{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:34:32Z","timestamp":1761975272444},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002311","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T21:43:17Z","timestamp":1327614197000},"page":"e1002311","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Beyond Statistical Significance: Implications of Network Structure on Neuronal Activity"],"prefix":"10.1371","volume":"8","author":[{"given":"Ioannis","family":"Vlachos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad","family":"Aertsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ana.20368","article-title":"Imaging connectivity in the human cerebral cortex: the next frontier?","volume":"57","author":"M Mesulam","year":"2005","journal-title":"Ann Neurol"},{"key":"ref2","article-title":"Analysis of parallel spike trains","author":"S Gruen","year":"2010"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature03252","article-title":"Excitatory cortical neurons form fine-scale functional networks.","volume":"433","author":"Y Yoshimura","year":"2005","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1371\/journal.pbio.0030068","article-title":"Highly nonrandom features of synaptic connectivity in local cortical circuits.","volume":"3","author":"S Song","year":"2005","journal-title":"PLoS Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1126\/science.1175509","article-title":"Gabaergic hub neurons orchestrate synchrony in developing hippocampal networks.","volume":"326","author":"P Bonifazi","year":"2009","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.neuron.2010.11.029","article-title":"An embedded subnetwork of highly active neurons in the neocortex.","volume":"68","author":"L Yassin","year":"2010","journal-title":"Neuron"},{"key":"ref7","article-title":"Distance and layer-dependent properties of horizontal projections onto layer 5 pyramidal neurons.","author":"P Schnepel","year":"2011"},{"key":"ref8","article-title":"Cortical control of arm movement [PhD thesis]","author":"S Waldert","year":"2011"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-8993(91)90499-L","article-title":"Visually induced signal-locked neuronal activity changes in precentral motor areas of the monkey: hierarchical progression of signal processing.","volume":"540","author":"A Riehle","year":"1991","journal-title":"Brain Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1086\/228311","article-title":"Economic action and social structure: the problem of embeddedness.","volume":"91","author":"M Granovetter","year":"1985","journal-title":"Am J Sociol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1073\/pnas.0912983107","article-title":"Multifractal network generator.","volume":"107","author":"G Palla","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/1073858406293182","article-title":"Small-world brain networks.","volume":"12","author":"DS Bassett","year":"2006","journal-title":"Neuroscientist"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fncom.2011.00005","article-title":"The non-random brain: efficiency, economy, and complex dynamics.","volume":"5","author":"O Sporns","year":"2011","journal-title":"Front Comput Neurosci"},{"key":"ref14","first-page":"167","article-title":"The structure and function of complex networks.","volume":"45","author":"MEJ Newman","year":"2003","journal-title":"SIAM Rev Soc Ind Appl Math"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.physrep.2008.09.002","article-title":"Synchronization in complex networks.","volume":"469","author":"A Arenas","year":"2008","journal-title":"Phys Rep"},{"key":"ref16","first-page":"1","article-title":"Identification of influential spreaders in complex networks.","volume":"5","author":"M Kitsak","year":"2010","journal-title":"Nat Phys"},{"key":"ref17","article-title":"The basis of sensation","author":"ED Adrian","year":"1928"},{"key":"ref18","first-page":"646","article-title":"Topographic organization and modality representation in first somatic area of cat's cerebral cortex by method of single unit analysis.","volume":"183","author":"VB Mountcastle","year":"1955","journal-title":"Am J Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1152\/jn.1957.20.4.408","article-title":"Modality and topographic properties of single neurons of cat's somatic sensory cortex.","volume":"20","author":"VB Mountcastle","year":"1957","journal-title":"J Neurophysiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1113\/jphysiol.1962.sp006837","article-title":"Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.","volume":"160","author":"DH Hubel","year":"1962","journal-title":"J Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1068\/p010371","article-title":"Single units and sensation: a neuron doctrine for perceptual psychology?","volume":"1","author":"HB Barlow","year":"1972","journal-title":"Perceptron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1523\/JNEUROSCI.02-11-01527.1982","article-title":"On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex.","volume":"2","author":"AP Georgopoulos","year":"1982","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nn947","article-title":"Connecting cortex to machines: recent advances in brain interfaces.","volume":"5","author":"JP Donoghue","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.27.070203.144233","article-title":"Cortical neural prosthetics.","volume":"27","author":"AB Schwartz","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/neuro.10.005.2009","article-title":"On the precarious path of reverse neuro-engineering.","volume":"3","author":"S Marom","year":"2009","journal-title":"Front Comput Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1126\/science.273.5283.1868","article-title":"Dynamics of ongoing activity: explanation of the larger variability in evoked cotical responses.","volume":"273","author":"A Arieli","year":"1996","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06447","article-title":"Behavioural report of single neuron stimulation in somatosensory cortex.","volume":"451","author":"AR Houweling","year":"2008","journal-title":"Nature"},{"key":"ref28","first-page":"1","article-title":"Cubic: cumulant based inference of higher-order correlations in massively parallel spike trains.","volume":"1\u20132","author":"B Staude","year":"2009","journal-title":"J Comput Neurosci"},{"key":"ref29","article-title":"Spikes: exploring the neural code","author":"F Rieke","year":"1999"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrn2578","article-title":"Extracting information from neuronal populations: information theory and decoding approaches.","volume":"10","author":"RQ Quiroga","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.1093173","article-title":"Synfire chains and cortical songs: Temporal modules of cortical activity.","volume":"304","author":"Y Ikegaya","year":"2004","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuron.2007.01.017","article-title":"Stochastic emergence of repeating cortical motifs in spontaneous membrane potential uctuations in vivo.","volume":"53","author":"A Mokeichev","year":"2007","journal-title":"Neuron"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511574566","article-title":"Corticonics: Neural Circuits of the Cerebral Cortex","author":"M Abeles","year":"1991"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1126\/science.278.5345.1950","article-title":"Spike synchronization and rate modulation differentially involved in motor cortical function.","volume":"278","author":"A Riehle","year":"1997","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"021905","DOI":"10.1103\/PhysRevE.79.021905","article-title":"Serial correlations in neural spike trains: experimental evidence, stochastic modeling and single neuron variability.","volume":"79","author":"F Farkhooi","year":"2009","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn1888","article-title":"Neural correlations, population coding and computation.","volume":"7","author":"BB Averbeck","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1152\/jn.00697.2004","article-title":"A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects.","volume":"93","author":"W Truccolo","year":"2005","journal-title":"J Neurophysiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5486\/PMD.1959.6.3-4.12","article-title":"On random graphs I.","volume":"6","author":"P Erd\u00f6s","year":"1959","journal-title":"Publicationes Mathematicae"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.286.5439.509","article-title":"Emergence of scaling in random networks.","volume":"286","author":"A Barabasi","year":"1999","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevLett.97.188104","article-title":"Eigenvalue spectra of random matrices for neural networks.","volume":"97","author":"K Rajan","year":"2006","journal-title":"Phys Rev Lett"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1162\/neco.2008.02-07-474","article-title":"Correlations and population dynamics in cortical networks.","volume":"20","author":"B Kriener","year":"2008","journal-title":"Neural Comput"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1002059","DOI":"10.1371\/journal.pcbi.1002059","article-title":"How structure determines correlations in neuronal networks.","volume":"7","author":"V Pernice","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.socnet.2007.04.002","article-title":"Some unique properties of eigenvector centrality.","volume":"29","author":"P Bonacich","year":"2007","journal-title":"Soc Networks"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biosystems.2006.02.008","article-title":"Small-world connectivity, motif composition, and complexity of fractal neuronal connections.","volume":"85","author":"O Sporns","year":"2006","journal-title":"BioSystems"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2009.03.020","article-title":"Reading the book of memory: sparse sampling versus dense mapping of connectomes.","volume":"62","author":"HS Seung","year":"2009","journal-title":"Neuron"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e1002038","DOI":"10.1371\/journal.pcbi.1002038","article-title":"Neurobiologically realistic determinants of self-organized criticality in large networks of spiking neurons.","volume":"7","author":"M Rubinov","year":"2011","journal-title":"Plos Comput Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1523\/JNEUROSCI.3424-08.2009","article-title":"Dynamical response properties of neocortical neuron ensembles: multiplicative versus additive noise.","volume":"29","author":"C Boucsein","year":"2009","journal-title":"J Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnins.2011.00032","article-title":"Beyond the cortical column: abundance and physiology of horizontal connections imply a strong role for inputs from the surround.","volume":"5","author":"C Boucsein","year":"2011","journal-title":"Front Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.04.001.2009","article-title":"Precisely timed signal transmission in neocortical networks with reliable intermediate-range projections.","volume":"3","author":"MP Nawrot","year":"2009","journal-title":"Front Neural Circuits"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1152\/jn.1989.61.5.900","article-title":"Dynamics of neuronal firing correlation: modulation of \u201ceffective connectivity\u201d.","volume":"61","author":"A Aertsen","year":"1989","journal-title":"J Neurophysiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0167-2789(94)90278-X","article-title":"Dynamics of functional coupling in the cerebral cortex: an attempt at a model-based interpretation.","volume":"75","author":"A Aertsen","year":"1994","journal-title":"Physica D"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature09802","article-title":"Network anatomy and in vivo physiology of visual cortical neurons.","volume":"471","author":"DD Bock","year":"2011","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nn.2765","article-title":"Transfection via wholecell recording in vivo: bridging single-cell physiology, genetics and connectomics.","volume":"14","author":"EA Rancz","year":"2011","journal-title":"Nat Neurosci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nature08897","article-title":"Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice.","volume":"464","author":"T Komiyama","year":"2010","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2011.04.003","article-title":"Microcircuits of functionally identified neurons in the rat medial entorhinal cortex.","volume":"70","author":"A Burgalossi","year":"2011","journal-title":"Neuron"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"10734","DOI":"10.1523\/JNEUROSCI.1016-08.2008","article-title":"The statistics of repeating patterns of cortical activity can be reproduced by a model network of stochastic binary neurons.","volume":"28","author":"A Roxin","year":"2008","journal-title":"J Neurosci"},{"key":"ref57","article-title":"Structure, dynamics and function of brains: exploring relations and constraints.","author":"A Aertsen","year":"2010"},{"key":"ref58","article-title":"Controllability of switching networks of multi-agent systems.","author":"B Liu","year":"2011","journal-title":"International Journal of Robust and Nonlinear Control"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.conb.2003.11.001","article-title":"Deep brain stimulation for Parkinson's disease.","volume":"13","author":"AL Benabid","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevE.66.016128","article-title":"Spread of epidemic disease on networks.","volume":"66","author":"M Newman","year":"2002","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nature08932","article-title":"Catastrophic cascade of failures in interdependent networks.","volume":"464","author":"SV Buldyrev","year":"2010","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","DOI":"10.1609\/icwsm.v3i1.13937","article-title":"Gephi: an open source software for exploring and manipulating networks.","author":"M Bastian","year":"2009"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/spe.4380211102","article-title":"Graph drawing by force-directed placement.","volume":"21","author":"TMJ Fruchterman","year":"1991","journal-title":"Software Pract Exper"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0378-8733(83)90028-X","article-title":"Network structure and minimum degree.","volume":"5","author":"SB Seidman","year":"1983","journal-title":"Soc Networks"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/jctb.1996.0036","article-title":"Sudden emergence of a giant k-core in a random graph.","volume":"67","author":"B Pittel","year":"1996","journal-title":"J Comb Theory B"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4249\/scholarpedia.1430","article-title":"NEST (neural simulation tool).","volume":"2","author":"MO Gewaltig","year":"2007","journal-title":"Scholarpedia"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T02:00:17Z","timestamp":1686708017000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002311"}},"subtitle":[],"editor":[{"given":"Olaf","family":"Sporns","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,26]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002311","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,26]]}}}