{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:10:36Z","timestamp":1773321036590,"version":"3.50.1"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1002322","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T21:38:49Z","timestamp":1325194729000},"page":"e1002322","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":123,"title":["Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome"],"prefix":"10.1371","volume":"7","author":[{"given":"Guillaume","family":"Guilbaud","sequence":"first","affiliation":[]},{"given":"Aur\u00e9lien","family":"Rappailles","sequence":"additional","affiliation":[]},{"given":"Antoine","family":"Baker","sequence":"additional","affiliation":[]},{"given":"Chun-Long","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Alain","family":"Arneodo","sequence":"additional","affiliation":[]},{"given":"Arach","family":"Goldar","sequence":"additional","affiliation":[]},{"given":"Yves","family":"d'Aubenton-Carafa","sequence":"additional","affiliation":[]},{"given":"Claude","family":"Thermes","sequence":"additional","affiliation":[]},{"given":"Benjamin","family":"Audit","sequence":"additional","affiliation":[]},{"given":"Olivier","family":"Hyrien","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10577-009-9100-8","article-title":"Domain-wide regulation of DNA replication timing during mammalian development.","volume":"18","author":"BD Pope","year":"2010","journal-title":"Chromosome Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.biochem.052308.103205","article-title":"Eukaryotic chromosome DNA replication: where, when, and how?","volume":"79","author":"H Masai","year":"2010","journal-title":"Annu Rev Biochem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/jcb.21828","article-title":"A revisionist replicon model for higher eukaryotic genomes.","volume":"105","author":"JL Hamlin","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.294.5540.115","article-title":"Replication dynamics of the yeast genome.","volume":"294","author":"MK Raghuraman","year":"2001","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1101\/gr.099796.109","article-title":"Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis.","volume":"20","author":"I Hiratani","year":"2010","journal-title":"Genome Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1038\/sj.emboj.7601390","article-title":"Genome-wide characterization of fission yeast DNA replication origins.","volume":"25","author":"C Heichinger","year":"2006","journal-title":"Embo J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1101\/gad.1246404","article-title":"Coordination of replication and transcription along a Drosophila chromosome.","volume":"18","author":"DM MacAlpine","year":"2004","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1371\/journal.pbio.0060245","article-title":"Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation.","volume":"6","author":"I Hiratani","year":"2008","journal-title":"PLoS Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1101\/gr.094060.109","article-title":"Predictable dynamic program of timing of DNA replication in human cells.","volume":"19","author":"R Desprat","year":"2009","journal-title":"Genome Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/hmg\/ddh016","article-title":"Replication timing of the human genome.","volume":"13","author":"K Woodfine","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1101\/gr.079566.108","article-title":"Global organization of replication time zones of the mouse genome.","volume":"18","author":"S Farkash-Amar","year":"2008","journal-title":"Genome Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1101\/gr.098947.109","article-title":"Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes.","volume":"20","author":"CL Chen","year":"2010","journal-title":"Genome Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1073\/pnas.0912402107","article-title":"Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.","volume":"107","author":"RS Hansen","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1101\/gr.099655.109","article-title":"Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types.","volume":"20","author":"T Ryba","year":"2010","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1046\/j.1365-2443.1997.1530351.x","article-title":"The efficiency and timing of initiation of replication of multiple replicons of Saccharomyces cerevisiae chromosome VI.","volume":"2","author":"M Yamashita","year":"1997","journal-title":"Genes Cells"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.1365-2443.1997.1520350.x","article-title":"Replication profile of Saccharomyces cerevisiae chromosome VI.","volume":"2","author":"KL Friedman","year":"1997","journal-title":"Genes Cells"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jmb.2007.10.046","article-title":"DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI.","volume":"375","author":"DM Czajkowsky","year":"2008","journal-title":"J Mol Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1091\/mbc.E05-07-0657","article-title":"DNA replication origins fire stochastically in fission yeast.","volume":"17","author":"PK Patel","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10577-009-9093-3","article-title":"Reconciling stochastic origin firing with defined replication timing.","volume":"18","author":"N Rhind","year":"2010","journal-title":"Chromosome Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/msb.2010.61","article-title":"Modeling genome-wide replication kinetics reveals a mechanism for regulation of replication timing.","volume":"6","author":"SC Yang","year":"2010","journal-title":"Mol Syst Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10577-009-9092-4","article-title":"Mathematical modelling of eukaryotic DNA replication.","volume":"18","author":"O Hyrien","year":"2010","journal-title":"Chromosome Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1093\/nar\/gkq343","article-title":"Mathematical modelling of whole chromosome replication.","volume":"38","author":"AP de Moura","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s004120050399","article-title":"Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci.","volume":"108","author":"R Berezney","year":"2000","journal-title":"Chromosoma"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0022-2836(68)90013-2","article-title":"On the mechanism of DNA replication in mammalian chromosomes.","volume":"32","author":"JA Huberman","year":"1968","journal-title":"J Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1083\/jcb.64.1.89","article-title":"Regulation of DNA replication on subchromosomal units of mammalian cells.","volume":"64","author":"R Hand","year":"1975","journal-title":"J Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0092-8674(78)90001-6","article-title":"Eucaryotic DNA: organization of the genome for replication.","volume":"15","author":"R Hand","year":"1978","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1083\/jcb.140.6.1285","article-title":"Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells.","volume":"140","author":"DA Jackson","year":"1998","journal-title":"J Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"28071","DOI":"10.1074\/jbc.M401574200","article-title":"Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.","volume":"279","author":"K Marheineke","year":"2004","journal-title":"J Biol Chem"},{"key":"ref29","first-page":"223","article-title":"Persistence length of chromatin determines origin spacing in Xenopus early-embryo DNA replication: quantitative comparisons between theory and experiment.","volume":"3","author":"S Jun","year":"2004","journal-title":"Cell Cycle"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1083\/jcb.152.1.15","article-title":"Replication Origins in Xenopus Egg Extract Are 5\u201315 Kilobases Apart and Are Activated in Clusters That Fire at Different Times.","volume":"152","author":"JJ Blow","year":"2001","journal-title":"J Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-4827(86)90583-5","article-title":"Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus.","volume":"165","author":"H Nakamura","year":"1986","journal-title":"Exp Cell Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1083\/jcb.116.5.1095","article-title":"Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences.","volume":"116","author":"RT O'Keefe","year":"1992","journal-title":"J Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1097-2765(00)80227-0","article-title":"The spatial position and replication timing of chromosomal domains are both established in early G1 phase.","volume":"4","author":"DS Dimitrova","year":"1999","journal-title":"Mol Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1083\/jcb.143.6.1415","article-title":"Spatial and temporal dynamics of DNA replication sites in mammalian cells.","volume":"143","author":"H Ma","year":"1998","journal-title":"J Cell Biol"},{"issue":"Pt 3","key":"ref35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1242\/jcs.103.3.857","article-title":"Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy.","volume":"103","author":"EM Manders","year":"1992","journal-title":"J Cell Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/excr.1996.0233","article-title":"Dynamic behavior of DNA replication domains.","volume":"226","author":"EM Manders","year":"1996","journal-title":"Exp Cell Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s004390050686","article-title":"Structure and dynamics of human interphase chromosome territories in vivo.","volume":"102","author":"D Zink","year":"1998","journal-title":"Hum Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1242\/jcs.01412","article-title":"Stable chromosomal units determine the spatial and temporal organization of DNA replication.","volume":"117","author":"N Sadoni","year":"2004","journal-title":"J Cell Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(02)00729-3","article-title":"DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters.","volume":"10","author":"A Sporbert","year":"2002","journal-title":"Mol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1000900","DOI":"10.1371\/journal.pgen.1000900","article-title":"S phase progression in human cells is dictated by the genetic continuity of DNA foci.","volume":"6","author":"A Maya-Mendoza","year":"2010","journal-title":"PLoS Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1083\/jcb.200905144","article-title":"Decreased replication origin activity in temporal transition regions.","volume":"187","author":"Z Guan","year":"2009","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.molcel.2005.10.029","article-title":"Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development.","volume":"20","author":"P Norio","year":"2005","journal-title":"Mol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1097-2765(00)80459-1","article-title":"Evidence that a single replication fork proceeds from early to late replicating domains in the IgH locus in a non-B cell line.","volume":"3","author":"OV Ermakova","year":"1999","journal-title":"Mol Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10577-009-9091-5","article-title":"Genome-wide analysis of the replication program in mammals.","volume":"18","author":"S Farkash-Amar","year":"2010","journal-title":"Chromosome Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1126\/science.277.5331.1518","article-title":"Dynamic molecular combing: stretching the whole human genome for high- resolution studies.","volume":"277","author":"X Michalet","year":"1997","journal-title":"Science"},{"key":"ref46","first-page":"575","article-title":"Use of DNA combing to study DNA replication in Xenopus and human cell-free systems","author":"K Marheineke","year":"2009"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.yexcr.2004.10.024","article-title":"Regulation of replication at the R\/G chromosomal band boundary and pericentromeric heterochromatin of mammalian cells.","volume":"304","author":"S Takebayashi","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0022-2836(75)90076-5","article-title":"Changes in the rate of DNA replication fork movement during S phase in mammalian cells.","volume":"94","author":"D Housman","year":"1975","journal-title":"J Mol Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00412-007-0145-1","article-title":"Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope.","volume":"117","author":"J Herrick","year":"2008","journal-title":"Chromosoma"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1158\/0008-5472.CAN-09-4691","article-title":"Spi-1\/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage.","volume":"70","author":"P Rimmele","year":"2010","journal-title":"Cancer Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1101\/gad.457807","article-title":"Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.","volume":"21","author":"XQ Ge","year":"2007","journal-title":"Genes Dev"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1242\/jcs.114.4.747","article-title":"The supply of exogenous deoxyribonucleotides accelerates the speed of the replication fork in early S-phase.","volume":"114","author":"J Malinsky","year":"2001","journal-title":"J Cell Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/sj.embor.7400736","article-title":"Broadening of DNA replication origin usage during metazoan cell differentiation.","volume":"7","author":"S Dazy","year":"2006","journal-title":"EMBO Rep"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/sj.embor.7400758","article-title":"HoxB domain induction silences DNA replication origins in the locus and specifies a single origin at its boundary.","volume":"7","author":"D Gregoire","year":"2006","journal-title":"EMBO Rep"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.200602108","article-title":"Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.","volume":"173","author":"AM Woodward","year":"2006","journal-title":"J Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2011.03.044","article-title":"Nucleotide deficiency promotes genomic instability in early stages of cancer development.","volume":"145","author":"AC Bester","year":"2011","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1091\/mbc.E06-08-0689","article-title":"Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells.","volume":"18","author":"C Conti","year":"2007","journal-title":"Mol Biol Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nature09745","article-title":"Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site.","volume":"470","author":"A Letessier","year":"2011","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1101\/gr.5427007","article-title":"Pan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areas.","volume":"17","author":"N Karnani","year":"2007","journal-title":"Genome Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrg2830","article-title":"Evaluating genome-scale approaches to eukaryotic DNA replication.","volume":"11","author":"DM Gilbert","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1128\/MCB.00380-10","article-title":"Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.","volume":"30","author":"SS Schultz","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1101\/gr.111328.110","article-title":"Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.","volume":"21","author":"LD Mesner","year":"2011","journal-title":"Genome Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","article-title":"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.","volume":"447","author":"E Birney","year":"2007","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1073\/pnas.0805208105","article-title":"Genome-wide studies highlight indirect links between human replication origins and gene regulation.","volume":"105","author":"JC Cadoret","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrm1008","article-title":"Replicating by the clock.","volume":"4","author":"A Goren","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.08.011","article-title":"Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers.","volume":"118","author":"N Gilbert","year":"2004","journal-title":"Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1093\/nar\/gkp631","article-title":"Open chromatin encoded in DNA sequence is the signature of \u2018master\u2019 replication origins in human cells.","volume":"37","author":"B Audit","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e5899","DOI":"10.1371\/journal.pone.0005899","article-title":"Universal temporal profile of replication origin activation in eukaryotes.","volume":"4","author":"A Goldar","year":"2009","journal-title":"PLoS One"},{"key":"ref69","article-title":"Do replication forks control late origin firing in S. cerevisiae?","author":"E Ma","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e2919","DOI":"10.1371\/journal.pone.0002919","article-title":"A dynamic stochastic model for DNA replication initiation in early embryos.","volume":"3","author":"A Goldar","year":"2008","journal-title":"PLoS ONE"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1006\/jmbi.2000.3500","article-title":"Mechanisms Ensuring Rapid and Complete DNA Replication Despite Random Initiation in Xenopus Early Embryos.","volume":"296","author":"I Lucas","year":"2000","journal-title":"J Mol Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1091\/mbc.E06-04-0298","article-title":"DNA replication origin interference increases the spacing between initiation events in human cells.","volume":"17","author":"R Lebofsky","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(03)00569-5","article-title":"Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.","volume":"114","author":"M Anglana","year":"2003","journal-title":"Cell"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/bies.10208","article-title":"Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem.","volume":"25","author":"O Hyrien","year":"2003","journal-title":"BioEssays"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1006\/jmbi.2000.3930","article-title":"Replication Fork Density Increases During DNA Synthesis in X. laevis Egg Extracts.","volume":"300","author":"J Herrick","year":"2000","journal-title":"J Mol Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nsmb.1419","article-title":"ATP-dependent chromatin remodeling shapes the DNA replication landscape.","volume":"15","author":"JA Vincent","year":"2008","journal-title":"Nat Struct Mol Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/35036309","article-title":"Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis.","volume":"2","author":"DS Dimitrova","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2144\/000113002","article-title":"An optimized easy method for preparing silanized surfaces for FISH and replication mapping on combed DNA fibers.","volume":"45","author":"H Labit","year":"2008","journal-title":"BioTechniques"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/nar\/29.7.1433","article-title":"Monitoring S phase progression globally and locally using BrdU incorporation in TK(+) yeast strains.","volume":"29","author":"A Lengronne","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/hmg\/ddq046","article-title":"ATR\/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells.","volume":"19","author":"E Despras","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-5193(83)90262-X","article-title":"A general expression for sequential DNA-fluorescence histograms.","volume":"102","author":"A Bertuzzi","year":"1983","journal-title":"J Theor Biol"},{"key":"ref82","first-page":"357","article-title":"Biomathematics and Cell Kinetics","author":"S Zietz","year":"1978"},{"key":"ref83","article-title":"A Wavelet Tour in Signal Processing","author":"S Mallat","year":"1998"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.physrep.2010.10.001","article-title":"Multi-scale coding of genomic information: from DNA sequence to genome structure and function.","volume":"498","author":"A Arneodo","year":"2011","journal-title":"Phys Rep"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/nar\/gkg129","article-title":"The UCSC Genome Browser Database.","volume":"31","author":"D Karolchik","year":"2003","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:24:52Z","timestamp":1640294692000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1002322"}},"subtitle":[],"editor":[{"given":"Christopher E.","family":"Pearson","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,12,29]]},"references-count":85,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1002322","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,29]]}}}