenomics J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/gut.47.5.717","article-title":"Co-amoxiclav jaundice: clinical and histological features and HLA class II association.","volume":"47","author":"J O'Donohue","year":"2000","journal-title":"Gut"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/hep.23720","article-title":"Pharmacogenetics of Drug-Induced Liver Injury.","volume":"52","author":"S Russmann","year":"2010","journal-title":"Hepatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.2217\/pgs.09.111","article-title":"Drug-induced liver injury: insights from genetic studies.","volume":"10","author":"RJ Andrade","year":"2009","journal-title":"Pharmacogenomics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrd2423","article-title":"Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.","volume":"6","author":"RA Wilke","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.1204432","article-title":"Advancing Regulatory Science.","volume":"331","author":"MA Hamburg","year":"2011","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"D901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: a knowledgebase for drugs, drug actions and drug targets.","volume":"36","author":"DS Wishart","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration.","volume":"34","author":"DS Wishart","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"D1035","DOI":"10.1093\/nar\/gkq1126","article-title":"DrugBank 3.0: a comprehensive resource for \u2018Omics\u2019 research on drugs.","volume":"39","author":"C Knox","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/cmdc.200700026","article-title":"Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.","volume":"2","author":"A Bender","year":"2007","journal-title":"Chemmedchem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1021\/ci6005504","article-title":"Understanding false positives in reporter gene assays: in silico chemogenomics approaches to prioritize cell-based HTS data.","volume":"47","author":"TJ Crisman","year":"2007","journal-title":"J Chem Inf Model"},{"key":"ref45","first-page":"199","article-title":"Circular fingerprints: Flexible molecular descriptors with applications from physical chemistry to ADME.","volume":"9","author":"RC Glen","year":"2006","journal-title":"Idrugs"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1021\/jm060902w","article-title":"Bridging chemical and biological space: \u201cTarget fishing\u201d using 2D and 3D molecular descriptors.","volume":"49","author":"JH Nettles","year":"2006","journal-title":"J Med Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1021\/ci060003g","article-title":"Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases.","volume":"46","author":"Nidhi","year":"2006","journal-title":"J Chem Inf Model"},{"key":"ref48","article-title":"ATC The Anatomical Therapeutic Chemical (ATC) classification.","year":"2011","journal-title":"WHO Collaborating Centre for Drug Statistics and Methodology"},{"key":"ref49","first-page":"824","article-title":"SCAN: a structrural clustrering algorithm for networks.","author":"XYN Xu","year":"2007"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1471-2105-6-103","article-title":"Using co-occurrence network structure to extract synonymous gene and protein names from MEDLINE abstracts.","volume":"6","author":"AM Cohen","year":"2005","journal-title":"BMC Bioinformatics"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T22:53:20Z","timestamp":1742079200000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002310"}},"subtitle":[],"editor":[{"given":"Greg","family":"Tucker-Kellogg","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,12,15]]},"references-count":50,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002310","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,15]]}}}