{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T16:08:50Z","timestamp":1772294930001,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002316","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T21:55:11Z","timestamp":1327010111000},"page":"e1002316","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Senescent Cells in Growing Tumors: Population Dynamics and Cancer Stem Cells"],"prefix":"10.1371","volume":"8","author":[{"given":"Caterina A. M.","family":"La Porta","sequence":"first","affiliation":[]},{"given":"Stefano","family":"Zapperi","sequence":"additional","affiliation":[]},{"given":"James P.","family":"Sethna","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains.","volume":"25","author":"L Hayflick","year":"1961","journal-title":"Exp Cell Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.","volume":"444","author":"R Di Micco","year":"2006","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc2772","article-title":"Senescence in tumours: evidence from mice and humans.","volume":"10","author":"M Collado","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.humpath.2008.03.007","article-title":"Expression of \u03b3-H2AX in melanocytic lesions.","volume":"39","author":"MJ Wasco","year":"2008","journal-title":"Hum Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.","volume":"3","author":"D Bonnet","year":"1997","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature05574","article-title":"A single type of progenitor cell maintains normal epidermis.","volume":"446","author":"E Clayton","year":"2007","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1126\/science.1196236","article-title":"Intestinal stem cell replacement follows a pattern of neutral drift.","volume":"330","author":"C Lopez-Garcia","year":"2010","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1634\/stemcells.2007-0440","article-title":"Isolation and molecular characterization of cancer stem cells in MMTV-wnt-1 murine breast tumors.","volume":"26","author":"RW Cho","year":"2008","journal-title":"Stem Cells"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ejca.2007.01.017","article-title":"Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential.","volume":"43","author":"E Monzani","year":"2007","journal-title":"Eur J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/modpathol.3800720","article-title":"Increased expression of stem cell markers in malignant melanoma.","volume":"20","author":"WM Klein","year":"2007","journal-title":"Mod Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1016\/j.yexcr.2006.08.030","article-title":"SP analysis may be used to identify cancer stem cell populations.","volume":"312","author":"A Hadnagy","year":"2006","journal-title":"Exp Cell Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature06489","article-title":"Identification of cells initiating human melanomas.","volume":"451","author":"T Schatton","year":"2008","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbrc.2008.02.022","article-title":"MDR1 expression identifies human melanoma stem cells.","volume":"368","author":"GI Keshet","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nature09161","article-title":"Human melanomainitiating cells express neural crest nerve growth factor receptor CD271.","volume":"466","author":"AD Boiko","year":"2010","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cell.2010.04.020","article-title":"A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.","volume":"141","author":"A Roesch","year":"2010","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e15183","DOI":"10.1371\/journal.pone.0015183","article-title":"CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells.","volume":"5","author":"R Taghizadeh","year":"2010","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature07567","article-title":"Efficient tumour formation by single human melanoma cells.","volume":"456","author":"E Quintana","year":"2008","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ccr.2010.10.012","article-title":"Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized.","volume":"18","author":"E Quintana","year":"2010","journal-title":"Cancer Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2011.07.026","article-title":"Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.","volume":"146","author":"PB Gupta","year":"2011","journal-title":"Cell"},{"key":"ref20","article-title":"The theory of branching processes","author":"TE Harris","year":"1989"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1007\/b97371","article-title":"Branching processes in biology","author":"M Kimmel","year":"2002"},{"key":"ref22","first-page":"20","article-title":"Stochastic stem cell renewal.","volume":"15","author":"G Matioli","year":"1970","journal-title":"Rev Eur Etud Clin Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1242\/jcs.1988.Supplement_10.4","article-title":"Epithelial stem cells in vivo.","volume":"Suppl 10","author":"CS Potten","year":"1988","journal-title":"J Cell Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"P07028","DOI":"10.1088\/1742-5468\/2010\/07\/P07028","article-title":"Exact solution of a two-type branching process: clone size distribution in cell division kinetics.","volume":"2010","author":"T Antal","year":"2010","journal-title":"J Stat Mech"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.1073\/pnas.1007726107","article-title":"Role of symmetric and asymmetric division of stem cells in developing drug resistance.","volume":"107","author":"C Tomasetti","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"18545","DOI":"10.1073\/pnas.1010978107","article-title":"Accumulation of driver and passenger mutations during tumor progression.","volume":"107","author":"I Bozic","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1593\/neo.08572","article-title":"Pathways to tumorigenesis-modeling mutation acquisition in stem cells and their progeny.","volume":"10","author":"R Ashkenazi","year":"2008","journal-title":"Neoplasia"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e2213","DOI":"10.1371\/journal.pone.0002213","article-title":"Replicative senescence of mesenchymal stem cells: A continuous and organized process.","volume":"3","author":"W Wagner","year":"2008","journal-title":"PLoS ONE"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e5846","DOI":"10.1371\/journal.pone.0005846","article-title":"Aging and replicative senescence have related effects on human stem and progenitor cells.","volume":"4","author":"W Wagner","year":"2009","journal-title":"PLoS ONE"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/ijc.25482","article-title":"Survivin and escaping in therapyinduced cellular senescence.","volume":"128","author":"Q Wang","year":"2011","journal-title":"Int J Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1242\/jcs.00612","article-title":"Survivin is required for stable checkpoint activation in taxol-treated HeLa cells.","volume":"116","author":"A Carvalho","year":"2003","journal-title":"J Cell Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-4608(01)00396-X","article-title":"Amplification of hypoxiainducible factor 1alpha gene in prostate cancer.","volume":"128","author":"OR Saram\u00e4ki","year":"2001","journal-title":"Cancer Genet Cytogenet"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:43:37Z","timestamp":1540280617000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002316"}},"subtitle":[],"editor":[{"given":"Eytan","family":"Domany","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002316","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}